LOCUS       NM_022841              10885 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulatory factor X7 (RFX7), transcript variant 1,
            mRNA.
ACCESSION   NM_022841
VERSION     NM_022841.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10885)
  AUTHORS   Coronel,L., Riege,K., Schwab,K., Forste,S., Hackes,D., Semerau,L.,
            Bernhart,S.H., Siebert,R., Hoffmann,S. and Fischer,M.
  TITLE     Transcription factor RFX7 governs a tumor suppressor network in
            response to p53 and stress
  JOURNAL   Nucleic Acids Res 49 (13), 7437-7456 (2021)
   PUBMED   34197623
  REMARK    GeneRIF: Transcription factor RFX7 governs a tumor suppressor
            network in response to p53 and stress.
REFERENCE   2  (bases 1 to 10885)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 10885)
  AUTHORS   Gao,J. and Xu,C.
  TITLE     Structural basis for the recognition of RFX7 by ANKRA2 and RFXANK
  JOURNAL   Biochem Biophys Res Commun 523 (1), 263-266 (2020)
   PUBMED   31864703
  REMARK    GeneRIF: Structural basis for the recognition of RFX7 by ANKRA2 and
            RFXANK.
REFERENCE   4  (bases 1 to 10885)
  AUTHORS   Castro,W., Chelbi,S.T., Niogret,C., Ramon-Barros,C., Welten,S.P.M.,
            Osterheld,K., Wang,H., Rota,G., Morgado,L., Vivier,E., Raeber,M.E.,
            Boyman,O., Delorenzi,M., Barras,D., Ho,P.C., Oxenius,A. and
            Guarda,G.
  TITLE     The transcription factor Rfx7 limits metabolism of NK cells and
            promotes their maintenance and immunity
  JOURNAL   Nat Immunol 19 (8), 809-820 (2018)
   PUBMED   29967452
REFERENCE   5  (bases 1 to 10885)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 10885)
  AUTHORS   Berndt,S.I., Skibola,C.F., Joseph,V., Camp,N.J., Nieters,A.,
            Wang,Z., Cozen,W., Monnereau,A., Wang,S.S., Kelly,R.S., Lan,Q.,
            Teras,L.R., Chatterjee,N., Chung,C.C., Yeager,M.,
            Brooks-Wilson,A.R., Hartge,P., Purdue,M.P., Birmann,B.M.,
            Armstrong,B.K., Cocco,P., Zhang,Y., Severi,G.,
            Zeleniuch-Jacquotte,A., Lawrence,C., Burdette,L., Yuenger,J.,
            Hutchinson,A., Jacobs,K.B., Call,T.G., Shanafelt,T.D., Novak,A.J.,
            Kay,N.E., Liebow,M., Wang,A.H., Smedby,K.E., Adami,H.O., Melbye,M.,
            Glimelius,B., Chang,E.T., Glenn,M., Curtin,K.,
            Cannon-Albright,L.A., Jones,B., Diver,W.R., Link,B.K., Weiner,G.J.,
            Conde,L., Bracci,P.M., Riby,J., Holly,E.A., Smith,M.T.,
            Jackson,R.D., Tinker,L.F., Benavente,Y., Becker,N., Boffetta,P.,
            Brennan,P., Foretova,L., Maynadie,M., McKay,J., Staines,A.,
            Rabe,K.G., Achenbach,S.J., Vachon,C.M., Goldin,L.R., Strom,S.S.,
            Lanasa,M.C., Spector,L.G., Leis,J.F., Cunningham,J.M.,
            Weinberg,J.B., Morrison,V.A., Caporaso,N.E., Norman,A.D.,
            Linet,M.S., De Roos,A.J., Morton,L.M., Severson,R.K., Riboli,E.,
            Vineis,P., Kaaks,R., Trichopoulos,D., Masala,G., Weiderpass,E.,
            Chirlaque,M.D., Vermeulen,R.C., Travis,R.C., Giles,G.G.,
            Albanes,D., Virtamo,J., Weinstein,S., Clavel,J., Zheng,T.,
            Holford,T.R., Offit,K., Zelenetz,A., Klein,R.J., Spinelli,J.J.,
            Bertrand,K.A., Laden,F., Giovannucci,E., Kraft,P., Kricker,A.,
            Turner,J., Vajdic,C.M., Ennas,M.G., Ferri,G.M., Miligi,L.,
            Liang,L., Sampson,J., Crouch,S., Park,J.H., North,K.E., Cox,A.,
            Snowden,J.A., Wright,J., Carracedo,A., Lopez-Otin,C., Bea,S.,
            Salaverria,I., Martin-Garcia,D., Campo,E., Fraumeni,J.F. Jr., de
            Sanjose,S., Hjalgrim,H., Cerhan,J.R., Chanock,S.J., Rothman,N. and
            Slager,S.L.
