LOCUS       NM_001282116            9258 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens regulatory factor X3 (RFX3), transcript variant 3,
            mRNA.
ACCESSION   NM_001282116 XM_005251536
VERSION     NM_001282116.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9258)
  AUTHORS   Qian,Y., Cheng,B., Luo,J., Hu,Y., Gao,L. and Cheng,H.
  TITLE     CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate
            Tumorigenesis and Progression of Glioma
  JOURNAL   J Mol Neurosci 72 (6), 1195-1207 (2022)
   PUBMED   35416616
  REMARK    GeneRIF: CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate
            Tumorigenesis and Progression of Glioma.
REFERENCE   2  (bases 1 to 9258)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9258)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9258)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   5  (bases 1 to 9258)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9258)
  AUTHORS   Nakayama,A., Murakami,H., Maeyama,N., Yamashiro,N., Sakakibara,A.,
            Mori,N. and Takahashi,M.
  TITLE     Role for RFX transcription factors in non-neuronal cell-specific
            inactivation of the microtubule-associated protein MAP1A promoter
  JOURNAL   J Biol Chem 278 (1), 233-240 (2003)
   PUBMED   12411430
  REMARK    GeneRIF: Data show that two regulatory factor for X box (RFX1 and
            3) binding sites in exon1 of both the mouse and human
            microtubule-associated protein (MAP1A) gene are important for
            effective transcriptional repression in non-neuronal cells.
REFERENCE   7  (bases 1 to 9258)
  AUTHORS   Morotomi-Yano,K., Yano,K., Saito,H., Sun,Z., Iwama,A. and Miki,Y.
  TITLE     Human regulatory factor X 4 (RFX4) is a testis-specific dimeric
            DNA-binding protein that cooperates with other human RFX members
  JOURNAL   J Biol Chem 277 (1), 836-842 (2002)
   PUBMED   11682486
REFERENCE   8  (bases 1 to 9258)
  AUTHORS   Iwama,A., Pan,J., Zhang,P., Reith,W., Mach,B., Tenen,D.G. and
            Sun,Z.
  TITLE     Dimeric RFX proteins contribute to the activity and lineage
            specificity of the interleukin-5 receptor alpha promoter through
            activation and repression domains
  JOURNAL   Mol Cell Biol 19 (6), 3940-3950 (1999)
   PUBMED   10330134
REFERENCE   9  (bases 1 to 9258)
  AUTHORS   Emery,P., Durand,B., Mach,B. and Reith,W.
  TITLE     RFX proteins, a novel family of DNA binding proteins conserved in
            the eukaryotic kingdom
  JOURNAL   Nucleic Acids Res 24 (5), 803-807 (1996)
   PUBMED   8600444
REFERENCE   10 (bases 1 to 9258)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365202.19, AL354941.10 and
            AL133549.11.
            
            On Jan 23, 2020 this sequence version replaced NM_001282116.1.
            
            Summary: This gene is a member of the regulatory factor X gene
            family, which encodes transcription factors that contain a
            highly-conserved winged helix DNA binding domain. The protein
            encoded by this gene is structurally related to regulatory factors
            X1, X2, X4, and X5. It is a transcriptional activator that can bind
            DNA as a monomer or as a heterodimer with other RFX family members.
