LOCUS       NM_001297671            4725 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ral guanine nucleotide dissociation stimulator like 1
            (RGL1), transcript variant 4, mRNA.
ACCESSION   NM_001297671 XM_005245010
VERSION     NM_001297671.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4725)
  AUTHORS   Eves,B.J., Gebregiworgis,T., Gasmi-Seabrook,G.M.C., Kuntz,D.A.,
            Prive,G.G., Marshall,C.B. and Ikura,M.
  TITLE     Structures of RGL1 RAS-Association Domain in Complex with KRAS and
            the Oncogenic G12V Mutant
  JOURNAL   J Mol Biol 434 (9), 167527 (2022)
   PUBMED   35257782
  REMARK    GeneRIF: Structures of RGL1 RAS-Association Domain in Complex with
            KRAS and the Oncogenic G12V Mutant.
REFERENCE   2  (bases 1 to 4725)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4725)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4725)
  AUTHORS   Smith,M.J. and Ikura,M.
  TITLE     Integrated RAS signaling defined by parallel NMR detection of
            effectors and regulators
  JOURNAL   Nat Chem Biol 10 (3), 223-230 (2014)
   PUBMED   24441586
REFERENCE   5  (bases 1 to 4725)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   6  (bases 1 to 4725)
  AUTHORS   Sood,R., Makalowska,I., Carpten,J.D., Robbins,C.M., Stephan,D.A.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Pinkett,H.W., Graham,C.L.,
            Quesenberry,M.I., Baxevanis,A.D., Klinger,K.W., Trent,J.M. and
            Bonner,T.I.
  TITLE     The human RGL (RalGDS-like) gene: cloning, expression analysis and
            genomic organization
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 285-288 (2000)
   PUBMED   10760592
REFERENCE   7  (bases 1 to 4725)
  AUTHORS   Shao,H., Kadono-Okuda,K., Finlin,B.S. and Andres,D.A.
  TITLE     Biochemical characterization of the Ras-related GTPases Rit and Rin
  JOURNAL   Arch Biochem Biophys 371 (2), 207-219 (1999)
   PUBMED   10545207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK311716.1, AB023176.1 and BF197850.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001297671.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (3) has a distinct N-terminus and is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186779.1, AB023176.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360851.4/ ENSP00000354097.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AK311716.1         40-60
            22-4724             AB023176.1         1-4703
            4725-4725           BF197850.1         20-20               c
FEATURES             Location/Qualifiers
     source          1..4725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..4725
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /note="ral guanine nucleotide dissociation stimulator like
                     1"
                     /db_xref="GeneID:23179"
                     /db_xref="HGNC:HGNC:30281"
                     /db_xref="MIM:605667"
     exon            1..205
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2485
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /note="isoform 3 is encoded by transcript variant 4;
                     ralGDS-like 1"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation
                     stimulator-like 1 isoform 3"
                     /protein_id="NP_001284600.1"
                     /db_xref="CCDS:CCDS72992.1"
                     /db_xref="GeneID:23179"
                     /db_xref="HGNC:HGNC:30281"
                     /db_xref="MIM:605667"
                     /translation="MKLLWQAKMSSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARW
                     LGVEGDQLPPGHTVSQYETCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRG
                     FASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFR
                     EPPHFPCLQKLLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEE
                     ELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTI
