LOCUS       NM_001145664            2140 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulatory factor X8 (RFX8), transcript variant 1,
            mRNA.
ACCESSION   NM_001145664 XR_040157 XR_040158 XR_040159
VERSION     NM_001145664.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Sugiaman-Trapman,D., Vitezic,M., Jouhilahti,E.M., Mathelier,A.,
            Lauter,G., Misra,S., Daub,C.O., Kere,J. and Swoboda,P.
  TITLE     Characterization of the human RFX transcription factor family by
            regulatory and target gene analysis
  JOURNAL   BMC Genomics 19 (1), 181 (2018)
   PUBMED   29510665
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Liu,M., Ingle,J.N., Fridley,B.L., Buzdar,A.U., Robson,M.E.,
            Kubo,M., Wang,L., Batzler,A., Jenkins,G.D., Pietrzak,T.L.,
            Carlson,E.E., Goetz,M.P., Northfelt,D.W., Perez,E.A.,
            Williard,C.V., Schaid,D.J., Nakamura,Y. and Weinshilboum,R.M.
  TITLE     TSPYL5 SNPs: association with plasma estradiol concentrations and
            aromatase expression
  JOURNAL   Mol Endocrinol 27 (4), 657-670 (2013)
   PUBMED   23518928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092570.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001145664.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428343.6/ ENSP00000401536.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               AC092570.3         102967-103443       c
            478-601             AC092570.3         95108-95231         c
            602-712             AC092570.3         50693-50803         c
            713-766             AC092570.3         50055-50108         c
            767-880             AC092570.3         47182-47295         c
            881-1031            AC092570.3         45865-46015         c
            1032-1090           AC092570.3         43185-43243         c
            1091-1247           AC092570.3         41246-41402         c
            1248-1342           AC092570.3         38950-39044         c
            1343-1457           AC092570.3         34274-34388         c
            1458-1774           AC092570.3         30767-31083         c
            1775-2140           AC092570.3         25690-26055         c
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2140
                     /gene="RFX8"
                     /note="regulatory factor X8"
                     /db_xref="GeneID:731220"
                     /db_xref="HGNC:HGNC:37253"
     exon            1..477
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            478..601
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..1951
                     /gene="RFX8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein RFX8; regulatory factor X, 8; RFX
                     family member 8, lacking RFX DNA binding domain"
                     /codon_start=1
                     /product="DNA-binding protein RFX8 isoform 1"
                     /protein_id="NP_001139136.2"
                     /db_xref="CCDS:CCDS46376.1"
                     /db_xref="GeneID:731220"
                     /db_xref="HGNC:HGNC:37253"
                     /translation="MYEIYVETCGQNTENQVNPATFGKCEDHSPMKTDPVGSPLSEFR
                     RCPFLEQEQAKKYSCNMMAFLADEYCNYCRDILRNVEDLLTSFWKSLQQDTVMLMSLP
                     DVCQLFKCYDVQLYKGIEDVLLHDFLEDVSIQYLKSVQLFSKKFKLWLLNALEGVPAL
                     LQISKLKEVTLFVKRLRRKTYLSNMAKTMRMVLKSKRRVSVLKSDLQAIINQGTLATS
                     KKALASDRSGADELENNPEMKCLRNLISLLGTSTDLRVFLSCLSSHLQAFVFQTSRSK
                     EEFTKLAASFQLRWNLLLTAVSKAMTLCHRDSFGSWHLFHLLLLEYMIHILQSCLEEE
                     EEEEDMGTVKEMLPDDPTLGQPDQALFHSLNSSLSQACASPSMEPLGVMPTHMGQGRY
