LOCUS       NM_001145014            1198 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens ret finger protein like 4A (RFPL4A), mRNA.
ACCESSION   NM_001145014 XM_001718457 XM_001719234 XM_292796
VERSION     NM_001145014.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Naito,A., Yamamoto,H., Kagawa,Y., Naito,Y., Okuzaki,D., Otani,K.,
            Iwamoto,Y., Maeda,S., Kikuta,J., Nishikawa,K., Uemura,M.,
            Nishimura,J., Hata,T., Takemasa,I., Mizushima,T., Ishii,H.,
            Doki,Y., Mori,M. and Ishii,M.
  TITLE     RFPL4A increases the G1 population and decreases sensitivity to
            chemotherapy in human colorectal cancer cells
  JOURNAL   J Biol Chem 290 (10), 6326-6337 (2015)
   PUBMED   25605732
  REMARK    GeneRIF: These results indicate that RFPL4A is a novel factor that
            increases the G1 population and decreases sensitivity to
            chemotherapy and thus may be a promising therapeutic target for
            refractory tumor conditions.
REFERENCE   3  (bases 1 to 1198)
  CONSRTM   GENDEP Investigators; MARS Investigators; STAR*D Investigators
  TITLE     Common genetic variation and antidepressant efficacy in major
            depressive disorder: a meta-analysis of three genome-wide
            pharmacogenetic studies
  JOURNAL   Am J Psychiatry 170 (2), 207-217 (2013)
   PUBMED   23377640
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Grutter,C., Briand,C., Capitani,G., Mittl,P.R., Papin,S.,
            Tschopp,J. and Grutter,M.G.
  TITLE     Structure of the PRYSPRY-domain: implications for autoinflammatory
            diseases
  JOURNAL   FEBS Lett 580 (1), 99-106 (2006)
   PUBMED   16364311
REFERENCE   5  (bases 1 to 1198)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   6  (bases 1 to 1198)
  AUTHORS   Rajkovic,A., Lee,J.H., Yan,C. and Matzuk,M.M.
  TITLE     The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3
            ubiquitin-protein ligase expressed in adult germ cells
  JOURNAL   Mech Dev 112 (1-2), 173-177 (2002)
   PUBMED   11850190
  REMARK    GeneRIF: The ret finger protein-like 4 gene, Rfpl4, encodes a
            putative E3 ubiquitin-protein ligase expressed in adult germ cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008749.6.
            
            On Apr 5, 2021 this sequence version replaced NM_001145014.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA454993.1, SRR5189667.94594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434937.3/ ENSP00000392936.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC008749.6         65195-65273
            80-374              AC008749.6         67890-68184
            375-1198            AC008749.6         68696-69519
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1198
                     /gene="RFPL4A"
                     /gene_synonym="RFPL4; RNF210"
                     /note="ret finger protein like 4A"
                     /db_xref="GeneID:342931"
                     /db_xref="HGNC:HGNC:16449"
                     /db_xref="MIM:612601"
     exon            1..79
                     /gene="RFPL4A"
                     /gene_synonym="RFPL4; RNF210"
                     /inference="alignment:Splign:2.1.0"
     exon            80..374
                     /gene="RFPL4A"
                     /gene_synonym="RFPL4; RNF210"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..952
                     /gene="RFPL4A"
                     /gene_synonym="RFPL4; RNF210"
                     /note="ret finger protein-like 4; RING finger protein 210"
                     /codon_start=1
                     /product="ret finger protein-like 4A"
                     /protein_id="NP_001138486.1"
                     /db_xref="CCDS:CCDS46201.1"
                     /db_xref="GeneID:342931"
                     /db_xref="HGNC:HGNC:16449"
                     /db_xref="MIM:612601"
                     /translation="MAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDG
                     EGLLCRFCSVVSQKDDIKPKYKLRALVSIIKELEPKLKSVLTMNPRMRKFQVDMTFDV
                     DTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGRHYWEVDVGTS
                     QVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGI
                     FLDVGMRSIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQDDQSILSICSVINPS
                     AASAPVSSEGK"
     exon            375..1198
                     /gene="RFPL4A"
                     /gene_synonym="RFPL4; RNF210"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcaggca gctctcactc cagatctgag ctgtccgcag aagcagctgg aggccagggg
       61 agaaactcca gaaggagaga catttgccat ggctgagcac ttcaaacaga tcattagatg
      121 tcctgtctgt ctaaaagatc ttgaagaagc cgtgcaactg aaatgtggat atgcctgctg
      181 cctccagtgc ctcaattcac tccagaagga gcccgatggg gaaggtttac tgtgccgttt
      241 ctgctctgtg gtctctcaga aggatgacat caagcccaag tacaagctga gggcgctggt
      301 ttccatcatc aaggaactag agcccaagct gaaatctgtt ctaacaatga acccaaggat
      361 gaggaagttt caagtggata tgacgttcga tgtggacaca gccaacaact atctcatcat
      421 ttctgaagac ctgaggagtt tccgaagtgg ggatttgagc cagaatagga aggagcaagc
      481 tgagaggttc gacactgccc tgtgcgtcct gggcacccct cgcttcactt ccggccgcca
      541 ttactgggag gtggacgtgg gcaccagcca agtgtgggat gtgggcgtgt gcaaggaatc
      601 tgtgaaccga caggggaaga ttgtgctttc ttcagaacac ggcttcttga ctgtgggttg
      661 cagagaagga aaggtctttg ctgccagcac tgtgcctatg actcctctct gggtgagtcc
      721 ccagttgcac agagtgggga ttttcctgga tgtaggtatg aggtccattg ccttttacaa
      781 tgttagtgat gggtgccata tctacacatt catcgagatt cctgtttgcg agccctggcg
      841 tccatttttt gctcataaac gtggaagtca agatgatcag agcatcctga gtatctgttc
      901 tgtgatcaat ccatccgctg ccagtgcccc agtttcttct gagggaaagt aaataaacat
      961 ttgaacataa tcatctttag gaagtttcag tgctcccata gccatagcta agaacttttc
     1021 cgctagatac acataggtac aaagggacag aagggaaaga gccatcactc tgtaaaccat
     1081 gaacagaaag caattatatt aatgagggga aaattacatt gtacttaaag tttgtcatgt
     1141 tgttttcttt ggggcttatg tttatatttc tgttcaataa atattttgaa aattcaga
//
