LOCUS       NM_001372078           10706 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens REV3 like, DNA directed polymerase zeta catalytic
            subunit (REV3L), transcript variant 4, mRNA.
ACCESSION   NM_001372078
VERSION     NM_001372078.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10706)
  AUTHORS   Li,C., Fan,S., Li,P., Bai,Y., Wang,Y., Cui,Y., Li,M., Wang,R.,
            Shao,Y., Wang,Y., Zheng,S., Wang,R., Gao,L., Li,M., Zheng,Y.,
            Wang,F., Gao,S., Feng,S., Wang,J., Qu,X. and Li,X.
  TITLE     A sophisticated mechanism governs Pol zeta activity in response to
            replication stress
  JOURNAL   Nat Commun 15 (1), 7562 (2024)
   PUBMED   39215012
  REMARK    GeneRIF: A sophisticated mechanism governs Pol zeta activity in
            response to replication stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10706)
  AUTHORS   Jamwal,R.S., Mahajan,N., Bhat,G.R., Bhat,A., Shah,R., Verma,S.,
            Sharma,M., Sharma,B., Qadri,R.A., Kumar,R. and Bhat,A.
  TITLE     REV3L single nucleotide variants lead to increased susceptibility
            towards non-small cell lung cancer in the population of Jammu and
            Kashmir
  JOURNAL   Cancer Epidemiol 75, 102047 (2021)
   PUBMED   34655923
  REMARK    GeneRIF: REV3L single nucleotide variants lead to increased
            susceptibility towards non-small cell lung cancer in the population
            of Jammu and Kashmir.
REFERENCE   3  (bases 1 to 10706)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   4  (bases 1 to 10706)
  AUTHORS   Ben Yamin,B., Ahmed-Seghir,S., Tomida,J., Despras,E., Pouvelle,C.,
            Yurchenko,A., Goulas,J., Corre,R., Delacour,Q., Droin,N.,
            Dessen,P., Goidin,D., Lange,S.S., Bhetawal,S.,
            Mitjavila-Garcia,M.T., Baldacci,G., Nikolaev,S., Cadoret,J.C.,
            Wood,R.D. and Kannouche,P.L.
  TITLE     DNA polymerase zeta contributes to heterochromatin replication to
            prevent genome instability
  JOURNAL   EMBO J 40 (21), e104543 (2021)
   PUBMED   34533226
  REMARK    GeneRIF: DNA polymerase zeta contributes to heterochromatin
            replication to prevent genome instability.
REFERENCE   5  (bases 1 to 10706)
  AUTHORS   Taglialatela,A., Leuzzi,G., Sannino,V., Cuella-Martin,R.,
            Huang,J.W., Wu-Baer,F., Baer,R., Costanzo,V. and Ciccia,A.
  TITLE     REV1-Polzeta maintains the viability of homologous
            recombination-deficient cancer cells through mutagenic repair of
            PRIMPOL-dependent ssDNA gaps
  JOURNAL   Mol Cell 81 (19), 4008-4025 (2021)
   PUBMED   34508659
  REMARK    GeneRIF: REV1-Polzeta maintains the viability of homologous
            recombination-deficient cancer cells through mutagenic repair of
            PRIMPOL-dependent ssDNA gaps.
REFERENCE   6  (bases 1 to 10706)
  AUTHORS   Lin,W., Wu,X. and Wang,Z.
  TITLE     A full-length cDNA of hREV3 is predicted to encode DNA polymerase
            zeta for damage-induced mutagenesis in humans
  JOURNAL   Mutat Res 433 (2), 89-98 (1999)
   PUBMED   10102035
REFERENCE   7  (bases 1 to 10706)
  AUTHORS   Karayianni,E., Magnanini,C., Orphanos,V., Negrini,M.,
            Maniatis,G.M., Spathas,D.H., Barbanti-Brodano,G. and Morelli,C.
  TITLE     Transcriptional map of chromosome region 6q16-->q21
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 263-266 (1999)
   PUBMED   10575223
REFERENCE   8  (bases 1 to 10706)
  AUTHORS   Gibbs,P.E., McGregor,W.G., Maher,V.M., Nisson,P. and Lawrence,C.W.
