LOCUS       NM_002915               2306 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens replication factor C subunit 3 (RFC3), transcript
            variant 1, mRNA.
ACCESSION   NM_002915
VERSION     NM_002915.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Guo,Z. and Guo,L.
  TITLE     Abnormal activation of RFC3, A YAP1/TEAD downstream target,
            promotes gastric cancer progression
  JOURNAL   Int J Clin Oncol 29 (4), 442-455 (2024)
   PUBMED   38383698
  REMARK    GeneRIF: Abnormal activation of RFC3, A YAP1/TEAD downstream
            target, promotes gastric cancer progression.
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Avs,K.R., Pandi,C., Kannan,B., Pandi,A., Jayaseelan,V.P. and
            Arumugam,P.
  TITLE     RFC3 serves as a novel prognostic biomarker and target for head and
            neck squamous cell carcinoma
  JOURNAL   Clin Oral Investig 27 (11), 6961-6969 (2023)
   PUBMED   37861747
  REMARK    GeneRIF: RFC3 serves as a novel prognostic biomarker and target for
            head and neck squamous cell carcinoma.
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Ren,K., Zhu,Y., Sun,H., Li,S., Duan,X., Li,S., Li,Y., Li,B. and
            Chen,L.
  TITLE     IRF2 inhibits ZIKV replication by promoting FAM111A expression to
            enhance the host restriction effect of RFC3
  JOURNAL   Virol J 18 (1), 256 (2021)
   PUBMED   34930359
  REMARK    GeneRIF: IRF2 inhibits ZIKV replication by promoting FAM111A
            expression to enhance the host restriction effect of RFC3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Uhlmann,F., Cai,J., Gibbs,E., O'Donnell,M. and Hurwitz,J.
  TITLE     Deletion analysis of the large subunit p140 in human replication
            factor C reveals regions required for complex formation and
            replication activities
  JOURNAL   J Biol Chem 272 (15), 10058-10064 (1997)
   PUBMED   9092549
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Wood,R.D. and Shivji,M.K.
  TITLE     Which DNA polymerases are used for DNA-repair in eukaryotes?
  JOURNAL   Carcinogenesis 18 (4), 605-610 (1997)
   PUBMED   9111189
  REMARK    Review article
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Uhlmann,F., Cai,J., Flores-Rozas,H., Dean,F.B., Finkelstein,J.,
            O'Donnell,M. and Hurwitz,J.
  TITLE     In vitro reconstitution of human replication factor C from its five
            subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6521-6526 (1996)
   PUBMED   8692848
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Okumura,K., Nogami,M., Taguchi,H., Dean,F.B., Chen,M., Pan,Z.Q.,
            Hurwitz,J., Shiratori,A., Murakami,Y., Ozawa,K. et al.
  TITLE     Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3),
            and 40-kDa (RFC2) subunit genes of human replication factor C to
            chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23
  JOURNAL   Genomics 25 (1), 274-278 (1995)
   PUBMED   7774928
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   O'Donnell,M., Onrust,R., Dean,F.B., Chen,M. and Hurwitz,J.
  TITLE     Homology in accessory proteins of replicative polymerases--E. coli
            to humans
  JOURNAL   Nucleic Acids Res 21 (1), 1-3 (1993)
   PUBMED   8441605
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000149.2 and AA447424.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002915.3.
            
            Summary: The elongation of primed DNA templates by DNA polymerase
            delta and DNA polymerase epsilon requires the accessory proteins
            proliferating cell nuclear antigen (PCNA) and replication factor C
            (RFC). RFC, also named activator 1, is a protein complex consisting
            of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene
            encodes the 38 kDa subunit. This subunit is essential for the
            interaction between the 140 kDa subunit and the core complex that
            consists of the 36, 37, and 40 kDa subunits. Alternatively spliced
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.123849.1,
                                           SRR1803615.175648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380071.8/ ENSP00000369411.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2302              BC000149.2         12-2313
            2303-2306           AA447424.1         11-14               c
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.2"
     gene            1..2306
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /note="replication factor C subunit 3"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
     exon            1..117
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1101
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /note="isoform 1 is encoded by transcript variant 1; RFC,
