LOCUS       NM_030941               2691 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens RNA exonuclease 5 (REXO5), transcript variant 1, mRNA.
ACCESSION   NM_030941
VERSION     NM_030941.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2691)
  AUTHORS   Gerstberger,S., Meyer,C., Benjamin-Hong,S., Rodriguez,J.,
            Briskin,D., Bognanni,C., Bogardus,K., Steller,H. and Tuschl,T.
  TITLE     The Conserved RNA Exonuclease Rexo5 Is Required for 3' End
            Maturation of 28S rRNA, 5S rRNA, and snoRNAs
  JOURNAL   Cell Rep 21 (3), 758-772 (2017)
   PUBMED   29045842
REFERENCE   2  (bases 1 to 2691)
  AUTHORS   Silva,S., Homolka,D. and Pillai,R.S.
  TITLE     Characterization of the mammalian RNA exonuclease 5/NEF-sp as a
            testis-specific nuclear 3' --> 5' exoribonuclease
  JOURNAL   RNA 23 (9), 1385-1392 (2017)
   PUBMED   28539487
REFERENCE   3  (bases 1 to 2691)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2691)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   5  (bases 1 to 2691)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007646.1 and AC004381.1.
            
            On Jun 2, 2019 this sequence version replaced NM_030941.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 3
            both encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007646.1, AF332193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261377.11/ ENSP00000261377.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1860              BC007646.1         29-1888
            1861-1861           AC004381.1         200342-200342
            1862-2691           BC007646.1         1890-2719
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2691
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /note="RNA exonuclease 5"
                     /db_xref="GeneID:81691"
                     /db_xref="HGNC:HGNC:24661"
     exon            1..179
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            180..319
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2506
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative RNA exonuclease NEF-sp"
                     /codon_start=1
                     /product="RNA exonuclease 5 isoform 1"
                     /protein_id="NP_112203.2"
                     /db_xref="CCDS:CCDS10591.1"
                     /db_xref="GeneID:81691"
                     /db_xref="HGNC:HGNC:24661"
                     /translation="MEPEREGTERHPRKVRESRQAPNKLVGAAEAMKAGWDLEESQPE
                     AKKARLSTILFTDNCEVTHDQLCELLKYAVLGKSNVPKPSWCQLFHQNHLNNVVVFVL
                     QGMSQLHFYRFYLEFGCLRKAFRHKFRLPPPSSDFLADVVGLQTEQRAGDLPKTMEGP
                     LPSNAKAAINLQDDPIIQKYGSKKVGLTRCLLTKEEMRTFHFPLQGFPDCENFLLTKC
                     NGSIADNSPLFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPENKILDYLTSFS
                     GITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDTSLLYV
                     REQGRRFKLKFLAKVILGKDIQCPDRLGHDATEDARTILELARYFLKHGPKKIAELNL
                     EALANHQEIQAAGQEPKNTAEVLQHPNTSVLECLDSVGQKLLFLTRETDAGELPSSRN
                     CQTIKCLSNKEVLEQARVEIPLFPFSIVQFSFKAFSPVLTEEMNKRMRIKWTEISTVY
                     AGPFSKNCNLRALKRLFKSFGPVQSMTFVLETRQPHLCIQYEVLEAAQLAIESLDGIL
                     VDGICIKVQRPVTELTLDCDTLVNELEGDSENQGSIYLSGVSETFKEQLLQEPRLFLG
                     LEAVILPKDLKSGKQKKYCFLKFKSFGSAQQALNILTGKDWKLKGRHALTPRHLHAWL
                     RGLPPESTRLPGLRVVPPPFEQEALQTLKLDHPKIAAWRWSRKIGKLYNSLCPGTLCL
                     ILLPGTKSTHGSLSGLGLMGIKEEEESAGPGLCS"
     exon            320..432
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            433..559
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            560..656
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            657..797
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            798..886
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1002
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1141
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1236
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1339
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1443