  TITLE     Genome-wide association study identifies multiple risk loci for
            chronic lymphocytic leukemia
  JOURNAL   Nat Genet 45 (8), 868-876 (2013)
   PUBMED   23770605
REFERENCE   7  (bases 1 to 10885)
  AUTHORS   Crowther-Swanepoel,D., Broderick,P., Di Bernardo,M.C.,
            Dobbins,S.E., Torres,M., Mansouri,M., Ruiz-Ponte,C., Enjuanes,A.,
            Rosenquist,R., Carracedo,A., Jurlander,J., Campo,E., Juliusson,G.,
            Montserrat,E., Smedby,K.E., Dyer,M.J., Matutes,E., Dearden,C.,
            Sunter,N.J., Hall,A.G., Mainou-Fowler,T., Jackson,G.H.,
            Summerfield,G., Harris,R.J., Pettitt,A.R., Allsup,D.J.,
            Bailey,J.R., Pratt,G., Pepper,C., Fegan,C., Parker,A., Oscier,D.,
            Allan,J.M., Catovsky,D. and Houlston,R.S.
  TITLE     Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence
            chronic lymphocytic leukemia risk
  JOURNAL   Nat Genet 42 (2), 132-136 (2010)
   PUBMED   20062064
REFERENCE   8  (bases 1 to 10885)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 10885)
  AUTHORS   Aftab,S., Semenec,L., Chu,J.S. and Chen,N.
  TITLE     Identification and characterization of novel human tissue-specific
            RFX transcription factors
  JOURNAL   BMC Evol Biol 8, 226 (2008)
   PUBMED   18673564
  REMARK    GeneRIF: RFX7 is a winged helix transcription factor expressed
            ubiquitously in all tissues examined, especially brain tissue.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 10885)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068726.5, AC084783.2 and KF456052.1.
            
            On May 10, 2019 this sequence version replaced NM_022841.6.
            
            Summary: RFX7 is a member of the regulatory factor X (RFX) family
            of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008
            [PubMed 18673564]).[supplied by OMIM, Mar 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.675153.1,
                                           DRR138518.479905.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000559447.8/ ENSP00000453281.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AC068726.5         51399-51833         c
            436-598             AC068726.5         51079-51241         c
            599-632             AC084783.2         146533-146566       c
            633-715             AC084783.2         111664-111746       c
            716-838             AC084783.2         110041-110163       c
            839-955             AC084783.2         70817-70933         c
            956-1040            AC084783.2         69432-69516         c
            1041-1248           AC084783.2         68622-68829         c
            1249-1544           AC084783.2         65344-65639         c
            1545-3603           AC084783.2         61825-63883         c
            3604-3977           KF456052.1         1-374               c
            3978-10885          AC084783.2         54543-61450         c
FEATURES             Location/Qualifiers
     source          1..10885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..10885
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /note="regulatory factor X7"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
     exon            1..435
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..598
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..4820
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulatory factor X domain containing 2; DNA-binding
