LOCUS       NM_001166287           11309 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens repulsive guidance molecule BMP co-receptor a (RGMA),
            transcript variant 3, mRNA.
ACCESSION   NM_001166287
VERSION     NM_001166287.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11309)
  AUTHORS   Lun,J., Zhang,Y., Yu,M., Zhai,W., Zhu,L., Liu,H., Guo,J., Zhang,G.,
            Qiu,W. and Fang,J.
  TITLE     Circular RNA circHIPK2 inhibits colon cancer cells through
            miR-373-3p/RGMA axis
  JOURNAL   Cancer Lett 593, 216957 (2024)
   PUBMED   38762192
  REMARK    GeneRIF: Circular RNA circHIPK2 inhibits colon cancer cells through
            miR-373-3p/RGMA axis.
REFERENCE   2  (bases 1 to 11309)
  AUTHORS   Liu,D., Zusman,B.E., Shaffer,J.R., Li,Y., Arockiaraj,A.I., Liu,S.,
            Weeks,D.E., Desai,S.M., Kochanek,P.M., Puccio,A.M., Okonkwo,D.O.,
            Conley,Y.P. and Jha,R.M.
  TITLE     Decreased DNA Methylation of RGMA is Associated with Intracranial
            Hypertension After Severe Traumatic Brain Injury: An Exploratory
            Epigenome-Wide Association Study
  JOURNAL   Neurocrit Care 37 (1), 26-37 (2022)
   PUBMED   35028889
  REMARK    GeneRIF: Decreased DNA Methylation of RGMA is Associated with
            Intracranial Hypertension After Severe Traumatic Brain Injury: An
            Exploratory Epigenome-Wide Association Study.
REFERENCE   3  (bases 1 to 11309)
  AUTHORS   Kousathanas,A., Pairo-Castineira,E., Rawlik,K., Stuckey,A.,
            Odhams,C.A., Walker,S., Russell,C.D., Malinauskas,T., Wu,Y.,
            Millar,J., Shen,X., Elliott,K.S., Griffiths,F., Oosthuyzen,W.,
            Morrice,K., Keating,S., Wang,B., Rhodes,D., Klaric,L., Zechner,M.,
            Parkinson,N., Siddiq,A., Goddard,P., Donovan,S., Maslove,D.,
            Nichol,A., Semple,M.G., Zainy,T., Maleady-Crowe,F., Todd,L.,
            Salehi,S., Knight,J., Elgar,G., Chan,G., Arumugam,P., Patch,C.,
            Rendon,A., Bentley,D., Kingsley,C., Kosmicki,J.A., Horowitz,J.E.,
            Baras,A., Abecasis,G.R., Ferreira,M.A.R., Justice,A., Mirshahi,T.,
            Oetjens,M., Rader,D.J., Ritchie,M.D., Verma,A., Fowler,T.A.,
            Shankar-Hari,M., Summers,C., Hinds,C., Horby,P., Ling,L.,
            McAuley,D., Montgomery,H., Openshaw,P.J.M., Elliott,P., Walsh,T.,
            Tenesa,A., Fawkes,A., Murphy,L., Rowan,K., Ponting,C.P., Vitart,V.,
            Wilson,J.F., Yang,J., Bretherick,A.D., Scott,R.H., Hendry,S.C.,
            Moutsianas,L., Law,A., Caulfield,M.J. and Baillie,J.K.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   4  (bases 1 to 11309)
  AUTHORS   Tang,J., Zeng,X., Li,H., Ju,L., Feng,J. and Yang,J.
  TITLE     Repulsive Guidance Molecule-a and Central Nervous System Diseases
  JOURNAL   Biomed Res Int 2021, 5532116 (2021)
   PUBMED   33997000
  REMARK    GeneRIF: Repulsive Guidance Molecule-a and Central Nervous System
            Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11309)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 11309)
  AUTHORS   Xia,Y., Yu,P.B., Sidis,Y., Beppu,H., Bloch,K.D., Schneyer,A.L. and
            Lin,H.Y.
  TITLE     Repulsive guidance molecule RGMa alters utilization of bone
            morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
  JOURNAL   J Biol Chem 282 (25), 18129-18140 (2007)
   PUBMED   17472960
  REMARK    GeneRIF: RGMa facilitates the use of ActRIIA by endogenous BMP2 and
            BMP4 ligands that otherwise prefer signaling via BMPRII and
            increased utilization of ActRIIA leads to generation of an enhanced
            BMP signal
REFERENCE   7  (bases 1 to 11309)
  AUTHORS   Schwab,J.M., Monnier,P.P., Schluesener,H.J., Conrad,S.,
            Beschorner,R., Chen,L., Meyermann,R. and Mueller,B.K.
