LOCUS       NP_002908                331 aa            linear   PRI 27-APR-2025
DEFINITION  beta-1,3-N-acetylglucosaminyltransferase radical fringe [Homo
            sapiens].
ACCESSION   NP_002908 XP_946460
VERSION     NP_002908.1
DBSOURCE    REFSEQ: accession NM_002917.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Mikami,T., Ohnaka,Y., Nakamura,A., Kurosaka,A. and Itoh,N.
  TITLE     Radical fringe negatively modulates Notch signaling in postmitotic
            neurons of the rat brain
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 138-144 (2001)
   PUBMED   11165380
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Moran,J.L., Johnston,S.H., Rauskolb,C., Bhalerao,J., Bowcock,A.M.
            and Vogt,T.F.
  TITLE     Genomic structure, mapping, and expression analysis of the
            mammalian Lunatic, Manic, and Radical fringe genes
  JOURNAL   Mamm Genome 10 (6), 535-541 (1999)
   PUBMED   10341080
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Johnston,S.H., Rauskolb,C., Wilson,R., Prabhakaran,B., Irvine,K.D.
            and Vogt,T.F.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135056.4, BF435018.1, AF108139.1, AK094016.1, AF038196.1 and
            BC014495.1.
            
            On Mar 4, 2006 this sequence version replaced XP_946460.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.425078.1,
                                           SRR1163658.120588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310496.9/ ENSP00000307971.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..331
                     /product="beta-1,3-N-acetylglucosaminyltransferase radical
                     fringe"
                     /EC_number="2.4.1.222"
                     /note="O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase; radical fringe
                     homolog"
                     /calculated_mol_wt=36293
     Site            7..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y644.3)"
     Region          34..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y644.3)"
     Region          55..305
                     /region_name="Fringe"
                     /note="Fringe-like; pfam02434"
                     /db_xref="CDD:367085"
     Site            113
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Y644.3)"
     CDS             1..331
                     /gene="RFNG"
                     /coded_by="NM_002917.2:46..1041"
                     /db_xref="CCDS:CCDS32773.1"
                     /db_xref="GeneID:5986"
                     /db_xref="HGNC:HGNC:9974"
                     /db_xref="MIM:602578"
ORIGIN      
        1 msrargalcr aclalaaala allllplplp rapapartpa paprappsrp aapslrpddv
       61 fiavkttrkn hgprlrlllr twisrarqqt fiftdgddpe lelqggdrvi ntncsavrtr
      121 qalcckmsve ydkfiesgrk wfchvdddny vnarsllhll ssfspsqdvy lgrpsldhpi
      181 eatervqggr tvttvkfwfa tggagfclsr glalkmspwa slgsfmstae qvrlpddctv
      241 gyivegllga rllhsplfhs hlenlqrlpp dtllqqvtls hggpenphnv vnvaggfslh
      301 qdptrfksih cllypdtdwc prqkqgapts r
//