                     protein RFX7; regulatory factor X domain-containing
                     protein 2; regulatory factor X, 7"
                     /codon_start=1
                     /product="DNA-binding protein RFX7 isoform 1"
                     /protein_id="NP_073752.6"
                     /db_xref="CCDS:CCDS92005.1"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
                     /translation="MAEEQQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASA
                     LQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSNGEKSDQNAMSSSR
                     AQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPN
                     MKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEV
                     ISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPAGMKGIT
                     QPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESAAKKSE
                     SATSNGVTNLPNGNPSILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLP
                     LNVQVVTQHMQSVKQAPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTV
                     LFTSSPIKTAVVPASHMSSLNVVKMTTISLTPSNSNTPLKHSASVSSATGTTEESRSV
                     PQIKNGSVVSLQSPGSRSSSAGGTSAVEVKVEPETSSDEHPVQCQENSDEAKAPQTPS
                     ALLGQKSNTDGALQKPSNEGVIEIKATKVCDQRTKCKSRCNEMLPGTSTGNNQSTITL
                     SVASQNLTFTSSSSPPNGDSINKDPKLCTKSPRKRLSSTLQETQVPPVKKPIVEQLSA
                     ATIEGQKQGSVKKDQKVPHSGKTEGSTAGAQIPSKVSVNVSSHIGANQPLNSSALVIS
                     DSALEQQTTPSSSPDIKVKLEGSVFLLDSDSKSVGSFNPNGWQQITKDSEFISASCEQ
                     QQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHSQIQESSLNQIQAHSSDQLP
                     LQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTL
                     QSQSVTPGAPMSSHTSSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGS
                     QSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPIS
                     SSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGHGILPSYQE
                     LVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNNTNKQEGFAVP
                     APLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEV
                     HVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQANSKKITNVLLSKLDSDND
                     DAVRGLGMNNLPSNYTARMNLTQILEPSTVFPSANPQNMIDSSTSVYEFQTPSYLTKS
                     NSTGQINFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDSLQTNQQLVGQGASDLTNTAS
                     DFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSES
                     MNSMTSSGFEWIESKDHPTVEMLG"
     exon            599..632
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..715
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..838
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..955
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1040
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1248
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1544
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..10885
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7607..7612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /note="hexamer: ATTAAA"
     polyA_site      7628
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /note="major polyA site"
     regulatory      10858..10863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /note="hexamer: AATAAA"
     polyA_site      10885
