LOCUS       NM_002916               1365 bp    mRNA    linear   PRI 15-NOV-2024
DEFINITION  Homo sapiens replication factor C subunit 4 (RFC4), transcript
            variant 1, mRNA.
ACCESSION   NM_002916
VERSION     NM_002916.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Guan,S., Feng,L., Wei,J., Wang,G. and Wu,L.
  TITLE     Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal
            carcinoma in vitro and in vivo
  JOURNAL   Front Med 17 (1), 132-142 (2023)
   PUBMED   36562948
  REMARK    GeneRIF: Knockdown of RFC4 inhibits the cell proliferation of
            nasopharyngeal carcinoma in vitro and in vivo.
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Zhang,J., Meng,S., Wang,X., Wang,J., Fan,X., Sun,H., Ning,R.,
            Xiao,B., Li,X., Jia,Y., Kong,D., Chen,R., Wang,C., Ma,D. and Li,S.
  TITLE     Sequential gene expression analysis of cervical malignant
            transformation identifies RFC4 as a novel diagnostic and prognostic
            biomarker
  JOURNAL   BMC Med 20 (1), 437 (2022)
   PUBMED   36352434
  REMARK    GeneRIF: Sequential gene expression analysis of cervical malignant
            transformation identifies RFC4 as a novel diagnostic and prognostic
            biomarker.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Wang,J., Luo,F.F., Huang,T.J., Mei,Y., Peng,L.X., Qian,C.N. and
            Huang,B.J.
  TITLE     The upregulated expression of RFC4 and GMPS mediated by DNA copy
            number alteration is associated with the early diagnosis and immune
            escape of ESCC based on a bioinformatic analysis
  JOURNAL   Aging (Albany NY) 13 (17), 21758-21777 (2021)
   PUBMED   34520390
  REMARK    GeneRIF: The upregulated expression of RFC4 and GMPS mediated by
            DNA copy number alteration is associated with the early diagnosis
            and immune escape of ESCC based on a bioinformatic analysis.
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Liu,L., Tao,T., Liu,S., Yang,X., Chen,X., Liang,J., Hong,R.,
            Wang,W., Yang,Y., Li,X., Zhang,Y., Li,Q., Liang,S., Yu,H., Wu,Y.,
            Guo,X., Lai,Y., Ding,X., Guan,H., Wu,J., Zhu,X., Yuan,J., Li,J.,
            Su,S., Li,M., Cai,X., Cai,J. and Tian,H.
  TITLE     An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis
            and stemness
  JOURNAL   Nat Commun 12 (1), 2693 (2021)
   PUBMED   33976158
  REMARK    GeneRIF: An RFC4/Notch1 signaling feedback loop promotes NSCLC
            metastasis and stemness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Cujec,T.P., Cho,H., Maldonado,E., Meyer,J., Reinberg,D. and
            Peterlin,B.M.
  TITLE     The human immunodeficiency virus transactivator Tat interacts with
            the RNA polymerase II holoenzyme
  JOURNAL   Mol Cell Biol 17 (4), 1817-1823 (1997)
   PUBMED   9121429
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Wood,R.D. and Shivji,M.K.
  TITLE     Which DNA polymerases are used for DNA-repair in eukaryotes?
  JOURNAL   Carcinogenesis 18 (4), 605-610 (1997)
   PUBMED   9111189
  REMARK    Review article
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Uhlmann,F., Cai,J., Flores-Rozas,H., Dean,F.B., Finkelstein,J.,
            O'Donnell,M. and Hurwitz,J.
  TITLE     In vitro reconstitution of human replication factor C from its five
            subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6521-6526 (1996)
   PUBMED   8692848
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Okumura,K., Nogami,M., Taguchi,H., Dean,F.B., Chen,M., Pan,Z.Q.,
            Hurwitz,J., Shiratori,A., Murakami,Y., Ozawa,K. et al.
  TITLE     Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3),
            and 40-kDa (RFC2) subunit genes of human replication factor C to
            chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23
  JOURNAL   Genomics 25 (1), 274-278 (1995)
   PUBMED   7774928
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Chen,M., Pan,Z.Q. and Hurwitz,J.
  TITLE     Studies of the cloned 37-kDa subunit of activator 1 (replication
            factor C) of HeLa cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5211-5215 (1992)
   PUBMED   1351677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA359927.1, BC017452.1,
            AC112907.7 and AA521171.1.
            
            On Aug 13, 2020 this sequence version replaced NM_002916.4.