            Multiple transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Aug 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.228756.1,
                                           SRR14038195.590129.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617270.5/ ENSP00000482598.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AL365202.19        157716-157970       c
            256-380             AL365202.19        27441-27565         c
            381-478             AL354941.10        71659-71756         c
            479-737             AL354941.10        55251-55509         c
            738-812             AL354941.10        26538-26612         c
            813-994             AL354941.10        18069-18250         c
            995-1114            AL354941.10        13123-13242         c
            1115-1236           AL354941.10        2332-2453           c
            1237-1349           AL133549.11        160729-160841       c
            1350-1465           AL133549.11        156232-156347       c
            1466-1620           AL133549.11        155600-155754       c
            1621-1718           AL133549.11        151437-151534       c
            1719-1868           AL133549.11        148164-148313       c
            1869-2077           AL133549.11        142220-142428       c
            2078-2231           AL133549.11        133261-133414       c
            2232-2274           AL133549.11        114076-114118       c
            2275-9258           AL133549.11        103526-110509       c
FEATURES             Location/Qualifiers
     source          1..9258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.2"
     gene            1..9258
                     /gene="RFX3"
                     /note="regulatory factor X3"
                     /db_xref="GeneID:5991"
                     /db_xref="HGNC:HGNC:9984"
                     /db_xref="MIM:601337"
     exon            1..255
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..380
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2513
                     /gene="RFX3"
                     /note="isoform b is encoded by transcript variant 3; DNA
                     binding protein RFX3; transcription factor RFX3;
                     regulatory factor X, 3 (influences HLA class II
                     expression)"
                     /codon_start=1
                     /product="transcription factor RFX3 isoform b"
                     /protein_id="NP_001269045.1"
                     /db_xref="CCDS:CCDS6449.1"
                     /db_xref="GeneID:5991"
                     /db_xref="HGNC:HGNC:9984"
                     /db_xref="MIM:601337"
                     /translation="MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQ
                     TVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQ
                     VTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIE
                     MAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLD
                     PVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQ
                     QPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFG
                     EVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPT
                     DGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRP
                     IPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQA
                     ARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTL
                     EQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFH
                     LIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDE
                     ELDDSSEPQAKREKTELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCS
                     ATGNTYTAV"
     exon            381..478
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..737
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..812
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..994
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1114
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1236
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1349
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1465
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1620
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1718
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1868
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2077
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2231
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2274
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..9258
                     /gene="RFX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9232..9237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFX3"
                     /note="hexamer: AATAAA"
     polyA_site      9258
                     /gene="RFX3"
                     /note="major polyA site"
ORIGIN      
        1 ccctccccca cccctccccg tgcgagtgtc tccctctccc tctcgctctc tctctctctc
       61 cctctctctc tctcttttgt gagttatagc aaccgttgcc ttgtgaatca agcgccatag
      121 tcaccgtagt cctggcgact gttacccatc aacaacaact actcctctcc tcctcctcct
      181 cctcttcctc ctcctcctcc ccaccaccac catctccatc acccaccaac aacaccacaa
      241 taatccacag ccaagagacc atcatgcaga catcagagac tgggtcggac acaggctcga
      301 cagtgacctt acaaacatct gtggctagtc aagcagcagt gcctacgcag gtggtacagc
      361 aagtaccagt acaacaacag gtacagcagg tacagactgt gcagcaggta caacatgtct
      421 atcccgctca ggtgcagtat gtggaaggaa gcgatactgt ctataccaat ggagcaatcc
      481 gaacaacaac gtatccttac acagagacac agatgtacag ccaaaatact ggagggaatt
      541 actttgatac tcaagggagt tccgcccagg tgactaccgt ggtctcatcc cacagtatgg
      601 tgggcactgg tgggattcag atgggcgtca caggaggaca actcatcagc agctctggag
      661 gaacctatct gatcggcaac tcaatggaga attctggtca ctcagtgaca cacacaactc
      721 gggcctcccc agcgacaatt gaaatggcga ttgagacgct gcaaaagtct gacggtctgt
      781 ccactcacag aagctctctt ctcaacagcc atctccagtg gctgttggac aattatgaga
      841 cagcagaagg agtgagcctt cccagaagca ctctgtacaa ccactacctt cgacactgtc
      901 aggaacacaa actggaccca gtcaatgctg cctcttttgg aaaattaata agatcaattt
      961 ttatggggct acgaaccagg agattgggca ctagaggaaa ctccaaatac cactactatg
     1021 ggattcgtgt caagccagat tcccctctta atcgtctgca agaagacatg cagtatatgg
     1081 ctatgagaca acaacccatg caacagaaac aaaggtacaa gcctatgcag aaagtggatg
     1141 gggttgcaga tggtttcaca ggaagtggtc aacagacagg cacatctgtt gagcaaactg
     1201 taattgccca aagccaacat catcaacagt ttttagatgc atctcgagca cttccagagt
     1261 ttggagaagt tgaaatctct tctctgccag atggtactac ctttgaggat atcaagtcac
     1321 tgcagagtct ttatagagag cactgtgagg caatattgga cgttgttgtg aatcttcaat