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
ORIGIN      
        1 ggctgcgcgc actgggctgc ctccggggct ggcagggcag cggcggccgc ggcggcggcg
       61 gggccgggag cgagcggcgg cggcggcggc ggcgtgggga gtggcgtgga gcggtgcctg
      121 gggctgcagc agcacgggga cccggcagta gaaagccccg gggacaagga aggaaggctt
      181 ggccgccaaa tccctgagca accgttcttc ttggattttg gggggagcct gcccccccca
      241 cttcgtcttc aaacgccccc atctcacccc cccacagccc cggccgctga cgggaggagg
      301 cggcggcgcc agcggggggc tgaggggcgc cgccatgcct ctcccgcggt gaagcgcccc
      361 ggccgtgagg agccgctggt ctccccggtg atgttcccca ggcggcaggc gaaagcgact
      421 cactcgagcc ctgggcgatg gcagaggaac aacaacagcc gccaccacag cagcctgatg
      481 cccatcagca gcttcccccc agcgccccca actcgggggt ggccctgcca gcccttgtgc
      541 ccgggctgcc agggacagag gccagcgcgc tgcaacacaa gatcaagaac tccatctgca
      601 aaactgtaca atctaaagtg gactgcattt tgcaagaagt tgagaagttt acagacctag
      661 agaaactcta cctctacctt cagctgcctt ctggtctcag caatggagag aaaagtgatc
      721 agaatgccat gtcatctagt cgggcacaac aaatgcatgc cttttcctgg attcggaata
      781 ccctagagga acatccggag acttcactgc ccaaacagga agtctatgat gagtacaaga
      841 gctattgtga caatcttggt taccatccat taagtgctgc tgattttgga aagatcatga
      901 aaaacgtctt tccaaacatg aaggcacgtc gtttgggcac aagaggcaaa tctaaatatt
      961 gctacagtgg actaagaaaa aaagcttttg ttcatatgcc aacactgccc aaccttgact
     1021 ttcacaaaac tggagatggg ttggaaggag ctgaaccttc tgggcagctt caaaatattg
     1081 atgaagaagt tatctcttct gcttgccgtc ttgtgtgtga gtgggcccag aaagtgttaa
     1141 gccaaccatt tgacaccgtc ttggaattag cccgcttcct tgtaaaaagt cactatatag
     1201 gcaccaagtc aatggcagct ctaactgtaa tggcagcagc accagcagga atgaaaggaa
     1261 ttacccagcc ttctgctttt atacctacag ctgaaagtaa ttcctttcag cctcaggtga
     1321 agactttgcc atctccaatt gatgctaaac agcagttgca acggaaaatc cagaagaagc
     1381 agcaagaaca gaaactacaa tcccctttgc caggagaatc tgcagcaaaa aagtcagaaa
     1441 gtgctacaag caatggagtg actaatcttc ctaatggaaa tccttcaatc ctttctcctc
     1501 aacctattgg tatcgttgtg gcagctgtcc ctagtcccat tccggtccag cggactaggc
     1561 aattggtaac ttcaccgagt ccaatgagtt cttctgacgg caaagttctt cccctcaatg
     1621 tacaggtggt cactcagcac atgcagtctg tgaaacaggc accaaagact ccccagaacg
     1681 ttccagccag tcctggtggg gatcgttctg cccggcaccg ttaccctcag atcttaccca
     1741 aaccagcgaa caccagtgca ctcaccattc gctctccaac tactgtcctc tttactagta
     1801 gtcccatcaa aactgctgtt gtacccgctt cacacatgag ttctctaaat gtggtgaaaa
     1861 tgacaacaat atccctcaca cccagcaaca gtaacacccc tcttaaacat tctgcctcag
     1921 tcagcagtgc tacaggaaca acagaagaat caaggagtgt tccacagatc aagaatggtt
     1981 ctgtcgtgtc gcttcagtct cctgggtcca ggagcagcag tgcgggggga acatctgctg
     2041 tggaagtcaa agtggaaccc gaaacatcat cagatgagca tcctgtacag tgccaagaga
     2101 actctgatga ggctaaagct ccccagacac ctagtgccct tttggggcag aaaagtaata
     2161 cagacggagc actgcagaaa ccttcaaatg aaggtgtcat tgaaataaaa gcaactaagg
     2221 tctgtgacca gaggaccaaa tgtaaaagtc gctgtaatga aatgctgcca ggcacgtcaa
     2281 caggcaataa tcaaagcact atcactctat cagttgcttc tcagaactta actttcacca
     2341 gcagcagctc accacctaat ggtgactcaa tcaataaaga ccctaaatta tgcactaaaa
     2401 gcccaagaaa acgactgtct tctacattgc aggagaccca ggtgcctcct gtaaagaaac
     2461 caattgtgga acagctttca gcagctacca tagaagggca gaaacaaggc agtgttaaga
     2521 aggaccaaaa ggttccacat tcagggaaaa cagaaggttc aacagcaggt gctcagattc
     2581 ctagcaaggt atcagtaaat gtcagttcac acataggagc aaatcaaccc ttgaattcct
     2641 ctgcccttgt tatcagtgat tcagctttgg aacagcaaac aaccccatca tcatctccag
