LOCUS       NM_134428               9325 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens regulatory factor X3 (RFX3), transcript variant 2,
            mRNA.
ACCESSION   NM_134428
VERSION     NM_134428.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9325)
  AUTHORS   Qian,Y., Cheng,B., Luo,J., Hu,Y., Gao,L. and Cheng,H.
  TITLE     CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate
            Tumorigenesis and Progression of Glioma
  JOURNAL   J Mol Neurosci 72 (6), 1195-1207 (2022)
   PUBMED   35416616
  REMARK    GeneRIF: CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate
            Tumorigenesis and Progression of Glioma.
REFERENCE   2  (bases 1 to 9325)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9325)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9325)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   5  (bases 1 to 9325)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9325)
  AUTHORS   Nakayama,A., Murakami,H., Maeyama,N., Yamashiro,N., Sakakibara,A.,
            Mori,N. and Takahashi,M.
  TITLE     Role for RFX transcription factors in non-neuronal cell-specific
            inactivation of the microtubule-associated protein MAP1A promoter
  JOURNAL   J Biol Chem 278 (1), 233-240 (2003)
   PUBMED   12411430
  REMARK    GeneRIF: Data show that two regulatory factor for X box (RFX1 and
            3) binding sites in exon1 of both the mouse and human
            microtubule-associated protein (MAP1A) gene are important for
            effective transcriptional repression in non-neuronal cells.
REFERENCE   7  (bases 1 to 9325)
  AUTHORS   Morotomi-Yano,K., Yano,K., Saito,H., Sun,Z., Iwama,A. and Miki,Y.
  TITLE     Human regulatory factor X 4 (RFX4) is a testis-specific dimeric
            DNA-binding protein that cooperates with other human RFX members
  JOURNAL   J Biol Chem 277 (1), 836-842 (2002)
   PUBMED   11682486
REFERENCE   8  (bases 1 to 9325)
  AUTHORS   Iwama,A., Pan,J., Zhang,P., Reith,W., Mach,B., Tenen,D.G. and
            Sun,Z.
  TITLE     Dimeric RFX proteins contribute to the activity and lineage
            specificity of the interleukin-5 receptor alpha promoter through
            activation and repression domains
  JOURNAL   Mol Cell Biol 19 (6), 3940-3950 (1999)
   PUBMED   10330134
REFERENCE   9  (bases 1 to 9325)
  AUTHORS   Emery,P., Durand,B., Mach,B. and Reith,W.
  TITLE     RFX proteins, a novel family of DNA binding proteins conserved in
            the eukaryotic kingdom
  JOURNAL   Nucleic Acids Res 24 (5), 803-807 (1996)
   PUBMED   8600444
REFERENCE   10 (bases 1 to 9325)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU170404.1, DB461398.1,
            BC022191.2, AL133549.11 and BM666287.1.
            
            On Jun 2, 2019 this sequence version replaced NM_134428.2.
            
            Summary: This gene is a member of the regulatory factor X gene
            family, which encodes transcription factors that contain a
            highly-conserved winged helix DNA binding domain. The protein
            encoded by this gene is structurally related to regulatory factors
            X1, X2, X4, and X5. It is a transcriptional activator that can bind
            DNA as a monomer or as a heterodimer with other RFX family members.
