LOCUS       NM_144629               5419 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens raftlin family member 2 (RFTN2), mRNA.
ACCESSION   NM_144629
VERSION     NM_144629.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5419)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5419)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 5419)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055136.1, BC113361.1, BC039690.1 and AC020550.4.
            
            On May 17, 2019 this sequence version replaced NM_144629.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.232612.1,
                                           SRR1803615.186044.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295049.9/ ENSP00000295049.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AK055136.1         274-353
            81-1648             BC113361.1         1-1568
            1649-2396           BC039690.1         1510-2257
            2397-2397           AC020550.4         95324-95324
            2398-2840           BC039690.1         2258-2700
            2841-5419           AC020550.4         95768-98346
FEATURES             Location/Qualifiers
     source          1..5419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..5419
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /note="raftlin family member 2"
                     /db_xref="GeneID:130132"
                     /db_xref="HGNC:HGNC:26402"
                     /db_xref="MIM:618215"
     exon            1..268
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1635
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /note="raft-linking protein 2"
                     /codon_start=1
                     /product="raftlin-2"
                     /protein_id="NP_653230.2"
                     /db_xref="CCDS:CCDS2323.1"
                     /db_xref="GeneID:130132"
                     /db_xref="HGNC:HGNC:26402"
                     /db_xref="MIM:618215"
                     /translation="MGCGLRKLEDPDDSSPGKIFSTLKRPQVETKTEFAYEYVLLDFT
                     LQASSNPEVIKINSILDIVTKVENYYLKGYIVGAIHPVIQPVGQRKHLPASYLYRVVL
                     LRLKLSPKNSAAPSGQRRPRLVIEECPLTSEAQTNDAAKELIEKINVAAKRGMKFVGF
                     ISQHYSPSKFCNGTNHDGDIESMLHVRHGSDENCRSWNEGTLSGQSSESGIEEELHHE
                     SGQYQMEQNGSPTSSKSRKGEASDNKLYTVFNAFDDDSTSWAYQEGILSMKVTRKGSV
                     ISTLDADWLELTTFYYKQGLSLIDSFVFWETSKGEHLPKSLEGFFIYEEEGSGVPGSS
                     RKGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPVLRHDSEGNLATK
                     QIVFLQRPVMWNSAAQTPDKKASRHIKGEDKNKATSRSIGLDTTSSQPAESRHLPEEC
                     RLSPSRECWTKEGRLAQHNSFSGFSSSDNVLRELDDGQFDQEDGVTQVTCM"
     exon            269..452
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..567
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..847
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1057
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1179
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1283
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1362
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..5419
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2823..2828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /note="hexamer: AATAAA"
     polyA_site      2840
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /note="major polyA site"
     regulatory      5394..5399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /note="hexamer: AATGAA"
     polyA_site      5419
