LOCUS       NM_015523               1080 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA exonuclease 2 (REXO2), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_015523
VERSION     NM_015523.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Wang,H., Wang,X., Xu,L., Zhang,J. and Cao,H.
  TITLE     RUNX1 and REXO2 are associated with the heterogeneity and prognosis
            of IDH wild type lower grade glioma
  JOURNAL   Sci Rep 11 (1), 11836 (2021)
   PUBMED   34088969
  REMARK    GeneRIF: RUNX1 and REXO2 are associated with the heterogeneity and
            prognosis of IDH wild type lower grade glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Szewczyk,M., Malik,D., Borowski,L.S., Czarnomska,S.D., Kotrys,A.V.,
            Klosowska-Kosicka,K., Nowotny,M. and Szczesny,R.J.
  TITLE     Human REXO2 controls short mitochondrial RNAs generated by mtRNA
            processing and decay machinery to prevent accumulation of
            double-stranded RNA
  JOURNAL   Nucleic Acids Res 48 (10), 5572-5590 (2020)
   PUBMED   32365187
  REMARK    GeneRIF: Human REXO2 controls short mitochondrial RNAs generated by
            mtRNA processing and decay machinery to prevent accumulation of
            double-stranded RNA.
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Laitman,Y., Tzur,S., Attai,R., Tirosh,A. and Friedman,E.
  TITLE     Germline variant in REXO2 is a novel candidate gene in familial
            pheochromocytoma
  JOURNAL   Genet Res (Camb) 102, e3 (2020)
   PUBMED   32354376
  REMARK    GeneRIF: Germline variant in REXO2 is a novel candidate gene in
            familial pheochromocytoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1080)
  AUTHORS   Nicholls,T.J., Spahr,H., Jiang,S., Siira,S.J., Koolmeister,C.,
            Sharma,S., Kauppila,J.H.K., Jiang,M., Kaever,V., Rackham,O.,
            Chabes,A., Falkenberg,M., Filipovska,A., Larsson,N.G. and
            Gustafsson,C.M.
  TITLE     Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in
            Mammalian Mitochondria
  JOURNAL   Mol Cell 76 (5), 784-796 (2019)
   PUBMED   31588022
  REMARK    GeneRIF: Efficient RNA turnover by REXO2 is thus required to
            maintain promoter specificity and proper regulation of
            transcription in mammalian mitochondria.
REFERENCE   6  (bases 1 to 1080)
  AUTHORS   Young Park,A., Elvin,C.M., Hamdan,S.M., Wood,R.J., Liyou,N.E.,
            Hamwood,T.E., Jennings,P.A. and Dixon,N.E.
  TITLE     Hydrolysis of the 5'-p-nitrophenyl ester of TMP by
            oligoribonucleases (ORN) from Escherichia coli, Mycobacterium
            smegmatis, and human
  JOURNAL   Protein Expr Purif 57 (2), 180-187 (2008)
   PUBMED   18023590
  REMARK    GeneRIF: The expression in E. coli of orn and homologues from
            Mycobacterium smegmatis and human, and large-scale purification of
            the three enzymes, is reported.
REFERENCE   7  (bases 1 to 1080)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   8  (bases 1 to 1080)
  AUTHORS   Ito,S., Kita,K., Zhai,L., Wano,C., Suzuki,T., Yamaura,A. and
            Suzuki,N.
  TITLE     Involvement of human small fragment nuclease in the resistance of
            human cells to UV-C-induced cell death
  JOURNAL   Photochem Photobiol 80 (2), 281-285 (2004)
   PUBMED   15362935
  REMARK    GeneRIF: SFN expression is involved in resistance of RSa cells to
            UV-C-induced cell death through the roles it plays in the DNA
            repair process
REFERENCE   9  (bases 1 to 1080)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 1080)
  AUTHORS   Nguyen,L.H., Erzberger,J.P., Root,J. and Wilson,D.M. 3rd.
  TITLE     The human homolog of Escherichia coli Orn degrades small
            single-stranded RNA and DNA oligomers
  JOURNAL   J Biol Chem 275 (34), 25900-25906 (2000)
   PUBMED   10851236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC143701.1 and AI249345.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015523.3.
