LOCUS       NM_018124               4948 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ring finger and WD repeat domain 3 (RFWD3), transcript
            variant 1, mRNA.
ACCESSION   NM_018124
VERSION     NM_018124.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4948)
  AUTHORS   Moore,C.E., Yalcindag,S.E., Czeladko,H., Ravindranathan,R.,
            Wijesekara Hanthi,Y., Levy,J.C., Sannino,V., Schindler,D.,
            Ciccia,A., Costanzo,V. and Elia,A.E.H.
  TITLE     RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of
            stalled replication forks
  JOURNAL   J Cell Biol 222 (5) (2023)
   PUBMED   37036693
  REMARK    GeneRIF: RFWD3 promotes ZRANB3 recruitment to regulate the
            remodeling of stalled replication forks.
REFERENCE   2  (bases 1 to 4948)
  AUTHORS   Zhu,Y., Peng,X., Wang,X., Ying,P., Wang,H., Li,B., Li,Y., Zhang,M.,
            Cai,Y., Lu,Z., Niu,S., Yang,N., Zhong,R., Tian,J., Chang,J. and
            Miao,X.
  TITLE     Systematic analysis on expression quantitative trait loci
            identifies a novel regulatory variant in ring finger and WD repeat
            domain 3 associated with prognosis of pancreatic cancer
  JOURNAL   Chin Med J (Engl) 135 (11), 1348-1357 (2022)
   PUBMED   35830250
  REMARK    GeneRIF: Systematic analysis on expression quantitative trait loci
            identifies a novel regulatory variant in ring finger and WD repeat
            domain 3 associated with prognosis of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4948)
  AUTHORS   Gallina,I., Hendriks,I.A., Hoffmann,S., Larsen,N.B., Johansen,J.,
            Colding-Christensen,C.S., Schubert,L., Selles-Baiget,S., Fabian,Z.,
            Kuhbacher,U., Gao,A.O., Raschle,M., Rasmussen,S., Nielsen,M.L.,
            Mailand,N. and Duxin,J.P.
  TITLE     The ubiquitin ligase RFWD3 is required for translesion DNA
            synthesis
  JOURNAL   Mol Cell 81 (3), 442-458 (2021)
   PUBMED   33321094
  REMARK    GeneRIF: The ubiquitin ligase RFWD3 is required for translesion DNA
            synthesis.
REFERENCE   4  (bases 1 to 4948)
  AUTHORS   Hsu,R.Y.C., Giri,S., Wang,Y., Lin,Y.C., Liu,D., Wopat,S.,
            Chakraborty,A., Prasanth,K.V. and Prasanth,S.G.
  TITLE     The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner
  JOURNAL   Cell Cycle 19 (21), 2927-2938 (2020)
   PUBMED   33044890
  REMARK    GeneRIF: The E3 ligase RFWD3 stabilizes ORC in a p53-dependent
            manner.
REFERENCE   5  (bases 1 to 4948)
  AUTHORS   Jia,J., Yang,Y., Yan,T., Chen,T. and Lu,G.
  TITLE     Down-regulation of RFWD3 inhibits cancer cells proliferation and
            migration in gastric carcinoma
  JOURNAL   Gen Physiol Biophys 39 (4), 363-371 (2020)
   PUBMED   32902405
  REMARK    GeneRIF: Down-regulation of RFWD3 inhibits cancer cells
            proliferation and migration in gastric carcinoma.
REFERENCE   6  (bases 1 to 4948)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4948)
  AUTHORS   Markson,G., Kiel,C., Hyde,R., Brown,S., Charalabous,P., Bremm,A.,
            Semple,J., Woodsmith,J., Duley,S., Salehi-Ashtiani,K., Vidal,M.,
            Komander,D., Serrano,L., Lehner,P. and Sanderson,C.M.
  TITLE     Analysis of the human E2 ubiquitin conjugating enzyme protein
            interaction network
  JOURNAL   Genome Res 19 (10), 1905-1911 (2009)
   PUBMED   19549727
REFERENCE   8  (bases 1 to 4948)
  AUTHORS   van Wijk,S.J., de Vries,S.J., Kemmeren,P., Huang,A., Boelens,R.,
            Bonvin,A.M. and Timmers,H.T.
