LOCUS       NM_020211              11359 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens repulsive guidance molecule BMP co-receptor a (RGMA),
            transcript variant 4, mRNA.
ACCESSION   NM_020211
VERSION     NM_020211.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11359)
  AUTHORS   Lun,J., Zhang,Y., Yu,M., Zhai,W., Zhu,L., Liu,H., Guo,J., Zhang,G.,
            Qiu,W. and Fang,J.
  TITLE     Circular RNA circHIPK2 inhibits colon cancer cells through
            miR-373-3p/RGMA axis
  JOURNAL   Cancer Lett 593, 216957 (2024)
   PUBMED   38762192
  REMARK    GeneRIF: Circular RNA circHIPK2 inhibits colon cancer cells through
            miR-373-3p/RGMA axis.
REFERENCE   2  (bases 1 to 11359)
  AUTHORS   Liu,D., Zusman,B.E., Shaffer,J.R., Li,Y., Arockiaraj,A.I., Liu,S.,
            Weeks,D.E., Desai,S.M., Kochanek,P.M., Puccio,A.M., Okonkwo,D.O.,
            Conley,Y.P. and Jha,R.M.
  TITLE     Decreased DNA Methylation of RGMA is Associated with Intracranial
            Hypertension After Severe Traumatic Brain Injury: An Exploratory
            Epigenome-Wide Association Study
  JOURNAL   Neurocrit Care 37 (1), 26-37 (2022)
   PUBMED   35028889
  REMARK    GeneRIF: Decreased DNA Methylation of RGMA is Associated with
            Intracranial Hypertension After Severe Traumatic Brain Injury: An
            Exploratory Epigenome-Wide Association Study.
REFERENCE   3  (bases 1 to 11359)
  AUTHORS   Kousathanas,A., Pairo-Castineira,E., Rawlik,K., Stuckey,A.,
            Odhams,C.A., Walker,S., Russell,C.D., Malinauskas,T., Wu,Y.,
            Millar,J., Shen,X., Elliott,K.S., Griffiths,F., Oosthuyzen,W.,
            Morrice,K., Keating,S., Wang,B., Rhodes,D., Klaric,L., Zechner,M.,
            Parkinson,N., Siddiq,A., Goddard,P., Donovan,S., Maslove,D.,
            Nichol,A., Semple,M.G., Zainy,T., Maleady-Crowe,F., Todd,L.,
            Salehi,S., Knight,J., Elgar,G., Chan,G., Arumugam,P., Patch,C.,
            Rendon,A., Bentley,D., Kingsley,C., Kosmicki,J.A., Horowitz,J.E.,
            Baras,A., Abecasis,G.R., Ferreira,M.A.R., Justice,A., Mirshahi,T.,
            Oetjens,M., Rader,D.J., Ritchie,M.D., Verma,A., Fowler,T.A.,
            Shankar-Hari,M., Summers,C., Hinds,C., Horby,P., Ling,L.,
            McAuley,D., Montgomery,H., Openshaw,P.J.M., Elliott,P., Walsh,T.,
            Tenesa,A., Fawkes,A., Murphy,L., Rowan,K., Ponting,C.P., Vitart,V.,
            Wilson,J.F., Yang,J., Bretherick,A.D., Scott,R.H., Hendry,S.C.,
            Moutsianas,L., Law,A., Caulfield,M.J. and Baillie,J.K.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   4  (bases 1 to 11359)
  AUTHORS   Tang,J., Zeng,X., Li,H., Ju,L., Feng,J. and Yang,J.
  TITLE     Repulsive Guidance Molecule-a and Central Nervous System Diseases
  JOURNAL   Biomed Res Int 2021, 5532116 (2021)
   PUBMED   33997000
  REMARK    GeneRIF: Repulsive Guidance Molecule-a and Central Nervous System
            Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11359)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 11359)
  AUTHORS   Xia,Y., Yu,P.B., Sidis,Y., Beppu,H., Bloch,K.D., Schneyer,A.L. and
            Lin,H.Y.
  TITLE     Repulsive guidance molecule RGMa alters utilization of bone
            morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
  JOURNAL   J Biol Chem 282 (25), 18129-18140 (2007)
   PUBMED   17472960
  REMARK    GeneRIF: RGMa facilitates the use of ActRIIA by endogenous BMP2 and
            BMP4 ligands that otherwise prefer signaling via BMPRII and
            increased utilization of ActRIIA leads to generation of an enhanced
            BMP signal
REFERENCE   7  (bases 1 to 11359)
  AUTHORS   Schwab,J.M., Monnier,P.P., Schluesener,H.J., Conrad,S.,
            Beschorner,R., Chen,L., Meyermann,R. and Mueller,B.K.
