LOCUS       NM_001098535            1488 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ret finger protein like 3 (RFPL3), transcript variant
            1, mRNA.
ACCESSION   NM_001098535
VERSION     NM_001098535.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Zohud,B.A., Guo,P., Zohud,B.A., Li,F., Hao,J.J., Shan,X., Yu,W.,
            Guo,W., Qin,Y. and Cai,X.
  TITLE     Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear
            translocation and hTERT expression upregulation
  JOURNAL   Cell Death Dis 11 (10), 879 (2020)
   PUBMED   33082305
  REMARK    GeneRIF: Importin 13 promotes NSCLC progression by mediating RFPL3
            nuclear translocation and hTERT expression upregulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Lin,C., Qin,Y., Zhang,H., Gao,M.Y. and Wang,Y.F.
  TITLE     EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in
            non-small cell lung cancer cells
  JOURNAL   Oncol Rep 40 (1), 29-38 (2018)
   PUBMED   29749533
  REMARK    GeneRIF: EGF significantly upregulated RFPL3 and hTERT protein
            levels in the nonsmall cell lung cancer cells. RFPL3 and hTERT
            proteins upregulation by EGF were attenuated by pretreatment with
            AG1478 and erlotinib. EGF promoted proliferation and inhibited
            apoptosis; PD98059 decreased RFPL3 and hTERT protein expression;
            and RFPL3 overexpression increased the expression of hTERT and
            related MEKpathway proteins
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Qin,Y., Chen,W., Xiao,Y., Yu,W., Cai,X., Dai,M., Xu,T., Huang,W.,
            Guo,W., Deng,W. and Wu,T.
  TITLE     RFPL3 and CBP synergistically upregulate hTERT activity and promote
            lung cancer growth
  JOURNAL   Oncotarget 6 (29), 27130-27145 (2015)
   PUBMED   26318425
  REMARK    GeneRIF: RFPL3 and CBP have roles in upregulating hTERT activity
            and promoting lung cancer growth
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Chen,W., Lu,J., Qin,Y., Wang,J., Tian,Y., Shi,D., Wang,S., Xiao,Y.,
            Dai,M., Liu,L., Wei,G., Wu,T., Jin,B., Xiao,X., Kang,T.B., Huang,W.
            and Deng,W.
  TITLE     Ret finger protein-like 3 promotes tumor cell growth by activating
            telomerase reverse transcriptase expression in human lung cancer
            cells
  JOURNAL   Oncotarget 5 (23), 11909-11923 (2014)
   PUBMED   25481043
  REMARK    GeneRIF: These results demonstrate that RFPL3 is an important
            cellular factor which promotes lung cancer growth by activating
            hTERT expression
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Tan,B.H., Suzuki,Y., Takahashi,H., Ying,P.H.R., Takahashi,C.,
            Han,Q., Chin,W.X., Chao,S.H., Sawasaki,T., Yamamoto,N. and
            Suzuki,Y.
  TITLE     Identification of RFPL3 protein as a novel E3 ubiquitin ligase
            modulating the integration activity of human immunodeficiency
            virus, type 1 preintegration complex using a microtiter plate-based
            assay
  JOURNAL   J Biol Chem 289 (38), 26368-26382 (2014)
   PUBMED   25107902
  REMARK    GeneRIF: RFPL3 is a potential stimulator of human immunodeficiency
            virus, type 1 (HIV-1) preintegration complex integration.
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Bonnefont,J., Nikolaev,S.I., Perrier,A.L., Guo,S., Cartier,L.,
            Sorce,S., Laforge,T., Aubry,L., Khaitovich,P., Peschanski,M.,
            Antonarakis,S.E. and Krause,K.H.
  TITLE     Evolutionary forces shape the human RFPL1,2,3 genes toward a role
            in neocortex development
  JOURNAL   Am J Hum Genet 83 (2), 208-218 (2008)
   PUBMED   18656177
  REMARK    GeneRIF: the human RFPL1,2,3 genes have a role in neocortex
            development
REFERENCE   8  (bases 1 to 1488)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 1488)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 1488)
  AUTHORS   Seroussi,E., Kedra,D., Pan,H.Q., Peyrard,M., Schwartz,C.,
            Scambler,P., Donnai,D., Roe,B.A. and Dumanski,J.P.
