LOCUS       NM_001131066            2582 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rieske Fe-S domain containing (RFESD), transcript
            variant 3, mRNA.
ACCESSION   NM_001131066
VERSION     NM_001131066.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Volik,S., Raphael,B.J., Huang,G., Stratton,M.R., Bignel,G.,
            Murnane,J., Brebner,J.H., Bajsarowicz,K., Paris,P.L., Tao,Q.,
            Kowbel,D., Lapuk,A., Shagin,D.A., Shagina,I.A., Gray,J.W.,
            Cheng,J.F., de Jong,P.J., Pevzner,P. and Collins,C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN914641.1, BI551847.1, BC035110.2, BX114571.1 and AC008547.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001131066.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 3 encode the same protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.478011.1,
                                           SRR1803614.78625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380005.9/ ENSP00000369341.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DN914641.1         2-10
            10-550              BI551847.1         13-553
            551-1434            BC035110.2         1606-2489
            1435-1645           BX114571.1         405-615
            1646-2582           AC008547.6         101970-102906
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..2582
                     /gene="RFESD"
                     /note="Rieske Fe-S domain containing"
                     /db_xref="GeneID:317671"
                     /db_xref="HGNC:HGNC:29587"
     exon            1..41
                     /gene="RFESD"
                     /inference="alignment:Splign:2.1.0"
     exon            42..236
                     /gene="RFESD"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..809
                     /gene="RFESD"
                     /note="isoform 1 is encoded by transcript variant 3;
                     rieske domain-containing protein"
                     /codon_start=1
                     /product="Rieske domain-containing protein isoform 1"
                     /protein_id="NP_001124538.1"
                     /db_xref="CCDS:CCDS47248.1"
                     /db_xref="GeneID:317671"
                     /db_xref="HGNC:HGNC:29587"
                     /translation="MLKCFRNCLRPSSLSTLPLQYGILFPKLLACLVHLHFGHFSSAV
                     ISVTSFYLSMNLDGSAQDPEKREYSSVCVGREDDIKKSERMTAVVHDREVVIFYHKGE
                     YHAMDIRCYHSGGPLHLGDIEDFDGRPCIVCPWHKYKITLATGEGLYQSINPKDPSAK
                     PKWCSKGIKQRIHTVTVDNGNIYVTLSNEPFKCDSDFYATGDFKVIKSSS"
     exon            237..334
                     /gene="RFESD"
                     /inference="alignment:Splign:2.1.0"
     exon            335..510
                     /gene="RFESD"
                     /inference="alignment:Splign:2.1.0"
     exon            511..545
                     /gene="RFESD"
                     /inference="alignment:Splign:2.1.0"
     exon            546..2582
                     /gene="RFESD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      815..820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFESD"
                     /note="hexamer: AATATA"
     polyA_site      833
                     /gene="RFESD"
                     /note="major polyA site"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFESD"
                     /note="hexamer: AATAAA"
     polyA_site      1645