  TITLE     Central nervous system injury-induced repulsive guidance molecule
            expression in the adult human brain
  JOURNAL   Arch Neurol 62 (10), 1561-1568 (2005)
   PUBMED   16216939
  REMARK    GeneRIF: Following central nervous system injury, RGM, a novel,
            potent axonal growth inhibitor, is present in axonal growth
            impediments: the mature myelin, choroid plexus, and components of
            the developing scar.
REFERENCE   8  (bases 1 to 11359)
  AUTHORS   Babitt,J.L., Zhang,Y., Samad,T.A., Xia,Y., Tang,J., Campagna,J.A.,
            Schneyer,A.L., Woolf,C.J. and Lin,H.Y.
  TITLE     Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone
            morphogenetic protein co-receptor
  JOURNAL   J Biol Chem 280 (33), 29820-29827 (2005)
   PUBMED   15975920
REFERENCE   9  (bases 1 to 11359)
  AUTHORS   Rajagopalan,S., Deitinghoff,L., Davis,D., Conrad,S., Skutella,T.,
            Chedotal,A., Mueller,B.K. and Strittmatter,S.M.
  TITLE     Neogenin mediates the action of repulsive guidance molecule
  JOURNAL   Nat Cell Biol 6 (8), 756-762 (2004)
   PUBMED   15258590
REFERENCE   10 (bases 1 to 11359)
  AUTHORS   Brinks,H., Conrad,S., Vogt,J., Oldekamp,J., Sierra,A.,
            Deitinghoff,L., Bechmann,I., Alvarez-Bolado,G., Heimrich,B.,
            Monnier,P.P., Mueller,B.K. and Skutella,T.
  TITLE     The repulsive guidance molecule RGMa is involved in the formation
            of afferent connections in the dentate gyrus
  JOURNAL   J Neurosci 24 (15), 3862-3869 (2004)
   PUBMED   15084667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA805034.1, AL136826.1,
            AC087641.5 and AC013394.12.
            
            On Jun 2, 2019 this sequence version replaced NM_020211.2.
            
            Summary: This gene encodes a member of the repulsive guidance
            molecule family. The encoded protein is a
            glycosylphosphatidylinositol-anchored glycoprotein that functions
            as an axon guidance protein in the developing and adult central
            nervous system. This protein may also function as a tumor
            suppressor in some cancers. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (3) has a distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074910.1, AL136826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000329082.12/ ENSP00000330005.7
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               DA805034.1         4-186
            184-1779            AL136826.1         1-1596
            1780-5117           AC087641.5         127281-130618       c
            5118-11359          AC013394.12        1-6242
FEATURES             Location/Qualifiers
     source          1..11359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..11359
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="repulsive guidance molecule BMP co-receptor a"
                     /db_xref="GeneID:56963"
                     /db_xref="HGNC:HGNC:30308"
                     /db_xref="MIM:607362"
     exon            1..293
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1632
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 4; repulsive guidance molecule A; RGM domain
