LOCUS       NM_015150               2986 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens raftlin, lipid raft linker 1 (RFTN1), mRNA.
ACCESSION   NM_015150 XM_042841
VERSION     NM_015150.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Ozdemir,E.C., Uzunkaya,M., Gundogar,H. and Kurutas,E.B.
  TITLE     Association between raftlin and presepsin levels with periodontal
            healthy and disease conditions
  JOURNAL   Arch Oral Biol 160, 105880 (2024)
   PUBMED   38278125
  REMARK    GeneRIF: Association between raftlin and presepsin levels with
            periodontal healthy and disease conditions.
REFERENCE   2  (bases 1 to 2986)
  AUTHORS   Demirhan,I., Oner,E., Yuksel,Z., Yuksel,M. and Belge Kurutas,E.
  TITLE     Raftlin and 8-iso-prostaglandin F2alpha levels and gene network
            analysis in patients with Modic changes
  JOURNAL   Eur Spine J 32 (7), 2368-2376 (2023)
   PUBMED   37208489
  REMARK    GeneRIF: Raftlin and 8-iso-prostaglandin F2alpha levels and gene
            network analysis in patients with Modic changes.
REFERENCE   3  (bases 1 to 2986)
  AUTHORS   Hursitoglu,O., Kurutas,E.B., Strawbridge,R., Oner,E., Gungor,M.,
            Tuman,T.C. and Uygur,O.F.
  TITLE     Serum NOX1 and Raftlin as new potential biomarkers of Major
            Depressive Disorder: A study in treatment-naive first episode
            patients
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 121, 110670 (2023)
   PUBMED   36341844
  REMARK    GeneRIF: Serum NOX1 and Raftlin as new potential biomarkers of
            Major Depressive Disorder: A study in treatment-naive first episode
            patients.
REFERENCE   4  (bases 1 to 2986)
  AUTHORS   Lin,Y.T., Tsai,M.H., Su,Y.Y., Chen,W.C., Huang,S.C. and Chien,C.Y.
  TITLE     Expression of Major Lipid Raft Protein Raftlin in Chronic
            Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking
            Patients Correlated with Interleukin-17 and Tumor Necrosis
            Factor-alpha Levels
  JOURNAL   Biomolecules 12 (9), 1316 (2022)
   PUBMED   36139155
  REMARK    GeneRIF: Expression of Major Lipid Raft Protein Raftlin in Chronic
            Rhinosinusitis with Nasal Polyps in Smoking and Non-Smoking
            Patients Correlated with Interleukin-17 and Tumor Necrosis
            Factor-alpha Levels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2986)
  AUTHORS   Deng,C., Zhang,L., Ma,X., Cai,S., Jia,Y. and Zhao,L.
  TITLE     RFTN1 facilitates gastric cancer progression by modulating AKT/p38
            signaling pathways
  JOURNAL   Pathol Res Pract 234, 153902 (2022)
   PUBMED   35490655
  REMARK    GeneRIF: RFTN1 facilitates gastric cancer progression by modulating
            AKT/p38 signaling pathways.
REFERENCE   6  (bases 1 to 2986)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 2986)
  AUTHORS   Macgregor,S., Hewitt,A.W., Hysi,P.G., Ruddle,J.B., Medland,S.E.,
            Henders,A.K., Gordon,S.D., Andrew,T., McEvoy,B., Sanfilippo,P.G.,
            Carbonaro,F., Tah,V., Li,Y.J., Bennett,S.L., Craig,J.E.,
            Montgomery,G.W., Tran-Viet,K.N., Brown,N.L., Spector,T.D.,
            Martin,N.G., Young,T.L., Hammond,C.J. and Mackey,D.A.
  TITLE     Genome-wide association identifies ATOH7 as a major gene
            determining human optic disc size
  JOURNAL   Hum Mol Genet 19 (13), 2716-2724 (2010)
   PUBMED   20395239
REFERENCE   8  (bases 1 to 2986)
  AUTHORS   Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J.,
            Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M.,
            Ferrucci,L. and Kim,S.K.