  TITLE     A comprehensive framework of E2-RING E3 interactions of the human
            ubiquitin-proteasome system
  JOURNAL   Mol Syst Biol 5, 295 (2009)
   PUBMED   19690564
  REMARK    Erratum:[Mol Syst Biol. 2009;5:317]
REFERENCE   9  (bases 1 to 4948)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   10 (bases 1 to 4948)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP872110.1, BC059371.1, BC002574.2 and BM467919.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018124.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.21672.1,
                                           SRR1660805.195981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361070.9/ ENSP00000354361.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BP872110.1         5-51
            48-1268             BC059371.1         1-1221
            1269-4643           BC002574.2         650-4024
            4644-4948           BM467919.1         22-326
FEATURES             Location/Qualifiers
     source          1..4948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..4948
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /note="ring finger and WD repeat domain 3"
                     /db_xref="GeneID:55159"
                     /db_xref="HGNC:HGNC:25539"
                     /db_xref="MIM:614151"
     exon            1..92
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            93..612
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2419
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; RING
                     finger and WD repeat domain-containing protein 3; E3
                     ubiquitin-protein ligase RFWD3; RING finger protein 201;
                     RING-type E3 ubiquitin transferase RFWD3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RFWD3 isoform 1"
                     /protein_id="NP_060594.3"
                     /db_xref="CCDS:CCDS32486.1"
                     /db_xref="GeneID:55159"
                     /db_xref="HGNC:HGNC:25539"
                     /db_xref="MIM:614151"
                     /translation="MAHEAMEYDVQVQLNHAEQQPAPAGMASSQGGPALLQPVPADVV
                     SSQGVPSILQPAPAEVISSQATPPLLQPAPQLSVDLTEVEVLGEDTVENINPRTSEQH
                     RQGSDGNHTIPASSLHSMTNFISGLQRLHGMLEFLRPSSSNHSVGPMRTRRRVSASRR
                     ARAGGSQRTDSARLRAPLDAYFQVSRTQPDLPATTYDSETRNPVSEELQVSSSSDSDS
                     DSSAEYGGVVDQAEESGAVILEEQLAGVSAEQEVTCIDGGKTLPKQPSPQKSEPLLPS
                     ASMDEEEGDTCTICLEQWTNAGDHRLSALRCGHLFGYRCISTWLKGQVRKCPQCNKKA
                     RHSDIVVLYARTLRALDTSEQERMKSSLLKEQMLRKQAELESAQCRLQLQVLTDKCTR
                     LQRRVQDLQKLTSHQSQNLQQPRGSQAWVLSCSPSSQGQHKHKYHFQKTFTVSQAGNC
                     RIMAYCDALSCLVISQPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSY
                     LRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILV
                     YDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFPYGGVLAGTLEDASFWEQKMDF
                     SHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPIC
                     SCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTGDEAANSALLWDAASGSLLQDL
                     QTDQPVLDICPFEVNRNSYLATLTEKMVHIYKWE"
     exon            613..815
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            816..886
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1081
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1173
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1288
