LOCUS       NM_020385               2326 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens REX4 homolog, 3'-5' exonuclease (REXO4), transcript
            variant 1, mRNA.
ACCESSION   NM_020385
VERSION     NM_020385.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2326)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2326)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2326)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2326)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2326)
  AUTHORS   Krishnamurthy,N., Ngam,C.R., Berdis,A.J. and Montano,M.M.
  TITLE     The exonuclease activity of hPMC2 is required for transcriptional
            regulation of the QR gene and repair of estrogen-induced abasic
            sites
  JOURNAL   Oncogene 30 (47), 4731-4739 (2011)
   PUBMED   21602889
  REMARK    GeneRIF: determined that the catalytic activity of hPMC2 is
            required for repair of abasic sites that result from
            estrogen-induced DNA damage
REFERENCE   6  (bases 1 to 2326)
  AUTHORS   Montano,M.M., Wittmann,B.M. and Bianco,N.R.
  TITLE     Identification and characterization of a novel factor that
            regulates quinone reductase gene transcriptional activity
  JOURNAL   J Biol Chem 275 (44), 34306-34313 (2000)
   PUBMED   10908561
REFERENCE   7  (bases 1 to 2326)
  AUTHORS   Kwiatkowska,J., Slomski,R., Jozwiak,S., Short,M.P. and
            Kwiatkowski,D.J.
  TITLE     Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and
            evaluation as TSC1
  JOURNAL   Genomics 44 (3), 350-354 (1997)
   PUBMED   9325058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC387839.1, AL136894.1 and BC009274.2.
            
            On Nov 23, 2018 this sequence version replaced NM_020385.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF273304.1, AF295774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371942.8/ ENSP00000361010.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                DC387839.1         87-157
            72-1014             AL136894.1         89-1031
            1015-1015           BC009274.2         1004-1004
            1016-2326           AL136894.1         1033-2343
FEATURES             Location/Qualifiers
     source          1..2326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..2326
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /note="REX4 homolog, 3'-5' exonuclease"
                     /db_xref="GeneID:57109"
                     /db_xref="HGNC:HGNC:12820"
                     /db_xref="MIM:602930"
     exon            1..391
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1435
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Xenopus prevents mitotic catastrophe 2 homolog; RNA
                     exonuclease 4; exonuclease XPMC2; XPMC2 prevents mitotic
                     catastrophe 2 homolog; REX4, RNA exonuclease 4 homolog"
                     /codon_start=1
                     /product="RNA exonuclease 4 isoform 1"
                     /protein_id="NP_065118.2"
                     /db_xref="CCDS:CCDS6969.1"
                     /db_xref="GeneID:57109"
                     /db_xref="HGNC:HGNC:12820"
                     /db_xref="MIM:602930"
                     /translation="MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKARE
                     VSKKPASGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKI
                     IQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTK
                     ERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARK
                     QLGQSEGSVSLSLVKEQAFGGLTRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVY
                     DKYVKPTEPVTDYRTAVSGIRPENLKQGEELEVVQKEVAEMLKGRILVGHALHNDLKV
                     LFLDHPKKKIRDTQKYKPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMR
                     LYVMVKKEWESMARDRRPLLTAPDHCSDDA"
     exon            392..738
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     exon            739..882
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1076
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1165
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1240
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1315
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..2326
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /note="hexamer: AATAAA"
     polyA_site      2326
                     /gene="REXO4"
                     /gene_synonym="REX4; XPMC2; XPMC2H"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcaacg cgtgcggggt ctcttccgga gtcttttcct ggacggggtc cctgcggtgg
       61 gtgtgtttcg gcctggcctg ggcaggcgct tgtgctgcca gggcgccggg cccggggagg
      121 ccggggtctc gggtggccgc cggcccaggc gctggacggc agcaggatgg ggaaggcgaa
      181 ggtccccgcc tccaagcgcg ccccgagcag ccccgtggct aagccgggtc ctgtcaagac
      241 gctcactcgg aagaaaaaca agaagaaaaa aaggttttgg aaaagcaagg cgcgggaagt
      301 aagcaagaag ccagcaagcg gccccggtgc tgtggtgcga cctccaaagg caccagaaga
      361 cttttctcaa aactggaagg cgctgcaaga gtggctgctg aaacaaaaat ctcaggcccc
      421 agaaaagcct cttgtcatct ctcagatggg ttccaaaaag aagcccaaaa ttatccagca
      481 aaacaaaaaa gagacctcgc ctcaagtgaa gggagaggag atgccggcag gaaaagacca
      541 ggaggccagc aggggctctg ttccttcagg ttccaagatg gacaggaggg cgccagtacc
      601 tcgcaccaag gccagtggaa cagagcacaa taagaaagga accaaggaaa ggacaaatgg
      661 tgatattgtt ccagaacgag gggacatcga gcataagaag cggaaagcta aggaggcagc
      721 cccagcccca cccaccgagg aagacatctg gtttgacgac gtggacccag cggatatcga
      781 agctgccata ggtccagagg cggccaagat agcgaggaaa cagttgggtc agagcgaggg
      841 cagcgtcagc ctcagcctcg tgaaagagca ggccttcggc ggcctgacaa gagccttagc
      901 cttggactgt gagatggtgg gcgtgggccc taagggggag gagagcatgg ccgcccgtgt
      961 gtccatcgtg aaccagtatg ggaagtgcgt ttatgacaag tacgtcaaac caaccgagcc
     1021 cgtgacggac tataggacag cggtcagtgg gattcggcct gagaacctca agcagggaga
     1081 agagcttgaa gttgttcaga aggaagtggc agagatgctg aagggcagaa ttctagtggg
     1141 gcacgctctg cataatgacc taaaggtact atttcttgat catccaaaaa agaagattcg
     1201 ggacacacag aaatataaac ctttcaagag tcaagtaaag agtggaaggc cgtctctgag
     1261 actactttca gagaagatcc ttgggctcca ggtccagcag gcggagcact gttcaattca
     1321 ggatgcccag gcagcaatga ggctgtacgt catggtgaag aaggagtggg agagcatggc
     1381 ccgagacagg cgccccctgc tgactgctcc agaccactgc agtgacgacg cctagcagtc
     1441 ctgccctgct gctgctgccg ccccgctaca gaggcaatgt gaccagtcac agggacagat
     1501 cacatctccc cagagtggca actctggtga aaccttttca gaatcatggc agaggggcgt
     1561 ggcgtggtgc tactgagaag gtcctccttc ctcttgactt tgtggtctga aacctggtct
     1621 tactgtccat gtgtgtttgg gcccggatgg tcagggtggg gagcagggac ggccatgggc
     1681 acgcctggcc acgctttacc gactgctgac cccctgggcc aggtgaggtt ggggcctgtg
     1741 ggccgccagt ccatacggtg ctgtcactgc ccatcttcgg tgacaccctg gggtgaggtg
     1801 ctcagcacct tcctctcgag gagccacatt ttcctccttt gtgttagggg acataacaag
     1861 ctctgctggg cttgagggac ccagaccagg tgtctgcagt cagctcctga gacacagctg
     1921 gccggcacaa caggtgttac atcaggggtt tcctgtggcc gtttgaactt tgagcattta
     1981 tctaaattaa attggcccag ggttggctgg tgggtcaccc agcagaggct tctccccata
     2041 gcacgaggat gtgttgcctg ggcacggtga ctgcggttat tcctggaggt cggcagacat
     2101 gccaaccttg ggctatttga gctggagaag ctatgtgatg ctagccggtg gctttctggg
     2161 ctaggcccca gtttgaggct cccctgggaa ctagagccag gaacagccag tggcactgac
     2221 aaggggacgg agtccaaggc gttattgggc cacctgacag ctggacagaa aaggggcaga
     2281 cacaccgagg atgcgattta aaataaatgc agatgtttac ttggaa
//
