LOCUS       NM_014059                958 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of cell cycle (RGCC), mRNA.
ACCESSION   NM_014059 XM_001132553
VERSION     NM_014059.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 958)
  AUTHORS   Tatomir,A., Cuevas,J., Badea,T.C., Muresanu,D.F., Rus,V. and Rus,H.
  TITLE     Role of RGC-32 in multiple sclerosis and neuroinflammation - few
            answers and many questions
  JOURNAL   Front Immunol 13, 979414 (2022)
   PUBMED   36172382
  REMARK    GeneRIF: Role of RGC-32 in multiple sclerosis and neuroinflammation
            - few answers and many questions.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 958)
  AUTHORS   Vlaicu,S.I., Tatomir,A., Fosbrink,M., Nguyen,V., Boodhoo,D.,
            Cudrici,C., Badea,T.C., Rus,V. and Rus,H.
  TITLE     RGC-32' dual role in smooth muscle cells and atherogenesis
  JOURNAL   Clin Immunol 238, 109020 (2022)
   PUBMED   35462050
  REMARK    GeneRIF: RGC-32' dual role in smooth muscle cells and
            atherogenesis.
REFERENCE   3  (bases 1 to 958)
  AUTHORS   Yang,Z.H., Li,J., Chen,W.Z. and Kong,F.S.
  TITLE     Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates
            tongue squamous cell carcinoma aggressiveness through EMT and
            PI3K/AKT signalling
  JOURNAL   Cell Biochem Funct 38 (7), 943-954 (2020)
   PUBMED   32325539
  REMARK    GeneRIF: Oncogenic gene RGC-32 is a direct target of miR-26b and
            facilitates tongue squamous cell carcinoma aggressiveness through
            EMT and PI3K/AKT signalling.
REFERENCE   4  (bases 1 to 958)
  AUTHORS   Zhao,P., Wang,B., Zhang,Z., Zhang,W. and Liu,Y.
  TITLE     Response gene to complement 32 expression in macrophages augments
            paracrine stimulation-mediated colon cancer progression
  JOURNAL   Cell Death Dis 10 (10), 776 (2019)
   PUBMED   31601783
  REMARK    GeneRIF: Response gene to complement 32 expression in macrophages
            augments paracrine stimulation-mediated colon cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 958)
  AUTHORS   Kim,H.J., Jang,J., Lee,E.H., Jung,S., Roh,J.Y. and Jung,Y.
  TITLE     Decreased expression of response gene to complement 32 in psoriasis
            and its association with reduced M2 macrophage polarization
  JOURNAL   J Dermatol 46 (2), 166-168 (2019)
   PUBMED   30600542
  REMARK    GeneRIF: Study findings suggest that diminished RGC-32 expression
            and M2 macrophage polarization were associated with the
            pro-inflammatory microenvironment of psoriasis.
REFERENCE   6  (bases 1 to 958)
  AUTHORS   Fosbrink,M., Cudrici,C., Niculescu,F., Badea,T.C., David,S.,
            Shamsuddin,A., Shin,M.L. and Rus,H.
  TITLE     Overexpression of RGC-32 in colon cancer and other tumors
  JOURNAL   Exp Mol Pathol 78 (2), 116-122 (2005)
   PUBMED   15713436
  REMARK    GeneRIF: RGC-32 overexpression might be part of the deregulation of
            the cell cycle that is required for the growth of tumor cells
REFERENCE   7  (bases 1 to 958)
  AUTHORS   Fosbrink,M., Niculescu,F. and Rus,H.
  TITLE     The role of c5b-9 terminal complement complex in activation of the
            cell cycle and transcription
  JOURNAL   Immunol Res 31 (1), 37-46 (2005)
   PUBMED   15591621
  REMARK    Review article
REFERENCE   8  (bases 1 to 958)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 958)
  AUTHORS   Badea,T., Niculescu,F., Soane,L., Fosbrink,M., Sorana,H., Rus,V.,
            Shin,M.L. and Rus,H.
  TITLE     RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth
            muscle cells into S-phase
  JOURNAL   J Biol Chem 277 (1), 502-508 (2002)
   PUBMED   11687586
REFERENCE   10 (bases 1 to 958)
  AUTHORS   Badea,T.C., Niculescu,F.I., Soane,L., Shin,M.L. and Rus,H.