     2701 atataaaagt aaaacttgaa ggaagtgtct ttctcttgga cagtgattca aagtcagttg
     2761 gcagctttaa tccaaatgga tggcaacaaa tcactaaaga ttctgagttt atatctgcca
     2821 gttgtgaaca acagcaagat atcagtgtta tgacaattcc tgagcactct gatatcaatg
     2881 acttagagaa atctgtttgg gaattagaag gaatgccaca ggacacatat agccagcagc
     2941 tacatagcca gatacaggaa tcttctttaa atcaaataca agcacattct tcagatcagt
     3001 tacctctgca atctgaactg aaggagtttg agccttctgt ttcccagaca aatgaaagct
     3061 actttccttt tgatgatgaa cttacacaag atagtattgt ggaagagctg gtgcttatgg
     3121 agcagcaaat gtcaatgaac aattctcatt cttacggcaa ctgtttggga atgacccttc
     3181 agagtcagtc agtaactcca ggagctccaa tgtcatctca cacttccagc acccacttct
     3241 atcatccaat ccacagcaat ggcactccaa tccacacacc cacacccaca cccacaccca
     3301 ctcctactcc aaccccaacc ccaaccccga catctgaaat gattgctgga tctcagagtc
     3361 tgtcacggga gagcccttgc tccaggctag cccagactac acctgtggat agtgctttag
     3421 gaagtagccg acatacaccc attggtactc cacattctaa ctgcagcagt agtgtccccc
     3481 ccagccctgt tgaatgcagg aatccgtttg cattcactcc aataagctcc agtatggcat
     3541 atcatgacgc cagcattgtc tcaagtagtc ctgtgaaacc gatgcaaaga cccatggcca
     3601 cacaccctga caaaaccaag cttgaatgga tgaataatgg gtatagtggg gttggtaatt
     3661 catcagtttc tggccatggt attctcccaa gctatcagga actagtggaa gaccgtttca
     3721 ggaaacctca tgcttttgct gtgcctggac agtcttatca gtctcaatcc agacatcatg
     3781 acactcattt tggtcgtttg actcctgtct ctcctgtgca gcatcaaggt gccactgtaa
     3841 ataacaccaa caaacaggag ggttttgcag tccctgcccc tcttgataat aaaggaacta
     3901 attcatctgc cagcagcaac ttcagatgcc ggagtgtgag ccctgctgtt catcgccaac
     3961 gtaatcttag tggaagcacc ctctatccag tatctaatat cccacgatct aatgtgaccc
     4021 cctttggaag tccagttacc ccagaagttc atgttttcac aaatgttcac acagacgcat
     4081 gtgccaacaa catagctcaa agaagccaat cagttccatt gacagtcatg atgcagacag
     4141 ccttcccaaa cgctcttcag aagcaagcaa acagtaaaaa aataaccaat gttttgttga
     4201 gtaaacttga ttccgacaat gatgatgcag tgagaggttt gggaatgaac aacctgccct
     4261 ctaattatac agcccggatg aatctcactc agattttgga accttccact gtttttccta
     4321 gtgccaaccc acaaaatatg atcgattcca gcacttctgt ttatgagttc caaacaccat
     4381 cttacctcac caaaagtaat agcaccggtc agatcaattt ttctcctgga gataatcaag
     4441 cacaatcaga aattggagag caacaattag atttcaatag cactgttaaa gacctgttga
     4501 gtggagacag cttgcaaacc aaccagcagc tggtaggtca gggagcatct gatctcacta
     4561 atactgcatc tgatttctct agcgatatca ggttgtcttc tgagctctca ggcagcatca
     4621 atgatttgaa cactttagac ccaaatctac tgtttgatcc aggtcgtcag cagggacaag
     4681 atgatgaagc tacactggaa gaattaaaga atgacccatt atttcaacaa atttgcagtg
     4741 aatccatgaa ttctatgact tcatcaggtt ttgaatggat agaaagcaag gaccatccta
     4801 ctgttgaaat gttgggttaa attgtgtttt ataacatgta gcacactgta tctaaagaca
     4861 tatgtattgt atttgtctta atggaagtgc ctcccgcagc agaaatacta ttaattgtga
     4921 cattttaaaa gcgtttgctg cagaagtggt ttcttcagta ggaaatggtt agacttgcct
     4981 cagttcttaa caagtgtcta aagacagtag gctgtagaag aacaagtatt aggttttaaa
     5041 ttttataatg tgccccattt attcacattg attgactatc cagctgttac aagagcagtc
     5101 gatctttatt ttgtgtaagt tagtttcatt tcatcagatg atctgcacag aactcagaat
     5161 aaaccatcaa ttttaggtat aggctgtttt gttgttggca ttatctttta gatataaaat
     5221 catagctagg gtgaactgta gacaagaaag tcttccttga aacagggata atattcaggt
     5281 tattataaat atttaggctt gaagcataga gctactgtag ggtgaaaaat ctctgtagga
     5341 ctttctgggg cttcagtacc atttacaccc acgatgaagg gcttaaatag aaaataatgg