                     RATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSA
                     LQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSS
                     VKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRR
                     EFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTS
                     PKPRKSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEA
                     EEGSITPMDTPDEPQKKLSESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIH
                     KRSVSVTSITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRA
                     MLKHNLDSDPAEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQV
                     KLRSRTSLTLPRTAKRGCWSNRHSKITL"
     exon            206..316
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            317..525
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            526..603
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            604..788
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            789..913
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1129
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1233
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1318
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1408
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1495
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1528
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1650
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1740
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1927
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2182
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2297
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..4725
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4676..4681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /note="hexamer: AATAAA"
     polyA_site      4725
                     /gene="RGL1"
                     /gene_synonym="RGL"
                     /note="major polyA site"
ORIGIN      
        1 gtggcccgag tcgcgcgcac cggcggcggc gggggcagcg cggcgcgtgt ctgtgcgctg
       61 cggtcgctcg ggaccgggac cggggcgagg cgccgcgggg ctgagcccag cagacattgc
      121 gttggcctcc gagcagggcg catcatgcag cgttcgcgca ccggagagaa aactgagaat
      181 gaaattgctt tggcaagcta aaatgagctc gattcaggac tggggtgaag aggtagagga
      241 aggagctgtt taccatgtca ccctcaaaag agtccagatt caacaggctg ccaataaagg
      301 agcaagatgg ctaggggttg aaggggacca gctgcctcca ggacacacag tcagtcaata
      361 tgaaacctgt aagatcagga ccataaaagc tggcaccttg gagaagcttg tggagaacct
      421 gctgacagct tttggggaca atgactttac ctatatcagc atctttcttt caacgtacag
      481 aggctttgcc tccactaaag aagtgctgga actactgctg gacaggtatg gaaacctgac
      541 aagcccaaac tgtgaagaag atggaagcca aagttcatca gagtccaaaa tggtgatcag
      601 gaatgcaatc gcttccatac taagggcctg gcttgaccag tgtgcagaag acttccgaga
      661 gccccctcac ttcccttgct tacagaaact gctggattat ctcacacgga tgatgccggg
      721 ctctgaccca gaaagaagag cacaaaatct tcttgagcag tttcagaagc aagaagtgga
      781 aactgacaat gggcttccca acacgatctc cttcagcctg gaagaggaag aggaactgga
      841 gggtggagag tcagcagaat tcacgtgctt ctcagaagat ctcgtggcag agcagctgac
      901 ctacatggat gcacaactct tcaagaaagt agtgcctcac cactgcctgg gctgcatttg
      961 gtctcgaagg gataagaagg aaaacaaaca tttggctcct acgatccgtg ccaccatctc
     1021 tcagtttaat accctcacca aatgtgttgt cagcaccatc ctggggggca aagaactcaa
     1081 aactcagcag agagccaaaa tcattgagaa gtggatcaac atcgctcatg aatgtagact
     1141 cctgaagaat ttttcctcct tgagggccat cgtttcggca ctgcagtcta attccatcta
     1201 tcggttaaaa aagacttggg ctgccgtccc aagggaccga atgctgatgt ttgaagaact
     1261 ttcagatatc ttctcagacc ataataacca tttgaccagc cgagaactac tgatgaagga
     1321 aggaacctca aaatttgcaa acctggacag cagtgtgaaa gaaaaccaga agcgtaccca
     1381 gaggcggctg cagctccaga aggacatggg tgtgatgcag ggaactgtgc cctacctggg
     1441 caccttcctg actgacctga ccatgcttga cactgccctt caggactaca tcgagggtgg
     1501 actgataaac tttgagaaaa ggagaaggga atttgaagtg attgcccaga taaagctctt