  TITLE     Sequential use of transcriptional profiling, expression
            quantitative trait mapping, and gene association implicates MMP20
            in human kidney aging
  JOURNAL   PLoS Genet 5 (10), e1000685 (2009)
   PUBMED   19834535
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2986)
  AUTHORS   Cotsapas,C., Speliotes,E.K., Hatoum,I.J., Greenawalt,D.M.,
            Dobrin,R., Lum,P.Y., Suver,C., Chudin,E., Kemp,D., Reitman,M.,
            Voight,B.F., Neale,B.M., Schadt,E.E., Hirschhorn,J.N., Kaplan,L.M.
            and Daly,M.J.
  CONSRTM   GIANT Consortium
  TITLE     Common body mass index-associated variants confer risk of extreme
            obesity
  JOURNAL   Hum Mol Genet 18 (18), 3502-3507 (2009)
   PUBMED   19553259
  REMARK    Erratum:[Hum Mol Genet. 2010 Sep 15;19(18):3690-1]
REFERENCE   10 (bases 1 to 2986)
  AUTHORS   Saeki,K., Miura,Y., Aki,D., Kurosaki,T. and Yoshimura,A.
  TITLE     The B cell-specific major raft protein, Raftlin, is necessary for
            the integrity of lipid raft and BCR signal transduction
  JOURNAL   EMBO J 22 (12), 3015-3026 (2003)
   PUBMED   12805216
  REMARK    GeneRIF: These data suggest that Raftlin plays a pivotal role in
            the formation and/or maintenance of lipid rafts, therefore
            regulating B-cell antigen receptor-mediated signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU138240.1, D42043.1 and BC032349.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015150.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D42043.1, AY237654.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334133.9/ ENSP00000334153.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AU138240.1         78-133
            57-2974             D42043.1           1-2918
            2975-2986           BC032349.1         2664-2675
FEATURES             Location/Qualifiers
     source          1..2986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..2986
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /note="raftlin, lipid raft linker 1"
                     /db_xref="GeneID:23180"
                     /db_xref="HGNC:HGNC:30278"
                     /db_xref="MIM:618210"
     exon            1..258
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            259..411
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2003
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /note="raft-linking protein; proliferation-inducing
                     protein 9; proliferation-inducing protein 10; cell
                     migration-inducing gene 2 protein"
                     /codon_start=1
                     /product="raftlin"
                     /protein_id="NP_055965.1"
                     /db_xref="CCDS:CCDS33712.1"
                     /db_xref="GeneID:23180"
                     /db_xref="HGNC:HGNC:30278"
                     /db_xref="MIM:618210"
                     /translation="MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFT
                     TLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFR
                     AILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVG
                     VIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRN
                     QSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGK
                     MEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVN
                     AVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVP
                     LLNSLAAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFS
                     REEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGDMGNCVSGQQQEGGVSEEM
                     KGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGEDARDGDA
                     EEVRELGTVEEN"
     exon            412..598
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            599..707
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1092
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1296
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1412
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1516
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1598