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1520
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1671
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1848
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2063
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2275
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..4948
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4929..4934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /note="hexamer: AATAAA"
     polyA_site      4948
                     /gene="RFWD3"
                     /gene_synonym="FANCW; RNF201"
                     /note="major polyA site"
ORIGIN      
        1 ggcagttggc gtaggtgcat tcggagtgcg gccgaggtaa ctaccgagtc ttcggcgggc
       61 tcgcgagccc ggccgcggcc tgctggtttc agtgatggct catgaagcaa tggaatatga
      121 tgttcaggtg cagttaaatc atgccgaaca acagccagct cctgctggca tggccagcag
      181 ccaaggggga ccagccctcc tccagcctgt tcctgctgat gtggtcagca gccagggggt
      241 accatccatc ctccagccag ctcctgctga ggtgatcagc agccaagcga caccacccct
      301 gctccagcct gctccgcaac tgtctgttga cctgacagaa gtggaggtct tgggagaaga
      361 cactgtggag aacatcaatc caagaacttc agaacaacat aggcagggat ctgatggtaa
      421 tcacaccatc ccagcatctt cgttgcattc aatgaccaac ttcatcagcg gactgcagag
      481 acttcatggc atgctggaat tcctgagacc ttcatcttca aaccacagtg tagggccaat
      541 gagaacaaga aggagggtat ctgcttcacg gagggcaaga gccggagggt ctcagaggac
      601 agacagtgcc aggttgagag caccattgga tgcttacttt caggtgagca ggacccagcc
      661 tgacttgcca gctaccactt atgattcaga gactaggaat cctgtatctg aagagttgca
      721 ggtgtctagt agttctgatt ctgacagtga cagctctgca gagtatggag gggttgttga
      781 ccaggcagag gaatctggag ctgtcatttt agaagagcaa ctagcaggtg tctcagcaga
      841 gcaagaagtt acatgtatcg atggaggcaa gaccctcccc aaacagccat ctccccagaa
      901 gtctgagcct ctgctacctt ctgcttctat ggatgaggaa gaaggggaca cttgtacaat
      961 atgtctggaa cagtggacca atgctgggga ccaccggctc tcagcattac gctgtgggca
     1021 tctctttggg tataggtgca tttccacgtg gcttaaagga caagtacgaa aatgtcccca
     1081 gtgcaacaag aaagccaggc acagtgacat tgtcgtcctt tatgcccgaa ccctgagagc
     1141 tttggacact agtgaacagg agcgcatgaa aagttcccta ctgaaggaac agatgctaag
     1201 gaaacaggcc gagttagaat cagcacagtg ccgactccaa ctgcaggtcc tcactgataa
     1261 gtgcactagg cttcaaaggc gtgttcagga cttgcaaaaa cttacgtcac atcaaagtca
     1321 gaatttacag caacccaggg gctcccaagc atgggtcctg agctgctcac cctccagcca
     1381 gggccagcac aagcacaagt accacttcca aaagaccttc acagtatctc aggcaggaaa
     1441 ctgccggatc atggcatact gtgatgctct gagctgcctg gtgatatcac agccttctcc
     1501 tcaggcctct tttcttccag gctttggtgt taagatgttg agtactgcca acatgaagag
     1561 cagtcagtac attccgatgc atggcaaaca gatccgtgga ctggcgttta gcagttacct
     1621 cagaggcttg ctactctctg cttccctaga caacactatt aaactgacca gcctggagac
     1681 aaataccgtg gtccagactt ataatgctgg acgtcctgtc tggagctgtt gctggtgtct
     1741 tgatgaggct aactacatct atgctggact ggccaatggt tcaattctgg tatatgacgt
     1801 gcgaaacacg agcagtcatg tgcaggagtt agtagctcag aaagccagat gcccactggt
     1861 ctccctgtca tacatgccca gagctgcctc agctgcattt ccatatggtg gggtgctggc
     1921 tggaaccttg gaggatgctt cattctggga acagaaaatg gacttttctc attggcctca
     1981 tgtgctgccc ttggagccag ggggctgcat agactttcag acagagaaca gctcccggca
     2041 ctgtcttgtg acctacaggc ctgataaaaa tcacaccacc atacgaagtg tgctgatgga
     2101 aatgtcctac cgactggatg acactggaaa tccaatctgc tcctgccagc ctgtacatac
     2161 attttttgga ggacctactt gcaaactatt gaccaaaaat gccattttcc aaagcccaga