  TITLE     A human homolog of the Saccharomyces cerevisiae REV3 gene, which
            encodes the catalytic subunit of DNA polymerase zeta
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6876-6880 (1998)
   PUBMED   9618506
REFERENCE   9  (bases 1 to 10706)
  AUTHORS   Xiao,W., Lechler,T., Chow,B.L., Fontanie,T., Agustus,M.,
            Carter,K.C. and Wei,Y.F.
  TITLE     Identification, chromosomal mapping and tissue-specific expression
            of hREV3 encoding a putative human DNA polymerase zeta
  JOURNAL   Carcinogenesis 19 (5), 945-949 (1998)
   PUBMED   9635887
REFERENCE   10 (bases 1 to 10706)
  AUTHORS   Morelli,C., Mungall,A.J., Negrini,M., Barbanti-Brodano,G. and
            Croce,C.M.
  TITLE     Alternative splicing, genomic structure, and fine chromosome
            localization of REV3L
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 18-20 (1998)
   PUBMED   9925914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136310.15, AL512325.9 and
            AL080317.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene represents the catalytic
            subunit of DNA polymerase zeta, which functions in translesion DNA
            synthesis. The encoded protein can be found in mitochondria, where
            it protects DNA from damage. Defects in this gene are a cause of
            Mobius syndrome. [provided by RefSeq, Jan 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071798.1, AF157476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368802.8/ ENSP00000357792.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AL136310.15        25233-25701         c
            470-659             AL512325.9         24312-24501         c
            660-734             AL512325.9         19509-19583         c
            735-895             AL512325.9         13499-13659         c
            896-992             AL512325.9         905-1001            c
            993-1087            AL080317.11        133320-133414       c
            1088-1192           AL080317.11        132340-132444       c
            1193-1277           AL080317.11        131235-131319       c
            1278-1426           AL080317.11        130999-131147       c
            1427-1546           AL080317.11        124559-124678       c
            1547-1784           AL080317.11        123216-123453       c
            1785-1927           AL080317.11        120935-121077       c
            1928-6089           AL080317.11        115830-119991       c
            6090-7003           AL080317.11        110349-111262       c
            7004-7083           AL080317.11        108499-108578       c
            7084-7209           AL080317.11        107087-107212       c
            7210-7402           AL080317.11        102056-102248       c
            7403-7514           AL080317.11        100248-100359       c
            7515-7630           AL080317.11        94910-95025         c
            7631-7749           AL080317.11        92452-92570         c
            7750-7868           AL080317.11        87159-87277         c
            7869-8010           AL080317.11        78703-78844         c
            8011-8255           AL080317.11        76357-76601         c
            8256-8364           AL080317.11        74910-75018         c
            8365-8571           AL080317.11        72766-72972         c
            8572-8681           AL080317.11        65803-65912         c
            8682-8796           AL080317.11        58501-58615         c
            8797-8934           AL080317.11        56586-56723         c
            8935-9125           AL080317.11        54303-54493         c
            9126-9372           AL080317.11        53087-53333         c
            9373-9582           AL080317.11        50595-50804         c
            9583-10706          AL080317.11        42267-43390         c
FEATURES             Location/Qualifiers
     source          1..10706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..10706
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /note="REV3 like, DNA directed polymerase zeta catalytic
                     subunit"