     5401 aaaattaaat attactttaa ggaaagcaaa gctgcactaa aatttttaag ggaaaaaaaa
     5461 caagtagcca tttatatttg tgaccttgca ttaatattta aatgttgatt ttaatatgga
     5521 gctagcacac atagatgcgc aggcacgcac acacaaaaca agcaaatgta actccaggca
     5581 tttgtaattt aatataataa atacaagcat gttagaaaaa tgctttatgt cttattattt
     5641 gttaagttag gggaatgaga aggaaaacaa aagcattctc ttagtttcat cacaatggct
     5701 gcatgtacat attgagattc taactgagat ttactttgaa atttttcatt aaaatattcc
     5761 acaataatca gtttttttcc tcttcaattg agtgactgac tccctcactc ctcctgaata
     5821 tagtaatgta gtttgatcat aggatccctt tgaaaaacag gaaggaggat aacataaaaa
     5881 acaacaaaaa acatttcacc acctaaggtc tgaagccaca aatctttata tctctgatga
     5941 aacaaagggg atatcaatag tacttgaaga agaagagcat tttattactt gcttaattta
     6001 tttattgtga taaccacaat tgcaaaagaa gaactcagga tttgttttaa aatgtttctc
     6061 tctatggctc ccattttgtt ttgtgaataa ttatttatga gttgcatgtt gacacaaacc
     6121 tactcactgg ttgaaagctc catttaagtg agtttcaaga tcactttcaa agagattttt
     6181 aaattgccat tgtttttaaa gctaacataa aaccatttgc tatgctacct tgaacctagc
     6241 taagctttcc tttaccttag taagccaatc agaagactac aatcaatgaa tatttagcaa
     6301 atgtgctgaa gggtttaata aggttttgtt gttcaataaa tttgcaaggt agggtattaa
     6361 catattttga taaataaatg gtgctagagt tggcgcagag gtttatatat tgatatgtct
     6421 tagttattgg catttgtgtg tgtttgctgt tatcttgatt tcatgatttg ttaggtattt
     6481 ttttcttgat gctagttatt tcttcactgt acattgagac acagcactac tgcacaccaa
     6541 agtatgcaat acccaaagga aactgtgtga tttctcctga caaatgatgg gagcctttct
     6601 ttatgagata ctctgaaaag gagattttga ggccattcta atcccttgtt tacattatta
     6661 gcttcctact aatataaaaa taatggaaat cttttttgat aaaaatatta agactggagg
     6721 atttttaacc ccttgtacag tattgcagca aactctttaa atttggttga attcgtccag
     6781 caaactttct ggggttcata tattgcacta aatttgttga acctgtggta ggcacatctc
     6841 ttaggataaa tgcaaccaat acagtccaca gattaaactt tttaaatgtg tttcattatg
     6901 aaaagacaaa atgtcatcaa agtgacagat aaaattgtct tatgtagcaa tgtgcattga
     6961 tctcaatgag atatttctat tattctctta catgagaata ttacagcagg aagaattaag
     7021 tttagtttgc ttcaccatgt taatacatga tcacaaaatg tgcatgagtg ttattgactt
     7081 atcttgtaca gtactaggat tcctgtaacc actctttttt ttcttcgctg tattgaaact
     7141 ggttcagtgt taaccaggca agcatagtta ttcacaggtt atttacttta tgtttactaa
     7201 ttctgcttag ttattgttga atatgttctg ttccagatta tttttattgt tttgatgttt
     7261 aaaacatttt gcatactgtt tatcataaaa cttcatgaag taaataattt tgcatataat
     7321 tgcaataagc actgactttt gaactgaaaa gaaggaaagt gtttttttgt gcagtgcttc
     7381 tgaggttcat ataatagtct tgtactataa tgtgctttac tacacgataa atgacaaaaa
     7441 caagccctgt ttcatgtttc atttagtgca aaaagtcaga tttccccagt gttttgttgt
     7501 ctgttgtacc tgctgaaact acagtagttg aatattgcgg tagcatttca gttctctttt
     7561 tttattaaag tgctcaaaaa ttgtttttta aatgttttca aaaacaatta aaaacatttt
     7621 atattaaact gactggatct gaaggtgttt tatgggacat attttatata ggcaacacat
     7681 tttgtaaaca gacccaatgt tattcttcct ttgatgtcat taactttagg gagtgaataa
     7741 aaatgagcag aaggcagaac agtgctgctg atctgctgtg tgctattaat ccagaagaat
     7801 acacagatct tagttcattc atcaaaactc tgttgttcac ttaagattat taccaatgaa
     7861 tggtgcatgg catagaactt tatgttgtcc aaaaagccat ctttttctct ttcacatagt
     7921 gtttaaatgt tagcctatgg agtacctagg taagtatatt tctggagctc tgaatagaaa
     7981 atgagaaaat tttaagcata gctgtgttca aaagcagtat agacatttcc aggtaccaga
     8041 aataacaaac tgataagtgt aatgaatttg taagccagaa gctgggctac aggtctggaa
     8101 gcaggccgaa gtagccagaa atgtcagctc ctgcaaagta atgaaaccag ggtcttgaat