     1381 ttagcctgat agaaaaattg tggcaaacat tctggcgcta ttctccctct actccaactg
     1441 atggcactac cattaccgaa tcgagcaatc tgagtgaaat agaaagtcga cttccgaaag
     1501 caaagctgat aactctgtgc aaacatgagt ctatcctgaa atggatgtgt aactgtgacc
     1561 atgggatgta ccaggctttg gtggagattc tcatccccga cgtccttaga cctattccta
     1621 gtgccttgac ccaagccatt cgaaattttg caaaaagcct tgaaggttgg ctttccaatg
     1681 ccatgaacaa tattccacag agaatgatac aaaccaaggt tgccgctgta agtgcctttg
     1741 cccagactct gcgaagatac acgtcgctta atcacctggc ccaggcagct cgtgcagtgc
     1801 ttcagaacac ttcccaaatc aaccagatgc ttagtgacct caaccgtgtc gactttgcca
     1861 atgtccagga gcaggcttcc tgggtgtgcc agtgtgatga caacatggtt cagagactag
     1921 aaacagactt caagatgact cttcagcagc agagcaccct ggagcagtgg gctgcgtggc
     1981 ttgacaatgt gatgatgcaa gcactgaaac cctatgaagg aagacccagt tttcctaaag
     2041 ccgccaggca gtttctgcta aaatggtctt tctacagctc aatggttatt cgggacttaa
     2101 ccttacgcag tgctgctagc tttggctcct tccacctgat ccgtctactc tacgacgaat
     2161 atatgtttta cttagtagaa catcgtgttg ctcaggcaac aggagagact cctatagcag
     2221 tcatgggcga gtttggtgat ttaaatgccg tgtctcctgg aaatctggat aaagatgaag
     2281 gcagtgaagt agaaagtgaa atggatgaag aactggatga ctcttcagag cctcaagcca
     2341 aaagagagaa aacagagctg agccaggcat ttccagtggg ctgcatgcag cctgttctcg
     2401 agactggcgt gcaaccaagc ctcctgaatc caattcacag cgagcacatt gtcacaagta
     2461 ctcagactat cagacagtgc agcgctacag gaaataccta cactgcagtc taaagaatat
     2521 taaagcgtat ttttccagct tacattaacc ctgttgatat tgggcttaag ttgaaaattt
     2581 aataagcctg aaggtcgact gttgtcaaat tctatctgtg ctgaacatta actttttgga
     2641 gttgtgaaat ggaatgggtg tatgtatttt gccagatctt tttttttaac gtaaacaaat
     2701 tatttgcttc ttaataatga attttttccc ttagtttcag gtgtcaagaa ggatttttac
     2761 aacacttaat gtcaatgttt tgttttctta taattaaaaa gtaatttaca ttttttgtag
     2821 cttaaaatat tttattgttg attgttagtc ttggtgtatg atttcatgtg taagtttttt
     2881 aattagatgc acttctgtga aatatcaaaa gaaatgattt ttttgattta cactggaggc
     2941 atgcccattt ggcagcagat gcatcaaatt tgcttttgaa aggtgctttt cattggacag
     3001 aaccataaga cactattttg ataacatttt gagtatggag agagaataca gagcattttt
     3061 attatagtgc tagagggttt ggaaggtcat ctatttttct ctgaggaaaa aatgagctgt
     3121 acatttatca gttcagagta aatgacagaa ttgcaagaga ttatgctaat atgtacataa
     3181 tttgtgtaca taattattaa accatgttaa caatgcaagc ttccgttaaa cattgaattt
     3241 taactattat ttgcatacca attcctctgt ttaaagacta ctgattctgt atttgggacc
     3301 actgcacaga tgcattctgc tgttaagtgg gggctgttat agttagatac tgaagcagaa
     3361 aaaaaagact tgactttttt tttttaagtg tacatgctac ttatgctgag ctggacatac
     3421 aggaaaccat tccatttgga tgactttctt ttattccagg tctttttcct aatagtagtt
     3481 caatatgctg ctattataaa cgagaattta tagaatgcaa ggaatgtagc aacctacata
     3541 acgttatttc cttcaaaact atttcctggt ttctaaagta tgtggattta aattgtaaac
     3601 agaacctgaa ggcagtgtaa ctggcacacc tcactgttac ttatccccaa ttctgtagga
     3661 tttggatagg tggctggatg gaccattgcc attgaagaat gtacatcagg gatcatcgta
     3721 cctcggctat tacatggtgc cttaaaacag aactgaagct aaggtttagt aaggtttatt
     3781 ttgttcatgt gactaactct tcaatccatt tgacaaagtg tgcctgtcat tttcagattc
     3841 ctgaagtaag gacaggtgac atgttcttca aaggaaattt agggaaaaca aaggaaaaca
     3901 aaaagacaaa aatcagtttc cctctttgag tgaccgtgga tctatttttt attcttagag
     3961 ctgaatatta cttgattaca aatcagattg cttaagggtg tggaatagca ggctagtttt
