LOCUS       NM_001366508            4463 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens repulsive guidance molecule BMP co-receptor b (RGMB),
            transcript variant 1, mRNA.
ACCESSION   NM_001366508
VERSION     NM_001366508.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4463)
  AUTHORS   Novak,R., Ahmad,Y.A., Timaner,M., Bitman-Lotan,E.,
            Oknin-Vaisman,A., Horwitz,R., Hartmann,O., Reissland,M., Buck,V.,
            Rosenfeldt,M., Nikomarov,D., Diefenbacher,M.E., Shaked,Y. and
            Orian,A.
  TITLE     RNF4 RGMb BMP6 axis required for osteogenic differentiation and
            cancer cell survival
  JOURNAL   Cell Death Dis 13 (9), 820 (2022)
   PUBMED   36153321
  REMARK    GeneRIF: RNF4~RGMb~BMP6 axis required for osteogenic
            differentiation and cancer cell survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4463)
  AUTHORS   Malinauskas,T., Peer,T.V., Bishop,B., Mueller,T.D. and Siebold,C.
  TITLE     Repulsive guidance molecules lock growth differentiation factor 5
            in an inhibitory complex
  JOURNAL   Proc Natl Acad Sci U S A 117 (27), 15620-15631 (2020)
   PUBMED   32576689
  REMARK    GeneRIF: Repulsive guidance molecules lock growth differentiation
            factor 5 in an inhibitory complex.
REFERENCE   3  (bases 1 to 4463)
  AUTHORS   Sekiya,T. and Takaki,S.
  TITLE     RGMB enhances the suppressive activity of the monomeric secreted
            form of CTLA-4
  JOURNAL   Sci Rep 9 (1), 6984 (2019)
   PUBMED   31061392
  REMARK    GeneRIF: RGMB enhances the suppressive activity of the monomeric
            secreted form of CTLA-4.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4463)
  AUTHORS   Li,J., Ye,L., Shi,X., Chen,J., Feng,F., Chen,Y., Xiao,Y., Shen,J.,
            Li,P., Jiang,W.G. and He,J.
  TITLE     Repulsive guidance molecule B inhibits metastasis and is associated
            with decreased mortality in non-small cell lung cancer
  JOURNAL   Oncotarget 7 (13), 15678-15689 (2016)
   PUBMED   26910889
  REMARK    GeneRIF: Our results demonstrate that RGMB is an important
            inhibitor of non-small cell lung cancer metastasis and that low
            RGMB expression is a novel predictor or a poor prognosis.
REFERENCE   5  (bases 1 to 4463)
  AUTHORS   Li,P., Li,J., Yang,R., Zhang,F., Wang,H., Chu,H., Lu,Y., Dun,S.,
            Wang,Y., Zang,W., Du,Y., Chen,X., Zhao,G. and Zhang,G.
  TITLE     Study on expression of lncRNA RGMB-AS1 and repulsive guidance
            molecule b in non-small cell lung cancer
  JOURNAL   Diagn Pathol 10, 63 (2015)
   PUBMED   26055877
  REMARK    GeneRIF: RGMB was down-regulation in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4463)
  AUTHORS   Li,J., Ye,L., Mansel,R.E. and Jiang,W.G.
  TITLE     Potential prognostic value of repulsive guidance molecules in
            breast cancer
  JOURNAL   Anticancer Res 31 (5), 1703-1711 (2011)
   PUBMED   21617229
  REMARK    GeneRIF: Reduced expression of RGMB in breast cancer was associated
            with breast cancer.
REFERENCE   7  (bases 1 to 4463)
  AUTHORS   Salyakina,D., Ma,D.Q., Jaworski,J.M., Konidari,I., Whitehead,P.L.,
            Henson,R., Martinez,D., Robinson,J.L., Sacharow,S., Wright,H.H.,
            Abramson,R.K., Gilbert,J.R., Cuccaro,M.L. and Pericak-Vance,M.A.