  TITLE     Central nervous system injury-induced repulsive guidance molecule
            expression in the adult human brain
  JOURNAL   Arch Neurol 62 (10), 1561-1568 (2005)
   PUBMED   16216939
  REMARK    GeneRIF: Following central nervous system injury, RGM, a novel,
            potent axonal growth inhibitor, is present in axonal growth
            impediments: the mature myelin, choroid plexus, and components of
            the developing scar.
REFERENCE   8  (bases 1 to 11309)
  AUTHORS   Babitt,J.L., Zhang,Y., Samad,T.A., Xia,Y., Tang,J., Campagna,J.A.,
            Schneyer,A.L., Woolf,C.J. and Lin,H.Y.
  TITLE     Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone
            morphogenetic protein co-receptor
  JOURNAL   J Biol Chem 280 (33), 29820-29827 (2005)
   PUBMED   15975920
REFERENCE   9  (bases 1 to 11309)
  AUTHORS   Rajagopalan,S., Deitinghoff,L., Davis,D., Conrad,S., Skutella,T.,
            Chedotal,A., Mueller,B.K. and Strittmatter,S.M.
  TITLE     Neogenin mediates the action of repulsive guidance molecule
  JOURNAL   Nat Cell Biol 6 (8), 756-762 (2004)
   PUBMED   15258590
REFERENCE   10 (bases 1 to 11309)
  AUTHORS   Brinks,H., Conrad,S., Vogt,J., Oldekamp,J., Sierra,A.,
            Deitinghoff,L., Bechmann,I., Alvarez-Bolado,G., Heimrich,B.,
            Monnier,P.P., Mueller,B.K. and Skutella,T.
  TITLE     The repulsive guidance molecule RGMa is involved in the formation
            of afferent connections in the dentate gyrus
  JOURNAL   J Neurosci 24 (15), 3862-3869 (2004)
   PUBMED   15084667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA183348.1, AL136826.1,
            KF456122.1, AC087641.5 and AC013394.12.
            
            On Aug 13, 2020 this sequence version replaced NM_001166287.1.
            
            Summary: This gene encodes a member of the repulsive guidance
            molecule family. The encoded protein is a
            glycosylphosphatidylinositol-anchored glycoprotein that functions
            as an axon guidance protein in the developing and adult central
            nervous system. This protein may also function as a tumor
            suppressor in some cancers. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3,
            5 and 6 encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. Variants 2
            and 3 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1124954.1,
                                           SRR18074969.1652613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-547               DA183348.1         1-547
            548-1520            AL136826.1         415-1387
            1521-1654           KF456122.1         1-134               c
            1655-5067           AC087641.5         127281-130693       c
            5068-11309          AC013394.12        1-6242
FEATURES             Location/Qualifiers
     source          1..11309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..11309
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="repulsive guidance molecule BMP co-receptor a"
                     /db_xref="GeneID:56963"
                     /db_xref="HGNC:HGNC:30308"
                     /db_xref="MIM:607362"
     exon            1..243