                     PVGVSNMVLRILGFLVDTAMGNKLIQVLLEDETTESAVKLSLPMGQEALITLKDGQQF
                     VIQISDVPQSSEDIYFRENNANV"
     exon            602..712
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            713..766
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            767..880
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1031
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1090
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1247
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1342
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1457
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1774
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2140
                     /gene="RFX8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFX8"
                     /note="hexamer: GATAAA"
     polyA_site      2140
                     /gene="RFX8"
                     /note="major polyA site"
ORIGIN      
        1 acaaaggaag tgaacttgga gatggccagc agctccatgt cacacagcaa tgacactgac
       61 ataaatggct cttgagagca aggactggca ggacctggct acagatatgg ggactcacgt
      121 tgaggtggca ctgctcacct ggagcagcac actggagtca cctgggacca gcctcctaga
      181 agtccagatg cgcccgcctg ccagagagct ccgagatttt tcaaaactcc tagagacagt
      241 ggttttcagc aacggcgggc acattagcat cacccgggac cctgaaaaag ccggttggcc
      301 caggcggccc tcgcccagac caattcatca gaacctcttg gggtggggtg gggcggggct
      361 gggatgggga gcggcagccg gggtatcaat atttttgaaa actgcctgaa taactccaac
      421 gctcaagcaa gtcaaggaca cccacggact caacaccgcg accagattgg aaaaggtgtt
      481 ggtcgacaac ttctgcattt gcgaagagtg cagcgtccct cgctgtctca tgtatgagat
      541 ttacgtggag acctgtgggc aaaacactga gaaccaagtc aacccggcca cctttgggaa
      601 gtgtgaagat cattcaccga tgaagacaga cccagttgga tcccctttgt ctgaattcag
      661 gagatgtcca tttctggagc aagaacaggc aaagaaatac tcctgtaata tgatggcctt
      721 ccttgctgac gaatactgca actattgtcg agacatttta cgaaatgtgg aggacttgct
      781 tacttccttc tggaagtctc tgcagcaaga cacagtcatg ctgatgtcat tgcctgacgt
      841 gtgccagctc tttaaatgct acgacgtcca gctgtacaag ggaattgagg atgttctcct
      901 tcatgacttc ttggaagatg tttctattca gtacctgaaa tctgtgcagt tatttagtaa
      961 gaaatttaag ctgtggctcc ttaatgcttt ggaaggtgtt ccagccctct tgcagatctc
     1021 caaactcaaa gaagttactc tatttgtcaa aagactaaga agaaagacgt acctttccaa
     1081 catggctaag actatgcgaa tggtattgaa aagtaagagg cgtgtcagcg ttttgaagtc
     1141 agatctacag gccatcatca atcaaggcac tttggctact tctaagaaag ccctggcaag
     1201 tgaccggagt ggcgcagatg aactggagaa caacccagag atgaaatgtt taagaaactt
     1261 aatttctttg ctgggaacat caacagatct cagggtattc ctcagctgtc tgtcttcaca
     1321 tctccaagca tttgtgttcc agacaagcag aagcaaagaa gagtttacca aattggccgc
     1381 cagcttccag ctgagatgga atcttcttct cactgctgta agcaaagcca tgaccctctg
     1441 ccacagagat agttttggct cctggcatct gtttcacttg ttgcttttgg aatatatgat
     1501 tcatatactt cagtcatgcc tagaggagga agaggaggag gaggacatgg ggactgtcaa
     1561 ggaaatgcta ccagatgacc cgactctcgg ccagccagac caggcacttt tccattctct
     1621 gaattcctca ctgtcgcagg cgtgtgccag ccccagcatg gagccactgg gggtgatgcc
     1681 cacacacatg ggccagggcc gatatcccgt gggtgtgagc aacatggtcc tcaggatcct
     1741 gggcttcctg gtggacactg ccatgggcaa taagctcatc caggtgctgt tggaagatga
     1801 aaccactgaa agcgcagtta aactcagcct tcctatggga caagaagccc tcataaccct
     1861 aaaagatgga caacaatttg tgattcagat atcagatgta ccccaaagct ctgaagatat
     1921 ttatttcaga gaaaacaatg ctaatgtgtg agattattta tttgaataga gaataagaaa
     1981 actgatagac ttgcattctt aaaaatatta aatactaaag tttttctatt gacgaaagat
     2041 gatgttatgt atataataga tgtagcattg tctattttat gtttatatgt atttcaagga
     2101 ggtggtttcg ataaaatatg taaactgatt tggagaataa
//