                     family, member A; repulsive guidance molecule family
                     member a"
                     /codon_start=1
                     /product="repulsive guidance molecule A isoform 3
                     precursor"
                     /protein_id="NP_064596.2"
                     /db_xref="CCDS:CCDS45357.1"
                     /db_xref="GeneID:56963"
                     /db_xref="HGNC:HGNC:30308"
                     /db_xref="MIM:607362"
                     /translation="MQPPRERLVVTGRAGWMGMGRGAGRSALGFWPTLAFLLCSFPAA
                     TSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSA
                     VHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNY
                     THCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTI
                     IFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKY
                     IGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNA
                     EGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTL
                     AAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC
                     "
     exon            294..409
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     exon            410..924
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     exon            925..11359
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="hexamer: AGTAAA"
     polyA_site      3214
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="major polyA site"
     regulatory      11338..11343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="hexamer: AATAAA"
     polyA_site      11359
                     /gene="RGMA"
                     /gene_synonym="RGM"
ORIGIN      
        1 actctgcagt tgtctcccga gcgctggctg cgccgcccga gccgctgggc cggggaagca
       61 ctggccgttc gctcccgggc cggctccgcc aggcgctcgc aggcatgcag cccgggagca
      121 ggaggcgctc cccgggccgc tgctgagccg gccggggcgg cggggaccag cgccagcgga
      181 gcccctccca ccttgccccg gggcagacga gcggcgcccc gacaccccct cttctcccgc
      241 agccccgcca gcgccacccc ccgcgggccg caggggctca tgcagccgcc aagggagagg
      301 ctagtggtaa caggccgagc tggatggatg ggtatgggga gaggggcagg acgttcagcc
      361 ctgggattct ggccgaccct cgccttcctt ctctgcagct tccccgcagc cacctccccg
      421 tgcaagatcc tcaagtgcaa ctctgagttc tggagcgcca cgtcgggcag ccacgcccca
      481 gcctcagacg acacccccga gttctgtgca gccttgcgca gctacgccct gtgcacgcgg
      541 cggacggccc gcacctgccg gggtgacctg gcctaccact cggccgtcca tggcatagag
      601 gacctcatga gccagcacaa ctgctccaag gatggcccca cctcgcagcc acgcctgcgc
      661 acgctcccac cggccggaga cagccaggag cgctcggaca gccccgagat ctgccattac
      721 gagaagagct ttcacaagca ctcggccacc cccaactaca cgcactgtgg cctcttcggg
      781 gacccacacc tcaggacttt caccgaccgc ttccagacct gcaaggtgca gggcgcctgg
      841 ccgctcatcg acaataatta cctgaacgtg caggtcacca acacgcctgt gctgcccggc
      901 tcagcggcca ctgccaccag caagctcacc atcatcttca agaacttcca ggagtgtgtg
      961 gaccagaagg tgtaccaggc tgagatggac gagctcccgg ccgccttcgt ggatggctct
     1021 aagaacggtg gggacaagca cggggccaac agcctgaaga tcactgagaa ggtgtcaggc
     1081 cagcacgtgg agatccaggc caagtacatc ggcaccacca tcgtggtgcg ccaggtgggc
     1141 cgctacctga cctttgccgt ccgcatgcca gaggaagtgg tcaatgctgt ggaggactgg
