LOCUS       NM_153615               2725 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens ral guanine nucleotide dissociation stimulator like 4
            (RGL4), transcript variant 2, mRNA.
ACCESSION   NM_153615
VERSION     NM_153615.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Sun,Y., Zhang,Y., Ren,S., Li,X., Yang,P., Zhu,J., Lin,L., Wang,Z.
            and Jia,Y.
  TITLE     Low expression of RGL4 is associated with a poor prognosis and
            immune infiltration in lung adenocarcinoma patients
  JOURNAL   Int Immunopharmacol 83, 106454 (2020)
   PUBMED   32259700
  REMARK    GeneRIF: Low expression of RGL4 is associated with a poor prognosis
            and immune infiltration in lung adenocarcinoma patients.
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Hernandez-Munoz,I., Benet,M., Calero,M., Jimenez,M., Diaz,R. and
            Pellicer,A.
  TITLE     rgr oncogene: activation by elimination of translational controls
            and mislocalization
  JOURNAL   Cancer Res 63 (14), 4188-4195 (2003)
   PUBMED   12874025
REFERENCE   3  (bases 1 to 2725)
  AUTHORS   Leonardi,P., Kassin,E., Hernandez-Munoz,I., Diaz,R., Inghirami,G.
            and Pellicer,A.
  TITLE     Human rgr: transforming activity and alteration in T-cell
            malignancies
  JOURNAL   Oncogene 21 (33), 5108-5116 (2002)
   PUBMED   12140761
  REMARK    GeneRIF: Human rgr: transforming activity and alteration in T-cell
            malignancies [rgr: ralGDS-related]
REFERENCE   4  (bases 1 to 2725)
  AUTHORS   Hernandez-Munoz,I., Malumbres,M., Leonardi,P. and Pellicer,A.
  TITLE     The Rgr oncogene (homologous to RalGDS) induces transformation and
            gene expression by activating Ras, Ral and Rho mediated pathways
  JOURNAL   Oncogene 19 (23), 2745-2757 (2000)
   PUBMED   10851075
REFERENCE   5  (bases 1 to 2725)
  AUTHORS   D'Adamo,D.R., Novick,S., Kahn,J.M., Leonardi,P. and Pellicer,A.
  TITLE     rsc: a novel oncogene with structural and functional homology with
            the gene family of exchange factors for Ral
  JOURNAL   Oncogene 14 (11), 1295-1305 (1997)
   PUBMED   9178890
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000347.1.
            
            On Sep 21, 2020 this sequence version replaced NM_153615.1.
            
            Summary: This oncogene encodes a protein similar to guanine
            nucleotide exchange factor Ral guanine dissociation stimulator.
            Increased expression of this gene leads to translocation of the
            encoded protein to the cell membrane. The encoded protein can
            activate several pathways, including the Ras-Raf-MEK-ERK cascade.
            [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY101396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290691.10/ ENSP00000290691.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1197              AP000347.1         58653-59849
            1198-1391           AP000347.1         59975-60168
            1392-1714           AP000347.1         60309-60631
            1715-1930           AP000347.1         61399-61614
            1931-2034           AP000347.1         61987-62090
            2035-2104           AP000347.1         62590-62659
            2105-2179           AP000347.1         64254-64328
            2180-2254           AP000347.1         64811-64885
            2255-2278           AP000347.1         65478-65501
            2279-2400           AP000347.1         65852-65973
            2401-2725           AP000347.1         66484-66808
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..2725
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /note="ral guanine nucleotide dissociation stimulator like
                     4"
                     /db_xref="GeneID:266747"
                     /db_xref="HGNC:HGNC:31911"
                     /db_xref="MIM:612214"
     exon            1..1197
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     CDS             1019..2440
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RalGDS related oncogene; ral-GDS-related protein; Ral-GDS
                     related protein Rgr; ralGDS-like 4"
                     /codon_start=1
                     /product="ral-GDS-related protein isoform 2"
                     /protein_id="NP_705843.1"
                     /db_xref="CCDS:CCDS13811.1"
                     /db_xref="GeneID:266747"
                     /db_xref="HGNC:HGNC:31911"
                     /db_xref="MIM:612214"
                     /translation="MRKLLTNLPAAAVLSAQVYSAVLQGLWEENVCGTPGRTRVCTAL
                     LYGQVCPFQDSTDGLRTITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGL
                     EDHQEIVLGQLVLPEPNEAKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPA
                     ALGPPGYLHSAPGPAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTF
                     PPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNC
                     ITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTW
                     AGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPF
                     LGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYF
                     TRMEQLSDKESYKLSCQLEPENP"
     exon            1198..1391
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1714
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1930
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2034
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2104
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2179
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2254
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2278
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2400
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2725
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2706..2711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /note="hexamer: AATAAA"
     polyA_site      2725
                     /gene="RGL4"
                     /gene_synonym="Rgr"
                     /note="major polyA site"
ORIGIN      
        1 tgcacctctc ggagcctcgg ttggctcctc tggaacaggg agtagtgaga agacgaacct
       61 cacagggttc ttgtagggac tcaatgatct aagacacagc aaacaaaggg gtccctagag
      121 cctaaaactc tggaaaatct gctgggggtg ctgtgattca tgtttgttac ttttctcttc
      181 cccctcactt gaagcagctc tcagcattct gcctcaatgg cctgtatcac tcactgtttg
      241 gaaaaacaca tagaaaccaa gtctgcgatg gcactggtaa aggatgtctg agattccttc
      301 tggctggtct ttctccttga cacagacaga agaggggtcc cttggtgctg aaaaaggagc
      361 cacaggccca ctcagacatc tggagaggct cactggggtt ctccaaaggt tggggttcac
      421 tcattcaaca catacattca aaacacctca tttgtgcatc gctcttcttg gggcttggca
      481 taatttcata aacaaagcag atgacaatcc cccggccttg attctactca gagtcaggca
      541 ctcacagtag acagaataaa caagtcatat ctacagaatg ttacaggtga gaccctcatg
      601 gcctcctcta cgtatggtgg catcctccca gattctgact agaatgacgc agcccagcaa
      661 caaatataaa ctgggtggat ttagggttct gaagggcctt ttcacccaca aaacatgggg
      721 gaaaatatgt ggactctggc tggggagaga ctaaaggagc tctggggctc atacttctta
      781 taattcccac gagaaggctg acatctgggg acttccccca caagaggcaa atagtgagtt
      841 ctgtaaatgg agacttaggt cccctgcaaa gcagagggga ggctggggtc acagctggcc
      901 actgagagac ccatccccct cagcaccgtg gcttcccagc tctccctgtc ctcctccccc
      961 cgacatctgc cccttccctc ctaaccccag gaccagggga cccagatctg gagctttgat
     1021 gaggaagctg ctcacaaatc tgcctgcagc tgcagtcttg agtgcccagg tgtacagtgc
     1081 tgtgctccag ggcctttggg aagagaatgt ctgtgggacg ccagggcgca cgagggtctg
     1141 tacagccctg ctgtatggcc aggtctgccc cttccaggac agcactgatg gcttacgcac
     1201 catcacctcc attttgttca actggccccc cgaaaacact tcagtttact atcagccccc
     1261 gcaacggtca tctttccgga taaagctggc cttcaggaac ctctcctggc ctggactggg
     1321 cttggaggac catcaggaaa ttgtcctagg ccagttggtg cttccggagc ccaacgaggc
     1381 caagccagat gatcctgctc cacgtcctgg gcaacacgca ttaacaatgc cggccctgga
     1441 gccagcacca ccactgctgg cggacctggg gcctgctctg gagccagagt cacctgcagc
     1501 cctgggtcca ccaggatatc tacattcagc accagggcca gcaccagcac caggggaagg
     1561 gccccctcca gggacagtgc tggagccaca gtcagcccca gagtcctcct gtccctgtcg
     1621 tgggtctgta aagaaccaac ccagtgagga gctgcctgac atgacgacct tccctcccag
     1681 gctgctggca gagcagctga ccctcatgga tgcggagctg ttcaagaagg tggtgctcca
     1741 cgaatgcttg ggctgcatct ggggccaagg acatctgaag gggaatgagc acatggcacc
     1801 cacagttcgt gccaccatcg cacacttcaa caggctcacc aactgcatca ccacctcctg
     1861 cctcggggac cacagcatga gggcccggga cagggccagg gtggtggagc actggatcaa
     1921 ggtggccagg gagtgcctaa gcctcaacaa cttctcctcg gtgcacgtca tcgtctctgc
     1981 tctgtgcagc aacccaatag gtcagctaca caagacgtgg gcaggagtgt ccagcaaaag
     2041 catgaaagag ctaaaagaac tctgcaaaaa agacactgca gtgaagaggg acctactgat
     2101 caaggcgggg agctttaagg tggccaccca ggagaggaac ccccagagag tccagatgag
     2161 gctgcggagg cagaagaagg gtgtggtccc cttcctgggg gattttctga ctgagttaca
     2221 gaggctggat tcggccatcc cggacgacct ggatggcaac accaacaaga ggagcaagga
     2281 ggtccgagtt ctgcaggaaa tgcagctgct ccaagtggct gccatgaatt acaggcttcg
     2341 gcctcttgag aaatttgtca cctatttcac aagaatggag cagctcagtg acaaagagag
     2401 ctacaagctg tcctgccagc tggagcccga aaacccgtag gctggcaaca tcctgcagtg
     2461 gctgggaacc caccgggatg ctggccagaa caccggctct gcaccatccc tcacccagac
     2521 cgtagacacc agggaaccac atctaggagg ctggcagctc agctgcatct tgccctggat
     2581 cctcatcacc aactgctcct gctggccagg atcaggccat gggacttttg tgagtcaggc
     2641 gggagaccat tttatgttta ttttctttag tgtataagta agggtttttt cttaactttc
     2701 gttaaaataa aattttaaaa aacta
//