     4021 aataccaact tgttaacata aaatcatata tgttttagac cattcttatt tagttacaat
     4081 tttagaaagt taacaaagta agcaggtact tatcgaagtg catcttttca gtctaaatgt
     4141 ttgtctgtgt gtctaggtgc tggtgagtcc acatggacac atgagtgccc atggggcagg
     4201 agtctgctat aaagtcagaa ggtgagatcc tagagagtta cacccagccc cattttaatt
     4261 tgcatgaaaa gccaaggttc ttttaagcac tcaaattatt taatgattaa aacacaagaa
     4321 aggcacatct gttcatttaa atagttgtaa aaaactaatc agcaaaaata aatagataat
     4381 aaagccaaaa aaaaggaaag cacaaaatga ttgacagatt atcaaatgag gcctatatta
     4441 aacccaagat gtttatcttt ccagtggtat tggggtaagg ggggtggggg gttggaaaga
     4501 cgaggtgagc cagtctgtaa agttagaaat accaaatggc ttatcgggta atacacagtg
     4561 tatttaagct gttgttgctt aattgcctca gactactcaa ataacatcaa caacatttct
     4621 taagtaaaat ttaaatattt tagatgtaat tttaaaaact gatccaaatt ttttattata
     4681 caactcactc atatatttga aagtcttcac tagcatagta gcatcacctt catctaaatg
     4741 tcatttaaat tactgtcccc ctttttcctc ccaaaaagac aatggatttg taccaaaaca
     4801 cacacaaaaa aggcaaacaa aacatgataa tctgcaaaag ttcatgtatc tacttcattg
     4861 tgcataggaa gtgtttacag gtaaaattaa aatcaaaaat tgaaaaaaca ctcttcattt
     4921 tggctctcct ttctgaattt tttcagtttc ctgtctctac ccgccatcct ttgagtgata
     4981 ctatatctgt attggaccaa atgtatttac tggtttcatt ttgtttattg aatgacttta
     5041 aatgtattta ttatcattgt ttaatttaat gttggatata tttgtatcat tacaggaatc
     5101 tggtaataat gggcaaattt agattgatga ggcttaggga tcggggatgc tccaggattc
     5161 aacatttctt ccaattgttc atggtttgtt ctaaattagg acagattaag aactaataaa
     5221 acattattac atttgaactt gactcaataa aaatattctg atctccttta tgaatattag
     5281 gaatattctt tgtgattagt gtaagtagtt tggatcaaaa cataaaaaga agacctatgg
     5341 tttatgctac ttctagttat ttgtagttca cagtaaaaca tgcacagaca tacacacaaa
     5401 cattttcatc aatttcgaat ttgaattgtg aaaaatatat aagaaaataa aaacaattta
     5461 tacatttgag caaattgagc aatcacattt attgcattta tttccctttt tccctttttt
     5521 cactcattga aagtgtgggt tttctaaata atattagaca ctaacactca acagatttat
     5581 tcacaaatga cacaagtaca cattttaaga cttctttgta tttcttgcaa ttataaccaa
     5641 tcactagtca tgaaatatac ctacataaac caagtcctac actttcagtg aggaagaatg
     5701 taaggaaggt atgttgactg ttttcaagtt tcagaaaaga tattttcata tgataggatt
     5761 gagtatcatg ggtatagttt gatcttgaca tatagtttga aaatcatact caaaagattt
     5821 gcattcatga aaccagtgaa caatagggtg gaatggatga accatctcct tggaagacag
     5881 ggcccaattt tcaatttttt ctttggctat caagttgcta gtcacttatt caggattttc
     5941 atccaaactg tgtttggact gactgtataa gtcttactgc cttttcagaa atctgctttc
     6001 ctttgtgtga tttttcttgt actgtatagc acggtttatg cacctctctt tagatggtgt
     6061 actttaaaaa caaaagtaaa atttagaaaa tggttttaac actgcatacc taaaattagt
     6121 agtgtgcagc attgactgcc tttgatttgt agtagacaag taaaaatgaa tacgttcttg
     6181 tagaatgctg taaaagttat tcaggaatga atacggtttt agtgccgtaa tcatgaatct
     6241 ttttatatga atgcactgtc taaaagtgct aaatgcattt tcaaattttt aaaaattcct
     6301 cagatgatat atttgaaatg tctaaaataa tgctgtgctt gaaacattag tgtaaaagga
     6361 aaaaaaaaat agtgtcactg tgatgttggt cctccctgtg tggacacaag tagaaagaaa
     6421 aaacttggca agtcaccttt gtgtacaatt tgaggcagtg gttatataca ataaattgac
     6481 ctttattata tcccccagac acacacattc ttggtgagaa aagaacaacc atccagaaat
     6541 tgagatgaga acttttgtga tctgtatgaa tcacagcaga tcatggggga ggaggattgg
     6601 catgcagtgc tgttgaaaat tgggcttgtt gttagatcag aacaacctcc atgtatatgg