            
            Summary: This gene encodes a 3'-to-5' exonuclease specific for
            small (primarily 5 nucleotides or less in length) single-stranded
            RNA and DNA oligomers. This protein may have a role in DNA repair,
            replication, and recombination, and in RNA processing and
            degradation. It may also be involved in resistance of human cells
            to UV-C-induced cell death through its role in the DNA repair
            process. [provided by RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL110239.1, SRR5189667.111640.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000265881.10/
                                                  ENSP00000265881.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-872               BC143701.1         6-877
            873-1080            AI249345.1         11-218              c
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..1080
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /note="RNA exonuclease 2"
                     /db_xref="GeneID:25996"
                     /db_xref="HGNC:HGNC:17851"
                     /db_xref="MIM:607149"
     exon            1..209
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..776
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /note="small fragment nuclease; oligoribonuclease,
                     mitochondrial; RNA exonuclease 2 homolog; REX2, RNA
                     exonuclease 2 homolog"
                     /codon_start=1
                     /product="oligoribonuclease, mitochondrial precursor"
                     /protein_id="NP_056338.2"
                     /db_xref="CCDS:CCDS8371.1"
                     /db_xref="GeneID:25996"
                     /db_xref="HGNC:HGNC:17851"
                     /db_xref="MIM:607149"
                     /translation="MLGGSLGSRLLRGVGGSHGRFGARGVREGGAAMAAGESMAQRMV
                     WVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHG
                     KSGLTKAVKESTITLQQAEYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMK
                     HLHYRIIDVSTVKELCRRWYPEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKK
                     IDEKKRKIIENGENEKTVS"
     exon            210..293
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     exon            294..371
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     exon            372..483
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     exon            484..592
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     exon            593..646
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1080
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /note="hexamer: AATAAA"
     polyA_site      1080
                     /gene="REXO2"
                     /gene_synonym="CGI-114; REX2; RFN; SFN"
                     /note="major polyA site"
ORIGIN      
        1 gactattgcg cctgcgccag cgccggctgc gagactgggg ccgtggctgc tggtcccggg
       61 tgatgctagg cggctccctg ggctccaggc tgttgcgggg tgtaggtggg agtcacggac
      121 ggttcggggc ccgaggtgtc cgcgaaggtg gcgcagccat ggcggcaggg gagagcatgg
      181 ctcagcggat ggtctgggtg gacctggaga tgacaggatt ggacattgag aaggaccaga
      241 ttattgagat ggcctgtctg ataactgact ctgatctcaa cattttggct gaaggtccta
      301 acctgattat aaaacaacca gatgagttgc tggacagcat gtcagattgg tgtaaggagc
      361 atcacgggaa gtctggcctt accaaggcag tgaaggagag tacaattaca ttgcagcagg
      421 cagagtatga atttctgtcc tttgtacgac agcagactcc tccagggctc tgtccacttg
      481 caggaaattc agttcatgaa gataagaagt ttcttgacaa atacatgccc cagttcatga
      541 aacatcttca ttatagaata attgatgtga gcactgttaa agaactgtgc agacgctggt
      601 atccagaaga atatgaattt gcaccaaaga aggctgcttc tcatagggca cttgatgaca
      661 ttagtgaaag catcaaagag cttcagtttt accgaaataa catcttcaag aaaaaaatag
      721 atgaaaagaa gaggaaaatt atagaaaatg gggaaaatga gaagaccgtg agttgatgcc
      781 agttatcatg ctgccactac atcgttatct ggaggcaact tctggtggtt tttttttctc
      841 acgctgatgg cttggcagag caccttcggt taacttgcat ctccagattg attactcaag
      901 cagacagcac acgaaatact atttttctcc taatatgctg tttccattat gacacagcag
      961 ctcctttgta agtaccaggt catgtccatc ccttggtaca tatatgcatt tgcttttaaa
     1021 ccatttcttt tgtttaaata aataaataag taaataaagc tagttctatt gaaatgcaaa
//
