LOCUS       NM_002918               4375 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulatory factor X1 (RFX1), mRNA.
ACCESSION   NM_002918
VERSION     NM_002918.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4375)
  AUTHORS   Issac,J., Raveendran,P.S., Kunnummal,M., Angelin,M., Ravindran,S.,
            Basu,B. and Das,A.V.
  TITLE     RXR agonist, Bexarotene, effectively reduces drug resistance via
            regulation of RFX1 in embryonic carcinoma cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119510 (2023)
   PUBMED   37301270
  REMARK    GeneRIF: RXR agonist, Bexarotene, effectively reduces drug
            resistance via regulation of RFX1 in embryonic carcinoma cells.
REFERENCE   2  (bases 1 to 4375)
  AUTHORS   Chirichella,M., Bianchi,N., Dzafo,E., Foli,E., Gualdrini,F.,
            Kenyon,A., Natoli,G. and Monticelli,S.
  TITLE     RFX transcription factors control a miR-150/PDAP1 axis that
            restrains the proliferation of human T cells
  JOURNAL   PLoS Biol 20 (2), e3001538 (2022)
   PUBMED   35143476
  REMARK    GeneRIF: RFX transcription factors control a miR-150/PDAP1 axis
            that restrains the proliferation of human T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4375)
  AUTHORS   Mizukawa,T., Nishida,T., Akashi,S., Kawata,K., Kikuchi,S.,
            Kawaki,H., Takigawa,M., Kamioka,H. and Kubota,S.
  TITLE     RFX1-mediated CCN3 induction that may support chondrocyte survival
            under starved conditions
  JOURNAL   J Cell Physiol 236 (10), 6884-6896 (2021)
   PUBMED   33655492
  REMARK    GeneRIF: RFX1-mediated CCN3 induction that may support chondrocyte
            survival under starved conditions.
REFERENCE   4  (bases 1 to 4375)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4375)
  AUTHORS   Du,P., Gao,K., Cao,Y., Yang,S., Wang,Y., Guo,R., Zhao,M. and Jia,S.
  TITLE     RFX1 downregulation contributes to TLR4 overexpression in CD14+
            monocytes via epigenetic mechanisms in coronary artery disease
  JOURNAL   Clin Epigenetics 11 (1), 44 (2019)
   PUBMED   30857550
  REMARK    GeneRIF: Results show that RFX1 expression deficiency leads to the
            overexpression of TLR4 and the activation of CD14(+) monocytes in
            coronary artery disease (CAD) patients by regulating DNA
            methylation and histone modifications, which highlights the vital
            role of RFX1 in the pathogenesis of CAD.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4375)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
REFERENCE   7  (bases 1 to 4375)
  AUTHORS   Safrany,G. and Perry,R.P.
  TITLE     Transcription factor RFX1 helps control the promoter of the mouse
            ribosomal protein-encoding gene rpL30 by binding to its alpha
            element
  JOURNAL   Gene 132 (2), 279-283 (1993)
   PUBMED   8224874
REFERENCE   8  (bases 1 to 4375)
  AUTHORS   Herrero Sanchez,C., Reith,W., Silacci,P. and Mach,B.
  TITLE     The DNA-binding defect observed in major histocompatibility complex
            class II regulatory mutants concerns only one member of a family of
            complexes binding to the X boxes of class II promoters
  JOURNAL   Mol Cell Biol 12 (9), 4076-4083 (1992)
   PUBMED   1508204
REFERENCE   9  (bases 1 to 4375)
  AUTHORS   Pugliatti,L., Derre,J., Berger,R., Ucla,C., Reith,W. and Mach,B.
  TITLE     The genes for MHC class II regulatory factors RFX1 and RFX2 are
            located on the short arm of chromosome 19
  JOURNAL   Genomics 13 (4), 1307-1310 (1992)
   PUBMED   1505960
REFERENCE   10 (bases 1 to 4375)
  AUTHORS   Reith,W., Herrero-Sanchez,C., Kobr,M., Silacci,P., Berte,C.,
            Barras,E., Fey,S. and Mach,B.