            
            Summary: The elongation of primed DNA templates by DNA polymerase
            delta and DNA polymerase epsilon requires the accessory proteins
            proliferating cell nuclear antigen (PCNA) and replication factor C
            (RFC). RFC, also named activator 1, is a protein complex consisting
            of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene
            encodes the 37 kD subunit. This subunit forms a core complex with
            the 36 and 40 kDa subunits. The core complex possesses
            DNA-dependent ATPase activity, which was found to be stimulated by
            PCNA in an in vitro system. Alternatively spliced transcript
            variants encoding the same protein have been reported. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017452.1, SRR11853566.20625.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296273.7/ ENSP00000296273.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA359927.1         20-63
            45-1001             BC017452.1         1-957
            1002-1005           AC112907.7         57810-57813
            1006-1086           AC112907.7         59132-59212
            1087-1200           AC112907.7         59283-59396
            1201-1362           AC112907.7         59474-59635
            1363-1365           AA521171.1         44-46               c
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..1365
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /note="replication factor C subunit 4"
                     /db_xref="GeneID:5984"
                     /db_xref="HGNC:HGNC:9972"
                     /db_xref="MIM:102577"
     exon            1..193
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            194..335
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1296
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /note="A1 37 kDa subunit; activator 1 37 kDa subunit; RFC
                     37 kDa subunit; RF-C 37 kDa subunit; activator 1 subunit
                     4; replication factor C 37 kDa subunit; replication factor
                     C (activator 1) 4, 37kDa"
                     /codon_start=1
                     /product="replication factor C subunit 4"
                     /protein_id="NP_002907.1"
                     /db_xref="CCDS:CCDS3283.1"
                     /db_xref="GeneID:5984"
                     /db_xref="HGNC:HGNC:9972"
                     /db_xref="MIM:102577"
                     /translation="MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKY
                     RPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFR
                     LRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQ
                     AALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKE
                     NVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDG
                     VFAACQSGSFDKLEAVVKDLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEV
                     DKCLADGADEHLQLISLCATVMQQLSQNC"
     exon            336..414
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            415..494
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            495..614
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            615..758
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            759..879
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1005
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1086
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1200
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1365
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /note="hexamer: AATAAA"
     polyA_site      1365
                     /gene="RFC4"
                     /gene_synonym="A1; MRMNS; RFC37"
                     /note="major polyA site"
ORIGIN      
        1 gcttttcgcc cgccgttccg tggcgggaac tgaggcgact gtggggacat cagtgatcgt
       61 aagtctcctg ggcccgttat tctcagatta ggtgacggag ctaagacttc gagaccatct
      121 cgtccttttt gtatcgcgga aacctgagga acgagccggc ggcggtgacc tgcacgagaa
      181 gccaggctaa ctgggtgaag taccatgcaa gcatttctta aaggtacatc catcagtact
      241 aaacccccgc tgaccaagga tcgaggagta gctgccagtg cgggaagtag cggagagaac
      301 aagaaagcca aacccgttcc ctgggtggaa aaatatcgcc caaaatgtgt ggatgaagtt
      361 gctttccagg aagaagtggt tgcagtgctg aaaaaatctt tagaaggagc agatcttcct
      421 aatctcttgt tttacggacc acctggaact ggaaaaacat ccactatttt ggcagcagct
      481 agagaactct ttgggcctga acttttccga ttaagagttc ttgagttaaa tgcatctgat
      541 gaacgtggaa tacaagtagt tcgagagaaa gtgaaaaatt ttgctcaatt aactgtgtca
      601 ggaagtcgct cagatgggaa gccgtgtccg ccttttaaga ttgtgattct ggatgaagca
      661 gattctatga cctcagctgc tcaggcagct ttaagacgta ccatggagaa ggagtcgaaa
      721 accacccgat tctgtcttat ctgtaactat gtcagtcgaa taattgaacc cctgacctct
      781 agatgttcaa aattccgctt caagcctctg tcagataaaa ttcaacagca gcgattacta
      841 gacattgcca agaaggaaaa tgtcaaaatt agtgatgagg gaatagctta tcttgttaaa
      901 gtgtcagaag gagacttaag aaaagccatt acatttcttc aaagcgctac tcgattaaca
      961 ggtggaaagg agatcacaga gaaagtgatt acagacattg ccggggtaat accagctgag
     1021 aaaattgatg gagtatttgc tgcctgtcag agtggctctt ttgacaaact agaagctgtg
     1081 gtcaaggatt taatagatga gggtcatgca gcaactcagc tcgtcaatca actccatgat
     1141 gtggttgtag aaaataactt atctgataaa cagaagtcta ttatcacaga aaaacttgcc
     1201 gaagttgaca aatgcctagc agatggtgct gatgaacatt tgcaactcat cagcctttgt
     1261 gcaactgtga tgcagcagtt atctcagaat tgttaacgtg aatatatctg gatggggggt
     1321 tttgtaaata atgaagttgt aataaaaata aaatgaccaa aagca
//
