LOCUS       NM_002913               4870 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens replication factor C subunit 1 (RFC1), transcript
            variant 1, mRNA.
ACCESSION   NM_002913 NM_006081
VERSION     NM_002913.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4870)
  AUTHORS   Schaub,A., Erdmann,H., Scholz,V., Timmer,M., Cordts,I., Gunther,R.,
            Reilich,P., Abicht,A. and Schoberl,F.
  TITLE     Analysis and occurrence of biallelic pathogenic repeat expansions
            in RFC1 in a German cohort of patients with a main clinical
            phenotype of motor neuron disease
  JOURNAL   J Neurol 271 (9), 5804-5812 (2024)
   PUBMED   38916676
  REMARK    GeneRIF: Analysis and occurrence of biallelic pathogenic repeat
            expansions in RFC1 in a German cohort of patients with a main
            clinical phenotype of motor neuron disease.
REFERENCE   2  (bases 1 to 4870)
  AUTHORS   Milovanovic,A., Dragasevic-Miskovic,N., Thomsen,M., Borsche,M.,
            Hinrichs,F., Westenberger,A., Klein,C., Bruggemann,N.,
            Brankovic,M., Marjanovic,A., Svetel,M., Kostic,V.S. and Lohmann,K.
  TITLE     RFC1 and FGF14 Repeat Expansions in Serbian Patients with
            Cerebellar Ataxia
  JOURNAL   Mov Disord Clin Pract 11 (6), 626-633 (2024)
   PUBMED   38487929
  REMARK    GeneRIF: RFC1 and FGF14 Repeat Expansions in Serbian Patients with
            Cerebellar Ataxia.
REFERENCE   3  (bases 1 to 4870)
  AUTHORS   Kudo,K., Hori,K., Asamitsu,S., Maeda,K., Aida,Y., Hokimoto,M.,
            Matsuo,K., Yabuki,Y. and Shioda,N.
  TITLE     Structural polymorphism of the nucleic acids in pentanucleotide
            repeats associated with the neurological disorder CANVAS
  JOURNAL   J Biol Chem 300 (4), 107138 (2024)
   PUBMED   38447794
  REMARK    GeneRIF: Structural polymorphism of the nucleic acids in
            pentanucleotide repeats associated with the neurological disorder
            CANVAS.
REFERENCE   4  (bases 1 to 4870)
  AUTHORS   Miranda,C. M, Diaz,M., Hughes,G. R, Barreto,Y. M, Nakousi,C. N and
            Campero,S. M.
  TITLE     [Late-Onset Cerebellar Ataxia with Neuropathy: Uncovering the Role
            of RFC1 Gene Mutations]
  JOURNAL   Rev Med Chil 151 (4), 524-529 (2023)
   PUBMED   38687529
  REMARK    GeneRIF: [Late-Onset Cerebellar Ataxia with Neuropathy: Uncovering
            the Role of RFC1 Gene Mutations].
REFERENCE   5  (bases 1 to 4870)
  AUTHORS   Lu,Y. and Riegel,A.T.
  TITLE     The human DNA-binding protein, PO-GA, is homologous to the large
            subunit of mouse replication factor C: regulation by alternate 3'
            processing of mRNA
  JOURNAL   Gene 145 (2), 261-265 (1994)
   PUBMED   7914507
REFERENCE   6  (bases 1 to 4870)
  AUTHORS   Luckow,B., Bunz,F., Stillman,B., Lichter,P. and Schutz,G.
  TITLE     Cloning, expression, and chromosomal localization of the
            140-kilodalton subunit of replication factor C from mice and humans
  JOURNAL   Mol Cell Biol 14 (3), 1626-1634 (1994)
   PUBMED   8114700
REFERENCE   7  (bases 1 to 4870)
  AUTHORS   Bunz,F., Kobayashi,R. and Stillman,B.
  TITLE     cDNAs encoding the large subunit of human replication factor C
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11014-11018 (1993)
   PUBMED   8248204
REFERENCE   8  (bases 1 to 4870)
  AUTHORS   Lu,Y., Zeft,A.S. and Riegel,A.T.