                     /db_xref="GeneID:5980"
                     /db_xref="HGNC:HGNC:9968"
                     /db_xref="MIM:602776"
     exon            1..469
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..9723
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /EC_number="2.7.7.7"
                     /note="isoform a is encoded by transcript variant 4;
                     Rev-3, yeast, homolog-like (polymerase, DNA, zeta); DNA
                     polymerase zeta catalytic subunit; REV3-like, polymerase
                     (DNA directed), zeta, catalytic subunit"
                     /codon_start=1
                     /product="DNA polymerase zeta catalytic subunit isoform a"
                     /protein_id="NP_001359007.1"
                     /db_xref="CCDS:CCDS5091.2"
                     /db_xref="GeneID:5980"
                     /db_xref="HGNC:HGNC:9968"
                     /db_xref="MIM:602776"
                     /translation="MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGAT
                     PAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVF
                     KVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYL
                     LQLFIDYNLYGMNLINLAAVKFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDE
                     IPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRN
                     ETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAE
                     LTLHSEVLSPEMLQCTPANMVEVHKDKESSKGHTRHKVEEALINEEAILNLMENSQTF
                     QPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFGNNKYPQNSD
                     DEENEPQIEKEEMELSLVMSQRWDSNIEEHCAKKRSLCRNTHRSSTEDDDSSSGEEME
                     WSDNSLLLASLSIPQLDGTADENSDNPLNNENSRTHSSVIATSKLSVKPSIFHKDAAT
                     LEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNTEKGLDNSVTSFTNESTYS
                     MKYPGSLSSTVHSENSHKENSKKEILPVSSCESSIFDYEEDIPSVTRQVPSRKYTNIR
                     KIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVSSEGNEKGNSTALSSLFPSSF
                     TENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMF
                     FPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGHQETSTKSSETGSTKDN
                     FIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFGDGTLETEQSFGLYG
                     NKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLKSRKRRKMSKKLP
                     PVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDS
                     PATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKRSHAILSPP
                     SPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKE
                     AMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDDG
                     KKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQLLF
                     KQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHP
                     SVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGM
                     SSKIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQS
                     KHSETCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPR
                     SLSEAISQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLS
                     NKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSS
                     QLDNSVSDDSPIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVP
                     ADQNLPQKFLSDAVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPE
                     IFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSK
                     EVFLSLPQPNNSDWIQGHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVS
                     RNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLS
                     ETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSA
                     MTQNPRPGSPLRSGQGVVNKGSSNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEY
                     ERSKKLPKTKPTGVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQ
                     IALQAPTTGCSQTASESQMLPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPI
                     SPDSKALNGDDRPSSPVEELPSLAFENFLKPIKDGIQKSPCSEPQEPLVISPINTRAR