  TITLE     MHC class II regulatory factor RFX has a novel DNA-binding domain
            and a functionally independent dimerization domain
  JOURNAL   Genes Dev 4 (9), 1528-1540 (1990)
   PUBMED   2253877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK309824.1, AC020916.8,
            BC049826.1 and BM662273.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002918.4.
            
            Summary: This gene encodes a member of the regulatory factor X
            (RFX) family of transcription factors, which are characterized by a
            winged-helix DNA-binding domain. The encoded transcription factor
            contains an N-terminal activation domain and a C-terminal
            repression domain, and may activate or repress target gene
            expression depending on cellular context. This transcription factor
            has been shown to regulate a wide variety of genes involved in
            immunity and cancer, including the MHC class II genes and genes
            that may be involved in cancer progression. This gene exhibits
            altered expression in glioblastoma and the autoimmune disease
            systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049826.1, SRR14038196.271947.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254325.9/ ENSP00000254325.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AK309824.1         3-238
            237-238             AC020916.8         207015-207016       c
            239-1377            BC049826.1         202-1340
            1378-1378           AC020916.8         186088-186088       c
            1379-4165           BC049826.1         1342-4128
            4166-4365           BC049826.1         4130-4329
            4366-4375           BM662273.1         16-25               c
FEATURES             Location/Qualifiers
     source          1..4375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..4375
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /note="regulatory factor X1"
                     /db_xref="GeneID:5989"
                     /db_xref="HGNC:HGNC:9982"
                     /db_xref="MIM:600006"
     exon            1..218
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            219..589
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..3210
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /note="transcription factor RFX1; trans-acting regulatory
                     factor 1; enhancer factor C; MHC class II regulatory
                     factor RFX; regulatory factor X, 1 (influences HLA class
                     II expression)"
                     /codon_start=1
                     /product="MHC class II regulatory factor RFX1"
                     /protein_id="NP_002909.4"
                     /db_xref="CCDS:CCDS12301.1"
                     /db_xref="GeneID:5989"
                     /db_xref="HGNC:HGNC:9982"
                     /db_xref="MIM:600006"
                     /translation="MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPP
                     TAAATPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIV
                     VTVSEGAMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSP
                     LQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSS
                     KTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVA
                     QEVQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEA
                     AGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGG
                     GGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAE
                     GVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYG
                     LRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDI
                     SAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMV
                     NLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKH
                     CDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAA
                     AGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCED
                     RVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFY
                     SSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLAT
                     SLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLF
                     VQALPSS"
     exon            590..699
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            700..783
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            784..891
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1008
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1104
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1199
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1584
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1766
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1886
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2002
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2121
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2231
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2383
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2481
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2631
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2840
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2994
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3040
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..4375
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4349..4354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /note="hexamer: AATAAA"
     polyA_site      4375
                     /gene="RFX1"
                     /gene_synonym="EFC; RFX"
                     /note="major polyA site"
ORIGIN      
        1 agttgccccg gtgagggaaa cggaggcgcc atagccacgg tagtcgtggc gaccaagcaa
       61 cccggcaacg cgagtcaaca acaacaaccg cccggccgac ccccaccccc accccccagg
      121 cccggcccgg ggaccccagc acgtcccgtc cccttcccaa catcgactcc gagacctccg
      181 aaaagcgttt ccgcagacag aagtggggag aagcggagga attaaaaaaa aaaaaaagcc
      241 ttatttatta tcattttccc caccgttggc atggcaacac aggcgtatac tgagctacag
      301 gcagccccgc caccatccca gccgccacag gccccgccac aagcccagcc ccagccgcca
      361 ccgccaccac ccccagcggc accccagccc ccgcagccac ccaccgctgc tgccacccct
      421 cagccccaat atgtcaccga gctgcagagc ccccagcccc aggcacagcc accgggtggc
      481 cagaagcagt acgtgacgga gctcccggct gtacccgcac cctcgcagcc aaccggtgca
      541 cccacccctt cgcctgcacc ccagcagtac atcgtggtca ctgtctctga aggtgccatg
      601 cgggccagcg agacagtgtc ggaggccagc cccggctcca ccgccagcca gaccggcgtt
      661 cctactcagg tggttcagca ggtgcagggc acccagcagc ggctgctggt ccagacgagc
      721 gtgcaggcca agccaggcca cgtgtcgccc ctccagctga ccaacatcca agtgccccag
      781 caggctcttc ccacgcagcg tctggtggtg cagagcgcag ccccaggcag caaaggtggc
      841 caggtctccc tgacggtcca tggtacccag caggtgcact cgcccccaga gcagtcgccg
      901 gtgcaggcca acagctcttc cagcaagaca gccggggccc ccacgggcac agtgccacag
      961 cagctgcagg tccacggcgt ccagcagagt gtccccgtca cccaagagag atctgtggtc
     1021 caggccactc cacaagcgcc caaacccggc ccggtgcagc cgctgaccgt gcagggcctc
     1081 cagccagtcc acgtggctca agaggtgcag cagctccagc aggtgcccgt cccacacgtg
     1141 tactccagcc aggtgcagta tgtggagggc ggcgatgcca gctacacggc cagtgccatc
     1201 cgttccagca cctactccta tcccgagacg ccgctgtaca cgcagacggc aagcaccagc
     1261 tactacgagg ccgcaggcac ggccacccag gtcagcaccc ccgccacctc ccaggcggtg
     1321 gccagcagtg gctccatgcc catgtacgtg tccggcagcc aggtcgtcgc cagctccacc