  TITLE     Cloning and expression of a novel human DNA binding protein, PO-GA
  JOURNAL   Biochem Biophys Res Commun 193 (2), 779-786 (1993)
   PUBMED   8512577
REFERENCE   9  (bases 1 to 4870)
  AUTHORS   Cortese,A., Reilly,M.M. and Houlden,H.
  TITLE     RFC1 CANVAS / Spectrum Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   33237689
REFERENCE   10 (bases 1 to 4870)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA336360.1, BC051751.1 and
            BC035297.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002913.4.
            
            Summary: This gene encodes the large subunit of replication factor
            C, a five subunit DNA polymerase accessory protein, which is a
            DNA-dependent ATPase required for eukaryotic DNA replication and
            repair. The large subunit acts as an activator of DNA polymerases,
            binds to the 3' end of primers, and promotes coordinated synthesis
            of both strands. It may also have a role in telomere stability.
            Alternatively spliced transcript variants encoding different
            isoforms have been noted for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051751.1, SRR1803615.88138.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349703.7/ ENSP00000261424.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DA336360.1         20-208
            190-4472            BC051751.1         179-4461
            4473-4637           BC035297.1         4446-4610
            4638-4870           BC051751.1         4627-4859
FEATURES             Location/Qualifiers
     source          1..4870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..4870
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /note="replication factor C subunit 1"
                     /db_xref="GeneID:5981"
                     /db_xref="HGNC:HGNC:9969"
                     /db_xref="MIM:102579"
     exon            1..124
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..3565
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /note="isoform 1 is encoded by transcript variant 1;
                     replication factor C1; MHC binding factor, beta; A1 140
                     kDa subunit; RF-C 140 kDa subunit; activator 1 subunit 1;
                     DNA-binding protein PO-GA; activator 1 large subunit;
                     activator 1 140 kDa subunit; replication factor C large
                     subunit; replication factor C 140 kDa subunit; replication
                     factor C (activator 1) 1, 145kDa"
                     /codon_start=1
                     /product="replication factor C subunit 1 isoform 1"
                     /protein_id="NP_002904.3"
                     /db_xref="CCDS:CCDS3450.1"
                     /db_xref="GeneID:5981"
                     /db_xref="HGNC:HGNC:9969"
                     /db_xref="MIM:102579"
                     /translation="MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIK
                     VNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQD
                     PVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKL
                     TPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQ
                     LHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVS
                     DERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIE
                     PVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPK
                     ALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVM
                     GRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQ
                     KNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGD
                     SKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSE
                     DKKHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSK
                     SSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLI
                     KHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPA
                     MNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFA
                     AGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDMKKHLMLLSRAADSI
                     CDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHD
                     RIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLM
                     KEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSP
                     SLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKGKGKSSK
                     K"
     exon            125..253
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            254..329
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            330..452
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            453..685
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            686..763
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            764..841
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            842..929
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1216
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1324
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1504
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1609
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..2006
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2116
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2231
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2323
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2461
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2557
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2656
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2811
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2929
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3075
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3289
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3481
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..4870
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4847..4852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /note="hexamer: AATAAA"
     polyA_site      4870
                     /gene="RFC1"
                     /gene_synonym="A1; CANVAS; MHCBFB; PO-GA; RECC1; RFC;
                     RFC140"
                     /note="major polyA site"
ORIGIN      
        1 gtcttcgcct tcttgcactt cgcgggagaa gttgttggcg cgaatggatc ctgagcctcg
       61 ataacagatt cctcaaccgg cccacccgcc agccagccag cgccttcatc ctggggctgc
      121 gatggacatt cggaaattct ttggagtaat accaagtgga aagaaacttg taagtgaaac
      181 agtaaagaag aatgagaaaa caaagtctga tgaagaaact ttaaaagcaa agaaaggaat
      241 aaaggaaatc aaggtaaata gctcccgtaa agaggatgac ttcaaacaaa agcaaccaag
      301 caagaaaaag aggatcatct atgattcaga ttcagagtca gaggagacgt tgcaggtaaa
      361 aaatgccaaa aagccaccag aaaaactgcc agtatcttct aaacctggta aaatttcacg
      421 gcaggatcct gttacataca tttcagaaac agatgaagaa gatgacttta tgtgtaagaa
      481 ggcggcctct aaatcaaaag agaatggaag atctacaaat agtcatcttg gaacatcaaa
      541 catgaaaaag aatgaagaaa acactaagac caagaataag cctttatcac caataaaact
      601 tacacccaca tcagtacttg attattttgg aactggaagt gtccaaagat ctaataagaa
      661 gatggtggca agcaaaagaa aagagctttc acaaaataca gatgagtctg gattaaatga
      721 tgaagccatc gccaagcaat tacagcttga tgaagatgcg gagctggaga ggcagttgca
      781 tgaagatgaa gagtttgcca gaacattagc catgttggat gaagaaccca agaccaaaaa
      841 ggctcgaaag gacacagaag cgggagaaac gttttcatct gtccaagcca atttaagtaa
      901 agcagaaaaa cataaatatc ctcataaagt aaaaacagca caagtttcag atgaaagaaa
      961 gagctacagt cctaggaagc aaagtaaata tgaaagttca aaagaatctc agcaacattc
     1021 caagtcatca gctgacaaaa taggagaagt ctcttctccc aaggccagtt ctaagctggc
     1081 aattatgaaa agaaaagaag agagctctta taaagaaata gagcctgtgg cctcaaaaag
     1141 aaaagaaaat gccattaaat tgaaaggaga gacaaaaact cctaagaaaa ccaaaagttc
     1201 tccagctaaa aaagagtctg taagtcctga agattctgaa aagaaacgca ctaattatca
     1261 agcttatcga agctacttaa atcgagaagg tcccaaggct ctgggctcca aagaaatacc
     1321 aaagggagct gaaaattgct tggaaggcct tatatttgta atcacaggcg tgctggagtc
     1381 tattgaacga gatgaggcca agtctctaat tgaacgttat gggggaaaag taacaggaaa
     1441 tgtcagcaag aaaacaaatt atcttgtcat gggtcgtgat agtggacagt ccaagagtga
     1501 taaggccgca gccttgggga caaaaattat tgatgaagat ggcctgttga atctgattcg
