LOCUS       NM_002917               1865 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens RFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (RFNG), mRNA.
ACCESSION   NM_002917 XM_941367
VERSION     NM_002917.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Mikami,T., Ohnaka,Y., Nakamura,A., Kurosaka,A. and Itoh,N.
  TITLE     Radical fringe negatively modulates Notch signaling in postmitotic
            neurons of the rat brain
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 138-144 (2001)
   PUBMED   11165380
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Moran,J.L., Johnston,S.H., Rauskolb,C., Bhalerao,J., Bowcock,A.M.
            and Vogt,T.F.
  TITLE     Genomic structure, mapping, and expression analysis of the
            mammalian Lunatic, Manic, and Radical fringe genes
  JOURNAL   Mamm Genome 10 (6), 535-541 (1999)
   PUBMED   10341080
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Johnston,S.H., Rauskolb,C., Wilson,R., Prabhakaran,B., Irvine,K.D.
            and Vogt,T.F.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135056.4, BF435018.1, AF108139.1, AK094016.1, AF038196.1 and
            BC014495.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002917.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.425078.1,
                                           SRR1163658.120588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310496.9/ ENSP00000307971.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC135056.4         18138-18174         c
            38-47               BF435018.1         1-10
            48-312              AF108139.1         21-285
            313-504             AK094016.1         21-212
            505-707             AF038196.1         42-244
            708-1139            AK094016.1         886-1317
            1140-1661           BC014495.1         551-1072
            1662-1865           AF038196.1         1199-1402
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1865
                     /gene="RFNG"
                     /note="RFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:5986"
                     /db_xref="HGNC:HGNC:9974"
                     /db_xref="MIM:602578"
     exon            1..312
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1041
                     /gene="RFNG"
                     /EC_number="2.4.1.222"
                     /note="O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase; radical fringe
                     homolog"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase radical
                     fringe"
                     /protein_id="NP_002908.1"
                     /db_xref="CCDS:CCDS32773.1"
                     /db_xref="GeneID:5986"
                     /db_xref="HGNC:HGNC:9974"
                     /db_xref="MIM:602578"
                     /translation="MSRARGALCRACLALAAALAALLLLPLPLPRAPAPARTPAPAPR
                     APPSRPAAPSLRPDDVFIAVKTTRKNHGPRLRLLLRTWISRARQQTFIFTDGDDPELE
                     LQGGDRVINTNCSAVRTRQALCCKMSVEYDKFIESGRKWFCHVDDDNYVNARSLLHLL
                     SSFSPSQDVYLGRPSLDHPIEATERVQGGRTVTTVKFWFATGGAGFCLSRGLALKMSP
                     WASLGSFMSTAEQVRLPDDCTVGYIVEGLLGARLLHSPLFHSHLENLQRLPPDTLLQQ
                     VTLSHGGPENPHNVVNVAGGFSLHQDPTRFKSIHCLLYPDTDWCPRQKQGAPTSR"
     exon            313..361
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     exon            362..464
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     exon            465..618
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     exon            619..707
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     exon            708..873
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     exon            874..959
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1865
                     /gene="RFNG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFNG"
                     /note="hexamer: AGTAAA"
     polyA_site      1865
                     /gene="RFNG"
                     /note="major polyA site"
ORIGIN      
        1 ccggccaggt tctccgctcg cagcgccggg ggtcccggcg gccgcatgag ccgcgcgcgt
       61 ggggcgctgt gccgggcctg cctcgcgctg gccgcggccc tggccgcgct gctgttactg
      121 ccgctgccgc tgccccgcgc gcccgccccg gcccggaccc ccgccccggc cccgcgcgcg
      181 cccccgtccc ggcccgctgc ccccagcctg cggcctgacg acgtcttcat cgccgtcaag
      241 accacccgga agaaccacgg gccgcgcctg cggctgctgc tgcgcacctg gatctcccgg
      301 gcccgccagc agacgtttat cttcaccgac ggggacgacc ctgagctcga gctccagggc
      361 ggcgaccgtg tcatcaacac caactgctcg gcggtgcgca ctcgtcaggc cctctgctgc
      421 aagatgtccg tggagtatga caagttcatt gagtccgggc gcaagtggtt ttgccacgtg
      481 gatgatgaca attatgtgaa cgccaggagc ctcctgcacc tgctctccag cttctcaccc
      541 agccaggacg tctacctggg gcggcccagc ctggaccacc ccattgaggc caccgagagg
      601 gtccagggtg gcagaactgt gaccacggtc aagttctggt ttgctactgg tggggccggg
      661 ttctgcctca gcagaggcct tgccctcaag atgagcccat gggccagcct gggcagcttc
      721 atgagcacag ctgagcaggt gcggctgccg gatgactgca cagttggcta catcgtggag
      781 gggctcctgg gcgcccgcct gctgcacagc cccctcttcc actctcacct ggagaacctg
      841 cagaggctgc cgcccgacac cctgctccag caggttacct tgagccatgg gggtcctgag
      901 aacccacata acgtggtgaa cgtggctgga ggcttcagcc tgcatcaaga ccccacacgg
      961 tttaagtcta tccattgtct tctgtaccca gacacggact ggtgtcccag gcagaaacag
     1021 ggcgccccga cctctcggtg acaccaacca ccccgaccca gggctgcctg gctctgtccc
     1081 aggcgcgggg aaccagagcc ccctatgggc tcagtgggct ccctcaggtg ccacggccac
     1141 accagtgaga tgcaggcacc tggcagaccc tctggctagc ctgcagcccc ccctctccca
     1201 gcccctggtg ggctgcggtg atgggtgttt tgggagaacg aagacagcca ggctgatggc
     1261 cagggccgca gtgcccctcc ccccgaccca gccccaaggt tgatcccacg ggaacaggct
     1321 tccaccccag cacttgcgca cctgggaggg agctgccatc cgggctccat tacctgttgc
     1381 tgaaggcggg tgctaggctg gctgggtgtc aaggagcagg ctccaggcca aggtcctggc
     1441 ccagccacgg ccattgcaag ggctcagcct ggcaggcttt gtgggggacg ccgccctctc
     1501 tgccgcaggc tgggtgcacg gccgggcacc acagtgggac tcaggcccgg gaaggtcatg
     1561 ttctcgacca gagctttgct cccagtccag gcgcctcatt cggaggcctc ttgactggga
     1621 ccacagagat gttttctccg ctctgacttg tggctcagga ctactttctg ggtcgtgctc
     1681 ctgccccact gtgcctgggc ccataaacaa caggagcctt ttgttccgct gacctgccca
     1741 tcccagcaga cccacctccc cgcctggtgc cttccatgga gggaaatggg acaggggccg
     1801 tcatctcccc tctgcctcct gctttgctgt tgccgagcac gagtaaagct tttgttctta
     1861 cttca
//