                     TGKCESLCFHSTPIIQRKLLERLPEAPGLSPLSTEPKTQKLSNKKGSNTDTLRRVLLT
                     QAKNQFAAVNTPQKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHA
                     RTRRDLEPDPEFDPICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVFSQDIRYQTP
                     LLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALS
                     IDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYT
                     FENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIG
                     KTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVP
                     LIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLR
                     VPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA
                     LSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDT
                     KKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCV
                     LQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLI
                     KQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQ
                     VGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIG
                     IDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQ
                     PQHVAVILNQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELS
                     KAPYLRQLLDQF"
     exon            470..659
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            660..734
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..895
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..992
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1087
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1192
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1277
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1426
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1546
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1784
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1927
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..6089
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            6090..7003
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7004..7083
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7084..7209
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7210..7402
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7403..7514
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7515..7630
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7631..7749
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7750..7868
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            7869..8010
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8011..8255
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8256..8364
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8365..8571
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8572..8681
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8682..8796
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8797..8934
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            8935..9125
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            9126..9372
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            9373..9582
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     exon            9583..10706
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10688..10693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /note="hexamer: AATAAA"
     polyA_site      10706
                     /gene="REV3L"
                     /gene_synonym="POLZ; REV3"
                     /note="major polyA site"
ORIGIN      
        1 gtgacatcat catcatggca acaagagctg cagcctggga ccgaggagcc cgtgtgattc
       61 ccggcggtgg cggcagtggc ggcagcacca gcaccgacga aagctcgagg gcttctctcc
      121 tgcggcccct tgccgggtgc tcctgaggag gcggcggcag cagcgcctac accgccccgc
      181 ccgccgctcc tcgaggtgcc tctgtgtgag gggagggggc cgtgccgaga aggggagggg
      241 gcgccgccgc cgctgcggag ggagccgccg ccgctgctgc tgccgctgcc gggtcgccag
      301 tgaagggagg cagtggcggc ggcggcgaac atgttttcag taaggatagt gactgcagac
      361 tactacatgg ccagcccgct gcaggggctg gatacctgcc aatcccccct cacccaggcc