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     exon            244..359
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1582
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; repulsive guidance molecule A; RGM domain
                     family, member A; repulsive guidance molecule family
                     member a"
                     /codon_start=1
                     /product="repulsive guidance molecule A isoform 2
                     precursor"
                     /protein_id="NP_001159759.1"
                     /db_xref="CCDS:CCDS53973.1"
                     /db_xref="GeneID:56963"
                     /db_xref="HGNC:HGNC:30308"
                     /db_xref="MIM:607362"
                     /translation="MGMGRGAGRSALGFWPTLAFLLCSFPAATSPCKILKCNSEFWSA
                     TSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKD
                     GPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTD
                     RFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQA
                     EMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTF
                     AVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPT
                     APETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNK
                     DKLHLYERTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC"
     exon            360..874
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     exon            875..11309
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="hexamer: AGTAAA"
     polyA_site      3164
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="major polyA site"
     regulatory      11288..11293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGMA"
                     /gene_synonym="RGM"
                     /note="hexamer: AATAAA"
     polyA_site      11309
                     /gene="RGMA"
                     /gene_synonym="RGM"
ORIGIN      
        1 ctcccgctcg acgcccggct gcggagctgc ctggccatct cctgccctcg gggatgtcgg
       61 cgcagtgcac cgcgtgggct cgcgtcccgg cggccctttg cctcggcgcg ccggcgtacg
      121 ggaaggtgcg gaccttggat tgagggccga ggatgcccat tgccaagccg ccccggcttt
      181 cctaagtgga cgggagggca cggcgacgat tcagcgccgg ctcgcgccgc agctcaaccc
      241 aggggagagg ctagtggtaa caggccgagc tggatggatg ggtatgggga gaggggcagg
      301 acgttcagcc ctgggattct ggccgaccct cgccttcctt ctctgcagct tccccgcagc
      361 cacctccccg tgcaagatcc tcaagtgcaa ctctgagttc tggagcgcca cgtcgggcag
      421 ccacgcccca gcctcagacg acacccccga gttctgtgca gccttgcgca gctacgccct
      481 gtgcacgcgg cggacggccc gcacctgccg gggtgacctg gcctaccact cggccgtcca
      541 tggcatagag gacctcatga gccagcacaa ctgctccaag gatggcccca cctcgcagcc
      601 acgcctgcgc acgctcccac cggccggaga cagccaggag cgctcggaca gccccgagat
      661 ctgccattac gagaagagct ttcacaagca ctcggccacc cccaactaca cgcactgtgg
      721 cctcttcggg gacccacacc tcaggacttt caccgaccgc ttccagacct gcaaggtgca
      781 gggcgcctgg ccgctcatcg acaataatta cctgaacgtg caggtcacca acacgcctgt
      841 gctgcccggc tcagcggcca ctgccaccag caagctcacc atcatcttca agaacttcca
      901 ggagtgtgtg gaccagaagg tgtaccaggc tgagatggac gagctcccgg ccgccttcgt
      961 ggatggctct aagaacggtg gggacaagca cggggccaac agcctgaaga tcactgagaa
     1021 ggtgtcaggc cagcacgtgg agatccaggc caagtacatc ggcaccacca tcgtggtgcg