     6661 ttagaacgaa tcaattaatg gaatcctagt atttctgcaa gtttggtgat ttttaaaaac
     6721 tggaatagaa gcattaattc agtgcttagt tctagtatta gaaaacccct ttgatgtaat
     6781 gccttgtatt aaccctttga gcattgtaag atatacaatg ggggacaaaa gcctttcaga
     6841 tcatttattt agacttagac cggtaaagta tactctatat ccaaatgtct aattatgctg
     6901 tttttttaaa ggggggggta ggaagagaaa gtgtttccac gccgaacact tgcattttat
     6961 atacaactct taatttttct tcaagagggc ttgatatatt tattcccaaa tattcactgc
     7021 catctaagta agtgtactgt ttacagaaaa aaaaaatcaa cttttctagt atcacaccat
     7081 agtctctaga aaaggaggac aaatacatgg gcctggatag acctatgtca taactgattt
     7141 ctgcacattg aaggtaccta gattgccttt aaaaggtata aagaaagggt taagtttctt
     7201 ttttttttgt cttttttttc ccaaaatgaa tcaaaagatc tcatttattt agctttagaa
     7261 agtacaagtg taagtaaagc cttaggaaga aaggagttcg agtggattaa gagaatctga
     7321 actctttggg ggcagttagg ctatttggag ttagatcgct cataaaatat tgtttgcgaa
     7381 tttcacacag ggcataattt tatctatgct ccaaaacttt aatacgttgt caaaaaatta
     7441 tatatagata gaatggagag caaagcactt gattttaagc tcatctgtca ggagatgcta
     7501 tgactactgc ttctgatatc tctaaatgtc agtctgctta caccattgct gattttgttc
     7561 aagggaatct cttcgtgcac ttgattccct ctgttccctg cgtgatcgaa catgaaagca
     7621 gtgttgtctg cagatgtgct tgcgctgccc tagctgggtg caaataagag tgtaacctat
     7681 tctgatgtct ggtgaaagga catccatagc atagtgcaag tatgccgtaa acgttgcttt
     7741 ttaggcagtt taggaagtca gaccatgcaa attactcatg tgttaacatg caatactcaa
     7801 agggttttaa tttaactctc ttcttttgaa ttcttcatga tgatttactg taaatgcttc
     7861 tcagtttgca tgccttgatc attgctgcta gtgattttat gtgccagtag acctgagttt
     7921 agtttaccaa ttttacttaa atagtaaaag ccacttacaa agtgactgcc taggattttt
     7981 ttttcctttc atttgaaata attgataata tgttttttta aaaagaaaaa tgtgttttgt
     8041 ctcttctttt atttggttct ggtttgattc tttttctccc ctctttcctt tgtttttttt
     8101 ttttaaataa attatgatgt tgggattgga agccctgagt aatgaaaatc tttggtaaga
     8161 attgtttatg tagctcaata acgaggacaa caaatattct ttagaagaat tttgattctg
     8221 gggaggaaag aaaatataaa aactcccatt gactgttgat aaccaagtaa atttttcctt
     8281 cagtaaatta gtatttttga agaaacgatc gccttgtttt aacttgctaa acaacaattt
     8341 taaatgaccc aataaagaat ctattgaact ttattcgttt aaaaagcatc ttttgtacca
     8401 aagcaaattt ttttctctac tcatttccat catcaatttg gacctatggt ggtgaccaat
     8461 gcattggtta cagaaacttt aagtgagtgc cttgagaaaa cttggaaatt tgtgcctgag
     8521 gtggtaaact tttaattagg ttaattgtag tgcttaccaa tcagtaactt cactatcact
     8581 cagggctttc gtaccttcta ggtaaaactt ctttcattgt gtttttttaa gatactgtat
     8641 ttttttttaa gtgccatcat ttaaatttca cttagtaagt ggcagattac attattcagt
     8701 cccacaagca cagaaacata gtaacactag gagatatttg aacatttatt ttacaatcga
     8761 ctgaatatat tatgtaaatg aggtaagcaa cttttgtaga gattgtatgt gtgagataat
     8821 gtaatgttct tttccagttt ttggactaca gttgaataaa ctttttaatt atttaaaaac
     8881 atctttaccg aataacatgt gatggttttt tgtataatgt atttgatttt gtaaatacgt
     8941 atttcctgat gtgatttttg tgagaaatgc taaatctttt agtatatcat gtcctctcaa
     9001 aattggcagg agctaaataa tagtttgtgg gcgatttgta ttgtgtactg tacaataact
     9061 ggggaacttt tataattata aaaatatata ttaactttta gtgtgttgtt taaacaaatg
     9121 actggaacat actaaagata ttagtaggat ttttctgaat atttcagact tgaactcagg
     9181 ctagctttct tgtgtttttc aaaacaaaat ggtgtcttgt cttttaaaat caataaattt
     9241 gtttccttgt tacaaata
//