     2221 gaatgatggc aacatcctgg tgtgtactgg ggatgaagca gcaaattctg ccctgctgtg
     2281 ggatgctgcc agtggctcgt tgctccagga cctacagacc gatcagcctg tgttggacat
     2341 ctgcccattt gaggtgaacc gtaacagcta cttggctacc ttaacagaga agatggtcca
     2401 catctataag tgggagtgac tgtggtctcg aaaccttgaa ggcatgctgc tggttagatg
     2461 ttgtttgcta gcgcctagca gccccaagca agatccctgt ttattgtctg cagtctagaa
     2521 cattgggaat catggtttgt ttgcattagt atgattctag gaccctaggt cactgagaca
     2581 ctacagattg tgtatctgtt atgtccacta aaagagtaat tgatgggtac tttatctaca
     2641 ttatccattt cttgggttta aagccttcat taaccattat tgtatgttgg aaattcttat
     2701 tttctttatt ttctgtgtga ctttctggac cttagagagt gtcctctcat catctaggat
     2761 gtgagtgggc atcaagcatt ttctggggaa tatgacatcc catctgagtt gtcctgtcac
     2821 ttaagtatcc ttgaagggac taaccatcgt cttggtactg atttgatgca acgtagatgt
     2881 aaaagagtat tattcagttg aacacaagag ggcactgtag aaccttgtgt ccggtttatt
     2941 tctgaccttg aaggctgaca atcttttagt aacttgtctc atctccacac aagtgtgtga
     3001 tagcacacct gggtgtgctt tgtggcaata acacttgtgt tccaggtgtg aagtgctggg
     3061 acattggcag gcccagtgat ggaagcagct agtgaacgat tccctttgct aatgcctagt
     3121 gcattaagtt cattgctttg cgaaaggtaa ggaaagaggc cagttgtttg agcggtgggg
     3181 aagattttgt tttttctagc cagcttagga tctcaggatt ggttttatcc aagctagtgc
     3241 tttgaagaac actatctctt gccaggaaaa gatgagtgat aggtcaaagc ttttacttga
     3301 gtctccccta gtgtcagaga tcaggagaaa agacataaga gaatttacaa aagctattca
     3361 gactgctatt gaaaacatga gaagaacttg tctcccattt tgagagttcc tatctaaata
     3421 aagccaattc ctcagactga ggggctgttc ttaagtgttc tttatacatt ccagttatcc
     3481 agttaaagcc ttccccatgt gaagctgatg tttgattcca gtttcctttg atttgcctcc
     3541 ctaacctttt ctagggctca gtttgtattt ctttgccttg cctcagacta ctttgccaac
     3601 ccacttccac aacagaatat gcttcaagat gtgggcaggt cagtgtcctg ttcatgggag
     3661 aaaatggctt aacagtctga ttttctcaaa tgattattga agagttgtta tcgtttttat
     3721 tataaaacac ttctgacctg tcaattcaag agctgtttct aggatctttc tctccggcaa
     3781 ggggttgttg cactagattt ccccagagtt ccaagttcta gttgtgcctt ttaatgaccc
     3841 tttaatattt taggacataa ttttttcctt ttttaaattt ttttgtagaa atagatgttt
     3901 cactacgttg tccaggctgg tcttggactc ctggcctcaa gcaatcctcc cacctcagcc
     3961 tcctaaagtg ccaaaattat aggcgtgagc cactgcaccc ggcccctatt tgaagacgtc
     4021 ttttgtaaaa gctagcttct agaacctgag aaaagctctt ttctcagagg agatactcct
     4081 tttgatatgt taatgattaa gagtggttgc ccaggcctag tttcagtggc agaataggat
     4141 tggaattaaa aagcagaact catctggctt cagcagattg ccaccaagag gatacaggtg
     4201 gtcaggtcct ggctggcttt gtctttgggc ctgggcaggc ttaggatttg actttctttg
     4261 aagtacctga tgctgattga ttccactaat agtaggaagc aagagactta actatgaggg
     4321 acgttatgtg aatcttaagt cttaccagtc cttgcattag tacattaaat ttggatgttt
     4381 tggaagcaaa ttcatacgat cgtgagtgat ttctccaaag aaaaaaagcc ttgtccagcc
     4441 tgaccaacat ggtgaaaccc catctctact aaaaatacaa aaattaactg ggtgcagtgg
     4501 tgcgcatgcc tgtagtccca gctacttggg aggctgaggc aggagaattg cttgaaccct
     4561 gggaggcaga ggttgcagtg agtcgagatc gcgccactgc actccagcct cggtgacaga
     4621 gcaagactcc atctcaaaaa aaacaaacaa acaaaaaaaa accctgatgc cattcccagt
     4681 ccccgttgta ggacatcaca tttataaatc caggctttag tcttctgggc tccaccagtc
     4741 tctgccccac catattcctt tgtcactacc tctaagtttt tttccccact tgaggatttg
     4801 gagttaaacg aactcaaaat gtcttgtcat tgtatgtatt cttgcccctg ctttgaaaac
     4861 agggccatgg gaactctgtt tatgccctgt tttaatgttt ctgttttatg ttttactgtt
     4921 aatatgaaaa taaagaattt gctatgta
//
