LOCUS       NM_004761               2896 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ral guanine nucleotide dissociation stimulator like 2
            (RGL2), transcript variant 1, mRNA.
ACCESSION   NM_004761
VERSION     NM_004761.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2896)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (bases 1 to 2896)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   3  (bases 1 to 2896)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2896)
  AUTHORS   Hershkovitz,D., Gross,Y., Nahum,S., Yehezkel,S., Sarig,O., Uitto,J.
            and Sprecher,E.
  TITLE     Functional characterization of SAMD9, a protein deficient in
            normophosphatemic familial tumoral calcinosis
  JOURNAL   J Invest Dermatol 131 (3), 662-669 (2011)
   PUBMED   21160498
  REMARK    GeneRIF: SAMD9, an IFN-gamma-responsive protein, interacts with
            RGL2 to diminish the expression of EGR1, a protein of direct
            relevance to the pathogenesis of ectopic calcification and
            inflammation.
REFERENCE   5  (bases 1 to 2896)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   6  (bases 1 to 2896)
  AUTHORS   Ando,A., Kikuti,Y.Y., Abe,K., Shigenari,A., Kawata,H., Ikemura,T.,
            Kimura,M. and Inoko,H.
  TITLE     cDNA cloning, northern hybridization, and mapping analysis of a
            putative GDS-related protein gene at the centromeric ends of the
            human and mouse MHC regions
  JOURNAL   Immunogenetics 49 (4), 354-356 (1999)
   PUBMED   10079301
REFERENCE   7  (bases 1 to 2896)
  AUTHORS   Herberg,J.A., Beck,S. and Trowsdale,J.
  TITLE     TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form
            a dense cluster at the centromeric end of the MHC
  JOURNAL   J Mol Biol 277 (4), 839-857 (1998)
   PUBMED   9545376
REFERENCE   8  (bases 1 to 2896)
  AUTHORS   Herberg,J.A., Sgouros,J., Jones,T., Copeman,J., Humphray,S.J.,
            Sheer,D., Cresswell,P., Beck,S. and Trowsdale,J.
  TITLE     Genomic analysis of the Tapasin gene, located close to the TAP loci
            in the MHC
  JOURNAL   Eur J Immunol 28 (2), 459-467 (1998)
   PUBMED   9521053
REFERENCE   9  (bases 1 to 2896)
  AUTHORS   Peterson,S.N., Trabalzini,L., Brtva,T.R., Fischer,T.,
            Altschuler,D.L., Martelli,P., Lapetina,E.G., Der,C.J. and
            White,G.C. 2nd.
  TITLE     Identification of a novel RalGDS-related protein as a candidate
            effector for Ras and Rap1
  JOURNAL   J Biol Chem 271 (47), 29903-29908 (1996)
   PUBMED   8939933
REFERENCE   10 (bases 1 to 2896)
  AUTHORS   Isomura,M., Okui,K., Fujiwara,T., Shin,S. and Nakamura,Y.
  TITLE     Isolation and mapping of RAB2L, a human cDNA that encodes a protein
            homologous to RalGDS
  JOURNAL   Cytogenet Cell Genet 74 (4), 263-265 (1996)
   PUBMED   8976381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL050259.1 and BX648015.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004761.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL050259.1, BC032681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000497454.6/ ENSP00000420211.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2891              AL050259.1         20-2910
            2892-2896           BX648015.1         2683-2687
FEATURES             Location/Qualifiers
     source          1..2896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2896
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /note="ral guanine nucleotide dissociation stimulator like
                     2"
                     /db_xref="GeneID:5863"
                     /db_xref="HGNC:HGNC:9769"
                     /db_xref="MIM:602306"
     exon            1..73
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            74..270
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2448
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GDS-related protein; ralGDS-like factor; ras-associated
                     protein RAB2L; ralGDS-like 2"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation
                     stimulator-like 2 isoform 1"
                     /protein_id="NP_004752.1"
                     /db_xref="CCDS:CCDS4774.1"
                     /db_xref="GeneID:5863"
                     /db_xref="HGNC:HGNC:9769"
                     /db_xref="MIM:602306"
                     /translation="MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQE
                     EEEEEEEEAPVSVWDEEEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVR
                     HLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAI
                     SVLSTWLASHPEDFGSEAKGQLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQ
                     APDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRD
                     RPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEK
                     WIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEED
                     NYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDEL
                     ENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSC
                     EVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPL
