LOCUS       NM_001100418             767 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens required for excision 1-B domain containing (REX1BD),
            transcript variant 1, mRNA.
ACCESSION   NM_001100418
VERSION     NM_001100418.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 767)
  AUTHORS   Gao,J. and Li,F.
  TITLE     Heterochromatin repeat organization at an individual level: Rex1BD
            and the 14-3-3 protein coordinate to shape the epigenetic landscape
            within heterochromatin repeats
  JOURNAL   Bioessays 46 (7), e2400030 (2024)
   PUBMED   38679759
  REMARK    GeneRIF: Heterochromatin repeat organization at an individual
            level: Rex1BD and the 14-3-3 protein coordinate to shape the
            epigenetic landscape within heterochromatin repeats.
            Review article
REFERENCE   2  (bases 1 to 767)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 767)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 767)
  AUTHORS   Razanskas,R. and Sasnauskas,K.
  TITLE     A novel human protein is able to interact with hepatitis B virus
            core deletion mutant but not with the wild-type protein
  JOURNAL   Virus Res 146 (1-2), 130-134 (2009)
   PUBMED   19770013
  REMARK    GeneRIF: A human protein of unknown function FLJ20850 interacted
            specifically with deletion mutant hepatitis B core proteins.
REFERENCE   5  (bases 1 to 767)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 767)
  AUTHORS   Cenkci,B., Petersen,J.L. and Small,G.D.
  TITLE     REX1, a novel gene required for DNA repair
  JOURNAL   J Biol Chem 278 (25), 22574-22577 (2003)
   PUBMED   12697762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012078.1.
            
            On May 21, 2020 this sequence version replaced NM_001100418.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000857.1, BC012078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358607.11/ ENSP00000351422.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-767               BC012078.1         3-769
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..767
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /note="required for excision 1-B domain containing"
                     /db_xref="GeneID:55049"
                     /db_xref="HGNC:HGNC:26098"
     exon            1..103
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..610
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C19orf60; required for excision
                     1-B domain-containing protein"
                     /codon_start=1
                     /product="required for excision 1-B domain-containing
                     protein isoform 1"
                     /protein_id="NP_001093888.1"
                     /db_xref="CCDS:CCDS42524.1"
                     /db_xref="GeneID:55049"
                     /db_xref="HGNC:HGNC:26098"
                     /translation="MITETAAEPTVPAVPAAEEATEARGREEPAWPWKDAPIRTLVQR
                     IHQLQAERAQGFRRLEEWLAPVQGLRAWGRGLRVPTCRRGHRQYLRSGPDYDFARYRS
                     TVHGVTQAFAAASREVLAVEAELGGPRRQPLLAGHVRSLQELEQTRLGTVALLQLMET
                     PELAGQEDAVRMQQLKMKVIKTMEAISEVLQDLRFDAESAE"
     exon            104..186
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            187..457
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            458..537
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            538..767
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      746..751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /note="hexamer: AATAAA"
     polyA_site      767
                     /gene="REX1BD"
                     /gene_synonym="C19orf60"
                     /note="major polyA site"
ORIGIN      
        1 agtcatgatc accgagaccg cggcggagcc tacggtccct gcagtgcctg ctgctgagga
       61 ggccaccgaa gctcggggac gcgaggagcc ggcgtggccc tggaaagacg ccccgatccg
      121 gacgctggtg cagcgcatcc accagctgca ggctgagcgc gcgcagggct tccgccgact
      181 ggaggagtgg ttggcgccgg tgcagggcct gagagcctgg gggcgcggcc tcagggtccc
      241 cacatgccgc agaggccacc gccagtacct gcgcagcggc cctgactacg acttcgcgcg
      301 ctaccggagc acagtgcacg gggtgaccca ggccttcgcc gccgcctcgc gggaggtgct
      361 ggcggtggaa gcagagctgg gcgggcctcg caggcagccg ctgctcgccg gccacgtgcg
      421 cagcctgcag gagctggagc agacgcggct gggcacggtg gccctgctgc agttgatgga
      481 gacgccagag ctggcggggc aggaggacgc tgtacggatg cagcagctga aaatgaaggt
      541 aattaaaacc atggaggcga tcagcgaggt tctccaggac cttaggtttg atgcggaatc
      601 tgccgagtga tggcggctcc ccagggatgc gccgagggag atgggaaacg gggcggatgg
      661 cgcccagccc agccctaact gccagctggc tggggttgcg ccccactgcg ctgctgacct
      721 tcctgcagtt ccagacacct cccacaataa agagctcctc ctctgta
//