                     /gene="RFESD"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFESD"
                     /note="hexamer: AATAAA"
     polyA_site      2582
                     /gene="RFESD"
ORIGIN      
        1 gcagtagcgt cacgcggagg cggagcgagg actcggggac agttaccacc tatttgcaat
       61 tcaaggagaa tataagacag agaagaaagc tgtgaatgaa tttcatttga ttagcaatag
      121 attggacact ctactgatct tgcctctcta caacctctct tccacctgac ctctaaatgt
      181 tgaagtgttt caggaattgt cttagacctt cttccttatc tacacttcct ctccaatatg
      241 gaattctctt ccccaagctg ttggcatgtc tagttcattt gcattttggg catttcagct
      301 cagctgtcat ctcagtgacc agtttttatc tgagcatgaa tcttgatggc tctgcacaag
      361 atcctgaaaa gagggaatat tcttctgtgt gtgtgggcag agaagatgac attaaaaaat
      421 ctgaaagaat gacagctgtt gtccatgata gagaagtggt cattttctac cacaagggag
      481 aatatcatgc tatggatatt cgctgttacc actcaggagg acctttacat ttgggagata
      541 tagaggattt tgatggacga ccgtgtatag tttgcccctg gcataaatac aaaattactt
      601 tggcaacagg agaaggtctg taccagtcta taaaccctaa agatccatca gcaaaaccca
      661 agtggtgctc caaaggaata aagcaaagga ttcacacagt gacagtagac aacggaaata
      721 tttatgtgac tctttctaat gaacctttta agtgtgactc tgatttttat gccactggag
      781 acttcaaagt aattaagagt tcttcctgat aaaaaatata tagaaatgaa aaatgttgtg
      841 tatgcttgaa aacattttta gaataactct gcttcagttt taaaggtgat gaaatttttc
      901 aacataggca caactgttta aaattcacat acatttgaga ggtttaagag cacacatact
      961 tagtatgatg taaggattat catcaggatc aatagaatac attttatcga atcttctgga
     1021 ttaattagaa acctgaaggt tataggtttg ggatgttctg tttaagaagg ataaaaataa
     1081 atttggagta aacaaataat aggtaaaaat taaggattag taagaaaaaa ttttttaatt
     1141 taaaaaattt aatttttaaa ataggaaaaa atccctgttt gatgtagcag acttaattct
     1201 ggaaaagttt tagtatatac aaagtaaaca gactatataa tgaacttcca tcactcagct
     1261 ttaacagtta tcagcattct tccattcttg ttttatttat acctctgtgg atttgctacc
     1321 tctcctattt gattgttatt tttacatttt taggaaagtt taaatacatt gaaatgttca
     1381 cctctgaact gtgcaacctt cctaaataac agacttttta tacttaaaaa atgcctccaa
     1441 aaatgagata ggtttacctg ctgaacttga aaataagaaa cttaaccact gttaagtgat
     1501 ctgtgatcaa ggcagatctt gaagtaagga agccagacac agctgctgcc cagccatgag
     1561 agatgtaaag tctcctattc agtgagccaa tgttctttga atgcctatat gaaattttca
     1621 aataaagatt tttaaaaacg ttttagaact ttgtgaatgt aggcacaact aagtgtctcc
     1681 tataaatatt atagagagga gatctagggt tttgttcctt ggagttcccg agcaaggttg
     1741 atgttcagtt ggttcaccct ggttttatca tgtcagttat ttatggtcag taccattcag
     1801 ttgcaatgat ggtcataccg taccagttgt aatgtattta aaataacacc ccaagcaccc
     1861 accatgcaaa aatcagcagc acatagtggt gatttttgca tggtcagtgc tcatgcaaaa
     1921 atcaccacta tgtgggacca gaaatagcta aaatgagtag atgatgaatt cagagtgaga
     1981 agaactgtca agattggaac ctagtctcaa agcacagtag tatttttaaa ggaatagaat
     2041 taagaatcta aatctaatac ttaacattct aaggagccga cctggactct ttctcttggt
     2101 tattataaaa atagtaaatg agtaaggtcc gtatagtaaa gactctgctt acttaccttt
     2161 actacatatt attacacttc cttttctgtt ggagtttgga tagcatgagt agcacttggt
     2221 cctcatttct cagacaacca acgaaccaga cttgggcttt ttatagatac tgtttgtggt
     2281 agcagctact tactaagtac agaaaatgta ctatctctca ggaaggtaca tcccagtcta
     2341 ttctatcatg tgataatcct tcaatgccca gtcaggtctt aacacatgtc cagaatataa
     2401 agtgtacaga agaaatcaaa gtactttctt caggcaaaaa ctagccctgg tttgcaggaa
     2461 taattacaga aatattttct cataggagcc actggcaata atgagtagtg tgcacttgat
     2521 ttttcattct aaatttgtat ctctaaatct agaaataaaa atcatatcat gtactgtctt
     2581 ca
//