            Multiple transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Aug 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022191.2, SRR14372079.3704812.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               BU170404.1         4-188
            186-186             DB461398.1         175-175
            187-2977            BC022191.2         168-2958
            2978-8668           AL133549.11        104183-109873       c
            8669-9325           BM666287.1         14-670              c
FEATURES             Location/Qualifiers
     source          1..9325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.2"
     gene            1..9325
                     /gene="RFX3"
                     /note="regulatory factor X3"
                     /db_xref="GeneID:5991"
                     /db_xref="HGNC:HGNC:9984"
                     /db_xref="MIM:601337"
     exon            1..255
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..322
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            323..447
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2580
                     /gene="RFX3"
                     /note="isoform b is encoded by transcript variant 2; DNA
                     binding protein RFX3; transcription factor RFX3;
                     regulatory factor X, 3 (influences HLA class II
                     expression)"
                     /codon_start=1
                     /product="transcription factor RFX3 isoform b"
                     /protein_id="NP_602304.1"
                     /db_xref="CCDS:CCDS6449.1"
                     /db_xref="GeneID:5991"
                     /db_xref="HGNC:HGNC:9984"
                     /db_xref="MIM:601337"
                     /translation="MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQ
                     TVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQ
                     VTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIE
                     MAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLD
                     PVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQ
                     QPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFG
                     EVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPT
                     DGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRP
                     IPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQA
                     ARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTL
                     EQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFH
                     LIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDE
                     ELDDSSEPQAKREKTELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCS
                     ATGNTYTAV"
     exon            448..545
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            546..804
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..879
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1061
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1181
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1303
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1416
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1532
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1687
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1785
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1935
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2144
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2298
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2341
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..9325
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9299..9304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFX3"
                     /note="hexamer: AATAAA"
     polyA_site      9325
                     /gene="RFX3"
                     /note="major polyA site"
