LOCUS       NM_021026               1496 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ret finger protein like 1 (RFPL1), transcript variant
            1, mRNA.
ACCESSION   NM_021026
VERSION     NM_021026.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Bonnefont,J., Laforge,T., Plastre,O., Beck,B., Sorce,S., Dehay,C.
            and Krause,K.H.
  TITLE     Primate-specific RFPL1 gene controls cell-cycle progression through
            cyclin B1/Cdc2 degradation
  JOURNAL   Cell Death Differ 18 (2), 293-303 (2011)
   PUBMED   20725088
  REMARK    GeneRIF: hRFPL1 antiproliferative activity led to an increased cell
            population in G(2)/M phase and specific cyclin B1 and Cdc2
            downregulations.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Shrestha,S., Irvin,M.R., Taylor,K.D., Wiener,H.W., Pajewski,N.M.,
            Haritunians,T., Delaney,J.A., Schambelan,M., Polak,J.F.,
            Arnett,D.K., Chen,Y.D. and Grunfeld,C.
  TITLE     A genome-wide association study of carotid atherosclerosis in
            HIV-infected men
  JOURNAL   AIDS 24 (4), 583-592 (2010)
   PUBMED   20009918
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Bonnefont,J., Nikolaev,S.I., Perrier,A.L., Guo,S., Cartier,L.,
            Sorce,S., Laforge,T., Aubry,L., Khaitovich,P., Peschanski,M.,
            Antonarakis,S.E. and Krause,K.H.
  TITLE     Evolutionary forces shape the human RFPL1,2,3 genes toward a role
            in neocortex development
  JOURNAL   Am J Hum Genet 83 (2), 208-218 (2008)
   PUBMED   18656177
  REMARK    GeneRIF: the human RFPL1,2,3 genes have a role in neocortex
            development
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Seroussi,E., Kedra,D., Pan,H.Q., Peyrard,M., Schwartz,C.,
            Scambler,P., Donnai,D., Roe,B.A. and Dumanski,J.P.
  TITLE     Duplications on human chromosome 22 reveal a novel Ret Finger
            Protein-like gene family with sense and endogenous antisense
            transcripts
  JOURNAL   Genome Res 9 (9), 803-814 (1999)
   PUBMED   10508838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000041.2 and CR456562.2.
            
            On Jun 22, 2007 this sequence version replaced NM_021026.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010228.1, CR456562.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354373.2/ ENSP00000346342.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC000041.2         20414-20591
            179-588             CR456562.2         1-410
            589-1496            AC000041.2         23379-24286
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..1496
                     /gene="RFPL1"
                     /gene_synonym="RNF78"
                     /note="ret finger protein like 1"
                     /db_xref="GeneID:5988"
                     /db_xref="HGNC:HGNC:9977"
                     /db_xref="MIM:605968"
     exon            1..582
                     /gene="RFPL1"
                     /gene_synonym="RNF78"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1163
                     /gene="RFPL1"
                     /gene_synonym="RNF78"
                     /note="isoform 1 is encoded by transcript variant 1; RING
                     finger protein 78"
                     /codon_start=1
                     /product="ret finger protein-like 1 isoform 1"
                     /protein_id="NP_066306.2"
                     /db_xref="CCDS:CCDS13857.2"
                     /db_xref="GeneID:5988"
                     /db_xref="HGNC:HGNC:9977"
                     /db_xref="MIM:605968"
                     /translation="MKRLSLVTTNRLSPHGNFLPLCTFPLAVDMAALFQEASSCPVCS
                     DYLEKPMSLECGCAVCFKCINSLQKEPHGEDLLCCCCSMVSQKNKIRPSWQLERLASH
                     IKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGCITQNRQDLA
                     ERFDVSICILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHRKGRIHLTTERGFWTV
                     SLRDGSRLSASTVPLTFLFVDRKLQRVGIFLDMGMQNVSFFDAEGGSHVYTFRSVSAE
                     EPLHLFFAPPSPPNGDKSVLSICPVINPGTTDAPVHPGEAK"
     exon            583..1496
                     /gene="RFPL1"
                     /gene_synonym="RNF78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1478..1483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFPL1"
                     /gene_synonym="RNF78"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="RFPL1"
                     /gene_synonym="RNF78"
                     /note="major polyA site"
ORIGIN      
        1 gccgtgtcac tggctcaggc tcagttgctg ggtcaccagt agaatggacc cttcctccac
       61 ctcagttcag agcacagtga tgattcgtga ctttctttcc caatagaact tcaaatctct
      121 gaagacgggg ggtgggggga tgtgcttgag tgtttgtact catggtcttg ttctagaagt
      181 gacaaagctg ggacacaata cctttatgca tgaaaaggtt gtcacttgtc acaactaaca
      241 ggctttcacc tcacggaaat tttcttccct tgtgcacttt tcccctggca gtggacatgg
      301 ctgcactctt ccaagaagca agcagctgtc ccgtctgctc agactatcta gagaaaccaa
      361 tgtccctgga gtgtggatgc gctgtctgct tcaagtgcat caattcactg cagaaggagc
      421 cccatgggga ggatctactt tgctgttgct gttccatggt ctctcagaag aacaaaatca
      481 ggcccagttg gcagctagag aggctggctt cccacatcaa ggaactggag cccaagctga
      541 agaagattct gcagatgaac ccaaggatgc ggaagttcca agtggatatg accttggatg
      601 ccgacacagc caacaacttc ctcctcattt ctgacgacct caggagcgtc cgaagtgggt
      661 gcatcacaca gaatcggcaa gaccttgccg agagatttga cgtgtccatt tgcatcctgg
      721 gctcccctcg ctttacctgt ggccgccact actgggaggt ggacgtggga acaagcacag
      781 aatgggacct gggagtctgc agagaatctg ttcaccgcaa agggaggatc catctgacca
      841 cagagcgtgg attctggact gtgagtttga gggatggaag ccgcctctct gccagcacgg
      901 tgccgctgac tttcctcttc gtagaccgca agttacagcg agtggggatt tttctggata
      961 tgggcatgca gaacgtttcc ttttttgatg ctgaaggtgg ttcccatgtc tatacattca
     1021 ggagtgtctc tgctgaggag ccactgcact tgttttttgc tcctccaagt ccacctaatg
     1081 gtgataagag tgtcttgagt atctgtcctg tgataaaccc gggcactact gatgctccag
     1141 tccatcctgg ggaggccaaa taagccccca ctgcaaaaaa acaaaaaaca ggttaagaaa
     1201 attacttggg tgggcagact taggaacgct ctactcggta aaagcgttat acaaagtcat
     1261 aggagaaaaa tatgggacaa ttcatgatta tacttaatct aatttgatta gtttataaat
     1321 tgagtcctaa gtattaatta ttgccaccat ccaactcatt gagtcttatg gttcacatct
     1381 tgtttcctat agaaatattc tgtattctgg gatcaatttc caaatgcttt tttatttctg
     1441 taagttcaaa ttaatgtatt atagaagtta tgagttaaat aaacattgga atatca
//
