LOCUS       NM_020695               4609 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RNA exonuclease 1 homolog (REXO1), mRNA.
ACCESSION   NM_020695
VERSION     NM_020695.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4609)
  AUTHORS   Bhatia,S., Pilquil,C., Roth-Albin,I. and Draper,J.S.
  TITLE     Demarcation of stable subpopulations within the pluripotent hESC
            compartment
  JOURNAL   PLoS One 8 (2), e57276 (2013)
   PUBMED   23437358
  REMARK    GeneRIF: Loss of REX1 expression demarcates stable, OCT4-positive
            lineage pluripotent human embryonic stem cells.
REFERENCE   2  (bases 1 to 4609)
  AUTHORS   Bhandari,D.R., Seo,K.W., Roh,K.H., Jung,J.W., Kang,S.K. and
            Kang,K.S.
  TITLE     REX-1 expression and p38 MAPK activation status can determine
            proliferation/differentiation fates in human mesenchymal stem cells
  JOURNAL   PLoS One 5 (5), e10493 (2010)
   PUBMED   20463961
  REMARK    GeneRIF: These findings showed that REX1 regulates the
            proliferation/differentiation of human mesenchymal stem cells
            through the suppression of p38 MAPK signaling via the direct
            suppression of MKK3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4609)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   4  (bases 1 to 4609)
  AUTHORS   Tamura,K., Miyata,K., Sugahara,K., Onishi,S., Shuin,T. and Aso,T.
  TITLE     Identification of EloA-BP1, a novel Elongin A binding protein with
            an exonuclease homology domain
  JOURNAL   Biochem Biophys Res Commun 309 (1), 189-195 (2003)
   PUBMED   12943681
  REMARK    GeneRIF: cloning and characterization of a novel human exonuclease
            domain-containing protein, Elongin A-binding protein 1; it is
            capable of binding not only the NH(2)-terminal approximately 120
            amino acid region of Elongin A, but also that of SII
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012615.4 and BC032244.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020695.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032964.1, BC032244.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000170168.9/ ENSP00000170168.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC012615.4         40901-40930         c
            31-239              BC032244.1         11-219
            240-240             AC012615.4         40691-40691         c
            241-2399            BC032244.1         221-2379
            2400-2400           AC012615.4         14085-14085         c
            2401-2780           BC032244.1         2381-2760
            2781-2781           AC012615.4         11573-11573         c
            2782-4232           BC032244.1         2762-4212
            4233-4609           AC012615.4         7695-8071           c
FEATURES             Location/Qualifiers
     source          1..4609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4609
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /note="RNA exonuclease 1 homolog"
                     /db_xref="GeneID:57455"
                     /db_xref="HGNC:HGNC:24616"
                     /db_xref="MIM:609614"
     exon            1..282
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..3791
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /note="REX1, RNA exonuclease 1 homolog; transcription
                     elongation factor B polypeptide 3-binding protein 1;
                     elongin-A-binding protein 1"
                     /codon_start=1
                     /product="RNA exonuclease 1 homolog"
                     /protein_id="NP_065746.3"
                     /db_xref="CCDS:CCDS32866.1"
                     /db_xref="GeneID:57455"
                     /db_xref="HGNC:HGNC:24616"
                     /db_xref="MIM:609614"
                     /translation="MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGD
                     GGEAPPAAGLGYDPYNPELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEV
                     ELEQRRYRELLETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLS
                     PDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPS
                     GKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLC
                     DPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGL
                     RETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDG
                     AQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGR
                     PDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDA
                     PKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGP
                     PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNEST
                     SVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAV
                     PPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPR
                     LAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPSLQ
                     SLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPS
                     KNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSLSRPSS
                     PRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSSCRT
                     CCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVAK
                     QHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHV
                     VYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLES
                     DLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGA
                     CMHLVIWKVREDAKTKR"
     exon            283..2036
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2141
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2355
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2519
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2651
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2775
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2889
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3027
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3141
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3215
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3326
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3442
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3581
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3702
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..4609
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /note="hexamer: AATAAA"
     polyA_site      4609
                     /gene="REXO1"
                     /gene_synonym="EloA-BP1; ELOABP1; REX1; TCEB3BP1"
                     /note="major polyA site"
ORIGIN      
        1 gggggcctcg gagcaagatg gcggcggcgg ggtccgtgag gcgcgggcgg cggcgaccgc
       61 ggcgccagtg agggggccct ggggcccggg cggctccggg ccggggcccc gccgcgggac
      121 ggaccatgct acgctccact ggcttcttcc gggccattga ctgcccctat tggtctgggg
      181 cgcccggggg gccctgccgg cggccctact gccacttccg gcaccgcggg gcccggggct
      241 ccggcgcgcc cggtgacggc ggagaggcgc cccccgcagc agggctgggt tacgacccct
      301 acaaccctga gctgcccaag ccccccgcgc agagggagaa tggcaccctg ggcctggggg
      361 aggagccgcg cccggatgtg ctggagttgg agctggtcaa ccaggccatc gaggccgtgc
      421 gcagtgaggt ggagctggag cagcggcgct accgggagct gctggagacg acccgtgagc
      481 accgctccgc cgaggccccc gccctggcgc cccgcggccc caacgccagc cccactgtgg
      541 gcccggacga ggatgccttc ccactggcct tcgactacag ccccggcagc cacggcctat
      601 taagccctga tgccggctac cagcccaccc cactggccgc ccctgccgag ccgggcagca
      661 agtactcgct ggcgtccctg gacaggggtc agggcagagg tggagggggt ggcggtgccc
      721 tggaatacgt ccccaaggct gtgagccagc cccggcggca cagccgcccc gttcccagtg
      781 gcaagtacgt ggtggacaac tccaggccac ccacagacct ggagtatgac cctctctcca
      841 actactcggc ccggcacctc agcagggcca gctcccggga tgagcgggcc gccaagcggc
      901 cccggggctc ccgcggcagt gagccctaca cacctgctcc caagaagctc tgtgacccct
      961 ttggcagttg cgatgcaagg ttctcagact cagaagatga ggccgccacg gtcccaggta
     1021 acgagcccac cacggccagc acccccaaag ccagggccga ccctgagatc aaggccaccg
     1081 ggcagccacc ctccaaagag ggcctggagg ccgagggggg cggcctgcgg gagaccaagg
     1141 agacggccgt gcagtgcgac gtgggggacc tccagccgcc cccagccaag cccgcctccc
     1201 cagcccaggt ccagtcctca caggatgggg gctgccccaa ggagggaaaa cccaagaaga
     1261 aaaaaaccgg ggccccacct gcccccagct gcaaagacgg ggcccagggg aaggacaaga