     1201 gacagccagg gtctctacct ctgcctgcgg ggctgccccc tcaaccagca gatcgacttc
     1261 caggccttcc acaccaatgc tgagggcacc ggtgcccgca ggctggcagc cgccagccct
     1321 gcacccacag cccccgagac cttcccatac gagacagccg tggccaagtg caaggagaag
     1381 ctgccggtgg aggacctgta ctaccaggcc tgcgtcttcg acctcctcac cacgggcgac
     1441 gtgaacttca cactggccgc ctactacgcg ttggaggatg tcaagatgct ccactccaac
     1501 aaagacaaac tgcacctgta tgagaggact cgggacctgc caggcagggc ggctgcgggg
     1561 ctgcccctgg ccccccggcc cctcctgggc gccctcgtcc cgctcctggc cctgctccct
     1621 gtgttctgct agacgcgtag atgtggaggg aggcgcgggc tccgtcctct cggcttcccc
     1681 atgtgtgggc tgggaccgcc cacggggtgc agatctcctg gcgtgtccac catggccccg
     1741 cagaacgcca gggaccgcct gctgccaagg gctcaggcac ggacccctcc ccttctagtg
     1801 cacgtgacaa ggttgtggtg actggtgcca tgatgtttga cagtagagct gtgtgagagg
     1861 gagagcagct cccctcgccc cgcccctgca gtgtgaatgt gtgaaacatc ccctcaggct
     1921 gaagcccccc acccccacca gagacacact gggaaccgtc agagtcagct ccttccccct
     1981 cgcaatgcac tgaaaggccc ggccgactgc tgctcgccga tccgtggggc cccctgtgcc
     2041 cgccacacgc acgcacacac tcttacacga gagcacactc gatcccccta ggccagcggg
     2101 gacaccccag ccacacaggg aggcatcctt ggggcttggc cccaggcagg gcaaccccgg
     2161 ggcgctgctt ggcaccttag cagactgctg gaaccttttg gccagtaggt cgtgcccgcc
     2221 tggtgccttc tggcctgtgg cctccctgcc catgttcacc tggctgctgt gggtaccagt
     2281 gcaggtcccg gttttcaggc acctgctcag ctgcccgtct ctggcctggg cccctgcccc
     2341 ttccaccctg tgcttagaaa gtcgaagtgc ttggttctaa atgtctaaac agagaagaga
     2401 tccttgactt ctgttcctct ctctcctgca gatgcaagag ctcctgggca ggggtgcctg
     2461 ggccccaggg tgtggcagga gacccagtgg atggggccag ctggcctgcc ctgatcctct
     2521 gcttcctcct cacaacccca agagccccca gcccggtcca tccacgtctg gagtctgggg
     2581 agaggagcag ggtcttagga ctctcagctc tgagcatccc tggcagggtc ttcaacctct
     2641 aatctcttcc cttaagccct gtggccacac agccaggaga gacttgccgc tggctcccgc
     2701 ctcatttcag cccagggtgc tcatccaggg gcccagaaca gtcccacctg tgctgctgtg
     2761 cccacagcac aaagccaggc ttcactccca aaagtgcagc caggccctgg agggtgatcc
     2821 tgccagcagc cctacagctc cacaccctac ccacccatcg gcagcccctc tgctgttccc
     2881 cagggacctc tcatacactg gccaggaggc tgcagaacgt gtgtctcccc ctccctccaa
     2941 gaggtcctgc tccctctgcc agaaccgtgt gtgggcgggt gggagggcgc tcggggcccg
     3001 gcccctccct ctccctgctg gttttagttg gtccctatgt tggaagtaaa aagtgaagca
     3061 ctttattttg gttgtgtttg ctcacgttct gcttggaagt ggggacccct cactgcgtcc
     3121 acgtgtctgc gacctgtgtg gagtgtcacc gcgtgtacat actgtaaatt atttattaat
     3181 ggctaaatgc aagtaaagtt tggttttttt gttattttct tttagacgtg ttggagtttg
     3241 ttttctgaac agactttggc tcccttgagg cgggtggagg atggactttg gtggtgggat
     3301 cccctgcagc aagtgtgtgt gtgtgcgcgc atgtgtgtgt gcgcgcatgt gtgtatgcat
     3361 gcctgtgtgt gtgcgtgcct gtgtgcgtgc atgtacgcat gtgtgcgcat gcctgtgtgt
     3421 gcgcccatgc ctatgtgtgt gcatgtaggc atgtgtgtgc gcatgtgtat gtgcgtgaga
     3481 atggtgtgaa ggcggataga agatgcagca gtttaacagc caccacacat tgcttttgta
     3541 aagtcacttt tcctcctcac gatgagctgt ctttggagct tggcaggccc agatcctctt
     3601 gttctagtga cagtggaaca cagtcaggga gacaggtgac tatgtggtgg agagacatat
     3661 ggtgccctct gggatgagat gggtgggata gcctgagatc tgggatgact ccctctcagc