                     38 kD subunit; A1 38 kDa subunit; RF-C 38 kDa subunit;
                     activator 1 subunit 3; activator 1 38 kDa subunit;
                     replication factor C 38 kDa subunit; replication factor C
                     (activator 1) 3, 38kDa"
                     /codon_start=1
                     /product="replication factor C subunit 3 isoform 1"
                     /protein_id="NP_002906.1"
                     /db_xref="CCDS:CCDS9352.1"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
                     /translation="MSLWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPS
                     GAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGN
                     SDRVVIQEMLKTVAQSQQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCR
                     LILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEK
                     SCRNLRKALLMCEACRVQQYPFTADQEIPETDWEVYLRETANAIVSQQTPQRLLEVRG
                     RLYELLTHCIPPEIIMKGLLSELLHNCDGQLKGEVAQMAAYYEHRLQLGSKAIYHLEA
                     FVAKFMALYKKFMEDGLEGMMF"
     exon            118..255
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            256..323
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            324..421
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            422..603
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            604..740
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            741..839
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            840..909
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     exon            910..2306
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /note="hexamer: AATAAA"
     polyA_site      2306
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /note="major polyA site"
ORIGIN      
        1 aagcgtaggc ccccgggaac tcgagctgcc atgagcctct gggtggacaa gtatcggccc
       61 tgctccttgg gacggctgga ctatcacaag gagcaggcgg cccagctgcg gaacctggtg
      121 cagtgtggtg actttcctca tctgttagtg tacggaccat caggtgctgg aaaaaagaca
      181 agaattatgt gtattctacg tgaactttat ggtgttggag tggaaaaatt gagaattgaa
      241 catcagacca tcacaactcc atctaaaaaa aaaattgaaa ttagcaccat tgcaagtaac
      301 taccaccttg aagttaatcc tagtgatgct ggaaatagtg accgagtagt cattcaggag
      361 atgttgaaaa cagtggcaca atcacaacaa cttgaaacaa actctcaaag ggattttaaa
      421 gtggtattat tgacagaagt tgacaaactc accaaagatg ctcagcatgc cttgcgaaga
      481 accatggaaa aatatatgtc tacctgcaga ttgatcttgt gctgcaattc tacatctaaa
      541 gtgatcccac ctattcgtag taggtgcttg gcggttcgtg tgcctgctcc cagcattgaa
      601 gatatttgcc acgtgttatc tactgtgtgt aagaaggaag gtctgaatct tccttcacaa
      661 ctggctcata gacttgcaga gaagtcttgt agaaatctca gaaaagccct gcttatgtgt
      721 gaagcctgca gagtgcaaca atatcctttt actgcagatc aagaaatccc tgagacagat
      781 tgggaggtgt atctgaggga gactgcaaat gctattgtca gtcagcaaac tccacaaagg
      841 ctccttgaag ttcgtggaag gctgtatgag cttctaactc attgtattcc tcctgagata
      901 ataatgaagg gccttctctc agaactgtta cataattgtg atggacaact gaaaggggag
      961 gtggcacaaa tggcagctta ctatgagcat cgtctacagc tgggtagcaa agccatttat
     1021 cacttggaag cgtttgtggc caaattcatg gcactttata agaagttcat ggaggatgga
     1081 ttggaaggca tgatgttctg acttctgtca gttattcttg caaagatttc tcagtatcag
     1141 tatttacata cagcttatat taaaagagct gtgggtaaat taactgaact taatcatgtc
     1201 gtatttgcgt ttttttggta ataacttctc tgtgaactat taatcatcct ctgagttaaa
     1261 taattgctcc tatactattg aagtatgtag ttttgtacat aacttagaga ctttagagtc
     1321 taagaaaatg atcttaattt actttaagca ttggttattc aagtattcat tgttgatcct
     1381 cctattctct tccgtctaat ctctcacctg ctaaaggaga tttacacatt agaaagcaaa
     1441 gattattttc atttatccag atgaccattt tctgccacag gtaacatgat tgtttgacac
     1501 accattatat ttaattctag tttctctcaa tgaataattg tatttttgta ggaaatgtaa
     1561 gatttcattc tgaaacataa ttattggtat ggacaaaatt gcagatacca tttctgttga
     1621 ggctgcagat ttccaacttt tatttcagtg gttcagatta gtattaggtc ggtactaaga
     1681 aataagcatg ttttcactaa tttaagtact tgagactctt gaagaaaatt cagaatgaag
     1741 ttctggagaa aggtatgtta ctgtagtaat tactctttga acaggttttg tgttttgtca
     1801 ttagctctgc cctttttaat taaatatttt ggttcatgga ccaaagggtt tacttgacaa
     1861 atttgtgtga cagactccga acaattcctt tactacgaag tataatttat aaaataaaat
     1921 atacccattt taagggtaca gtttgatttt tgaccagtga aactatgatc ccaatcaagg
     1981 tatagatgcc gtcaccccaa aaagttccct ccatatccct ttgcagtcag ttcatcccta
     2041 ccctggccca gatgatcact gatcttgtca ttatagatga gttttgccag ttcaagaatt
     2101 taatggaatc agatattgta agcattcttg tgtaatactt cattctctct cattattgag
     2161 attcatccat attgttgaat gtttcactag ttaatgttta ttgttcaata tttttgtata
     2221 tacttttaaa gcctattcac ttgctgatgg atctttggtt tgtttccagg tttggttatt
     2281 atgaataaag ttgctgtgaa tactta
//