  TITLE     Molecular cloning and characterization of RGC-32, a novel gene
            induced by complement activation in oligodendrocytes
  JOURNAL   J Biol Chem 273 (41), 26977-26981 (1998)
   PUBMED   9756947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451897.1 and BC066334.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014059.2.
            
            Summary: This gene is thought to regulate cell cycle progression.
            It is induced by p53 in response to DNA damage, or by sublytic
            levels of complement system proteins that result in activation of
            the cell cycle. The encoded protein localizes to the cytoplasm
            during interphase and to centrosomes during mitosis. The protein
            forms a complex with polo-like kinase 1. The protein also
            translocates to the nucleus in response to treatment with
            complement system proteins, and can associate with and increase the
            kinase activity of cell division cycle 2 protein. In different
            assays and cell types, overexpression of this protein has been
            shown to activate or suppress cell cycle progression. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066334.1, ERR279873.1070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379359.4/ ENSP00000368664.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               DB451897.1         145-310
            167-958             BC066334.1         167-958
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..958
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /note="regulator of cell cycle"
                     /db_xref="GeneID:28984"
                     /db_xref="HGNC:HGNC:20369"
                     /db_xref="MIM:610077"
     exon            1..207
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..572
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /note="response gene to complement 32 protein"
                     /codon_start=1
                     /product="regulator of cell cycle RGCC"
                     /protein_id="NP_054778.2"
                     /db_xref="CCDS:CCDS41880.1"
                     /db_xref="GeneID:28984"
                     /db_xref="HGNC:HGNC:20369"
                     /db_xref="MIM:610077"
                     /translation="MKPPAAQGSPAAAAAAAPALDSAAAEDLSDALCEFDAVLADFAS
                     PFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRNSFSFSDEKLNSPTDST
                     PALLSATVTPQKAKLGDTKELEAFIADLDKTLASM"
     exon            208..393
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /inference="alignment:Splign:2.1.0"
     exon            394..501
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /inference="alignment:Splign:2.1.0"
     exon            502..564
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /inference="alignment:Splign:2.1.0"
     exon            565..958
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /note="hexamer: AATAAA"
     polyA_site      958
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /note="major polyA site"
ORIGIN      
        1 agggcgggcg cggaccgtgc tgggagcggc gcggctggag cgcagcgccg aagggactgg
       61 cagggctgaa gtgtgcggga cagcaagccc ccgaatagcc ccggctgcca cctcgcagga
      121 cccaaggcca cgcgcgccgg gcccagctga gccgcctcat gaagccgccc gcggcgcagg
      181 gcagccccgc ggccgccgcg gccgcagccc cggccctgga ctcggcggcc gcggaggacc
      241 tgtcggacgc gctgtgcgag tttgacgcgg tgctggccga cttcgcgtcg cccttccacg
      301 agcgccactt ccactacgag gagcacctgg agcgcatgaa gcggcgcagc agcgccagtg
      361 tcagcgacag cagcggcttc agcgactcgg agagtgcaga ttcactttat aggaacagct
      421 tcagcttcag tgatgaaaaa ctgaattctc caacagactc taccccagct cttctctctg
      481 ccactgtcac tcctcagaaa gctaaattag gagacacaaa agagctagaa gccttcattg
      541 ctgatcttga caaaacttta gcaagtatgt gaaacaagaa gttctgggtc ctttcatcat
      601 aagggagaag cttcagaaag ttccgaggac ctgctaaaat cagctactag aatctgctgc
      661 cagaggggac aaagacgtgc actcaacctt ctaccaggcc actctcaggc tcaccttaaa
      721 atcagccctt gatcccattt ctgggcaatt tagacagtga aactgacttt gtttacctgc
      781 ttgcagcata ttagaacaga cgatccatgc taatattgta ttttctctta aaacatagct
      841 ttcctgtaat ttaaagtgct tttatgaaaa tatttgtaat taattatata tagttggaaa
      901 tagcagtaag ctttcccatt ataatatatt tttgtataca aataaaattt gaactgaa
//