                     /gene="RFTN2"
                     /gene_synonym="C2orf11; Raftlin-2"
                     /note="major polyA site"
ORIGIN      
        1 gttatctata gtttagctga aaacaaaatc aaagcagtta agtctgtaac tttctttttg
       61 cagcttaaac aacagaattt gctgctctcc ctcccctttc ctgcaattta attccttaca
      121 gattttgcca tggggtgcgg acttagaaag ctagaagacc ctgatgatag cagccctgga
      181 aaaatatttt ctaccctgaa gagaccgcaa gtggaaacaa agacagaatt tgcttacgaa
      241 tatgtattgc tggattttac tctacaagct tcatcaaacc cagaagtcat caagataaat
      301 tcaattctgg atatagtaac aaaagtggaa aactattatc ttaaaggata tattgtcggg
      361 gctattcatc ctgttataca acctgtgggg cagcgaaaac acctacctgc aagttaccta
      421 tacagagtgg tgctattgcg cttgaaatta agcccaaaga attcggcagc acccagtgga
      481 caaagacgcc caaggctcgt gattgaggaa tgtcccctaa cttctgaggc acaaacaaat
      541 gacgcagcaa aagaactgat agaaaagatt aatgtcgctg ctaaaagagg aatgaaattt
      601 gttggattca tatcacagca ttattctcca tctaaattct gcaatggaac caaccatgat
      661 ggagatatag aatcgatgct acatgtgaga cacggttcag atgaaaactg tagaagttgg
      721 aatgaaggga cgttaagtgg gcagtcatct gaaagcggaa ttgaggaaga acttcatcat
      781 gaaagtggac agtatcaaat ggaacaaaat ggcagcccta cttcctctaa atcaagaaag
      841 ggagaagcct cagataacaa attgtataca gtcttcaatg cttttgatga tgattcaacc
      901 tcctgggcct atcaggaagg catcctgtca atgaaagtaa caagaaaagg atcagtcatt
      961 agtacacttg atgctgattg gctggagtta actacctttt attataaaca aggcttgtct
     1021 ttaattgatt cttttgtatt ctgggaaaca tctaaagggg aacatttgcc taaatctttg
     1081 gaaggatttt ttatctatga agaagaaggt tctggagttc caggttctag taggaaagga
     1141 aatgatgcca tcgtagtaga acaatggact gttattgagg gatgtgaaat caaaacagat
     1201 tatggccctc tgctgcacac tctggctgaa ttcggatggc ttctgacaag cgtgttgccc
     1261 acacctgtat tgagacatga cagtgaaggg aatttggcta caaagcagat cgtattcctt
     1321 cagaggccag ttatgtggaa ttcagctgct caaacaccag ataagaaagc cagccgccac
     1381 ataaaaggtg aagacaagaa taaagccact agtagaagca tcggattaga cacaacctcg
     1441 tcacaacctg cagagagcag acacctgcct gaggagtgcc gcctttctcc ctcccgggaa
     1501 tgctggacaa aggagggaag gctggcacag cacaacagct tctctgggtt cagcagcagt
     1561 gacaacgtcc tccgggaatt agacgacgga cagtttgatc aggaagatgg agtgactcag
     1621 gtcacttgta tgtgagccat gaggtgaagc aaaggaaggc cctgtaaata attgttaaaa
     1681 tcattgccaa ctgaccttat tgtattactt tctctgcatt tatgtaatat ttttgaattt
     1741 ttccagaccc agcctttcct ctaatctatg taaactttgg cacaacctcc cagacaagga
     1801 agaataacca acatatttat acatttagaa tcatgtttac acttctctca actaaaacat
     1861 ctggttaaac agatgttcca ttcggttatt acacaataat ctatttcagc ttctcatgaa
     1921 tgtacaaagt agactttctt acaattcctg gtaaggagac tgaatatctc aatcagtatt
     1981 ttacccaatt agagagagtt ctcaggaagt tacagtctta tttaagctga aaaataacct
     2041 ctctctctct ttttttttct ctctctctca tacacacaca cagctaatta gtgcaaataa
     2101 atatctattt cccaaatata ataattaatc cacattttgt ctttaactat agcatgtata
     2161 tacaaagcaa gcccctatgt gttaaaatat tttttgaaaa aaatcttttt tatgtatctt
     2221 tgcttttaaa gggtcatgtc accaaccctg tactgattca ttgtacataa atgttgttgc
     2281 tcctaaaagc ctaaaaatgc agacagcaaa gcagcatctc ttaaaattca atatgaaaag
     2341 aacccataat ctcaatacat aaatacctta gtagagagta agatttaatt tttttttatt
     2401 ttaaagtcca aatactatga agaggaaaaa tatcaacttc aatttgaaac tgaagtcttt
     2461 tacatctgtc tagatttgaa ttctgctttt attttgactt gttaaatcct gaagaatgtt
     2521 gaaacctaga attttcaatc tggcaggagt agaaagatgc tcatagcaca cgcgatatgt
     2581 atgataacat attttgtttc atcttgcttt tctttcccct tctaatagag gtggctttgc
