LOCUS       NP_073752               1460 aa            linear   PRI 27-APR-2025
DEFINITION  DNA-binding protein RFX7 isoform 1 [Homo sapiens].
ACCESSION   NP_073752
VERSION     NP_073752.6
DBSOURCE    REFSEQ: accession NM_022841.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1460)
  AUTHORS   Coronel,L., Riege,K., Schwab,K., Forste,S., Hackes,D., Semerau,L.,
            Bernhart,S.H., Siebert,R., Hoffmann,S. and Fischer,M.
  TITLE     Transcription factor RFX7 governs a tumor suppressor network in
            response to p53 and stress
  JOURNAL   Nucleic Acids Res 49 (13), 7437-7456 (2021)
   PUBMED   34197623
  REMARK    GeneRIF: Transcription factor RFX7 governs a tumor suppressor
            network in response to p53 and stress.
REFERENCE   2  (residues 1 to 1460)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 1460)
  AUTHORS   Gao,J. and Xu,C.
  TITLE     Structural basis for the recognition of RFX7 by ANKRA2 and RFXANK
  JOURNAL   Biochem Biophys Res Commun 523 (1), 263-266 (2020)
   PUBMED   31864703
  REMARK    GeneRIF: Structural basis for the recognition of RFX7 by ANKRA2 and
            RFXANK.
REFERENCE   4  (residues 1 to 1460)
  AUTHORS   Castro,W., Chelbi,S.T., Niogret,C., Ramon-Barros,C., Welten,S.P.M.,
            Osterheld,K., Wang,H., Rota,G., Morgado,L., Vivier,E., Raeber,M.E.,
            Boyman,O., Delorenzi,M., Barras,D., Ho,P.C., Oxenius,A. and
            Guarda,G.
  TITLE     The transcription factor Rfx7 limits metabolism of NK cells and
            promotes their maintenance and immunity
  JOURNAL   Nat Immunol 19 (8), 809-820 (2018)
   PUBMED   29967452
REFERENCE   5  (residues 1 to 1460)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (residues 1 to 1460)
  AUTHORS   Berndt,S.I., Skibola,C.F., Joseph,V., Camp,N.J., Nieters,A.,
            Wang,Z., Cozen,W., Monnereau,A., Wang,S.S., Kelly,R.S., Lan,Q.,
            Teras,L.R., Chatterjee,N., Chung,C.C., Yeager,M.,
            Brooks-Wilson,A.R., Hartge,P., Purdue,M.P., Birmann,B.M.,
            Armstrong,B.K., Cocco,P., Zhang,Y., Severi,G.,
            Zeleniuch-Jacquotte,A., Lawrence,C., Burdette,L., Yuenger,J.,
            Hutchinson,A., Jacobs,K.B., Call,T.G., Shanafelt,T.D., Novak,A.J.,
            Kay,N.E., Liebow,M., Wang,A.H., Smedby,K.E., Adami,H.O., Melbye,M.,
            Glimelius,B., Chang,E.T., Glenn,M., Curtin,K.,
            Cannon-Albright,L.A., Jones,B., Diver,W.R., Link,B.K., Weiner,G.J.,
            Conde,L., Bracci,P.M., Riby,J., Holly,E.A., Smith,M.T.,
            Jackson,R.D., Tinker,L.F., Benavente,Y., Becker,N., Boffetta,P.,
            Brennan,P., Foretova,L., Maynadie,M., McKay,J., Staines,A.,
            Rabe,K.G., Achenbach,S.J., Vachon,C.M., Goldin,L.R., Strom,S.S.,
            Lanasa,M.C., Spector,L.G., Leis,J.F., Cunningham,J.M.,
            Weinberg,J.B., Morrison,V.A., Caporaso,N.E., Norman,A.D.,
            Linet,M.S., De Roos,A.J., Morton,L.M., Severson,R.K., Riboli,E.,
            Vineis,P., Kaaks,R., Trichopoulos,D., Masala,G., Weiderpass,E.,
            Chirlaque,M.D., Vermeulen,R.C., Travis,R.C., Giles,G.G.,
            Albanes,D., Virtamo,J., Weinstein,S., Clavel,J., Zheng,T.,
            Holford,T.R., Offit,K., Zelenetz,A., Klein,R.J., Spinelli,J.J.,
            Bertrand,K.A., Laden,F., Giovannucci,E., Kraft,P., Kricker,A.,
            Turner,J., Vajdic,C.M., Ennas,M.G., Ferri,G.M., Miligi,L.,
            Liang,L., Sampson,J., Crouch,S., Park,J.H., North,K.E., Cox,A.,
            Snowden,J.A., Wright,J., Carracedo,A., Lopez-Otin,C., Bea,S.,
            Salaverria,I., Martin-Garcia,D., Campo,E., Fraumeni,J.F. Jr., de
            Sanjose,S., Hjalgrim,H., Cerhan,J.R., Chanock,S.J., Rothman,N. and
            Slager,S.L.
  TITLE     Genome-wide association study identifies multiple risk loci for
            chronic lymphocytic leukemia
  JOURNAL   Nat Genet 45 (8), 868-876 (2013)
   PUBMED   23770605
REFERENCE   7  (residues 1 to 1460)
  AUTHORS   Crowther-Swanepoel,D., Broderick,P., Di Bernardo,M.C.,
            Dobbins,S.E., Torres,M., Mansouri,M., Ruiz-Ponte,C., Enjuanes,A.,
            Rosenquist,R., Carracedo,A., Jurlander,J., Campo,E., Juliusson,G.,
            Montserrat,E., Smedby,K.E., Dyer,M.J., Matutes,E., Dearden,C.,
            Sunter,N.J., Hall,A.G., Mainou-Fowler,T., Jackson,G.H.,
            Summerfield,G., Harris,R.J., Pettitt,A.R., Allsup,D.J.,
            Bailey,J.R., Pratt,G., Pepper,C., Fegan,C., Parker,A., Oscier,D.,
            Allan,J.M., Catovsky,D. and Houlston,R.S.