ORIGIN      
        1 ccctccccca cccctccccg tgcgagtgtc tccctctccc tctcgctctc tctctctctc
       61 cctctctctc tctcttttgt gagttatagc aaccgttgcc ttgtgaatca agcgccatag
      121 tcaccgtagt cctggcgact gttacccatc aacaacaact actcctctcc tcctcctcct
      181 cctcttcctc ctcctcctcc ccaccaccac catctccatc acccaccaac aacaccacaa
      241 taatccacag ccaaggccac ttggtcattc tggcatttta tggtagagaa tacgttgagt
      301 ttggctctgg aaggaatatg agagaccatc atgcagacat cagagactgg gtcggacaca
      361 ggctcgacag tgaccttaca aacatctgtg gctagtcaag cagcagtgcc tacgcaggtg
      421 gtacagcaag taccagtaca acaacaggta cagcaggtac agactgtgca gcaggtacaa
      481 catgtctatc ccgctcaggt gcagtatgtg gaaggaagcg atactgtcta taccaatgga
      541 gcaatccgaa caacaacgta tccttacaca gagacacaga tgtacagcca aaatactgga
      601 gggaattact ttgatactca agggagttcc gcccaggtga ctaccgtggt ctcatcccac
      661 agtatggtgg gcactggtgg gattcagatg ggcgtcacag gaggacaact catcagcagc
      721 tctggaggaa cctatctgat cggcaactca atggagaatt ctggtcactc agtgacacac
      781 acaactcggg cctccccagc gacaattgaa atggcgattg agacgctgca aaagtctgac
      841 ggtctgtcca ctcacagaag ctctcttctc aacagccatc tccagtggct gttggacaat
      901 tatgagacag cagaaggagt gagccttccc agaagcactc tgtacaacca ctaccttcga
      961 cactgtcagg aacacaaact ggacccagtc aatgctgcct cttttggaaa attaataaga
     1021 tcaattttta tggggctacg aaccaggaga ttgggcacta gaggaaactc caaataccac
     1081 tactatggga ttcgtgtcaa gccagattcc cctcttaatc gtctgcaaga agacatgcag
     1141 tatatggcta tgagacaaca acccatgcaa cagaaacaaa ggtacaagcc tatgcagaaa
     1201 gtggatgggg ttgcagatgg tttcacagga agtggtcaac agacaggcac atctgttgag
     1261 caaactgtaa ttgcccaaag ccaacatcat caacagtttt tagatgcatc tcgagcactt
     1321 ccagagtttg gagaagttga aatctcttct ctgccagatg gtactacctt tgaggatatc
     1381 aagtcactgc agagtcttta tagagagcac tgtgaggcaa tattggacgt tgttgtgaat
     1441 cttcaattta gcctgataga aaaattgtgg caaacattct ggcgctattc tccctctact
     1501 ccaactgatg gcactaccat taccgaatcg agcaatctga gtgaaataga aagtcgactt
     1561 ccgaaagcaa agctgataac tctgtgcaaa catgagtcta tcctgaaatg gatgtgtaac
     1621 tgtgaccatg ggatgtacca ggctttggtg gagattctca tccccgacgt ccttagacct
     1681 attcctagtg ccttgaccca agccattcga aattttgcaa aaagccttga aggttggctt
     1741 tccaatgcca tgaacaatat tccacagaga atgatacaaa ccaaggttgc cgctgtaagt
     1801 gcctttgccc agactctgcg aagatacacg tcgcttaatc acctggccca ggcagctcgt
     1861 gcagtgcttc agaacacttc ccaaatcaac cagatgctta gtgacctcaa ccgtgtcgac
     1921 tttgccaatg tccaggagca ggcttcctgg gtgtgccagt gtgatgacaa catggttcag
     1981 agactagaaa cagacttcaa gatgactctt cagcagcaga gcaccctgga gcagtgggct
     2041 gcgtggcttg acaatgtgat gatgcaagca ctgaaaccct atgaaggaag acccagtttt
     2101 cctaaagccg ccaggcagtt tctgctaaaa tggtctttct acagctcaat ggttattcgg
     2161 gacttaacct tacgcagtgc tgctagcttt ggctccttcc acctgatccg tctactctac
     2221 gacgaatata tgttttactt agtagaacat cgtgttgctc aggcaacagg agagactcct
     2281 atagcagtca tgggcgagtt tggtgattta aatgccgtgt ctcctggaaa tctggataaa
     2341 gatgaaggca gtgaagtaga aagtgaaatg gatgaagaac tggatgactc ttcagagcct
     2401 caagccaaaa gagagaaaac agagctgagc caggcatttc cagtgggctg catgcagcct
     2461 gttctcgaga ctggcgtgca accaagcctc ctgaatccaa ttcacagcga gcacattgtc
     2521 acaagtactc agactatcag acagtgcagc gctacaggaa atacctacac tgcagtctaa
     2581 agaatattaa agcgtatttt tccagcttac attaaccctg ttgatattgg gcttaagttg
     2641 aaaatttaat aagcctgaag gtcgactgtt gtcaaattct atctgtgctg aacattaact
     2701 ttttggagtt gtgaaatgga atgggtgtat gtattttgcc agatcttttt ttttaacgta
     2761 aacaaattat ttgcttctta ataatgaatt ttttccctta gtttcaggtg tcaagaagga
     2821 tttttacaac acttaatgtc aatgttttgt tttcttataa ttaaaaagta atttacattt
     2881 tttgtagctt aaaatatttt attgttgatt gttagtcttg gtgtatgatt tcatgtgtaa
     2941 gttttttaat tagatgcact tctgtgaaat atcaaaagaa atgatttttt tgatttacac
     3001 tggaggcatg cccatttggc agcagatgca tcaaatttgc ttttgaaagg tgcttttcat
     3061 tggacagaac cataagacac tattttgata acattttgag tatggagaga gaatacagag
