LOCUS       NM_182705               3988 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens refilin B (RFLNB), mRNA.
ACCESSION   NM_182705 XM_936841
VERSION     NM_182705.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3988)
  AUTHORS   Mizuhashi,K., Kanamoto,T., Moriishi,T., Muranishi,Y., Miyazaki,T.,
            Terada,K., Omori,Y., Ito,M., Komori,T. and Furukawa,T.
  TITLE     Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the
            formation of cartilaginous skeletal elements
  JOURNAL   Hum Mol Genet 23 (11), 2953-2967 (2014)
   PUBMED   24436304
REFERENCE   2  (bases 1 to 3988)
  AUTHORS   Gay,O., Gilquin,B., Nakamura,F., Jenkins,Z.A., McCartney,R.,
            Krakow,D., Deshiere,A., Assard,N., Hartwig,J.H., Robertson,S.P. and
            Baudier,J.
  TITLE     RefilinB (FAM101B) targets filamin A to organize perinuclear actin
            networks and regulates nuclear shape
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11464-11469 (2011)
   PUBMED   21709252
REFERENCE   3  (bases 1 to 3988)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            LJII01000250.1 and AC141424.4.
            
            On May 2, 2023 this sequence version replaced NM_182705.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640199.4/ ENSP00000491376.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               LJII01000250.1     454136-454502
            368-471             AC141424.4         63758-63861         c
            472-3988            AC141424.4         57900-61416         c
FEATURES             Location/Qualifiers
     source          1..3988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..3988
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /note="refilin B"
                     /db_xref="GeneID:359845"
                     /db_xref="HGNC:HGNC:28705"
                     /db_xref="MIM:615928"
     exon            1..367
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..802
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /note="protein FAM101B; refilinB; regulator of filamin
                     protein B; filamin-interacting protein FAM101B; family
                     with sequence similarity 101, member B"
                     /codon_start=1
                     /product="refilin-B"
                     /protein_id="NP_874364.1"
                     /db_xref="GeneID:359845"
                     /db_xref="HGNC:HGNC:28705"
                     /db_xref="MIM:615928"
                     /translation="MVGRLSLQDVPELVDAKKKGDGVLDSPDSGLPPSPSPSHWGLAA
                     GGGGGERAAAPGTLEPDAAAATPAAPSPASLPLAPGCALRLCPLSFGEGVEFDPLPPK
                     EVRYTSLVKYDSERHFIDDVQLPLGLAVASCSQTVTCVPNGTWRNYKAEVRFEPRHRP
                     TRFLSTTIVYPKYPKAVYTTTLDYNCRKTLRRFLSSVELEAAELPGSDDLSDEC"
     exon            368..471
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /inference="alignment:Splign:2.1.0"
     exon            472..3988
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3965..3970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /note="hexamer: AATAAA"
     polyA_site      3988
                     /gene="RFLNB"
                     /gene_synonym="CFM1; FAM101B"
                     /note="major polyA site"
ORIGIN      
        1 gccggggcgg gcagcggcga gacccgggcg gcgcgcgggc ggcggggcag ggagggaggt
       61 agggcggccg ggcgggcagc ggccccggcc cgcgtctgcg cccctcgctg tcccgcgacc
      121 ccggcgcggg tgcctcgggc ccccctcgcg cgccgccatg gtgggccggc tgagcctaca
      181 ggatgtgccc gagctcgtgg acgcgaagaa gaagggcgac ggcgtcctgg acagcccgga
      241 ctcggggctg ccccccagcc ccagccccag ccactggggg ctcgcggcgg gcggaggcgg
      301 cggagagcgc gcggcggcac cggggacgct ggagcccgac gcggcggcgg cgacccccgc
      361 ggctccgagt ccagcgtctc tccccctggc tcccggctgt gcgctgaggc tttgtcccct
      421 gtcctttggc gaaggagtgg agtttgaccc cttaccacca aaggaagtaa ggtacacctc
      481 cttggtcaag tacgactccg agaggcactt catcgacgac gtgcagctgc ccctgggcct
      541 ggcggtggcc tcctgcagcc agacggtcac ctgtgtcccc aatggcacgt ggcgcaacta
      601 caaggccgag gtgcgcttcg agccacgcca caggcccacc cgcttcctca gtaccaccat
      661 cgtgtacccc aagtacccca aggccgtcta caccaccacc ctggattaca actgccgcaa