     1081 ccaggtgggc cgctacctga cctttgccgt ccgcatgcca gaggaagtgg tcaatgctgt
     1141 ggaggactgg gacagccagg gtctctacct ctgcctgcgg ggctgccccc tcaaccagca
     1201 gatcgacttc caggccttcc acaccaatgc tgagggcacc ggtgcccgca ggctggcagc
     1261 cgccagccct gcacccacag cccccgagac cttcccatac gagacagccg tggccaagtg
     1321 caaggagaag ctgccggtgg aggacctgta ctaccaggcc tgcgtcttcg acctcctcac
     1381 cacgggcgac gtgaacttca cactggccgc ctactacgcg ttggaggatg tcaagatgct
     1441 ccactccaac aaagacaaac tgcacctgta tgagaggact cgggacctgc caggcagggc
     1501 ggctgcgggg ctgcccctgg ccccccggcc cctcctgggc gccctcgtcc cgctcctggc
     1561 cctgctccct gtgttctgct agacgcgtag atgtggaggg aggcgcgggc tccgtcctct
     1621 cggcttcccc atgtgtgggc tgggaccgcc cacggggtgc agatctcctg gcgtgtccac
     1681 catggccccg cagaacgcca gggaccgcct gctgccaagg gctcaggcac ggacccctcc
     1741 ccttctagtg cacgtgacaa ggttgtggtg actggtgcca tgatgtttga cagtagagct
     1801 gtgtgagagg gagagcagct cccctcgccc cgcccctgca gtgtgaatgt gtgaaacatc
     1861 ccctcaggct gaagcccccc acccccacca gagacacact gggaaccgtc agagtcagct
     1921 ccttccccct cgcaatgcac tgaaaggccc ggccgactgc tgctcgccga tccgtggggc
     1981 cccctgtgcc cgccacacgc acgcacacac tcttacacga gagcacactc gatcccccta
     2041 ggccagcggg gacaccccag ccacacaggg aggcatcctt ggggcttggc cccaggcagg
     2101 gcaaccccgg ggcgctgctt ggcaccttag cagactgctg gaaccttttg gccagtaggt
     2161 cgtgcccgcc tggtgccttc tggcctgtgg cctccctgcc catgttcacc tggctgctgt
     2221 gggtaccagt gcaggtcccg gttttcaggc acctgctcag ctgcccgtct ctggcctggg
     2281 cccctgcccc ttccaccctg tgcttagaaa gtcgaagtgc ttggttctaa atgtctaaac
     2341 agagaagaga tccttgactt ctgttcctct ctctcctgca gatgcaagag ctcctgggca
     2401 ggggtgcctg ggccccaggg tgtggcagga gacccagtgg atggggccag ctggcctgcc
     2461 ctgatcctct gcttcctcct cacaacccca agagccccca gcccggtcca tccacgtctg
     2521 gagtctgggg agaggagcag ggtcttagga ctctcagctc tgagcatccc tggcagggtc
     2581 ttcaacctct aatctcttcc cttaagccct gtggccacac agccaggaga gacttgccgc
     2641 tggctcccgc ctcatttcag cccagggtgc tcatccaggg gcccagaaca gtcccacctg
     2701 tgctgctgtg cccacagcac aaagccaggc ttcactccca aaagtgcagc caggccctgg
     2761 agggtgatcc tgccagcagc cctacagctc cacaccctac ccacccatcg gcagcccctc
     2821 tgctgttccc cagggacctc tcatacactg gccaggaggc tgcagaacgt gtgtctcccc
     2881 ctccctccaa gaggtcctgc tccctctgcc agaaccgtgt gtgggcgggt gggagggcgc
     2941 tcggggcccg gcccctccct ctccctgctg gttttagttg gtccctatgt tggaagtaaa
     3001 aagtgaagca ctttattttg gttgtgtttg ctcacgttct gcttggaagt ggggacccct
     3061 cactgcgtcc acgtgtctgc gacctgtgtg gagtgtcacc gcgtgtacat actgtaaatt
     3121 atttattaat ggctaaatgc aagtaaagtt tggttttttt gttattttct tttagacgtg
     3181 ttggagtttg ttttctgaac agactttggc tcccttgagg cgggtggagg atggactttg
     3241 gtggtgggat cccctgcagc aagtgtgtgt gtgtgcgcgc atgtgtgtgt gcgcgcatgt
     3301 gtgtatgcat gcctgtgtgt gtgcgtgcct gtgtgcgtgc atgtacgcat gtgtgcgcat
     3361 gcctgtgtgt gcgcccatgc ctatgtgtgt gcatgtaggc atgtgtgtgc gcatgtgtat
     3421 gtgcgtgaga atggtgtgaa ggcggataga agatgcagca gtttaacagc caccacacat
     3481 tgcttttgta aagtcacttt tcctcctcac gatgagctgt ctttggagct tggcaggccc
     3541 agatcctctt gttctagtga cagtggaaca cagtcaggga gacaggtgac tatgtggtgg