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1564
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1669
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1807
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1900
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2117
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2305
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2424
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2691
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /note="hexamer: AATAAA"
     polyA_site      2691
                     /gene="REXO5"
                     /gene_synonym="NEF-sp"
                     /note="major polyA site"
ORIGIN      
        1 gttgttggca gctgtggcta aggaggggag aacctctgct ccccgcccgt cttctcttct
       61 gcgtttcccg ggctaggggg cgtggggagt ggttttaggc ggcgaagccg ctcggcagca
      121 ccttccttct ttgccaggca gacgcccgtt gtagccgttg gggaaccgtt gagaatccgc
      181 catggagcca gagagggaag ggaccgagag acaccccagg aaggtcaggg aaagcaggca
      241 ggccccaaat aagctggtcg gggcagctga ggcgatgaaa gccggttggg atctcgagga
      301 gagtcagccc gaggccaaga aagcccgctt atctaccatt ttatttactg acaactgtga
      361 agtaacccat gaccagctgt gtgaattgct gaagtatgca gttctgggca aatccaatgt
      421 tccaaaaccc agctggtgcc agctttttca tcaaaaccac ctaaacaacg tagtggtttt
      481 tgttctgcag ggaatgagtc agctacactt ttacaggttc tatttggagt ttggatgtct
      541 tcgaaaagca ttcagacata aattccgctt gcctccacca tcatctgatt ttctagctga
      601 tgttgttggg ctacaaactg aacaaagagc tggagatctg cccaagacaa tggaagggcc
      661 tttaccttct aatgcaaaag ccgccatcaa ccttcaggat gatcccatca ttcaaaagta
      721 tggctctaag aaagtgggct tgaccagatg ccttctgaca aaggaggaaa tgagaacgtt
      781 tcactttcca ttacaaggtt ttcctgattg tgaaaacttt ttacttacca aatgtaatgg
      841 ttctatagca gacaatagtc ctctctttgg acttgactgt gaaatgtgcc tcacatccaa
      901 ggggagagag ctaacacgca tctcactggt tgctgaagga ggctgctgtg ttatggatga
      961 actggtcaaa cctgaaaaca agattctgga ctacctcacc agcttttcgg gaatcacgaa
     1021 gaagattctt aacccagtga cgaccaaact caaagatgta cagaggcagt taaaagcact
     1081 gcttcctcct gatgctgtgt tagtgggcca ctccttagat ttggatctca gagcactgaa
     1141 aatgatacat ccatatgtta ttgatacatc gttgctttat gtcagagagc agggcagaag
     1201 atttaagctc aagttcttag ccaaagttat tttggggaag gatatacagt gtccagacag
     1261 acttggtcat gatgccacag aagatgctag aacaatcctt gaattggctc ggtatttcct
     1321 taagcatggc ccaaaaaaga ttgcagaact aaatctagaa gcactagcta atcaccaaga
     1381 aatacaagca gcaggccaag agcctaaaaa cacagcagaa gtacttcagc acccaaacac
     1441 aagtgtttta gaatgcttgg attcagtggg tcagaagctt ctttttttga cccgggagac
     1501 agatgctggt gaacttccat cttccagaaa ttgtcaaact attaagtgtc tttcaaataa
     1561 agaggttctt gagcaggcca gagtggaaat ccccctgttt cccttcagca ttgttcagtt
     1621 ctcttttaag gccttttcac ctgtcctcac tgaggagatg aacaaaagga tgaggatcaa
     1681 gtggacagag atatcaactg tctatgctgg gccatttagc aaaaattgca atctcagggc
     1741 tctgaagagg ctgtttaaaa gctttggccc agtccagtca atgacttttg ttcttgaaac
     1801 ccgtcagcct catctctgta tacagtatga agtcctagaa gctgcccagc tggccataga
     1861 atccttggat ggtattctgg tagatggtat ctgcatcaag gtgcagaggc ctgtgacaga
     1921 gctcacgctt gattgtgaca ccctcgtgaa tgagctggaa ggagattctg aaaaccaagg
     1981 ctctatatat ctgtctggag tgagtgaaac cttcaaagaa cagctattgc aggagccccg
     2041 cctctttctt ggcctggaag ctgtgatctt gcctaaagat cttaaaagtg gaaagcagaa
     2101 aaaatactgt ttcctgaaat tcaaaagttt tggcagtgcc cagcaggccc tcaacattct
     2161 cacaggcaag gactggaagc tgaaaggcag gcatgcccta acccccaggc acctccatgc
     2221 ctggctcaga ggcttaccac ctgaatcaac aaggctccca gggcttcgtg ttgtacctcc
     2281 cccctttgaa caggaggcct tgcagactct gaaactggac cacccgaaga tagcagcctg
     2341 gcgctggagc cggaagattg gaaagctcta caacagcttg tgcccgggca ctctctgcct
     2401 catcctgctg ccaggaacca agagcactca tggttcactc tctggtctag gactgatggg
     2461 aataaaagag gaagaagaaa gcgctggccc aggcctgtgt tcgtgagtcg gcctgccatg
     2521 tttccatgtg ccatttctta ccccttgtag gcaatggcaa agaatgtggt caggctgtag
     2581 cctccccaac cagcagacag ctttatggaa acttggtata gcagctaaaa gagtttagtt
     2641 tgtttatatg gcatgtataa gttttcaata aatgcctaaa gttcaagcat a
//