  TITLE     Variants in several genomic regions associated with asperger
            disorder
  JOURNAL   Autism Res 3 (6), 303-310 (2010)
   PUBMED   21182207
REFERENCE   8  (bases 1 to 4463)
  AUTHORS   Liu,X., Hashimoto,M., Horii,H., Yamaguchi,A., Naito,K. and
            Yamashita,T.
  TITLE     Repulsive guidance molecule b inhibits neurite growth and is
            increased after spinal cord injury
  JOURNAL   Biochem Biophys Res Commun 382 (4), 795-800 (2009)
   PUBMED   19324014
REFERENCE   9  (bases 1 to 4463)
  AUTHORS   Samad,T.A., Rebbapragada,A., Bell,E., Zhang,Y., Sidis,Y.,
            Jeong,S.J., Campagna,J.A., Perusini,S., Fabrizio,D.A.,
            Schneyer,A.L., Lin,H.Y., Brivanlou,A.H., Attisano,L. and Woolf,C.J.
  TITLE     DRAGON, a bone morphogenetic protein co-receptor
  JOURNAL   J Biol Chem 280 (14), 14122-14129 (2005)
   PUBMED   15671031
REFERENCE   10 (bases 1 to 4463)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008522.6.
            
            Summary: RGMB is a glycosylphosphatidylinositol (GPI)-anchored
            member of the repulsive guidance molecule family (see RGMA, MIM
            607362) and contributes to the patterning of the developing nervous
            system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM,
            Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.151516.1,
                                           SRR1803617.28856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513185.3/ ENSP00000423256.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               AC008522.6         121378-121921
            545-1053            AC008522.6         127295-127803
            1054-4463           AC008522.6         140800-144209
FEATURES             Location/Qualifiers
     source          1..4463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..4463
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /note="repulsive guidance molecule BMP co-receptor b"
                     /db_xref="GeneID:285704"
                     /db_xref="HGNC:HGNC:26896"
                     /db_xref="MIM:612687"
     exon            1..544
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1722
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; repulsive guidance molecule B; DRG11-responsive
                     axonal guidance and outgrowth of neurite; RGM domain
                     family, member B; repulsive guidance molecule family
                     member b"
                     /codon_start=1
                     /product="repulsive guidance molecule B isoform 1
                     precursor"
                     /protein_id="NP_001353437.1"
                     /db_xref="CCDS:CCDS93751.1"
                     /db_xref="GeneID:285704"
                     /db_xref="HGNC:HGNC:26896"
                     /db_xref="MIM:612687"
                     /translation="MGLRAAPSSAAAAAAEVEQRRSPGLCPPPLELLLLLLFSLGLLH
                     AGDCQQPAQCRIQKCTTDFVSLTSHLNSAVDGFDSEFCKALRAYAGCTQRTSKACRGN
                     LVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYHSHAGAREHRRGDQNPPSY
                     LFCGLFGDPHLRTFKDNFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKITI
                     IFKAHHECTDQKVYQAVTDDLPAAFVDGTTSGGDSDAKSLRIVERESGHYVEMHARYI
                     GTTVFVRQVGRYLTLAIRMPEDLAMSYEESQDLQLCVNGCPLSERIDDGQGQVSAILG
                     HSLPRTSLVQAWPGYTLETANTQCHEKMPVKDIYFQSCVFDLLTTGDANFTAAAHSAL
                     EDVEALHPRKERWHIFPSSGNGTPRGGSDLSVSLGLTCLILIVFL"
     exon            545..1053
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..4463
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4437..4442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /note="hexamer: AATAAA"
     polyA_site      4463
                     /gene="RGMB"
                     /gene_synonym="DRAGON"
                     /note="major polyA site"
ORIGIN      
        1 gcagagatat ccgggccgcc ggtgggtggt cgctagggct gggccagcct cttggaggtc
       61 cacgcccgcc gagcccacgc tggctggggc cggggtgccg gcgcgctcgg gactcgtctc
      121 agcagtcgct cacggtcttt gtgtcttctc ttccgcccct ttccctgcct gccgcctccg
      181 gccgccacga tgcccctgcg ccccgctgct gccgccgcgg actggctgcg ccggctgcgc
      241 gctgcttgct gcggcggtgg tggcgcccca tctgctacac gggcctgaag aaggaagaag
      301 aggaagcgaa gcgcgccccc cggcccatgc cgcagccacg ggcccagacc cgccacggcg
      361 cccgcgccgc cgccctcgcc ggagcccacg agacctgcat ggacgggcat gggcttgaga
      421 gcagcacctt ccagcgccgc cgctgccgcc gccgaggttg agcagcgccg cagccccggg
      481 ctctgccccc cgccgctgga gctgctgctg ctgctgctgt tcagcctcgg gctgctccac
      541 gcaggtgact gccaacagcc agcccaatgt cgaatccaga aatgcaccac ggacttcgtg
      601 tccctgactt ctcacctgaa ctctgccgtt gacggctttg actctgagtt ttgcaaggcc
      661 ttgcgtgcct atgctggctg cacccagcga acttcaaaag cctgccgtgg caacctggta
      721 taccattctg ccgtgttggg tatcagtgac ctcatgagcc agaggaattg ttccaaggat
      781 ggacccacat cctctaccaa ccccgaagtg acccatgatc cttgcaacta tcacagccac
      841 gctggagcca gggaacacag gagaggggac cagaaccctc ccagttacct tttttgtggc
      901 ttgtttggag atcctcacct cagaactttc aaggataact tccaaacatg caaagtagaa
      961 ggggcctggc cactcataga taataattat ctttcagttc aagtgacaaa cgtacctgtg
     1021 gtccctggat ccagtgctac tgctacaaat aagatcacta ttatcttcaa agcccaccat
     1081 gagtgtacag atcagaaagt ctaccaagct gtgacagatg acctgccggc cgcctttgtg
     1141 gatggcacca ccagtggtgg ggacagcgat gccaagagcc tgcgtatcgt ggaaagggag
     1201 agtggccact atgtggagat gcacgcccgc tatataggga ccacagtgtt tgtgcggcag
     1261 gtgggtcgct acctgaccct tgccatccgt atgcctgaag acctggccat gtcctacgag
     1321 gagagccagg acctgcagct gtgcgtgaac ggctgccccc tgagtgaacg catcgatgac
     1381 gggcagggcc aggtgtctgc catcctggga cacagcctgc ctcgcacctc cttggtgcag
     1441 gcctggcctg gctacacact ggagactgcc aacactcaat gccatgagaa gatgccagtg
     1501 aaggacatct atttccagtc ctgtgtcttc gacctgctca ccactggtga tgccaacttt
     1561 actgccgcag cccacagtgc cttggaggat gtggaggccc tgcacccaag gaaggaacgc
     1621 tggcacattt tccccagcag tggcaatggg actccccgtg gaggcagtga tttgtctgtc
     1681 agtctaggac tcacctgctt gatccttatc gtgtttttgt aggggttgtc ttttgttttg
     1741 gttttttatt ttttgtctat aacaaaattt taaaatatat attgtcataa tatattgagt
     1801 aaaagagtat atatgtatat accatgtata tgacaggatg tttgtcctgg gacacccacc
     1861 agattgtaca tactgtgttt ggctgttttc acatatgttg gatgtagtgt tctttgattg
     1921 tatcaatttt gttttgcagt tctgtgaaat gttttataat gtccctgccc agggacctgt