     3601 agagacatat ggtgccctct gggatgagat gggtgggata gcctgagatc tgggatgact
     3661 ccctctcagc cactgctatc agcctggagc cccagctgtt gggactgcct gccaccctcc
     3721 ctgccagtgc ccatcttctc atagcccggg cggagcagtg gtgctgcagg aggctgctgt
     3781 ccacgtcact gtgggaccag gtttattggc agctgtgatc acatttcatc tgtacaaact
     3841 acccagtgaa tcaggaagaa attcaggccc attttgccga tgaaacagac tctgagatta
     3901 actgacttgc ctagggctcc ttagcaacgg gaaggacaac ctgtgcacct aggttagtat
     3961 tgtcctgaag ccccttctct tcaaactaaa tgccatgagg cagaatagca gcacagttaa
     4021 gccagcctac atcctggctt ctccacctcc ccagcagtgt gaccatgggc aagtcacttc
     4081 acctctctga gcctgcatgc tgttctctgg aagatggggg ggtgcctgtc ccatacagtt
     4141 gtttggagag tcaggagttc attcctgtaa attgcttagg agagggcggg gcacacatgg
     4201 cttgtctggt cgtggggagg gagggggtgg tattatccca aagcaagata aatcagttaa
     4261 ggggagaagg aaaggggcga tacagaccct ggactcttgg gagaggtgaa cctgcaggct
     4321 agcaagggga ggagtcccaa gagtggccaa gttcattaat cccaggcaga ccaggaaggc
     4381 tgaagaaaaa ggagaacttt attttatttt tgaaatggag tctggcgtct tgctctgtcg
     4441 ccaggctgga gtgcagtggc accatcccag ctcactgcag cccctgcctc ccaggttcaa
     4501 gcaattctcc tgcctcagcc tcccaagtag ctgggactac aggcacacac caccacgcct
     4561 ggctaatttt ttgtatttta gtagagatgg tgtttcacca tgttgaccag tatggtcttg
     4621 atctcctgac ctcgtgatcc gcctgccttg gcctcccaaa gtgttgggat tacaggcgtg
     4681 agccaccacc gtgcccggcc aaaaaaggag aacgttctaa agccctgttc ttgcagggct
     4741 cccagagaga acacgggagt tgggtttggg aggcaggaac cagactggaa aggacaaaac
     4801 gtacccagca tcttccctgg cggccggaac cgtcactaca ggccccgtgc ccttagcagt
     4861 cccagggaca gagcgactca gggaggcagc aaggaggagc ggagccattg gtgctcgtcc
     4921 ggcacagaga acagttcctg agaagccagg gcacacagaa gaaaaagaaa aaagaaatct
     4981 ctactagacg aaaatgctaa atggcactag ccacaaagta ttcttggttt ggaatttttt
     5041 ttccaggacc ctaaatgtaa ccggctggaa ttctttccca agtgccatgc tacttactac
     5101 tggttgccct cacgagcatg gaaatgccgt cgtgaatatg gaacacagca tcctgagcta
     5161 aaagattccc aagaagcagc ttcatcttgc aggacgggct aggttgggag cctctggagg
     5221 ttcctggctg ccagctccgc ggaggcctgc ggcctggagg taaatgcatt agcacacgga
     5281 ggtgggcgcc tctccccgcc ccatcctgtc tcactgatgt gttgccgaga actggagttc
     5341 ttgtttagct aaccagaatg tgcaaggcta taggacagga gagaaatggc ctttaaaaca
     5401 aatgaatgag agtcacgatg aagggggcag acgggggggt gaaaatcatt accagaacac
     5461 ttgggcagag acccgtcaga gccaggcagg agacagtcat cagagctgtg ccagcaagtg
     5521 gcatggagca ggggtggcac ttgggctcgg gctgcaggca aacttggcgt caaaactggc
     5581 tcaacccgtc gcgagctgtg tggtctcctt gggatttttt gagccttaga ttccttattt
     5641 gtaaaatgga tttgtgagtc tccacctccc gaggtcagta tggaaatcca gtgagctaac
     5701 actcgtcaat ggcctcgcac atggccctgg caccacgcat ggaggccgcc aaaagtggcc
     5761 gcctcctctc tgcaattgca tttatttatc catttgataa ctctattggg tgtctaccca
     5821 gcattgttca ggggggtgtg aggggctacc gcaatgaccc agacagactg ctgtgcattc
     5881 ttattggaaa gacaaggcaa taaaccacag ttacaaaacc cagggtccca tggtaacgag
     5941 ctccacagag aaaagggaag tgggccagag gttccgagag acacacattt tggattgcag
     6001 gagggtgaga aggggcattc atctgtggtg gggttaaggg gaggcctccg actagctcac
     6061 ctgcatgaat ttcaggaaca agccatgcag agccggacag agcattctgt gcagagaaaa
     6121 cagtgtaaca gccctagagc agcagcagca aagggggagt ttaagggatg gtgggaagcc
