LOCUS       NM_001035223            2511 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ral guanine nucleotide dissociation stimulator like 3
            (RGL3), transcript variant 2, mRNA.
ACCESSION   NM_001035223 XM_290867
VERSION     NM_001035223.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2511)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101756.1, BC143530.1 and BM992649.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001035223.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. This
            results in a shorter protein (isoform 2) compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2483414.1, BC014426.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380456.8/ ENSP00000369823.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               BC101756.1         15-534
            521-527             BC143530.1         535-541
            528-1127            BC101756.1         542-1141
            1128-1128           BC143530.1         1142-1142
            1129-1664           BC101756.1         1143-1678
            1665-1665           BC143530.1         1679-1679
            1666-2246           BC101756.1         1680-2260
            2247-2511           BM992649.1         23-287              c
FEATURES             Location/Qualifiers
     source          1..2511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2511
                     /gene="RGL3"
                     /note="ral guanine nucleotide dissociation stimulator like
                     3"
                     /db_xref="GeneID:57139"
                     /db_xref="HGNC:HGNC:30282"
                     /db_xref="MIM:616743"
     exon            1..69
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..2169
                     /gene="RGL3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RalGEF-like protein 3, mouse homolog; ralGDS-like 3"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation
                     stimulator-like 3 isoform 2"
                     /protein_id="NP_001030300.3"
                     /db_xref="CCDS:CCDS32910.1"
                     /db_xref="GeneID:57139"
                     /db_xref="HGNC:HGNC:30282"
                     /db_xref="MIM:616743"
                     /translation="MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEG
                     PGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRT
                     FVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFR
                     DHPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVA
                     QTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVW
                     SQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRC
                     RELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREI
                     LFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFE
                     KRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAAS
                     CPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSVSPGSPPSSPRSRDAP
                     AGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQSSEARVIRVSIDND
                     HGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVF
                     YAMSPVAPRDFMLRRKEGTRNTLSVSPS"
     exon            70..183
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            184..407
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..461
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            462..673
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..816
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1032
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1136
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1221
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1278
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1365
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1398
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1520
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1616
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1685
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1782
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1935
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2050
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2511
                     /gene="RGL3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2511
                     /gene="RGL3"
                     /note="major polyA site"
ORIGIN      
        1 actcagcggc gccactgaga gggacgggcg ccggccatgg agcgcacagc aggcaaagag
       61 ctggccctgg caccgctgca ggactggggt gaagagaccg aggacggcgc ggtgtacagt
      121 gtctccctgc ggcggcagcg cagtcagcgc aggagcccgg cggagggccc cgggggcagc
      181 caggctccca gccccattgc caataccttc ctccactatc gaaccagcaa ggtgagggtg
      241 ctgagggcag cgcgcctgga gcggctggtg ggagagttgg tgtttggaga ccgtgagcag
      301 gaccccagct tcatgcccgc cttcctggcc acctaccgga cctttgtacc cactgcctgc
      361 ctgctgggct ttctgctgcc accaatgcca ccgcccccac ctcccggggt agagatcaag
      421 aagacagcgg tacaagatct gagcttcaac aagaacctga gggctgtggt gtcagtgctg
      481 ggctcctggc tgcaggacca ccctcaggat ttccgagacc accctgccca ttcggacctg
      541 ggcagtgtcc gaacctttct gggctgggcg gccccaggga gtgctgaggc tcaaaaagca
      601 gagaagcttc tggaagattt tttggaggag gctgagcgag agcaggaaga ggagccgcct
      661 caggtgtgga caggacctcc cagagttgcc caaacttctg acccagactc ttcagaggcc
      721 tgcgcggagg aagaggaagg gctcatgcct caaggtcccc agctcctgga cttcagcgtg
      781 gacgaggtgg ccgagcagct gaccctcata gacttggagc tcttctccaa ggtgaggctc
      841 tacgagtgct tgggctccgt gtggtcgcag agggaccggc cgggggctgc aggcgcctcc
      901 cccactgtgc gcgccaccgt ggcccagttc aacaccgtga ccggctgtgt gctgggttcc
      961 gtgctcggag caccgggctt ggccgccccg cagagggcgc agcggctgga gaagtggatc
     1021 cgcatcgccc agcgctgccg agaactgcgg aacttctcct ccttgcgcgc catcctgtcc
     1081 gccctgcaat ctaaccccat ctaccggctc aagcgcagct ggggggcagt gagccgggaa
     1141 ccgctatcta ctttcaggaa actttcgcag attttctccg atgagaacaa ccacctcagc
     1201 agcagagaga ttcttttcca ggaggaggcc actgagggat cccaagaaga ggacaacacc
     1261 ccaggcagcc tgccctcaaa accaccccca ggccctgtcc cctaccttgg caccttcctt
     1321 acggacctgg ttatgctgga cacagccctg ccggatatgt tggaggggga tctcattaac
     1381 tttgagaaga ggaggaagga gtgggagatc ctggcccgca tccagcagct gcagaggcgc
     1441 tgtcagagct acaccctgag cccccacccg cccatcctgg ctgccctgca tgcccagaac
     1501 cagctcaccg aggagcagag ctaccggctc tcccgggtca ttgagccacc agctgcctcc
     1561 tgccccagct ccccacgcat ccgacggcgg atcagcctca ccaagcgtct cagtgcgaag
     1621 cttgcccgag agaaaagctc atcacctagt gggagtcccg gggacccctc atcccccacc
     1681 tccagtgtgt ccccagggtc acccccctca agtcctagaa gcagagatgc tcctgctggc
     1741 agtcccccgg cctctccagg gccccagggc cccagcacca agctgcccct gagcctggac
     1801 ctgcccagcc cccggccctt cgctttgcct ctgggcagcc ctcgaatccc cctcccggcg
     1861 cagcagagct cggaggcccg tgtcatccgc gtcagcatcg acaatgacca cgggaacctg
     1921 tatcgaagca tcttgctgac cagtcaggac aaagccccca gcgtggtccg gcgagccttg
     1981 cagaagcaca atgtgcccca gccctgggcc tgtgactatc agctctttca agtccttcct
     2041 ggggaccggg tgctcctgat tcctgacaat gccaacgtct tctatgccat gagtccagtc
     2101 gcccccagag acttcatgct gcggcggaaa gaggggaccc ggaacactct gtctgtctcc
     2161 ccaagctgag gcagccctgt cctctccaca agacacaagt cccacaggca agcttgcgac
     2221 tcttctcctg gaaagctgcc atcccccagt agaggccact gtgctgtgta tcccaggacc
     2281 accacccaac tgtagcccat tggaccccat ctctttttct gactctgttg gtactagatc
     2341 catattccaa agacatcagc ccatgggtgg ctggtggaga gctcaatccc ataaatgtag
     2401 aaagaggtgg ggcatggata cgtcaaatcc ctccccagag aaatcttata aatgttagag
     2461 acgcatcaga agtgacagat gcggatgaaa atagtgacca gagttatgaa a
//