     1321 ccaaggacaa gggccgaggg cggcctgtgg agaagccccg tgcggacaag aagggcccgc
     1381 aggccagcag cccccggcgc aaggcagagc ggccggaagg gaccaagaag aagccatctt
     1441 cggccactcc tgtggccacc tcagggaaag ggaggcctga ccggccagcg cggcggccga
     1501 gccccacaag cggggactcc cgaccggcgg ccggcagagg cccaccccgc cccctccagc
     1561 tgcccgacag gaagagcacc aaggccccgt cggggaagct agtggagcgg aaagcccgct
     1621 cactagacga gggcgcctcc caggacgccc ccaagctgaa gaagcgggcc ctgagccacg
     1681 ccgacctctt tggggacgag agtgaggacg aggccgcagg gccaggggtg ccgagcgtgt
     1741 ggccctctgc cctccccagc ctcagctcgg actcagactc cgactcagac tccagcctgg
     1801 gcttcccgga ggcgcagggg ccgcccaagc ggctcaaggc ctccccgccc ccctcccccg
     1861 ccccatcctc ctcctcctcc tcctcctcct ccacctccag cgcgggggcg gatgtggact
     1921 actcggccct ggagaaggag gtggactttg actccgaccc catggaggag tgcctgcgga
     1981 tcttcaacga gtccaccagc gtcaagacgg aggacagagg ccggctggcc cggcagcccc
     2041 ccaaggaaga gaagagtgag gagaaggggc tttcgggtct gaccactctg ttccccgggc
     2101 agaagaggag gatctcccac ctttccaagc aaggccagga ggtggagccc ccgaggaggg
     2161 gtcccgcggt gcccccggcc cggcccccga cggcgcagga ggtgtgctac ctgcgggccc
     2221 agcaggcgca gagggcatcg gcgagcttgc tgcaggcccc cgccaggctg gcagagaagt
     2281 cgccctccgt ccacatttcc gcccctggcg agaagaggag gatcgcccac atccccaacc
     2341 cccgcctggc tgcagccccc acaggtgcca agaggaccct tgcggccagc ggcagccagt
     2401 cctccaacgg ccctgagcca ggtggccagc agctgaaaac acgcacattg tcggggatgg
     2461 cgtccaagac taccaccacc atcatcccta agcgaatcgc ccacagtcca tccttacaga
     2521 gtttaaagaa acccattatc cccaaagagt ttgggggcaa agtccccacc gtcatccgcc
     2581 agcgctatct caacctgttc atcgaggagt gtctcaagtt ctgtacctcc aaccaggagg
     2641 ccatagagaa ggcactgaac gaggagaagg tggcctatga ccgcagcccc agcaagaaca
     2701 tctacctgaa tgtggccgtg aacaccctca agaagctcag gggcctggcc cccagcgctg
     2761 tgcccggcct cagcaaaacc agtggccgca gggttgtgtc ccacgaggtg gtgttggggg
     2821 gcaggttggc cgccaagacc agcttctcgc tcagccgtcc aagcagcccc cgggtggagg
     2881 acctgaaagg ggctgccctg tacagccgcc tcagggagta cctgctcacc caggaccagc
     2941 tcaaggagaa cggctacccc ttcccgcacc cagagcggcc cgggggcgca atcatcttca
     3001 cagctgagga gaagaggccc aaggactctt cctgcaggac ctgctgccgc tgtggcaccg
     3061 agtacctcgt gtcctcttca ggccgctgca tccgggacga ggagtgttat taccactggg
     3121 gacggctgcg ccggaaccgg gtggccggag gctgggagac ccagtacatg tgctgctcgg
     3181 ctgccgccgg ctctgtcggc tgccaagtcg caaagcaaca cgtgcaggat ggccggaagg
     3241 agcgccttga gggcttcgtg aagacctttg agaaagagct ctcaggagac acccacccgg
     3301 ggatctacgc cctggactgc gagatgtcct acaccacata tggcctggag ctgacgcgcg
     3361 tcacggtggt cgacacggac gtgcacgtgg tttatgacac cttcgtgaag cctgacaacg
     3421 agatcgtgga ctacaacacc aggttttcgg gggtgacgga ggctgacctt gccgacacaa
     3481 gtgtcacgct gcgtgacgtc caggccgttc tgctgagcat gttcagcgct gacaccatcc
     3541 tcatcggaca cagcctggag agcgacctcc tggccctgaa ggtcatccac agcaccgtgg
     3601 tggacacgtc tgtgctcttc ccccaccgcc tgggcctccc ctacaagcgg tccctgcgga
     3661 acctcatggc cgactacctc agacagatca tccaggacaa tgtggatggg cacagctcca
     3721 gcgaggacgc cggcgcctgc atgcacctgg tgatctggaa ggttcgagaa gacgccaaga
     3781 ccaagcgatg acgcctgccc gcctcccacc cgcctctcct gccgtcccgc tggtccttag
     3841 ccccatgcct cttccaaaac agtgcaataa atctccggta acccgtccac ctggccgagg
     3901 cagcccagag cagcgggatg agctggcggc cagagaacgc ccagcccagc ccacccccgc
     3961 tcacgtcctg ccgcacccct ccgccggtcc ccaccctctg ccccccagcc ctctggcgtc
     4021 tctagaaact gctgctgatg gagaccagga cagagcccgc ccccacccgg cccgcagccc
     4081 ctcctgcccc tcctgccagg ccctccctcc cgggtggtgg ccggcacctc tgctcctcac
     4141 gtgggtcgcg gggcgggctt gtcccaggtt tgtttgagac agtctttttt tattttgtat
     4201 tgttattttt attattttta atttaaacct gatgacttgc acagcatctt tcccaccggg
     4261 aagagcgggc ctgctgcctt ccctcctgcg gggtgggggt gggacagacc ccagtggggg
     4321 ccagggccac actcagcgca gtgtgggctg gacccgcctc tgtgctccag gggctggccg
     4381 gtcttcgggg gcgccggctt ccaccactcg ccgccccacc cctgcactcc gtgacctctg
     4441 agaacccagc tggcccctcg ttagccccag ggtctgccgt ctagagggag cccaccggcc
     4501 tccggacact gtcttcccgc tagagccccg tcctcctctg cggggctctc cggaccccct
     4561 tccccctcac ctccaggcag ggacagaata aatgtttgta tggatttta
//