  TITLE     Duplications on human chromosome 22 reveal a novel Ret Finger
            Protein-like gene family with sense and endogenous antisense
            transcripts
  JOURNAL   Genome Res 9 (9), 803-814 (1999)
   PUBMED   10508838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021937.1 and CR456564.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010232.1, CR456564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249007.4/ ENSP00000249007.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL021937.1         46409-46566
            159-1261            CR456564.1         1-1103
            1262-1488           AL021937.1         49477-49703
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1488
                     /gene="RFPL3"
                     /gene_synonym="RNF120"
                     /note="ret finger protein like 3"
                     /db_xref="GeneID:10738"
                     /db_xref="HGNC:HGNC:9980"
                     /db_xref="MIM:605970"
     exon            1..578
                     /gene="RFPL3"
                     /gene_synonym="RNF120"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1159
                     /gene="RFPL3"
                     /gene_synonym="RNF120"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="ret finger protein-like 3 isoform 1"
                     /protein_id="NP_001092005.1"
                     /db_xref="CCDS:CCDS43011.1"
                     /db_xref="GeneID:10738"
                     /db_xref="HGNC:HGNC:9980"
                     /db_xref="MIM:605970"
                     /translation="MKRLSLVTTNRLSPQGNFLPLCTFPLAVDMAALFQEASSCPVCS
                     DYLEKPMSLECGCTVCLKCINSLQKEPHGEDLLCCCCSMVSQRNKIRPNRQLERLVSH
                     IKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGLITQNRQDLA
                     ERFDVSVCILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHCKGKIQLTTELGFWTV
                     SLRDGSRLSASTVPLTFLLVDRKLQRVGIFLDMGMQNVSFFDAESGSHVYTFRSVSAE
                     EPLRPFLAPSIPPNGDQGVLSICPLMNSGTTDAPVRPGEAK"
     exon            579..1488
                     /gene="RFPL3"
                     /gene_synonym="RNF120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFPL3"
                     /gene_synonym="RNF120"
     polyA_site      1488
                     /gene="RFPL3"
                     /gene_synonym="RNF120"
ORIGIN      
        1 gccacgtcac tggctcaggc tcagctgctg ggtcaccagg agaatggacc cttcctccac
       61 ctcagctcag agcacagtga tgattcgtga ctttcccaat agaacttcaa atctctgagg
      121 acggggggtg gggggatgtg cttgagtgtt tgtactcatg gtcttgttct cggagtgaca
      181 aagctggaac acaatacctc tatgcatgaa aaggttgtca cttgtcacaa ctaacaggct
      241 ttcacctcaa ggaaattttc ttcccttgtg tacttttccc ctggcagtgg acatggctgc
      301 actcttccaa gaagcaagca gctgtcccgt ctgctcagac tatctggaaa aaccaatgtc
      361 cctggagtgt ggatgcaccg tctgcctcaa gtgcatcaat tcgctgcaga aggagcccca
      421 tggggaggat ctgctttgct gttgctgttc catggtctct cagaggaaca aaatcaggcc
      481 caatcggcag ctagagaggc tggtttccca catcaaggaa ctggagccca agctgaagaa
      541 gattctacag atgaacccaa ggatgcggaa gttccaagtg gatatgacct tggatgccga
      601 cacagccaac aacttcctcc tcatttctga cgacctcagg agcgtccgaa gtgggctcat
      661 cacacagaat cggcaagacc ttgccgagag atttgacgtg tccgtttgca tcctgggctc
      721 ccctcgcttt acctgtggcc gccactactg ggaggtggac gtgggaacaa gcacagaatg
      781 ggacctggga gtctgcagag aatctgttca ctgcaaaggg aagatccagc tgaccacaga
      841 gcttggattc tggactgtga gtttgaggga tggaagccgc ctctctgcca gcacggtgcc
      901 gctgactttc ctcttagtag accgcaagtt acagcgagtg gggatttttc tggatatggg
      961 catgcagaac gtttcctttt ttgatgctga aagtggttcc catgtctata cattcaggag
     1021 cgtctctgct gaggagccac tgcgcccatt tttggctcct tcaattccac ctaatggtga
     1081 tcaaggtgtc ttgagcatct gtcctttgat gaactcaggc actactgatg ctccagtccg
     1141 tcctggggag gccaaataag ccgccactgc aaaaaaaaac agggtcagaa aattacttgg
     1201 gtgggtagac ttaggaattt tctacttggt aaaagcatta tacagtcata ggagaaagat
     1261 atgggacatt tctataatct atattctaat ttgattcgat tattgagtcg taagtattaa
     1321 ttattgccac catccaactc attgagtctt atggttcaca tcttgtttcc tatagaaatg
     1381 ttctgtattc tcggatcaat ttccaaatgc tttacttttt catttctgta agttcaaatc
     1441 aatgtttaaa ttatagaagt tatgaggtaa ataaacattt ggatatca
//