     3121 catttttatt atagtgctag agggtttgga aggtcatcta tttttctctg aggaaaaaat
     3181 gagctgtaca tttatcagtt cagagtaaat gacagaattg caagagatta tgctaatatg
     3241 tacataattt gtgtacataa ttattaaacc atgttaacaa tgcaagcttc cgttaaacat
     3301 tgaattttaa ctattatttg cataccaatt cctctgttta aagactactg attctgtatt
     3361 tgggaccact gcacagatgc attctgctgt taagtggggg ctgttatagt tagatactga
     3421 agcagaaaaa aaagacttga cttttttttt ttaagtgtac atgctactta tgctgagctg
     3481 gacatacagg aaaccattcc atttggatga ctttctttta ttccaggtct ttttcctaat
     3541 agtagttcaa tatgctgcta ttataaacga gaatttatag aatgcaagga atgtagcaac
     3601 ctacataacg ttatttcctt caaaactatt tcctggtttc taaagtatgt ggatttaaat
     3661 tgtaaacaga acctgaaggc agtgtaactg gcacacctca ctgttactta tccccaattc
     3721 tgtaggattt ggataggtgg ctggatggac cattgccatt gaagaatgta catcagggat
     3781 catcgtacct cggctattac atggtgcctt aaaacagaac tgaagctaag gtttagtaag
     3841 gtttattttg ttcatgtgac taactcttca atccatttga caaagtgtgc ctgtcatttt
     3901 cagattcctg aagtaaggac aggtgacatg ttcttcaaag gaaatttagg gaaaacaaag
     3961 gaaaacaaaa agacaaaaat cagtttccct ctttgagtga ccgtggatct attttttatt
     4021 cttagagctg aatattactt gattacaaat cagattgctt aagggtgtgg aatagcaggc
     4081 tagttttaat accaacttgt taacataaaa tcatatatgt tttagaccat tcttatttag
     4141 ttacaatttt agaaagttaa caaagtaagc aggtacttat cgaagtgcat cttttcagtc
     4201 taaatgtttg tctgtgtgtc taggtgctgg tgagtccaca tggacacatg agtgcccatg
     4261 gggcaggagt ctgctataaa gtcagaaggt gagatcctag agagttacac ccagccccat
     4321 tttaatttgc atgaaaagcc aaggttcttt taagcactca aattatttaa tgattaaaac
     4381 acaagaaagg cacatctgtt catttaaata gttgtaaaaa actaatcagc aaaaataaat
     4441 agataataaa gccaaaaaaa aggaaagcac aaaatgattg acagattatc aaatgaggcc
     4501 tatattaaac ccaagatgtt tatctttcca gtggtattgg ggtaaggggg gtggggggtt
     4561 ggaaagacga ggtgagccag tctgtaaagt tagaaatacc aaatggctta tcgggtaata
     4621 cacagtgtat ttaagctgtt gttgcttaat tgcctcagac tactcaaata acatcaacaa
     4681 catttcttaa gtaaaattta aatattttag atgtaatttt aaaaactgat ccaaattttt
     4741 tattatacaa ctcactcata tatttgaaag tcttcactag catagtagca tcaccttcat
     4801 ctaaatgtca tttaaattac tgtccccctt tttcctccca aaaagacaat ggatttgtac
     4861 caaaacacac acaaaaaagg caaacaaaac atgataatct gcaaaagttc atgtatctac
     4921 ttcattgtgc ataggaagtg tttacaggta aaattaaaat caaaaattga aaaaacactc
     4981 ttcattttgg ctctcctttc tgaatttttt cagtttcctg tctctacccg ccatcctttg
     5041 agtgatacta tatctgtatt ggaccaaatg tatttactgg tttcattttg tttattgaat
     5101 gactttaaat gtatttatta tcattgttta atttaatgtt ggatatattt gtatcattac
     5161 aggaatctgg taataatggg caaatttaga ttgatgaggc ttagggatcg gggatgctcc
     5221 aggattcaac atttcttcca attgttcatg gtttgttcta aattaggaca gattaagaac
     5281 taataaaaca ttattacatt tgaacttgac tcaataaaaa tattctgatc tcctttatga
     5341 atattaggaa tattctttgt gattagtgta agtagtttgg atcaaaacat aaaaagaaga
     5401 cctatggttt atgctacttc tagttatttg tagttcacag taaaacatgc acagacatac
     5461 acacaaacat tttcatcaat ttcgaatttg aattgtgaaa aatatataag aaaataaaaa
     5521 caatttatac atttgagcaa attgagcaat cacatttatt gcatttattt ccctttttcc
     5581 cttttttcac tcattgaaag tgtgggtttt ctaaataata ttagacacta acactcaaca
     5641 gatttattca caaatgacac aagtacacat tttaagactt ctttgtattt cttgcaatta
     5701 taaccaatca ctagtcatga aatataccta cataaaccaa gtcctacact ttcagtgagg
     5761 aagaatgtaa ggaaggtatg ttgactgttt tcaagtttca gaaaagatat tttcatatga
     5821 taggattgag tatcatgggt atagtttgat cttgacatat agtttgaaaa tcatactcaa
     5881 aagatttgca ttcatgaaac cagtgaacaa tagggtggaa tggatgaacc atctccttgg
     5941 aagacagggc ccaattttca attttttctt tggctatcaa gttgctagtc acttattcag
     6001 gattttcatc caaactgtgt ttggactgac tgtataagtc ttactgcctt ttcagaaatc
     6061 tgctttcctt tgtgtgattt ttcttgtact gtatagcacg gtttatgcac ctctctttag
     6121 atggtgtact ttaaaaacaa aagtaaaatt tagaaaatgg ttttaacact gcatacctaa
     6181 aattagtagt gtgcagcatt gactgccttt gatttgtagt agacaagtaa aaatgaatac