      421 cctgtcaaga aggtgccggt ggtgcgagtc ttcggagcga ccccggcagg tcagaagaca
      481 tgtcttcatc tacatggcat ctttccttac ctctatgtgc catacgatgg ttatggacag
      541 cagccagaaa gctatctttc tcagatggca ttcagtatcg acagagcact taatgtggct
      601 ttaggcaatc catcttccac tgctcagcat gtgttcaaag tgtcattagt atcaggaatg
      661 cctttttatg gttatcatga gaaggaaaga cactttatga agatctatct ttacaatcct
      721 acaatggtga aaaggatatg tgaacttttg caaagcggag ccataatgaa taaattttac
      781 cagcctcatg aagcgcatat tccctacctc ctacagctct tcattgacta caatctttat
      841 ggcatgaatt taataaatct ggctgctgtc aagttccgaa aagcaagaag gaaaagtaat
      901 acattgcatg caactggatc ctgcaagaat catttatcag gaaattctct tgctgatact
      961 ttatttcggt gggaacaaga tgaaatacca agctctttaa tattggaagg tgttgaacca
     1021 cagagtacat gtgaattaga agtggatgct gtagctgctg atatcttaaa tcgtctggac
     1081 attgaagctc aaattggtgg aaaccctggt ctacaggcca tatgggaaga tgaaaagcaa
     1141 cggcgaagaa acagaaatga aacttctcaa atgagccaac ctgagtcaca agatcacagg
     1201 tttgtgccag caacagaaag tgaaaaaaaa tttcagaaga gacttcagga aattctcaaa
     1261 cagaatgatt tctctgtaac attatcagga tctgtggact acagcgatgg atcccaggag
     1321 ttctctgctg agttaacatt gcactctgag gttctgtctc ctgaaatgct tcagtgtaca
     1381 ccagccaata tggtagaagt tcacaaagac aaagagtcaa gcaaaggtca cactagacac
     1441 aaagtggaag aagctcttat taatgaagaa gcaattttga accttatgga aaatagtcag
     1501 acttttcagc ctttgaccca aagactgagt gagtcacctg ttttcatgga cagtagtcct
     1561 gatgaggctc tggtacatct tcttgctggt ttggaaagtg atggatatcg gggggaaaga
     1621 aataggatgc catcaccatg tcgctccttt ggaaataata aatatccaca aaatagtgat
     1681 gatgaagaaa atgaaccaca gattgaaaaa gaggaaatgg agcttagttt ggtgatgtcc
     1741 cagagatggg acagcaatat tgaagaacat tgtgccaaaa agagatcact gtgcagaaat
     1801 acccacagaa gttcaactga agatgatgac tcatcttcag gagaagaaat ggaatggagt
     1861 gataacagtt tgcttctagc cagtctttct atacctcagt tagatggaac tgcagatgaa
     1921 aatagtgaca atccattgaa caatgaaaat tctagaaccc actcttctgt aattgcaaca
     1981 agcaagcttt cagttaaacc ctccatcttt cacaaagatg ctgctacatt agaaccctca
     2041 tcttctgcta agattacctt tcagtgtaaa cacacaagtg ccctttcttc ccatgttttg
     2101 aacaaggaag atttaattga agacctttca cagacaaaca aaaatacaga aaaaggtcta
     2161 gataactcag tcacttcttt tacaaacgaa agcacttatt ctatgaaata ccctggatct
     2221 ttaagcagta ctgttcattc agaaaattct cataaagaga atagtaagaa agagatcctc
     2281 ccagtatctt cctgtgaaag tagtattttt gattatgaag aagatattcc atctgttaca
     2341 agacaagtac caagtagaaa atatacaaac attagaaaaa tcgaaaagga ttcccctttt
     2401 atacatatgc accgtcaccc taacgagaat acattgggca aaaattcttt caacttttct
     2461 gacttaaatc attcaaaaaa taaagtatcc tctgaaggaa atgaaaaagg aaacagcaca
     2521 gctctgagta gtttattccc ttcatcattt actgaaaatt gtgaattact gtcatgctca
     2581 ggggagaata gaactatggt gcattctctt aatagcactg ctgatgaaag tggactaaat
     2641 aaacttaaaa ttaggtatga agaatttcaa gaacataaaa cagaaaagcc aagcctcagc
     2701 cagcaagcag cacactatat gttttttccc agtgttgttc tttctaactg tcttactaga
     2761 ccacagaaac tatctcctgt cacatataaa ttacaacctg gcaataaacc atcccggtta
     2821 aaattgaata aaaggaaact tgcaggtcat caggagactt ctaccaaaag tagtgagact
     2881 ggatccacaa aagataattt tatacaaaat aatccttgta atagtaatcc tgagaaggat
     2941 aatgcattgg ctagtgattt aactaaaacc actcgtggag cttttgaaaa taaaacaccc
     3001 acagatggtt ttatagactg tcactttgga gatggaacgt tagaaactga gcagtccttt
     3061 ggactatatg gaaataaata cacacttaga gccaaacgca aggtaaatta tgagactgaa
     3121 gacagtgagt caagttttgt aactcacaac tcaaaaatta gtctacctca tcccatggaa
     3181 attggtgaaa gtttagatgg aactctcaaa tcccgaaaac gaagaaaaat gtctaaaaag
     3241 ctgccccctg tcatcataaa gtatattatt attaatagat ttagagggag aaaaaatatg
     3301 cttgtgaagc taggaaaaat agactctaaa gaaaaacaag taatattaac agaagaaaaa
     3361 atggaactat ataaaaagct tgcacctttg aaggactttt ggccaaaagt tcccgactcc
     3421 cctgcaacca aatatcccat ttatccacta acaccaaaga aaagtcacag aagaaagtca
     3481 aaacataaat ctgctaagaa aaaaactggt aaacaacaaa ggacaaataa tgaaaatatt
     3541 aaaagaactt tgtctttcag gaaaaaacgg tcacatgcta ttctttctcc tccctcacca
     3601 tcttacaatg ctgaaaccga agattgtgac ctgaattata gtgatgttat gtctaaacta
     3661 ggttttcttt ctgagagaag cacaagtccc ataaattctt ctccacctcg ctgctggtct