      721 gacgctgagg aggtttctgt ccagcgtgga gctcgaagcc gcggagctcc cgggcagcga
      781 cgacctctct gatgaatgct gacccagcag gctgggctgg ggtcggaccg gctctcccgc
      841 tgtcctgccc ccgactgccc tggccaagct gggcgacctt acccttcacg tcattccagc
      901 cccagaggag tctaacctag agatacctcc aagcgcggcc gggggaagag aaaaaaaaga
      961 aaaaatcact gcatctcata attattgaga tctttgtgtt gtaattttca agctgttttt
     1021 agagggaata tatgtcctgg tttgctgctg tgttgtttcc ccaaagtctc aatcagatga
     1081 ggcaacaaaa agaccaccag aattgcagga aagcagcagc agtctgggat agggaggggg
     1141 gaggagagct ctccctccgt ggtcagtttg tcagaagaaa agcatggaaa aagtgagatt
     1201 taagaaatct cagccacggg tgtcttcact gcacaaaagt ggtgctaatt cagtaaacag
     1261 tgacacctgt gtgggttcaa tctgtggaga gttgagttcc attcctttgt ttttaaattt
     1321 ccacctccat ttgtgtttcc tattaaccta aactcttgta attctctaaa tcttttttca
     1381 tgatataaaa aaaaaagaaa atcccaaacc acaatttaag atgccttttt tttttaaaaa
     1441 aaaaggttct ccgtgttgcc acctgctccg ggaaggccag gccgatgggc ggccaggttt
     1501 gggagcagcg gcttcggctc cgattgcttc ctgacggtca gttccaagca caggctctga
     1561 gaaacgcctc gaacccttgg tatctggtga ccgtctccgc aggcttccgt gagtctccga
     1621 taggtgtttt gggcttttgg aatactttca gaatactttc ccattttttc ataaggcaaa
     1681 acggagtgga cggccttttt ttgagagaaa cagcattcta agagtgtgct tggaaaacac
     1741 actttttggg agtccacgtg gggagtggac actcaggaca ggaagcggtg gccctaagac
     1801 ctgcggccac ccggaggagg cagacgcagg cgatgacctg gttcatcatg agaggagcta
     1861 gagttgactc agtcttagga tctcgatggc gtcagaattg cagagggttt ctgccagtgc
     1921 cttaggtcta attcagaaag caaggaaggc tgggcacggt ggctggcgcc tgtagtctca
     1981 gctacttgga aactgaggca ggaggatctc ttgagcccaa gaattcgaga ccggtctggc
     2041 aacatagtga gcctccatct ctaaaaaaaa gtggcaaagc tgaggaaatc tgtgccccca
     2101 tcccccgaca ccagacaagc taaggtgcat tcagagtagg gaacgatgtc aaaacctggc
     2161 cgccgtggtg gcgcgcattc ctctcacacc accgtacgga ggcaggtgac agtcaactga
     2221 aatgtcccca aggaccgtgt gaattcggct ggcgtggccc agcagcgggg tggaccaggg
     2281 tgcggtggct tcagacctgc ctcccgccac cccgtcctcc cctaacccct tcttgggacc
     2341 tcctgccaat ccctgtggtg tttgagtaaa gaaagtggct gatggtttta cttttttctt
     2401 ccaatattgg aaagaacaaa ctagatattc cccttgaaca catccaaatt atttccagtg
     2461 cctgagggtt accgagcact gtaagctcag ctcggctgta gctccgggtt tctgccgatg
     2521 gcctccatct gcgccgaaag ctgaactgag ccccgcggtg ccccggagcc acagcagcag
     2581 gtgcagcgac aatcgccgtc gtgcgcagtc gctggagtcc tggagagcca cgctgtcctc
     2641 tgcagacaac agcatcagtc cgctgtgccc caatgcatcg acgccctgtg gacggggcct
     2701 gcagtccacc cgtggtctga gcttgccggg ctgaagctcg gctgggaccc agggaggggc
     2761 caccctggga cccacagtct cctcagtcac gtgcagagca aaaaatgctt cctgtgtttg
     2821 gaagagcaag tgacgcagca tttattgata aaaatggatt tttctgtctg atttcatgct
     2881 gtggtcgttt aagtggtcaa tgtctttttt tttttttttt ttgacatgga gtctcgctct
     2941 gttgcccagg ctgagtggaa tggcgccaac tcagctcact gcaaccttca cctcccaggc
     3001 tcaagcgact ctcctgcctc agcctcctga gcagctggga ttacaggtgc ccaccaccac
     3061 gcccagctaa tttttgtatt tttagtagag acggggtttc accatgttgg ccaggctggt
     3121 ctcgaacacc tgaccttgtg atccacccgc ctcggcctcc caataatttg taagttatgt
     3181 tagcgggatc ctcaaggcct tgctttgccc cgtggagacg cttgctcgga tgagctcagg
     3241 aaacagtacc ggctgcgtgg caggtctggg tgttgtgtgc gaggacgtgg cctttgaaca
     3301 ccgctgtgtt ctcagaggtc cttaggagat attttttttt gtcttagggg gactgtgtta
     3361 agttcagaca aatcatgctg ggtgtgtaga gagtgtgaaa tacgtcagtg aagtaagtag
     3421 cagtgagcga ttgtgaatgt gtaatgtaaa tggaaaaccg ggttttaccg tgttaagtta
     3481 ttcactaggg agccagtcgt agttctttgt aatcctcttt cttccaaacc tgctttgctg
     3541 aaagttgcag aaaaggaagt gtgtggagag aaacagaacc cttcagggtg ggtcagagga
     3601 cgccatccac agtggattcg tgttcgtttg caggtggaag cagtgatttt taggacccac
     3661 tgattaaaaa caaacattcc caagtgtctc tgagagatgc tgtttatttg ttaattaaaa
     3721 agcttttttc tctgtctttt aaattatggc tttcatgtaa taaggatatt tttagtgaaa
     3781 aattgttttc ctttcaaatt acagaccttt taaaaaaact taatttgagc gagtaccttt
     3841 tcatttgaca cttttcctgt ttctaacctt aggaaaccag aatagcgttt ggcagacacg
     3901 acgttttcag tttacctttg acacctgccc cactccattt tgctttgtga tgtcttcatt
     3961 taacaataaa ttatctgaaa aaacaaaa
//