     8161 ggagtttcct cactcttgaa actgagaagc aacaacaacc agtgccaggg actatatatt
     8221 gtagacagat cttctcaaac agcctactcc tctgtttaca tagatctttg tagatctgtg
     8281 atagttccac tatcaccata gatctggagc cctcagtttg aacaggtggt agaagcaatt
     8341 acaaaaggaa aggagtggag attaggaagg gagaggtaaa gagcaggaag gctcccatga
     8401 aagctgagcc tgcagatcaa aattcaaaag tacttgaaga aaaactaatc ccaagaaagg
     8461 caatcagtca ctcaagagaa aatgaaagta atgaactacc tagataatac tataaaatta
     8521 gtatgttagg atcctcagtg ctcaatgaca tggaagggta aaatgtcaga gcaggcaaac
     8581 ataagaacca gtgcatagag tcaaccagta agaaattctg ggggtgaaaa tactgtgtaa
     8641 cacctgaggt gattttggtt tcaagtaatt gaaaacccaa cactggctta aaccataagg
     8701 acacttactt ttagcttaat aatagtggag ataggaggtt caagggttca ttcaatggtt
     8761 cattgtttac aggcaccaga tcctgtttgt gtttctgttc catcatcttc agctttgctt
     8821 tgctgtgtct attacctcat agtcacaaga tggctgccac agctcagatg ttataccctc
     8881 ataacatccc aagcaggata gtaagagcag ttcttagcct tttatcagag agaaaaaaaa
     8941 atctcagaat cttccattaa gcactccata cacacacact gttagtctca ttgtattaaa
     9001 caaaggctca tcctaaggcc aattacttag cttagatcct taattaatgc tttataggta
     9061 ggaggggggg cccatttcct ggagcatgtg gtcattcatc ttaaatgagt tccatcacct
     9121 agggaagata ttagggactt gctctttggg aggcaaccag tagtggtcac tgcaaaaaat
     9181 agctaggtaa gatgagtaag atcttgtacc cacctttgag gggcttacaa tcataaagag
     9241 ttaagtacat gttctttgtt aagtgccaac agtatgtata ctacactatg tagaagaaaa
     9301 aataagaatt tgaaatctgc cgaactaagt ttactggtgc taactgttaa ctggtatctt
     9361 gccttccccc tatgagctga aaaatcaggt attattgagt atcacaaatg caagttgcct
     9421 cagctcctac agcataagaa aagaccaaac tttttatttt gttaaatctg aagtacagat
     9481 ttattttgac atgcattgtt ataaatgaat ttttaaataa ttaaagttat aaatttatgg
     9541 atgggatcac ttattaatat tgcatcatct gaaattttaa aaatatgtat gccagtcttg
     9601 ttgctataat ctgcttagaa aaaagaacaa aacaaaaaga ctacattttt caagatttga
     9661 tttttaagaa gtacttaatt cttggagagg agaagagagt catataaata aaatatatca
     9721 tgagagtgat attactgtgg tatatagagt atttctttgc attagaccca gtgttagttt
     9781 gcatatattc tcatgtcctc attgtaacaa tttttagcga gtattatttt tcaggtgaga
     9841 aaattttact tcagagatta actggtggag gtaacataat aacaggaaga gccaggatta
     9901 tcttaatttc aaatcccact tcataccatt atgctatact taagatatgt gttcacagtg
     9961 tacctactgc agttgtatga tctggttgct tctttgaaat tttcattctg gttttaaatt
    10021 tagaattgag tttgattttt gtggagttct ttatttaacc tcccatcctt atatgtcaac
    10081 aattcttttt catttttatt gcttttagat ttacctgtag tttgtaattt tcctccaaat
    10141 tacttgaatc cttttccctc ccttctctcc atagaaatac cctgatgtat taggagaatg
    10201 aagatttaaa aacaaaattt tgttttccac acagcttttc aagcatattt catacaggta
    10261 tactctagtc atatttatgt ttaaatcact taaaatgtca tcaaaataaa aatgggactt
    10321 tttttttaac agatgataaa gtgcctaaaa tatgtcagtc tctgtacaag gtgctagaga
    10381 agacacctgc cattttgaaa ttttgcaata taatgaaaaa gacacagtga atgtctttgc
    10441 aggatgcaat gaggtcacta tagcagaggc ggatacttac cagtagtatg cattctcccc
    10501 ttcttcttta ctgtaaaagt ccttgatttt tagctgagca cacagccatc tgaccaaaag
    10561 gctgcatctg ccaacttccc ttgcagttaa gtggagacac ttaccaagta ctcaaagaga
    10621 tgtaaccaaa aggtttgggt gctacttctt tgcagtgttc ttgtccttcc tctctgctgg
    10681 ctggaatgca aatgtgatgg ctagaactca agcagccctc ctggacttca tgttaaagac
    10741 acatgctgag gatgattgag caacaagata caaggagccc agggcatgat gactttggaa
    10801 gggaagatgc ccaactagtc ctgactgctt acctctggat gtgttttaca tgagagaaat
    10861 aaatgtcttt ctggtttaac tcaca
//