     1981 tagaaagcac tttatttttt atatattaaa tatttatgtg tgtgcttggt tgatatgtat
     2041 agtacatata cacagacatc catatgcagc gtttcctttg aaggtgacca gttgtttgta
     2101 gctattcttg gctgtacctt cctgcccttt cccattgcta ctgatttgcc acggtgtgca
     2161 gcttttactc gccaccttcc ggtggagctg cctcgttcct ttgaactatg ccctcaccct
     2221 tctgccctca cttgatttga aagggtcgtt aactctccct tacaggtgct ttgactctta
     2281 aacgctgatc ttaagaagct ctcttcatct aagagctgtt actttttcag aagggggggt
     2341 attattggta ttctgattac tctcaattct aattgttata tatttgagcc catacagtgt
     2401 attaggttga accatagaaa ctgctattct cgtaggtcaa aagggtctag tgatggaagt
     2461 tttgtagata agtaccaggc atctcagtaa ctcctagact ttttctcatc ccatgccccg
     2521 ttttaaattg tcagttttcc ctctgactct tctgtgttaa aacatgaaac tataaattta
     2581 gtaattatca tgccttgctc tttttaatct atatgactga tgcaagcccc tcttcttaac
     2641 cgtttcttgg ctttgagccc agaaacacag ctctccctgt ctccaactcc agtaagccct
     2701 cctcagcctc accttacgaa tccaaagaac tggggtttgt taggttcttt ctctaatgta
     2761 gaggcccaga tcccatcaca aagtttttca ttcttccttg tccaccatga tcttcatcac
     2821 agtctttgat atgtctgcat gcaaagtgga acagagttgg gcggcaatga cagaagagct
     2881 tccttggcct gactcggtgt gcggccactt cggcactgct taatccagat attcttgtta
     2941 actaagcatt gtgcttccca ggtggtctga agtcaggtac tctctctctc aacacctgta
     3001 gttgaatatg atttggtcag ttgctcgttg taacttggag aaattcctat aaagtaagat
     3061 ctccttgcct cttccatcca ttgttggcac ccccttgcaa aaggaaaaga acagcaaaag
     3121 tcaggagcag taatctgaga aagttaactc caggataggt aggtttctat tgttatagct
     3181 agatgtaaat ctttagttcc aagaagtgat agagtttctg ctttaataat ttgttgataa
     3241 gtttacataa acagaaataa aagatactat ctttaccgta gtagttcagg ccaagattat
     3301 gcttagtttt agttctccag gtagttactt ttgccatgtc ctattgatca gtgacactgc
     3361 cagaggccca taccggcaag aggaagagga cgtcattttg taaagtttaa cttcttagcg
     3421 aactgatgtg ccacccagtc acagagtgga gttgtgaatt catgtagagg tggcaaacct
     3481 ctaccttgtg ttgatgagag aataatcttg ggcagtctgg gaaaataagg aaggcatctc
     3541 cttcttactc atggagattc aactatagag agttgaaacc taaacccgcc ttccttttat
     3601 agaagctgga ctagagacgg actgaccatc agctctgaac tgtggctttt tttgttcacc
     3661 tatgatgcca tgtaccaaat tcagaagcta tcgttaataa tttgttttat aattgagtag
     3721 tacaagcgag gaaaaaatac ggaggataac cactattttt gtgcaaataa tatgaaagtg
     3781 aagtaaaagc aatagaagaa atttctatag gatctgggtt tagagtgtgt atcattaata
     3841 aatatacctt tgctcttttc agggaaaata acaaccaccc ttactgatag ttgggaaaag
     3901 aagattgggt tattttgcca tatcatttag ctggaagtga catttaaaag caccctgcat
     3961 cactagtaat agtgtatttt gctattctgc ccttgtaatc ggtgtccctg taaaacaatc
     4021 cccacagatt actttcagaa atagatgtat ttctctacgt aagggccagg tttattttct
     4081 ccttttttga gatttctaga aaaaatgctg cttgcacatg ttggttcttg aaaccttagc
     4141 tagaagaatt tcaggtcata ccaacatgtg gataggctat agctgttcag aggtctcctg
     4201 ggggagctta aaacggggga aacactggtt ttcacagatg ctccacatgg ctgtctttaa
     4261 aagactcaaa actttttttt gtcctctttg ttatgcttgg aagctccccc ccccccaaca
     4321 gtgtgtcgag tctttgcaaa gaaaccttta gatgtggttc atagatatat gaatacgtat
     4381 ctgtgtaaaa cagtgagtgt gcagtgtgta aatactttaa attattatgc tagaaaaata
     4441 aagttacata ccttgctgtg gaa
//
