LOCUS       NM_001394555            1937 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens ret finger protein like 2 (RFPL2), transcript variant
            11, mRNA.
ACCESSION   NM_001394555
VERSION     NM_001394555.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Bonnefont,J., Nikolaev,S.I., Perrier,A.L., Guo,S., Cartier,L.,
            Sorce,S., Laforge,T., Aubry,L., Khaitovich,P., Peschanski,M.,
            Antonarakis,S.E. and Krause,K.H.
  TITLE     Evolutionary forces shape the human RFPL1,2,3 genes toward a role
            in neocortex development
  JOURNAL   Am J Hum Genet 83 (2), 208-218 (2008)
   PUBMED   18656177
  REMARK    GeneRIF: the human RFPL1,2,3 genes have a role in neocortex
            development
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   Seroussi,E., Kedra,D., Pan,H.Q., Peyrard,M., Schwartz,C.,
            Scambler,P., Donnai,D., Roe,B.A. and Dumanski,J.P.
  TITLE     Duplications on human chromosome 22 reveal a novel Ret Finger
            Protein-like gene family with sense and endogenous antisense
            transcripts
  JOURNAL   Genome Res 9 (9), 803-814 (1999)
   PUBMED   10508838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL008723.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.127171.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652607.2/ ENSP00000498332.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AL008723.8         47563-47929         c
            368-585             AL008723.8         45189-45406         c
            586-731             AL008723.8         37201-37346         c
            732-1022            AL008723.8         35758-36048         c
            1023-1937           AL008723.8         33294-34208         c
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1937
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /note="ret finger protein like 2"
                     /db_xref="GeneID:10739"
                     /db_xref="HGNC:HGNC:9979"
                     /db_xref="MIM:605969"
     exon            1..367
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /inference="alignment:Splign:2.1.0"
     exon            368..585
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..1603
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /note="isoform 2 is encoded by transcript variant 11; RING
                     finger protein 79"
                     /codon_start=1
                     /product="ret finger protein-like 2 isoform 2"
                     /protein_id="NP_001381484.1"
                     /db_xref="CCDS:CCDS43009.2"
                     /db_xref="GeneID:10739"
                     /db_xref="HGNC:HGNC:9979"
                     /db_xref="MIM:605969"
                     /translation="MEVAELGFPETAVSQSRICLCAVLCGHWDFADMMVIRSLSLIRL
                     EGVEGRDPVGGGNLTNKRPSCAPSPQDLSAQWKQLEDRGASSRRVDMAALFQEASSCP
                     VCSDYLEKPMSLECGCAVCLKCINSLQKEPHGEDLLCCCSSMVSRKNKIRRNRQLERL
                     ASHIKELEPKLKKILQMNPRMRKFQVDMTLDANTANNFLLISDDLRSVRSGRIRQNRQ
                     DLAERFDVSVCILGSPRFTCGRHCWEVDVGTSTEWDLGVCRESVHRKGRIQLTTELGF
                     WTVSLRDGGRLSATTVPLTFLFVDRKLQRVGIFLDMGMQNVSFFDAESGSHVYTFRSV
                     SAEEPLRPFLAPSVPPNGDQGVLSICPLMNSGTTDAPVRPGEAK"
     exon            586..731
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1022
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1937
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /note="hexamer: AATAAA"
     polyA_site      1937
                     /gene="RFPL2"
                     /gene_synonym="RNF79"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcta cgcaggccga cgcagatgag cctggaaggg caagccaccc ctcttggcat
       61 cctttatata ctgagtttaa tgcaaatgaa gtttctcgac tacatagtct gatcggatga
      121 gagaaacctc taggcctact ctgatcgggc tttgttatct tgttctgatt ggttatccta
      181 agacttgctg tcatccagtc agaacgtgaa aataaagcac aatcagagta gacctagagg
      241 tttttctctc atccaatctg aacatgtagt ccagaaacct tacttgcata acctcggtct
      301 gtggggggag gggttcttgc cattccaggc acttctgcgt ctgccagccc atctgctcca
      361 tgcccaggct tttctggctt tgtctgcccg gatgcccagt gccctgagaa ggagctacat
      421 gccacgggct ggaggctaga gcctgtggca ccatgatttg cctccgatgg aggtggctga
      481 attaggcttc ccagagactg cagtgtccca atccaggatc tgtctatgtg ctgtattgtg
      541 tggccactgg gactttgcag acatgatggt gataaggagc ctgagcctca tcaggttaga
      601 gggtgtggaa gggcgtgacc cagtgggagg tgggaatctc accaataaaa ggccctcgtg
      661 tgccccttcc ccacaagacc tgagcgccca gtggaagcag ctggaggaca gaggagcttc
      721 cagcagaaga gtggacatgg ctgcactctt ccaagaagca agcagctgtc ccgtctgctc
      781 agactatctg gaaaaaccaa tgtccctgga gtgtggatgc gccgtctgcc tcaagtgcat
      841 taattcactg cagaaggagc cccatgggga ggatctactt tgctgttgct cttccatggt
      901 ctctcggaag aacaaaatca ggcgcaatcg gcagctagag aggctggctt cccacatcaa
      961 ggaactggag cccaagctga agaagattct gcagatgaac ccaaggatgc ggaagttcca
     1021 agtggatatg accttggatg ccaacacagc caacaacttc ctcctcattt ctgacgacct
     1081 caggagcgtc cgaagtgggc gcatcagaca gaatcggcaa gaccttgccg agagatttga
     1141 cgtgtccgtt tgcatcctgg gctcccctcg ctttacctgt ggccgccact gctgggaggt
     1201 ggacgtggga acaagcacag aatgggacct gggagtctgc agagaatctg ttcaccgcaa
     1261 agggaggatc cagctgacca cagagcttgg attctggact gtgagtttga gggatggagg
     1321 ccgcctctct gccaccacgg tgccgctgac tttcctcttc gtagaccgca agttacagcg
     1381 agtggggatt tttctggata tgggcatgca gaacgtttcc ttttttgatg ctgaaagtgg
     1441 ttcccatgtc tatacattca ggagcgtatc tgctgaggag ccattgcgcc catttttggc
     1501 tccttcagtt ccacctaatg gtgatcaagg tgtcttgagc atctgtcctt tgatgaactc
     1561 aggcactact gatgctccag tccgtcctgg ggaggccaaa taagccctca ctccaaaaaa
     1621 acaaaaaaca gggtaagaaa attacttggg tgggtagact taggaacgct ctacttcgta
     1681 aaagcattat acaaagtcac gggagaaaaa tatgggacat ttcttgattg tacttaatct
     1741 aatttgatta gattatagag tcctaagtat taattattgc caccatcaaa ctcattgagt
     1801 cctatggttc acatcttgtt tcctatagaa atgtcctgta ttctgggatc aatttccaaa
     1861 tgctttactt ttttatttct gcaagttcaa attaatgtat tatagaagtt atgagttaaa
     1921 taaagattgg aatatca
//