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..2986
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /note="hexamer: AATAAA"
     polyA_site      2986
                     /gene="RFTN1"
                     /gene_synonym="MIG2; PIB10; PIG9; RAFTLIN"
                     /note="major polyA site"
ORIGIN      
        1 gctggagccg gagcgcgccg ggcgctgggc gcagcgagcg agagcgcggc ggccgcgggc
       61 tccggcgagg gacagacgca ccgatcgccg gagggacaga cacacgacca cgcggcgcca
      121 ccgcccacgc ctccacccac cggcgcccaa gtcctccccg cgccgcctcc tctgtatggc
      181 acaaactttc ctcccgggac ggaacacgct gcctcaggga gcccgcgacc gcgccttctc
      241 ctccgccggt cccatacgct gctgaaatgg gttgcggatt gaacaagtta gagaaacgtg
      301 atgaaaaacg gcctgggaat atttattcaa ctttgaagag gcctcaggtg gaaaccaaga
      361 tagatgtgtc ctatgaatac cgcttcctgg agttcacgac tctgagtgct gcggagctcc
      421 ctgggtcctc agcagtgagg ctggcctccc tgcgtgacct gcccgcccag ctcctggagc
      481 tgtaccagca gggcttctcg ctggcggccc tgcacccctt cgtgcagccc acccatgagc
      541 gggagaagac gcccctggag cacatcttta gagccatcct gatcaagaaa accgacagat
      601 ctcagaaaac tgatcttcac aatgaaggct acatcttgga attagattgc tgttcctcct
      661 tagaccaccc gacagaccag aaactcatcc cagagttcat taagaagatc caggaggctg
      721 caagccaggg cctgaaattc gttggtgtta tacctcagta ccattcctct gtgaactcgg
      781 caggcagcag tgctccggtg tctactgcca acagcaccga ggatgccaga gatgcaaaaa
      841 acgcacgtgg ggatcacgcg tcactggaga atgagaaacc ggggactggg gatgtgtgca
      901 gtgctccggc tgggagaaac caaagcccag agcccagctc aggccccaga ggggaggtgc
      961 ccctcgccaa gcagcccagc tcaccctccg gagagggaga tggtggagaa ctttcaccac
     1021 agggggtgag caagacactg gatggaccgg agagcaaccc cttggaggtg catgaagagc
     1081 cactctcagg gaaaatggag atcttcaccc ttttcaacaa accgaagagc catcagaagt
     1141 gccggcaata ctaccctgtc accattcctc tccatgtctc caagaatggc cagacagtga
     1201 gcggtttgga cgccaactgg ttagagcaca tgagcgacca cttccggaaa ggaggcatgc
     1261 tggtgaacgc agtcttctac cttggaatag tgaatgattc cttacatggc ttgacagatg
     1321 gagtattcat ctttgaagct gtttccacag aagatagcaa aaccatacag ggctatgatg
     1381 ctattgtggt tgaacaatgg acagtcctgg aaggtgtcga agtgcagaca gactacgtgc
     1441 ccctgctgaa ctcgctggcg gcctatggct ggcagctcac ctgtgtgcta ccaactcccg
     1501 tcgtcaagac taccagcgag gggagtgtat ccaccaagca gattgtcttt cttcagagac
     1561 cttgtctacc tcagaaaatc aagaagaagg aatcgaagtt tcagtggcga ttctccagag
     1621 aagaaatgca caacaggcag atgaggaaat caaaaggtaa actcagtgcc agagacaaac
     1681 aacaagcaga agaaaatgag aagaacttag aagaccagtc ttccaaagct ggagacatgg
     1741 gaaactgtgt ttcaggacag cagcaggagg gtggagtctc cgaggagatg aagggccctg
     1801 tccaagagga caagggagaa cagctgtccc ctggtggcct gctgtgtggg gtgggtgtgg
     1861 agggtgaggc tgtgcagaat ggtcctgcca gccacagcag ggccctggtg gggatttgca
     1921 ctgggcactc caatcctgga gaggatgcca gggacgggga tgctgaggaa gtcagagagc
     1981 ttggtacggt tgaagaaaac tgagtcttgg gcaatttgtg ctaaaactag gtgagttgcc
     2041 aaacccaagg catcttacca acagctggtt tgggggctgg tttccctggt gttgtgtgtt
     2101 acctaccctt tggcttggct tgacctctcc ttgtgagctc acctgagccc tcccagggcc
     2161 aggttcctga cagtgttggt ttttgcacat ccactggaaa ggtgtcatta atgacccagt
     2221 gttagaatgc aagaggtcag gttattctag ccctcatggc tgaaggccca gtcctggctc
     2281 caccactcct ccagccagag ggtctggacc atccagtgcc tgtcctcgcc acagggcctc
     2341 cagggagcat tcgggtcaaa tccatggaca ccctgggcta caaaccaagg ctgctgttca
     2401 tcccacatcg tgtggggcag tgtccatccc ctgcagctac ttggtgactt aacaactcca
     2461 ggagccctgt cagctgccct cctccaccta aaccccttcg actcttctgc tttgacaaag
     2521 aaaatgacat tggggagggg aggtgctccg cctcccagct tttctcaaaa tagtcctata
     2581 gatactggta atctggaaat gaagaagtaa ttctgtctct gcacctactt ttgcagaatg
     2641 ttcaaggaag tattctgtgt tagtattaat gccaaaaagt tgtttttaaa ggttttgtac
     2701 tcagcacatc atacaaacca cattacttct gtcacttcag ggcatcggga ctggctggcg
     2761 cccttgttat gtgctatttt aatcagtgta acattggtca agttgttacc catgtatgct
     2821 gtgtttatca tgtgtatatc gtccagaaag tattaaggct ttaggtagat gcaactggcg
     2881 aaccttggag agggaatgct gattgtcttg accaaaccca cagcctgtct cttctcttgt
     2941 ttagttactt acggcaataa atcatctatg agttagtgca ccgtga
//