     6241 gttcttgtag aatgctgtaa aagttattca ggaatgaata cggttttagt gccgtaatca
     6301 tgaatctttt tatatgaatg cactgtctaa aagtgctaaa tgcattttca aatttttaaa
     6361 aattcctcag atgatatatt tgaaatgtct aaaataatgc tgtgcttgaa acattagtgt
     6421 aaaaggaaaa aaaaaatagt gtcactgtga tgttggtcct ccctgtgtgg acacaagtag
     6481 aaagaaaaaa cttggcaagt cacctttgtg tacaatttga ggcagtggtt atatacaata
     6541 aattgacctt tattatatcc cccagacaca cacattcttg gtgagaaaag aacaaccatc
     6601 cagaaattga gatgagaact tttgtgatct gtatgaatca cagcagatca tgggggagga
     6661 ggattggcat gcagtgctgt tgaaaattgg gcttgttgtt agatcagaac aacctccatg
     6721 tatatggtta gaacgaatca attaatggaa tcctagtatt tctgcaagtt tggtgatttt
     6781 taaaaactgg aatagaagca ttaattcagt gcttagttct agtattagaa aacccctttg
     6841 atgtaatgcc ttgtattaac cctttgagca ttgtaagata tacaatgggg gacaaaagcc
     6901 tttcagatca tttatttaga cttagaccgg taaagtatac tctatatcca aatgtctaat
     6961 tatgctgttt ttttaaaggg gggggtagga agagaaagtg tttccacgcc gaacacttgc
     7021 attttatata caactcttaa tttttcttca agagggcttg atatatttat tcccaaatat
     7081 tcactgccat ctaagtaagt gtactgttta cagaaaaaaa aaatcaactt ttctagtatc
     7141 acaccatagt ctctagaaaa ggaggacaaa tacatgggcc tggatagacc tatgtcataa
     7201 ctgatttctg cacattgaag gtacctagat tgcctttaaa aggtataaag aaagggttaa
     7261 gtttcttttt tttttgtctt ttttttccca aaatgaatca aaagatctca tttatttagc
     7321 tttagaaagt acaagtgtaa gtaaagcctt aggaagaaag gagttcgagt ggattaagag
     7381 aatctgaact ctttgggggc agttaggcta tttggagtta gatcgctcat aaaatattgt
     7441 ttgcgaattt cacacagggc ataattttat ctatgctcca aaactttaat acgttgtcaa
     7501 aaaattatat atagatagaa tggagagcaa agcacttgat tttaagctca tctgtcagga
     7561 gatgctatga ctactgcttc tgatatctct aaatgtcagt ctgcttacac cattgctgat
     7621 tttgttcaag ggaatctctt cgtgcacttg attccctctg ttccctgcgt gatcgaacat
     7681 gaaagcagtg ttgtctgcag atgtgcttgc gctgccctag ctgggtgcaa ataagagtgt
     7741 aacctattct gatgtctggt gaaaggacat ccatagcata gtgcaagtat gccgtaaacg
     7801 ttgcttttta ggcagtttag gaagtcagac catgcaaatt actcatgtgt taacatgcaa
     7861 tactcaaagg gttttaattt aactctcttc ttttgaattc ttcatgatga tttactgtaa
     7921 atgcttctca gtttgcatgc cttgatcatt gctgctagtg attttatgtg ccagtagacc
     7981 tgagtttagt ttaccaattt tacttaaata gtaaaagcca cttacaaagt gactgcctag
     8041 gatttttttt tcctttcatt tgaaataatt gataatatgt ttttttaaaa agaaaaatgt
     8101 gttttgtctc ttcttttatt tggttctggt ttgattcttt ttctcccctc tttcctttgt
     8161 tttttttttt taaataaatt atgatgttgg gattggaagc cctgagtaat gaaaatcttt
     8221 ggtaagaatt gtttatgtag ctcaataacg aggacaacaa atattcttta gaagaatttt
     8281 gattctgggg aggaaagaaa atataaaaac tcccattgac tgttgataac caagtaaatt
     8341 tttccttcag taaattagta tttttgaaga aacgatcgcc ttgttttaac ttgctaaaca
     8401 acaattttaa atgacccaat aaagaatcta ttgaacttta ttcgtttaaa aagcatcttt
     8461 tgtaccaaag caaatttttt tctctactca tttccatcat caatttggac ctatggtggt
     8521 gaccaatgca ttggttacag aaactttaag tgagtgcctt gagaaaactt ggaaatttgt
     8581 gcctgaggtg gtaaactttt aattaggtta attgtagtgc ttaccaatca gtaacttcac
     8641 tatcactcag ggctttcgta ccttctaggt aaaacttctt tcattgtgtt tttttaagat
     8701 actgtatttt tttttaagtg ccatcattta aatttcactt agtaagtggc agattacatt
     8761 attcagtccc acaagcacag aaacatagta acactaggag atatttgaac atttatttta
     8821 caatcgactg aatatattat gtaaatgagg taagcaactt ttgtagagat tgtatgtgtg
     8881 agataatgta atgttctttt ccagtttttg gactacagtt gaataaactt tttaattatt
     8941 taaaaacatc tttaccgaat aacatgtgat ggttttttgt ataatgtatt tgattttgta
     9001 aatacgtatt tcctgatgtg atttttgtga gaaatgctaa atcttttagt atatcatgtc
     9061 ctctcaaaat tggcaggagc taaataatag tttgtgggcg atttgtattg tgtactgtac
     9121 aataactggg gaacttttat aattataaaa atatatatta acttttagtg tgttgtttaa
     9181 acaaatgact ggaacatact aaagatatta gtaggatttt tctgaatatt tcagacttga
     9241 actcaggcta gctttcttgt gtttttcaaa acaaaatggt gtcttgtctt ttaaaatcaa
     9301 taaatttgtt tccttgttac aaata
//