     1561 acagtctgcc tgcaacagct attgcatgac cccagaccaa aagttcatcc agtggttcca
     1621 gaggcagcag ctcctgacag aggaggagag ctatgccctg tcatgtgaga ttgaagcagc
     1681 tgctgacgcc agcaccacct cgcccaagcc tcggaagagc atggtgaaga gactcagcct
     1741 actgtttcta gggtctgaca tgatcaccag tcccactccc accaaagagc agcccaagtc
     1801 cactgccagc gggagctctg gtgaaagcat ggactctgtc agcgtgtcat cctgcgagtc
     1861 gaaccactca gaggctgagg agggctccat tactcccatg gacacccctg atgagcctca
     1921 aaaaaagctc tctgagtcct cctcatcctg ttcttctatc cattccatgg acacaaattc
     1981 ctcagggatg tcttccttaa tcaaccccct ctcctcccct ccgtcctgca acaacaaccc
     2041 caaaatccac aagcgctctg tctcggtgac gtccattacc tcgactgtgc tgcctcctgt
     2101 ttacaaccaa cagaatgaag acacctgcat aatccgcatc agtgtggaag acaataacgg
     2161 caacatgtac aagagcatca tgttgacgag ccaggataaa acccccgctg tgatccagag
     2221 agccatgctg aagcacaatc tggactcaga ccccgccgag gagtacgagc tggtgcaggt
     2281 catctcggag gacaaagaac ttgtgattcc agactcagca aatgtctttt atgccatgaa
     2341 cagccaagtg aactttgact tcattttgcg caaaaagaac tccatggaag aacaagtgaa
     2401 actgcgtagc cggaccagct tgacgttgcc caggacagct aaacggggct gctggagtaa
     2461 cagacacagc aaaatcaccc tctgaaggga gggaccagtg gccccttgtt tgccaaaggc
     2521 agagtggggc tgagaaacag gctgcggtga ttgcaattac catccggtgt tcgaggatca
     2581 ttggtgaagt cagcagatat ttattgagtt cctgtggtgt gcaaagcatt atgataggca
     2641 ccgtggggaa actggaaatg aatttgacat gaaaaggatg aacgattcac tgattctctt
     2701 tgactcattt gagactaaaa tgcagaatta ccaacattta aaacatatat atgcacatgt
     2761 atttggtatg catgtgtatc tatataaaaa tatataagag ggactttatg ggatagtatg
     2821 gactatggaa aaacaaattt gcacaatggc ctgggaagtt gaggtcactt tttacaggga
     2881 aatagaagaa actgagaacc tagtctcgta tattctgagt aaatggaatc agtcctggga
     2941 atagagagtg tcctttgtgc cagtattaca agaagcccaa actttatttt tataaaggga
     3001 gaggatgact ttctcaatca agtgccacca gataaaaaca actgcagagg ctggaactgc
     3061 cacaggctgt atgaaaggcc actttggaaa gggtttggat gagctggtgg ccttcaacct
     3121 ctgcctgcat ctgccacttt ctgctaccct agggaggcca ggaggagctt cggaggacca
     3181 tcgccccact ggtctagcca tcatgacacc tctggaggtg tcaagctcct gaaacaagct
     3241 catttcagtt tctggcaacc ccgtgtattt ccgttttccc cctaaagaac atatcataat
     3301 cattgcacaa ataaccatgt tctttggtaa tgaagccaga aaagaaagcg caaaagaatg
     3361 gtgactcatt tggactctta tctgtcttgg aatgtcactg cttcattgcc ttctctgatt
     3421 gccttttgca tgtaaaacta tgtgtctgga gtcttttgcc atctggatct tagtacctct
     3481 ttattatgtg caatttattc ctcaggtgtg gaaatttcta ctgcaattga ctacgtttga
     3541 ttattttgag cttgtgaaag atttctgaac agtgattgtc ccgttaatag cccctcagaa
     3601 gatgttccct gctgataaca gcatcctatt ttacttactt ttatagcatt actgtgccta
     3661 gtcgtgggga aagagatggg gctgtataga ttatctgaat catttgtcta agaggtacat
     3721 tcttccagat ggaatcaata actttttttt ttccaggttc ccgtgcttgc tatcacagta
     3781 tcattgttaa gtgacacttt tgtctctcat aacaccatca cactcttcct tccaagtctg
     3841 agctgtgctg gggtttgaac taaaagccat atgtggaata ttgacatgtg taagaagcac
     3901 tttcagaatg ttgtcctttt taagaaatga ttctcaaaat accagttttt attccaaaaa
     3961 tttagagaac aaacccggaa tatgaagtgc agattgtaac atggagctat ttttttttct
     4021 taatcccata atacagctcc taaaagttgt gtgggatttg cgttgcataa atagccatgt
     4081 gaattccaca agaagcacca gggaaagttt agagatttgc ggcaatggac cgaagaacgg
     4141 gccaggaagt cctccaattt cctttggtct ttccaggaga ttggactaca cattgtaaag
     4201 actgactggg tttcaactag tcaaaaagca ctttcttctg ttttcaatcc ctgttcgatt
     4261 tgtgcttctg tgcttgtagg agagatggcc agggtggcag ccctcatgca ggttgaagta
     4321 tatgtagcct cagcctgata ttcttggtgc gaaggtaaaa aaaaaaaaat aaataaaacc
     4381 attggcctgg ttgagggcgt gaccaccaag acatatatgt tgtgcccgtg ttcatcctgt
     4441 gtatttatac tgtatatgta gagtctagat ttatatactg caatgtaaaa tatatatata
     4501 tttacctttt ttaaagacaa tggaaattcc aagtagctaa aacttagctt catttattta
     4561 atgccacttt aaatgtctta aatttgtttc ctggtggaca gccgggtaat gcttttagct
     4621 gctcgcatgc ttgtctttct gcatctccat catctgttta ccttttggtt aaactaataa
     4681 actagtttgg gacttggctg gcatgtgctg ccagacccaa aggga
//