     6181 actgtcactg gacagtagca agtggacaga ccaggggtcc caggtgaggc cacagagcag
     6241 ccaaagtact gcagggctct ccggctccgg gaggacttga tgtttgactc cagttgccag
     6301 aggaagccgt tcacgggctt tgagtgtagg aatgatgtgt ccgacttggg tctttttatt
     6361 gttctttttt agagacaggg tctcactctg tcacccaggc tggagtgcag cggcacaatc
     6421 acagctcact gcagcctcca cttcctgggc tcaagcaatc ctcccacttc agccactcaa
     6481 gtagctggga ttacaggtgc ctgccgtcac acccggctaa ttgttaaatt tttttggaga
     6541 gacaggatct tgctgttttc ccaggctgat cttgaactcc tgggctcaag cgagacgtct
     6601 gtttcagcct cccaaagtgc tgggataaca ggtgtgagcc actgggcctg ccttggcttg
     6661 ggtattaaag gaattgttct agttactata tggaggtgac ttggggccgc tggggaagaa
     6721 agaggaagtc aggagccagt ctgaggcagt ggcaatgcag cgattatcag aaataatggg
     6781 ctcaatgata gactggataa agaaaatgtg gcacatatac gccatggagt actatgcagc
     6841 cataaaaagg gatgagttca tgtcctttgc agggacatgg atgaagctgg aaaccatcat
     6901 tctcagcaaa ctaacacaag aacagaaaac caaacaccgc atgttctcac tcgtaagtgg
     6961 gagttgaaca atgagaacac atggacacag ggaagggaac atcacacact ggggcctgtc
     7021 agtgggtggg gggctggggg agggagagca tcaggagaaa tacccaatgt agatgatgac
     7081 gggttcatag gtgcagcaaa ccaccatggc acgtgtatac ctatgtaaca aacttgtgcg
     7141 ttctgcacgt gtaccccata actgaaagta taatcataat tttaagaaaa gaaatgatgg
     7201 cctttggggt ctaataagaa ggtggggctg acagggcttg gggagagagc gagcttgaca
     7261 ggagaccacg atgtcttccc caggggtctg agcacctggg gaaatggtgg tgccatttac
     7321 catgactgga aagatcatgg gaggagcagg tttgggacac tgaaggcccg agagcccctg
     7381 gcaaaccacc agtgtaagtc caagagtcca aaagctgaag aacttggagt ccaatgtttg
     7441 agggtaaaaa acagccagca tgagaaaaag atgaaggcca gaagactcgt ccagtctagc
     7501 ccttccacat tcctctgccc gcttttatcc tagcctcgct ggcaggtgat tagatggtgc
     7561 ccacccaggt taagcgtggg tctctgtctc ccagttcact gactcaaatg ttaatttcct
     7621 ttggcgacag cctcacagac acacccagga acgatacttt gcatcctcca atccaatcaa
     7681 gttggcactc aatattaaac agtttcggcc gggagcggtg gctcacgcct gtaatcccag
     7741 cactttggga ggccaaagcg ggcagatcac taagtcagga gatcgagacc atcctggcta
     7801 acacggtgaa accccatctc tactaaaaat acaaaaaatt agccaggcgt ggtggtgggc
     7861 gcctgtagtc ccagctactc gggaggctga ggcaagagag tggcgtgaac ccgggaggca
     7921 gaacttgcag caagcagaga tcgcaccact gcactccagc ctccagcctg ggcgacagag
     7981 caagacaccg tctcaaaaaa aaaaaaaaaa caactaacag tttcgttcat taaggcaatg
     8041 tccatggggc agctcctgca tgccacgcca cccctgccct gacatactcc caggctgacc
     8101 agccagaact ggggagaggg catcttgaag aaacagtcca ccctccgccc tcgcatacct
     8161 gtgtctccca gcagacaaga cacacaaggg cagggactgc actttcctgt gtgcaaatct
     8221 caggtatggt ccagaaatca catctctttg gtctgattgg ccttacttac caaacccttg
     8281 aaacaatgga aagaagcttg ctgcaatggg aagacccctg ccccccaaac cctctaacca
     8341 ggagtctaca gacctcattc cgtggaagtt cccattgtcc cctgggaaac caccaccttc
     8401 tgaatcggca cagccaaggc ccccaaccct gctatcaaca gctttcctta gccaccttcc
     8461 ccatcctgca gggcttttca acatttcgac tttttaatcc ttccctccct aagatataga
     8521 catggtgtta gtagcagaac cctgaaggca aaggaacaga aactaacact ctcagaaagt
     8581 cctagcagga tggtctgaat taatagacag ctgcaggcag ccagtgtgca aggcacgctc
     8641 gtaatgtcag tggcgttccg gaatgagggc tgtgatccca ggcagcccag atcccaaggc
     8701 gaaaacattc atgtcgccca gcatcaccct gtccttgccc agggtgaccc tgagacggca