     3721 cactgctatc agcctggagc cccagctgtt gggactgcct gccaccctcc ctgccagtgc
     3781 ccatcttctc atagcccggg cggagcagtg gtgctgcagg aggctgctgt ccacgtcact
     3841 gtgggaccag gtttattggc agctgtgatc acatttcatc tgtacaaact acccagtgaa
     3901 tcaggaagaa attcaggccc attttgccga tgaaacagac tctgagatta actgacttgc
     3961 ctagggctcc ttagcaacgg gaaggacaac ctgtgcacct aggttagtat tgtcctgaag
     4021 ccccttctct tcaaactaaa tgccatgagg cagaatagca gcacagttaa gccagcctac
     4081 atcctggctt ctccacctcc ccagcagtgt gaccatgggc aagtcacttc acctctctga
     4141 gcctgcatgc tgttctctgg aagatggggg ggtgcctgtc ccatacagtt gtttggagag
     4201 tcaggagttc attcctgtaa attgcttagg agagggcggg gcacacatgg cttgtctggt
     4261 cgtggggagg gagggggtgg tattatccca aagcaagata aatcagttaa ggggagaagg
     4321 aaaggggcga tacagaccct ggactcttgg gagaggtgaa cctgcaggct agcaagggga
     4381 ggagtcccaa gagtggccaa gttcattaat cccaggcaga ccaggaaggc tgaagaaaaa
     4441 ggagaacttt attttatttt tgaaatggag tctggcgtct tgctctgtcg ccaggctgga
     4501 gtgcagtggc accatcccag ctcactgcag cccctgcctc ccaggttcaa gcaattctcc
     4561 tgcctcagcc tcccaagtag ctgggactac aggcacacac caccacgcct ggctaatttt
     4621 ttgtatttta gtagagatgg tgtttcacca tgttgaccag tatggtcttg atctcctgac
     4681 ctcgtgatcc gcctgccttg gcctcccaaa gtgttgggat tacaggcgtg agccaccacc
     4741 gtgcccggcc aaaaaaggag aacgttctaa agccctgttc ttgcagggct cccagagaga
     4801 acacgggagt tgggtttggg aggcaggaac cagactggaa aggacaaaac gtacccagca
     4861 tcttccctgg cggccggaac cgtcactaca ggccccgtgc ccttagcagt cccagggaca
     4921 gagcgactca gggaggcagc aaggaggagc ggagccattg gtgctcgtcc ggcacagaga
     4981 acagttcctg agaagccagg gcacacagaa gaaaaagaaa aaagaaatct ctactagacg
     5041 aaaatgctaa atggcactag ccacaaagta ttcttggttt ggaatttttt ttccaggacc
     5101 ctaaatgtaa ccggctggaa ttctttccca agtgccatgc tacttactac tggttgccct
     5161 cacgagcatg gaaatgccgt cgtgaatatg gaacacagca tcctgagcta aaagattccc
     5221 aagaagcagc ttcatcttgc aggacgggct aggttgggag cctctggagg ttcctggctg
     5281 ccagctccgc ggaggcctgc ggcctggagg taaatgcatt agcacacgga ggtgggcgcc
     5341 tctccccgcc ccatcctgtc tcactgatgt gttgccgaga actggagttc ttgtttagct
     5401 aaccagaatg tgcaaggcta taggacagga gagaaatggc ctttaaaaca aatgaatgag
     5461 agtcacgatg aagggggcag acgggggggt gaaaatcatt accagaacac ttgggcagag
     5521 acccgtcaga gccaggcagg agacagtcat cagagctgtg ccagcaagtg gcatggagca
     5581 ggggtggcac ttgggctcgg gctgcaggca aacttggcgt caaaactggc tcaacccgtc
     5641 gcgagctgtg tggtctcctt gggatttttt gagccttaga ttccttattt gtaaaatgga
     5701 tttgtgagtc tccacctccc gaggtcagta tggaaatcca gtgagctaac actcgtcaat
     5761 ggcctcgcac atggccctgg caccacgcat ggaggccgcc aaaagtggcc gcctcctctc
     5821 tgcaattgca tttatttatc catttgataa ctctattggg tgtctaccca gcattgttca
     5881 ggggggtgtg aggggctacc gcaatgaccc agacagactg ctgtgcattc ttattggaaa
     5941 gacaaggcaa taaaccacag ttacaaaacc cagggtccca tggtaacgag ctccacagag
     6001 aaaagggaag tgggccagag gttccgagag acacacattt tggattgcag gagggtgaga
     6061 aggggcattc atctgtggtg gggttaaggg gaggcctccg actagctcac ctgcatgaat
     6121 ttcaggaaca agccatgcag agccggacag agcattctgt gcagagaaaa cagtgtaaca
     6181 gccctagagc agcagcagca aagggggagt ttaagggatg gtgggaagcc actgtcactg
     6241 gacagtagca agtggacaga ccaggggtcc caggtgaggc cacagagcag ccaaagtact