                     LTRLAQHMKWPSVSSLDSALESSPSLHSPADPSHLSPPASSPRPSRGHRRSASCGSPL
                     SGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISR
                     VLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDGASHDFLLRQRRRSSTAT
                     PGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF"
     exon            271..354
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            355..533
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            534..584
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            585..882
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1134
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1238
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1323
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1392
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1467
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1500
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1622
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1718
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1830
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2121
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2236
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2896
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /note="hexamer: AATAAA"
     polyA_site      2896
                     /gene="RGL2"
                     /gene_synonym="HKE1.5; KE1.5; RAB2L"
                     /note="major polyA site"
ORIGIN      
        1 gactcggtcc ggggccggag accgacggca acagcggctc aggacccacg ctgcccccac
       61 ccctcccgag caggcgcccc catggcccga ccccgctgat tccttcactc ggccatgctc
      121 ccgcggcccc tgcggctgct tttggacacg agcccccccg ggggagtcgt actgagcagc
      181 ttccgaagcc gggaccccga agagggtggg ggcccaggtg gcctggtcgt gggcgggggg
      241 caggaggaag aggaggagga agaagaagag gcccctgtgt ccgtctggga tgaggaggag
      301 gatggtgccg tgtttaccgt cacaagccgc caatatcgac ctcttgatcc cttggtccct
      361 atgcctcccc cacgttcctc ccgacggctc cgagctggca ctctggaggc cctggtcaga
      421 cacctactgg atacccggac atcagggact gatgtgagct tcatgtcagc cttcctggct
      481 acccaccggg ccttcacctc cacgcctgcc ttgctagggc ttatggctga caggctggaa
      541 gcccttgaat ctcatcctac cgacgaacta gagaggacaa cagaggtagc catctctgta
      601 ctgtcaacct ggctggcctc tcaccctgag gattttggct ctgaggccaa gggtcagctt
      661 gaccggcttg agagcttctt acttcagaca gggtatgcag cagggaaggg tgttgggggg
      721 ggcagcgctg acctcatccg caatctccgg tcccgggtgg acccccaggc ccccgacctt
      781 cctaagcccc tggccctccc cggcgatccc cctgctgacc ccacggatgt cctggtgttc
      841 ctcgctgacc acttggccga acagctgacc ctgctagatg cggaactttt tctcaatttg
      901 atcccctctc agtgcctggg aggcctgtgg ggtcacagag accggccagg acattctcac
      961 ctctgcccat ctgtccgagc tactgtcaca cagtttaaca aggtggcagg ggcagtggtt
     1021 agttctgtcc tgggggctac ttccactgga gagggacctg gggaggtgac catacggcca
     1081 ctccgtcccc cacagagggc ccggctcctg gagaagtgga tccgcgtggc agaggagtgc
     1141 cggctgctcc gaaacttctc ttcagtttat gccgtggtgt cagccctgca gtccagcccc
     1201 atccacaggc ttcgggcagc ctggggggaa gcaaccaggg acagcctcag agtcttttcc
     1261 agcctctgcc agattttctc cgaggaggat aattattccc agagtcggga gctgctcgtg
     1321 caggaggtga agctgcagtc tcctctggag ccacactcca agaaggcccc gaggtctggc
     1381 tcccggggtg ggggtgtggt cccatacctt ggcaccttcc tgaaggacct tgtgatgctg
     1441 gatgcagcct ccaaggatga gttggagaat ggatacatca attttgacaa gcggaggaag
     1501 gagtttgcag tcctttctga gttgcgacgg ctccagaatg aatgtcgtgg ctataacctc
     1561 caacctgacc atgatatcca gaggtggcta caggggctcc ggccactgac agaggctcag
     1621 agccatcgtg tatcctgtga ggtggagcca cctggttcca gtgaccctcc tgccccacgg
     1681 gtgcttcggc caacattggt catctcgcag tggacagagg ttttgggctc tgttggggtc
     1741 cctaccccgc ttgtgtcctg tgaccggccc agtactgggg gagatgaggc gcctacaact
     1801 cctgctcctc tgctgactcg gctggcccag cacatgaagt ggccatctgt ctcgtcacta
     1861 gactctgcct tggaaagcag tccatccctg cacagtccag ctgaccccag ccacctctcc
     1921 ccaccagcct cctcccctag gccttctcga ggtcaccgcc gctcagcctc ctgtggctcc
     1981 ccgctgagtg ggggtgcaga agaggcctcc ggggggactg gatatggggg agagggatct
     2041 gggccagggg cctctgattg ccgtatcatc cgagtccaga tggagttggg ggaagatggc
     2101 agtgtctata agagcatttt ggtgacaagc caggacaagg ctccaagtgt catcagtcgt
     2161 gtccttaaga aaaacaatcg tgactctgca gtggcttcag agtatgagct ggtacagctg
     2221 ctaccagggg agcgagagct gactatccca gcctcggcta atgtattcta cgccatggat
     2281 ggagcttcac acgatttcct cctgcggcag cggcgaaggt cctctactgc tacacctggc
     2341 gtcaccagtg gcccgtctgc ctcaggaact cctccgagtg agggaggagg gggctccttt
     2401 cccaggatca aggccacagg gaggaagatt gcacgggcac tgttctgagg aggaagcccc
     2461 gttggcttac agaagtcatg gtgttcatac cagatgtggg tagccatcct gaatggtggc
     2521 aattatatca cattgagaca gaaattcaga aagggagcca gccaccctgg ggcagtgaag
     2581 tgccactggt ttaccagaca gctgagaaat ccagccctgt gggaactggt gtcttataac
     2641 caagttggat acctgtgtat agcttcccac cttccatgag tgcagcacac aggtagtgct
     2701 ggaaaaacgc atcagtttct gattcttggc catatcctaa catgcaaggg ccaagcaaag
     2761 gcttcaaggc tctgagcccc agggcagagg ggaatggcaa aatgtaggtc ctcgcaggag
     2821 ctcttcttcc cactctgggg gtttctatca ctgtgacaac actaagataa taaaccaaaa
     2881 cactacctga attcta
//