     1381 agcactgggg ctggggccag caacagcagc ggaggtggtg gcagtggtgg tggcggcggc
     1441 ggcgggggag gcggtggcgg gggtggcagt ggcagcaccg gaggcggcgg cagcggagca
     1501 ggcacctacg tgatccaagg cggctacatg ctgggcagtg ccagccagtc ttactctcac
     1561 accacccgtg cctcgccagc cacggtccag tggctcctgg acaactatga gacggctgag
     1621 ggcgtgagtc tgccacggag caccctctac tgccactact tactgcactg ccaggagcag
     1681 aagctggagc ccgtcaacgc cgcctccttc ggcaagctca tccgctccgt cttcatgggc
     1741 ctgcgaaccc gccgtctggg caccaggggc aactccaagt accactacta tggcctgcgc
     1801 atcaaggcca gctcacccct gctgcggctg atggaggacc agcagcacat ggccatgcgg
     1861 ggccagccct tctcgcagaa gcagaggctc aagcccatcc agaagatgga aggcatgacc
     1921 aacggcgtgg cggtggggca gcagccgagc acggggctgt cggacatcag cgcccaggtg
     1981 cagcagtacc agcaattttt ggatgcctct cggagcctcc ctgacttcac agagctcgac
     2041 ctccagggca aggtgctgcc tgagggcgtc gggcccgggg acatcaaagc cttccaggtc
     2101 ctgtaccggg aacactgtga ggccattgtc gacgtcatgg tgaacctgca gttcaccctg
     2161 gtggagacgc tgtggaagac cttctggagg tacaacctca gccagcccag tgaggcgcca
     2221 ccgctggctg tacatgacga ggccgagaag cgactgccca aagccatcct ggtgctcctc
     2281 tccaagttcg agcccgtgct ccaatggacc aagcactgtg acaacgtgct gtaccagggc
     2341 ctggtggaaa tcctcattcc cgacgtgctg cggcccatcc ccagtgcctt gacccaagcg
     2401 atccggaact ttgccaagag cctggagagc tggctcaccc acgccatggt caacatcccc
     2461 gaggagatgc tgcgggtgaa ggtggccgcg gctggcgcct tcgcgcagac actgcggcgc
     2521 tacacgtcgc tcaaccacct ggcgcaggcg gcgcgcgctg tgctgcagaa caccgcacag
     2581 atcaaccaga tgctgagcga cctcaaccgc gtggacttcg ccaacgtgca ggagcaggcc
     2641 tcgtgggtgt gccgctgcga ggaccgcgtg gtgcagcggc tggagcagga cttcaaggtg
     2701 acgctgcagc agcagaactc gctggagcag tgggcggcct ggctggacgg cgtggtgagc
     2761 caggtgctca agccctacca gggcagcgcc ggcttcccca aggccgccaa gctcttcctc
     2821 ctcaagtggt ccttctacag ctccatggtg atccgggacc tgaccctgcg cagcgccgcc
     2881 agcttcggtt ccttccacct catccggctg ctctacgacg agtacatgta ctacctgatc
     2941 gagcaccgcg tagcccaggc caagggcgag acccccatcg ccgtcatggg cgagttcgcc
     3001 aatctggcca cctccctgaa ccccctggac cccgacaaag acgaggagga agaagaggag
     3061 gaggagagcg aggacgagct gccgcaggac atctcactgg cggctggcgg cgagtcaccc
     3121 gcgctgggcc cggagaccct ggagccgccg gccaagctgg cgcggactga cgcgcgcggc
     3181 ctcttcgtgc aggcgctgcc ctccagctaa gcccttggcc tccccgcccc acccgccccc
     3241 gccacccctc cacgccaggg tccctcaaag cttctgtggc ttcgtggtca ctgctccagc
     3301 ctcagccagg gcagggaggg ggactccgag acagggaaga ccggggccct cctcccttat
     3361 ggggccggca caatcagtgg gctgggcgga gccgcagctg caaactctga cacaaaagac
     3421 gtgccttaag gaacccgccg cgtgcccagg tgccccgcgg ggcatccagc tcggcccctt
     3481 ggccgccccc ctcccaggcc ccagcgtctt ctccccagcc ccgtcctccc accaccccag
     3541 ggggcaggca ggcaggcccc ctcccgtgcg aaactgttaa cttattcagc tcgctggctt
     3601 tgcacagcct gtcctgggcc cagccctgag ccccgggccg gcgcaggtgg gcgtcacctg
     3661 gggactcccc actgtcagca gcagccccgg gacaccctac ccccagcaac cccactgctt
     3721 ccccttcttg gtattaagtg caattaaagc cgtgggtgtc gcatcttctc cagcgctggg
     3781 ccctcccttg cccccaagct caagaagggg gcactgcccg gcccggctgt gaggagggcg
     3841 gcagggggca cggcctccag cttccaaaga gcagcgagcc gcggagccgg ggagtgccca
     3901 cagaccccag cccccgcgcc cccgccctcc gccgctggtt tgtaatggaa ccttttctgt
     3961 gcccctatct tcccggagac cacgcttctc ctccgtgccg tgcgaccccc accccatgac
     4021 tattgtgcga ttcgtgagcg ccgcccgagc ggagttggta acttgttggg tttttttcca
     4081 accatcatgg ccttatctgt tccagttttc tcagtgtttt cagcctgtga gatagatgtt
     4141 tatggcaaga aaaaggaaaa aaaaatggaa atctgaccta ttgtataaaa atcactattt
     4201 tgtgtgctcc gcgtgctata gcttttgggg cggccctgcc cagtccccgt gcccacgggg
     4261 ctccctctcc cggtggtgaa agtgtccaca cgtgtggtag tctagtgtgc cgagctgttt
     4321 tctacctttt tgtagtcttt cttaaaacaa taaattccgc tgtgatattt gccta
//