     6301 gcagggctct ccggctccgg gaggacttga tgtttgactc cagttgccag aggaagccgt
     6361 tcacgggctt tgagtgtagg aatgatgtgt ccgacttggg tctttttatt gttctttttt
     6421 agagacaggg tctcactctg tcacccaggc tggagtgcag cggcacaatc acagctcact
     6481 gcagcctcca cttcctgggc tcaagcaatc ctcccacttc agccactcaa gtagctggga
     6541 ttacaggtgc ctgccgtcac acccggctaa ttgttaaatt tttttggaga gacaggatct
     6601 tgctgttttc ccaggctgat cttgaactcc tgggctcaag cgagacgtct gtttcagcct
     6661 cccaaagtgc tgggataaca ggtgtgagcc actgggcctg ccttggcttg ggtattaaag
     6721 gaattgttct agttactata tggaggtgac ttggggccgc tggggaagaa agaggaagtc
     6781 aggagccagt ctgaggcagt ggcaatgcag cgattatcag aaataatggg ctcaatgata
     6841 gactggataa agaaaatgtg gcacatatac gccatggagt actatgcagc cataaaaagg
     6901 gatgagttca tgtcctttgc agggacatgg atgaagctgg aaaccatcat tctcagcaaa
     6961 ctaacacaag aacagaaaac caaacaccgc atgttctcac tcgtaagtgg gagttgaaca
     7021 atgagaacac atggacacag ggaagggaac atcacacact ggggcctgtc agtgggtggg
     7081 gggctggggg agggagagca tcaggagaaa tacccaatgt agatgatgac gggttcatag
     7141 gtgcagcaaa ccaccatggc acgtgtatac ctatgtaaca aacttgtgcg ttctgcacgt
     7201 gtaccccata actgaaagta taatcataat tttaagaaaa gaaatgatgg cctttggggt
     7261 ctaataagaa ggtggggctg acagggcttg gggagagagc gagcttgaca ggagaccacg
     7321 atgtcttccc caggggtctg agcacctggg gaaatggtgg tgccatttac catgactgga
     7381 aagatcatgg gaggagcagg tttgggacac tgaaggcccg agagcccctg gcaaaccacc
     7441 agtgtaagtc caagagtcca aaagctgaag aacttggagt ccaatgtttg agggtaaaaa
     7501 acagccagca tgagaaaaag atgaaggcca gaagactcgt ccagtctagc ccttccacat
     7561 tcctctgccc gcttttatcc tagcctcgct ggcaggtgat tagatggtgc ccacccaggt
     7621 taagcgtggg tctctgtctc ccagttcact gactcaaatg ttaatttcct ttggcgacag
     7681 cctcacagac acacccagga acgatacttt gcatcctcca atccaatcaa gttggcactc
     7741 aatattaaac agtttcggcc gggagcggtg gctcacgcct gtaatcccag cactttggga
     7801 ggccaaagcg ggcagatcac taagtcagga gatcgagacc atcctggcta acacggtgaa
     7861 accccatctc tactaaaaat acaaaaaatt agccaggcgt ggtggtgggc gcctgtagtc
     7921 ccagctactc gggaggctga ggcaagagag tggcgtgaac ccgggaggca gaacttgcag
     7981 caagcagaga tcgcaccact gcactccagc ctccagcctg ggcgacagag caagacaccg
     8041 tctcaaaaaa aaaaaaaaaa caactaacag tttcgttcat taaggcaatg tccatggggc
     8101 agctcctgca tgccacgcca cccctgccct gacatactcc caggctgacc agccagaact
     8161 ggggagaggg catcttgaag aaacagtcca ccctccgccc tcgcatacct gtgtctccca
     8221 gcagacaaga cacacaaggg cagggactgc actttcctgt gtgcaaatct caggtatggt
     8281 ccagaaatca catctctttg gtctgattgg ccttacttac caaacccttg aaacaatgga
     8341 aagaagcttg ctgcaatggg aagacccctg ccccccaaac cctctaacca ggagtctaca
     8401 gacctcattc cgtggaagtt cccattgtcc cctgggaaac caccaccttc tgaatcggca
     8461 cagccaaggc ccccaaccct gctatcaaca gctttcctta gccaccttcc ccatcctgca
     8521 gggcttttca acatttcgac tttttaatcc ttccctccct aagatataga catggtgtta
     8581 gtagcagaac cctgaaggca aaggaacaga aactaacact ctcagaaagt cctagcagga
     8641 tggtctgaat taatagacag ctgcaggcag ccagtgtgca aggcacgctc gtaatgtcag
     8701 tggcgttccg gaatgagggc tgtgatccca ggcagcccag atcccaaggc gaaaacattc
     8761 atgtcgccca gcatcaccct gtccttgccc agggtgaccc tgagacggca cttggattct