     1561 gactatgcca ggcaagaaat ccaagtatga aatagcagtt gaaactgaga tgaagaaaga
     1621 gtccaaactg gagagaacac cccaaaaaaa tgtccaagga aaaagaaaaa ttagtccatc
     1681 taaaaaggaa tcagaatcta aaaagagcag gccgacttcc aaaagggaca gtttggcaaa
     1741 gacaataaaa aaggaaacag atgtgttttg gaaaagcctg gatttcaagg agcaggtggc
     1801 tgaggagaca agtggtgaca gcaaggctag gaatttggct gatgacagca gtgaaaacaa
     1861 agtggaaaat ttgctctggg tggataaata taagccaacc tcgctcaaga ccataattgg
     1921 acagcaaggt gaccagagct gtgccaacaa actcctacgc tggctccgaa actggcaaaa
     1981 gagttcttcc gaagataaaa aacacgcaaa gtttggtaaa ttttccggca aagatgatgg
     2041 ctctagtttt aaagcagcgt tgctgtcagg ccctcctggt gttggcaaaa ccaccacagc
     2101 ttccctggtg tgtcaggagt tgggatacag ctacgtggaa ctgaatgcaa gtgacacccg
     2161 gagtaagagc agtttgaagg cgattgttgc tgagtcactg aacaatacca gcatcaaagg
     2221 cttttattca aatggagcag cctcttcagt aagcacgaaa catgctctca tcatggatga
     2281 agtagatggc atggcaggca atgaggatag gggaggaatt caggaattaa ttggcctgat
     2341 aaaacatact aaaattccca ttatttgtat gtgcaatgat agaaatcatc ccaagattcg
     2401 ctctctggtt cattattgtt ttgatcttcg ttttcaaaga cctcgggttg aacagattaa
     2461 gggtgctatg atgtctattg catttaaaga aggtttaaag attccccctc cagctatgaa
     2521 tgaaataatt ttgggagcca atcaagatat cagacaggtt ttacataatc tgagtatgtg
     2581 gtgtgcacga agtaaagcat taacctatga ccaggccaaa gctgattctc acagagccaa
     2641 aaaggatatc aaaatgggcc catttgatgt tgcccggaaa gtgtttgcag ctggagagga
     2701 gactgctcac atgtcacttg tggacaagtc agatctcttt tttcatgatt attcaatagc
     2761 acccctcttc gtccaggaaa attacataca cgtgaagcct gtagcagcag ggggtgacat
     2821 gaaaaagcac ctgatgcttt taagcagagc agcagacagc atatgcgatg gtgacctagt
     2881 ggacagccag atccggagta agcaaaactg gagtcttctg cctgcgcagg ccatttatgc
     2941 cagtgttctt cctggagagt tgatgagggg gtacatgacc cagtttccca ccttcccaag
     3001 ctggctgggg aagcactcgt ctacaggcaa acatgatcgt attgttcagg acctggcctt
     3061 gcatatgagt ctcagaactt actccagcaa aaggactgta aacatggatt atctgtcgct
     3121 tctaagggat gcacttgtac agcccttgac ctcacaagga gtagacggag tacaggatgt
     3181 tgttgcactt atggacacat attatttgat gaaagaagac tttgagaata tcatggaaat
     3241 cagcagctgg ggtggcaaac ctagtccctt ttcaaagctg gatcccaagg tgaaagcagc
     3301 cttcacaaga gcttacaata aggaagccca ccttactcca tactcacttc aagctataaa
     3361 ggcatctaga cacagcacaa gcccatccct ggattcggaa tacaatgaag aattaaatga
     3421 agatgactct caatctgatg agaaagacca agatgctata gaaactgatg ccatgatcaa
     3481 gaaaaagaca aaatcttcaa agccttcaaa accagaaaaa gataaggagc ccagaaaagg
     3541 aaaaggaaaa agttcgaaga aatgaaacca tttttcacta gcgacagcca ctttttactc
     3601 tccctcctga ccagtccagc tggtctagag aaagccttgt tttttcccag agcaaccatg
     3661 ttttagcata atgggatgac ctggtgtccc attataaata aagggtggta tggctagaag
     3721 ggtatgagca gtaggcttat gtacacctct tatagaggtt gataggactg cttgggtcct
     3781 ccactgtcct ctgtcaatct agttagacgt gcttctgaat gactgtagaa ttggaactag
     3841 aaactacacc tgggctttgg agtcagattt tagttaacaa taatgagcct gggagcagta
     3901 gtactaaggc gtcttttgta ggcttaagaa tttatcctaa tggcctttat aggaccaatg
     3961 ctgatttttt ttaaaggcag ttcctattat gtggtgaaat tttgtaaata aatgattata
     4021 caaaacagtc accacctaga actgggtatt ctttgtacat tgtcagatat ctttcaaagt
     4081 ataaattagg aataaaaatg ttccacatga tatgtgtaca aattcttttt aagattgtca
     4141 tcttgtacag caaaatatta tgttggtata ttacttcctt attaatttgc aaatgattgg
     4201 attaaaaaag ctcactgtat tccttactaa cctgttgtgt gaaacataac attggcagtc
     4261 gaggagtcag aactcggatt cccagcctca ctccctctgt gtgtgttgac cacgtctctg
     4321 ctgtgaatag gatttcatgc agtggtctgt tatggggctt tgcagcgtgg ggggctgcag
     4381 aagattctca gacattctta tccttctgga gtctcaaccc atcaggttca gaccagtagg
     4441 aaccaggctg ggtcaggctc ttaatttcac tatggtgggg gacaaaatga acactggctt
     4501 ttgttcactt tgcccctgag agatctagtc ctgtcctgtg atggcttcca caaaccctgt
     4561 tggaagtttg ggttattcct ataactgtat gtgttgagtg gccgtgaggc tatggaccta
     4621 gcctggaatt tagatgtcta gctatttttt aatcttgttg gtaaatgctc agaggtctgt
     4681 gctacctctg tgaggtatat actaaaatga atgtaaaata aggatcgtat tccctgcttt
     4741 aaggaactgg tagtcttgtt tgggtgatga gacaaagttc ttgagacatt taaactgtat
     4801 ttaccagtgt gaaaaatgtc atttatggag attaattcat tatggaaata aaacattgcc
     4861 taagcccttg
//