     8761 cttggattct tccacatctg aactcaaacc tgctccctca gctctcccca gcaggaattg
     8821 gagccctctc caggccgttc agccaaagca gaatgtgtct ggccaagcag atctgcccag
     8881 agaagaacaa agacgtgttc agacactgtc tggggaattg gttttgagct cactctgagc
     8941 tccatctgtg caacaaggcc agcgtcagct gttacagaga aggggcttgt ggcagtttat
     9001 taccctggtg agctggctcg gggccatgct gaccgcagga ctgtaaagga cataaggcag
     9061 ttggcaatat gggaagcagc agtccccaaa gcaccccgtc aaggaaacga tgcaagagct
     9121 ctgtccactg gaccagcccc accctacccc gccacgccct ggcctagggg gagggacctt
     9181 gtgtttcacg ggcctggatg gccagggatg gacagtggca tgggcacaga cacacccaga
     9241 ccgaaggaag ggcccgggct ccagaaccag acccgatcca ggctcccagc tctgtcacct
     9301 actggctgca tgaaaagggt gggttttcct tgttttgcag cctcagctat ctcagctgtg
     9361 agggaacaat gacgccacct ccctcacgtg gcggtcctga agatgaaatg taatgcatgc
     9421 agcgcggcgg ccggcccacc gtgtgctctt agtaactggc cgctgttctc ttcagccctc
     9481 ccgttactga ccacctcgag ggcaccgttc ctccaagctg accatttcct gccagtcacc
     9541 cactgcccag ctcgcccagc catggagtgg gctctggtcc acgtgcatgg tgagctgcca
     9601 tctttgtcgt cctctggaca ccacgtctac ctccttggga aatagaaacg agtcctgcat
     9661 tgctttgtca aatttcacaa aaaccctaga aagcagatat tgccctggtt tacagacgga
     9721 cagacagaag caaagagaag ccaactgacc cactccaggt tacaagcagg gtctggtagg
     9781 agagcacgcg tccaccccac cgctcactgc gcccacctac tcctcgcttg agggcagaga
     9841 acgagctggg gcggggcgct ccagggggca caggcagcct gtgttcaagg catgctcgtg
     9901 agccccacag caggggcgga gtcaaaccag ggctctggtt ctggggtgag cagagggtgg
     9961 ggccaggccc ccactgggag gctgactgag gaggggctca aagggcaggc aggctccatc
    10021 agagcggttt gatgagcagg gccgctgagt ggccctcagg tcaaggctgg ggccgggacc
    10081 accagggacc aggtctgcgg ggccaggggt ccctccccag ggtggagcag gaaaactccg
    10141 gcaaccgcct tcttgagtgg acttgacctt ccctttctct gctaatgatc tcagattaat
    10201 cccttaaggc aagtgcccca gggtgggtgt tggttgcata aaacaagagg agtccttctt
    10261 cccttccttc ctggcacaaa catttgtagg ccacccccga tgtggctggt cgtagtctgg
    10321 atttgggggc acattcaggc attcaacaaa tacgtcatga ggccccgtga tgagctgggg
    10381 ggctatgctt gatgtcggca gtacagctgt ggtcgctcga atgaatgtgc ccgccctcac
    10441 gggactgacc tctagtggtg agagacagac actaaccgag tcacatgtgt gattacacgt
    10501 gtaatcatac ttacatatgt aacaacacga gttacacgtg cagtgtgggg agggggccct
    10561 tcacggtgac cagcccatca gggaagggga tgcgggtggc agaaggaagc ggcacaccct
    10621 tgtcctcacg gagctcacag gaggttctct gaccctcatc ttaagccaca ggctgtgtct
    10681 gagcctcact gccctagcta tcaactgggt gcaggactag gccttaatca ctgggcagcg
    10741 ggaagaacta cataagctca tactggcgca aagccccttg ggagaccgca gggaaagcca
    10801 ttgcatgagg tggtgacagg ctcggccttc agagtcgggc tagaatctga gttctgacaa
    10861 tgatccccgc cttgacccat ctctcctcag gccgccctga gccttccagt taggcctggg
    10921 ctttgggctt ccgtgtttgt ctctggattg ttcggtttta gcaagagtcc tgctaaattg
    10981 gtcttgctgg aatcctccgc cctccacatc tgattgccct tcctgtctga tcgtggtctt
    11041 catgccccac ggcctccagg ggacgtctga tcacctggcc tgccttcagc aagaatcccc
    11101 ccaggtgttt cctcttaaga ggttttccat ccactgagcc caccctgctc cttggccatc
    11161 aattcccact tgcctgtact gtattcagag gggaccccaa tctctcttcc cagctgcagc
    11221 ggtccctgtc caacactgcc ccccacctca aataaagtct ttcttactgt ctttaacata
    11281 tgccgtcaat aaagttttag cagatccaa
//