  TITLE     Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence
            chronic lymphocytic leukemia risk
  JOURNAL   Nat Genet 42 (2), 132-136 (2010)
   PUBMED   20062064
REFERENCE   8  (residues 1 to 1460)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (residues 1 to 1460)
  AUTHORS   Aftab,S., Semenec,L., Chu,J.S. and Chen,N.
  TITLE     Identification and characterization of novel human tissue-specific
            RFX transcription factors
  JOURNAL   BMC Evol Biol 8, 226 (2008)
   PUBMED   18673564
  REMARK    GeneRIF: RFX7 is a winged helix transcription factor expressed
            ubiquitously in all tissues examined, especially brain tissue.
            Publication Status: Online-Only
REFERENCE   10 (residues 1 to 1460)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068726.5, AC084783.2 and KF456052.1.
            
            On Jan 10, 2019 this sequence version replaced NP_073752.5.
            
            Summary: RFX7 is a member of the regulatory factor X (RFX) family
            of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008
            [PubMed 18673564]).[supplied by OMIM, Mar 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.675153.1,
                                           DRR138518.479905.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000559447.8/ ENSP00000453281.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     Protein         1..1460
                     /product="DNA-binding protein RFX7 isoform 1"
                     /note="regulatory factor X domain containing 2;
                     DNA-binding protein RFX7; regulatory factor X
                     domain-containing protein 2; regulatory factor X, 7"
                     /calculated_mol_wt=157221
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Region          43..100
                     /region_name="RFX5_N"
                     /note="RFX5 N-terminal domain; pfam18326"
                     /db_xref="CDD:375753"
     Region          105..183
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          188..193
                     /region_name="PxLPxI/L motif, mediates interaction with
                     ANKRA2 and RFXANK. /evidence=ECO:0000269|PubMed:25752541,
                     ECO:0000312|PDB:6MEW"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Region          <258..568
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          308..352
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            322
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Region          404..428
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            455
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Region          468..>745
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     Region          481..585
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            564
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Region          632..715
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            662
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            704
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Region          917..1015
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            988
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            1178
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     Site            1329
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (Q2KHR2.2)"
     CDS             1..1460
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /coded_by="NM_022841.7:438..4820"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS92005.1"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
ORIGIN      
        1 maeeqqqppp qqpdahqqlp psapnsgval palvpglpgt easalqhkik nsicktvqsk
       61 vdcilqevek ftdleklyly lqlpsglsng eksdqnamss sraqqmhafs wirntleehp
      121 etslpkqevy deyksycdnl gyhplsaadf gkimknvfpn mkarrlgtrg kskycysglr
      181 kkafvhmptl pnldfhktgd glegaepsgq lqnideevis sacrlvcewa qkvlsqpfdt
      241 vlelarflvk shyigtksma altvmaaapa gmkgitqpsa fiptaesnsf qpqvktlpsp
      301 idakqqlqrk iqkkqqeqkl qsplpgesaa kksesatsng vtnlpngnps ilspqpigiv
      361 vaavpspipv qrtrqlvtsp spmsssdgkv lplnvqvvtq hmqsvkqapk tpqnvpaspg
      421 gdrsarhryp qilpkpants altirspttv lftsspikta vvpashmssl nvvkmttisl
      481 tpsnsntplk hsasvssatg tteesrsvpq ikngsvvslq spgsrsssag gtsavevkve
      541 petssdehpv qcqensdeak apqtpsallg qksntdgalq kpsnegviei katkvcdqrt
      601 kcksrcneml pgtstgnnqs titlsvasqn ltftsssspp ngdsinkdpk lctksprkrl
      661 sstlqetqvp pvkkpiveql saatiegqkq gsvkkdqkvp hsgktegsta gaqipskvsv
      721 nvsshiganq plnssalvis dsaleqqttp ssspdikvkl egsvflldsd sksvgsfnpn
      781 gwqqitkdse fisasceqqq disvmtipeh sdindleksv welegmpqdt ysqqlhsqiq
      841 esslnqiqah ssdqlplqse lkefepsvsq tnesyfpfdd eltqdsivee lvlmeqqmsm
      901 nnshsygncl gmtlqsqsvt pgapmsshts sthfyhpihs ngtpihtptp tptptptptp
      961 tptptsemia gsqslsresp csrlaqttpv dsalgssrht pigtphsncs ssvppspvec
     1021 rnpfaftpis ssmayhdasi vssspvkpmq rpmathpdkt klewmnngys gvgnssvsgh
     1081 gilpsyqelv edrfrkphaf avpgqsyqsq srhhdthfgr ltpvspvqhq gatvnntnkq
     1141 egfavpapld nkgtnssass nfrcrsvspa vhrqrnlsgs tlypvsnipr snvtpfgspv
     1201 tpevhvftnv htdacannia qrsqsvpltv mmqtafpnal qkqanskkit nvllskldsd
     1261 nddavrglgm nnlpsnytar mnltqileps tvfpsanpqn midsstsvye fqtpsyltks
     1321 nstgqinfsp gdnqaqseig eqqldfnstv kdllsgdslq tnqqlvgqga sdltntasdf
     1381 ssdirlssel sgsindlntl dpnllfdpgr qqgqddeatl eelkndplfq qicsesmnsm
     1441 tssgfewies kdhptvemlg
//