     2641 cttgacccag cctttaacaa tctttaaaat tctacaaaat aaaggatttt catttatcta
     2701 tgaaaggctt actttgaaag atggaacctc caagtgaatt acaacttatt ctatcattga
     2761 tgaattcagc ctattatata tttttattaa cattgatgtt gacattgtaa gatcatttta
     2821 ataataaaac atcattttta ttgtgttatt gttttattga acacaaatat tcatataata
     2881 tgtttggttt gggggttttt tgtggctttt tttgagacgg agtctcactc tgtcacccag
     2941 gctggaatgc agtggcacag tcgcagctca ctgcaacctc cacctcctgg cttcaagcga
     3001 ttctcctgcc tcagcctcca gattagctgg aactacagcc agtgtgcgcc accacgccca
     3061 gctaattttt gtatttttag tagagatggg gtttcaccat gttggccagg atggtctcga
     3121 tctcttgacc tcatgatctg cctgccttgt cctcccaaaa tgctgggatt acaggcgtga
     3181 gccaccatgc ctggccttca tataatatgt tttatacata taacagatat gtattacatg
     3241 ttatcaatta tatagtgtat ctaaactaag tcaatctcca ttaattgctg ataaaattaa
     3301 caggaattat tccactttta tcatccagaa gtacagtata aaggaattta agaatattct
     3361 tctcagtctt attctatagc aatagctgtc aacaatattt gcagaaatgg tttttgtttt
     3421 gacttttaga tggacttgag ttccataatc aagagttagt ggatttttgg tagaaacaat
     3481 cactgcttca ggagtccata aaacgtaatg aagttaggaa gcacaaagaa caaatcagaa
     3541 agatctgttt ttcccaattc cagggtctac aagaggtaga gacttcttta tcattcagcc
     3601 cacatacata ggggattgga agtagtaaat taaaaacaga gataggaatt tatatttgac
     3661 taagaaaaaa ctcagaaata tagcaataac tttttttttt tttttttttt tttgagacag
     3721 agcctcactc tgtcacccag gctgcaatct cggcttactg caacctccgc ctcccaggtt
     3781 caagtgactc tcctgcctca gcctcctgag tagcagggat tacaggcctg caccaccatg
     3841 cctggctaag ttttgtaatt ttagtagaga tggggtttca ccatgttggc caggctggtc
     3901 tcgaactcct ggcctcaagc aatccaccca ccttggcctc ccaatgtgct gggattacag
     3961 gtgtgagcca ctgcacccag ccaagcaatc gcttttttaa aaaatttgtg taagcatact
     4021 ttctcagttt atttttttct cccctcccgt ttatttttaa tctgagttat ttcttattaa
     4081 aataactttt attaaaataa acttactagt ctgtcatatc ctcaaaactt gttttagaag
     4141 catttgctcc aacaattacc cttaagttat gtgatgaatt tgtatgatag cgaataattt
     4201 atgatcaagt ggttctagag tattttaaat gtgtgtaaat agctatgagc ctattatttt
     4261 aaaaaaagaa aaaaacttgg gctctctatg cctaaggagt taaatatgtc taattttatt
     4321 atctgccagt tgtatattca gttcttttta taacactatg atttccttag gggctctggc
     4381 atgtgaattt ttaaaacctg taagttataa tgaaaggtat caagatccca gatgttgggt
     4441 gaagatctgc cattcccctt ggtgtagtat ctatggcatt ttcatcttcg ttttcaatac
     4501 caagtgttaa ttccatcccc tttggattgt ataccacctt gttatctttt atggacacat
     4561 ttaacaccta cctaatcacc agggaaatca gctctatcag tgtcattaca attcatttca
     4621 gtaaaagaga aaaggaaagg tcaccctctt tgagagattc tagggctttc aggaggagga
     4681 gaagcaggag acagagctac agtctattca aatcacaact atctccaaat catttgtgtt
     4741 atcaggagca ggtgtttata tatttgaata taaatgtaac agatgcattt tcatttcttt
     4801 cattctggag tgccagagga gctgtcccgt tttcccgccc ttgcctgtta ttgattcctc
     4861 accaccattc cttcttggct ggaaggactg tggccctttc cctccccata tggctaaaga
     4921 ggatttcttt ctcttaactc ttcagagccc cagagtagta ctgtatggaa agtgtaaatt
     4981 cagatggaga atcaaatgaa gtgaaattgc taacaatggg gatagtatat aactaagaac
     5041 acattatata aaaatgtact agtggataca tagaaaaact agctaaatgt tactcatcag
     5101 aacttgtaac atatcaattt aaataacatt tgctggtaat ctatcatccc ttgagaatga
     5161 attttatttg tgtaatagtg caaagtttgc agaaccaggt ctgtcagata tttaagttct
     5221 gagatggtgt ttgaggcaga aaattaggca aaactgtaaa atgatgagcc tcagttttga
     5281 tgaggttcat aaagttttgg tgaagacgac tgcaaaagaa atgggttcta aacatgtttt
     5341 gagcattcaa atttttgtat gtaaaaatac caagtaatta aatcaatgga ataaatgaat
     5401 catttatgtg taagataaa
//