     8821 tccacatctg aactcaaacc tgctccctca gctctcccca gcaggaattg gagccctctc
     8881 caggccgttc agccaaagca gaatgtgtct ggccaagcag atctgcccag agaagaacaa
     8941 agacgtgttc agacactgtc tggggaattg gttttgagct cactctgagc tccatctgtg
     9001 caacaaggcc agcgtcagct gttacagaga aggggcttgt ggcagtttat taccctggtg
     9061 agctggctcg gggccatgct gaccgcagga ctgtaaagga cataaggcag ttggcaatat
     9121 gggaagcagc agtccccaaa gcaccccgtc aaggaaacga tgcaagagct ctgtccactg
     9181 gaccagcccc accctacccc gccacgccct ggcctagggg gagggacctt gtgtttcacg
     9241 ggcctggatg gccagggatg gacagtggca tgggcacaga cacacccaga ccgaaggaag
     9301 ggcccgggct ccagaaccag acccgatcca ggctcccagc tctgtcacct actggctgca
     9361 tgaaaagggt gggttttcct tgttttgcag cctcagctat ctcagctgtg agggaacaat
     9421 gacgccacct ccctcacgtg gcggtcctga agatgaaatg taatgcatgc agcgcggcgg
     9481 ccggcccacc gtgtgctctt agtaactggc cgctgttctc ttcagccctc ccgttactga
     9541 ccacctcgag ggcaccgttc ctccaagctg accatttcct gccagtcacc cactgcccag
     9601 ctcgcccagc catggagtgg gctctggtcc acgtgcatgg tgagctgcca tctttgtcgt
     9661 cctctggaca ccacgtctac ctccttggga aatagaaacg agtcctgcat tgctttgtca
     9721 aatttcacaa aaaccctaga aagcagatat tgccctggtt tacagacgga cagacagaag
     9781 caaagagaag ccaactgacc cactccaggt tacaagcagg gtctggtagg agagcacgcg
     9841 tccaccccac cgctcactgc gcccacctac tcctcgcttg agggcagaga acgagctggg
     9901 gcggggcgct ccagggggca caggcagcct gtgttcaagg catgctcgtg agccccacag
     9961 caggggcgga gtcaaaccag ggctctggtt ctggggtgag cagagggtgg ggccaggccc
    10021 ccactgggag gctgactgag gaggggctca aagggcaggc aggctccatc agagcggttt
    10081 gatgagcagg gccgctgagt ggccctcagg tcaaggctgg ggccgggacc accagggacc
    10141 aggtctgcgg ggccaggggt ccctccccag ggtggagcag gaaaactccg gcaaccgcct
    10201 tcttgagtgg acttgacctt ccctttctct gctaatgatc tcagattaat cccttaaggc
    10261 aagtgcccca gggtgggtgt tggttgcata aaacaagagg agtccttctt cccttccttc
    10321 ctggcacaaa catttgtagg ccacccccga tgtggctggt cgtagtctgg atttgggggc
    10381 acattcaggc attcaacaaa tacgtcatga ggccccgtga tgagctgggg ggctatgctt
    10441 gatgtcggca gtacagctgt ggtcgctcga atgaatgtgc ccgccctcac gggactgacc
    10501 tctagtggtg agagacagac actaaccgag tcacatgtgt gattacacgt gtaatcatac
    10561 ttacatatgt aacaacacga gttacacgtg cagtgtgggg agggggccct tcacggtgac
    10621 cagcccatca gggaagggga tgcgggtggc agaaggaagc ggcacaccct tgtcctcacg
    10681 gagctcacag gaggttctct gaccctcatc ttaagccaca ggctgtgtct gagcctcact
    10741 gccctagcta tcaactgggt gcaggactag gccttaatca ctgggcagcg ggaagaacta
    10801 cataagctca tactggcgca aagccccttg ggagaccgca gggaaagcca ttgcatgagg
    10861 tggtgacagg ctcggccttc agagtcgggc tagaatctga gttctgacaa tgatccccgc
    10921 cttgacccat ctctcctcag gccgccctga gccttccagt taggcctggg ctttgggctt
    10981 ccgtgtttgt ctctggattg ttcggtttta gcaagagtcc tgctaaattg gtcttgctgg
    11041 aatcctccgc cctccacatc tgattgccct tcctgtctga tcgtggtctt catgccccac
    11101 ggcctccagg ggacgtctga tcacctggcc tgccttcagc aagaatcccc ccaggtgttt
    11161 cctcttaaga ggttttccat ccactgagcc caccctgctc cttggccatc aattcccact
    11221 tgcctgtact gtattcagag gggaccccaa tctctcttcc cagctgcagc ggtccctgtc
    11281 caacactgcc ccccacctca aataaagtct ttcttactgt ctttaacata tgccgtcaat
    11341 aaagttttag cagatccaa
//