     3721 cccacagatc caagagctga agaaatcatg gctgctgcag aaaaagaggc aatgcttttt
     3781 aagggtccta atgtatataa gaagactgtt aattctcgta taggaaaaac tagtcgcgca
     3841 agagcacaga ttaagaaatc aaaagcaaag cttgctaatc cctctatagt tactaagaaa
     3901 aggaacaaac gaaatcagac aaataaacta gtagatgatg gaaaaaagaa accaagagca
     3961 aaacaaaaaa caaatgagaa aggtacatcg agaaagcata caacacttaa ggatgaaaaa
     4021 ataaaatctc agtctggtgc tgaggttaag tttgtactga aacaccagaa tgtgtctgaa
     4081 tttgcaagta gttctggagg ctctcaacta ctttttaaac agaaagatat gccactaatg
     4141 ggctctgctg tagatcatcc cctttctgct tccctaccca ctggaattaa tgcacaacag
     4201 aagttatctg gctgcttttc ttctttctta gaaagcaaga agtctgtaga tttgcagaca
     4261 ttccccagtt cacgagatga tttgcatcca tcagttgttt gtaattctat aggacctgga
     4321 gtctcaaaaa ttaatgttca aaggcctcat aatcaaagtg ctatgtttac tctaaaggaa
     4381 tcaacgttaa ttcaaaaaaa tatatttgac ctttccaatc atttatctca ggtagcacag
     4441 aatacacaga tatcttctgg tatgtcctca aagatagaag ataatgcaaa taatatacaa
     4501 agaaactatt tgtcatcaat cggaaagtta agtgaatatc gcaattccct agaatcaaag
     4561 ctggaccaag catatacccc taattttttg cattgcaaag acagtcagca gcagattgtg
     4621 tgcatagcgg aacagtcaaa gcacagtgaa acttgttctc cgggaaatac agcttcagag
     4681 gaaagccaaa tgcctaataa ttgctttgta acttccttga gaagtccaat caaacaaata
     4741 gcatgggagc aaaagcaaag gggctttatt ttagatatgt caaattttaa acctgaaaga
     4801 gtaaaaccga ggtcgttatc agaagcaatt tcacaaacca aagcactttc tcagtgtaaa
     4861 aatcgaaatg tgtcaacacc ttcagcattt ggtgaaggac agtctggact ggcagttcta
     4921 aaagaattgt tacaaaaaag acagcagaaa gcacaaaatg caaatactac acaagaccca
     4981 ttatccaata aacatcaacc aaataaaaat atttctggtt cccttgagca taacaaagca
     5041 aataaacgga cacgatcggt aacgtcccca agaaaacctc gaactcccag aagtacaaaa
     5101 caaaaagaaa aaatccccaa acttctcaaa gtagactctt taaatttaca aaactctagc
     5161 cagttggata actctgtatc agatgatagt cccatctttt tttcagatcc aggctttgaa
     5221 agttgttact cacttgaaga tagtttatct cctgaacata attataattt tgatattaac
     5281 acaataggtc agactggatt ttgtagcttt tattctggaa gtcagtttgt cccagctgat
     5341 cagaatttgc ctcagaagtt cctaagtgat gctgttcagg atctttttcc aggacaagct
     5401 atagaaaaaa atgagttttt aagtcatgac aaccagaaat gtgatgaaga caagcatcat
     5461 accacagact cagcctcatg gattagatct ggtactttaa gtcctgaaat ttttgagaag
     5521 tcaaccatag atagcaatga gaatcgtcgc cacaaccagt ggaaaaatag ctttcatcct
     5581 ctaacaactc ggtctaactc aataatggat tctttctgtg ttcagcaggc agaagactgt
     5641 ctaagtgaaa aatctagatt gaataggagt tcagtaagca aagaagtgtt tcttagcctc
     5701 ccacagccaa acaattcaga ctggattcaa ggtcacacca gaaaagaaat gggacagtct
     5761 cttgactcag ccaatacctc ttttactgca atactctcct cccctgatgg tgaacttgta
     5821 gacgtggcct gtgaagattt agaactgtat gtttcaagaa acaatgatat gttgacacca
     5881 actcctgata gttcaccaag atctactagc tctccttcac aatctaaaaa tggcagcttc
     5941 acccctcgaa ctgctaacat tctgaaacca cttatgtccc ccccaagtag ggaagaaatt
     6001 atggcaactt tgttggatca tgacctgtct gagactattt accaggaacc attttgcagt
     6061 aatccttctg atgtaccaga aaagcccagg gagattggtg gacggctcct catggtagaa
     6121 actcgacttg caaatgatct ggctgagttt gagggagact tttccttgga aggacttcgt
     6181 ctttggaaaa cagcattctc agcaatgact cagaatccaa ggccagggtc accccttcgc
     6241 agtggccaag gagttgtcaa taaagggtca agtaatagcc ctaagatggt tgaagataaa
     6301 aaaattgtga ttatgccttg caaatgtgcc ccaagtcgac aactggttca agtgtggctt
     6361 caagccaaag aagaatacga acgttccaag aaactgccta aaaccaagcc aactggagtt
     6421 gtaaaatctg ctgagaactt tagctcttca gttaacccag atgacaaacc tgtagtgcct
     6481 ccaaaaatgg atgtaagtcc atgtatactc cccactacag cacataccaa ggaggatgtt
     6541 gataattctc agattgcttt acaagcacca accacgggat gtagtcaaac tgcaagtgaa
     6601 agtcagatgc tgccaccagt tgcctctgca agtgatcccg aaaaagatga agatgatgat
     6661 gataactatt acattagtta tagctcccct gattctccag taattccccc ttggcaacaa
     6721 ccaatatccc cagattccaa agcattaaat ggagatgata gaccctcatc accagtagag
     6781 gagctgcctt cattggcttt tgagaacttc ttaaagccaa taaaagatgg tatacaaaaa
     6841 agcccctgca gtgagcctca agagcctcta gtgatatctc caattaatac tagggcaaga
     6901 actgggaaat gtgaatcact ttgctttcat agtacaccaa tcatacagag aaaacttctg
     6961 gaaaggcttc ctgaagcacc tggccttagc ccattatcaa cagaaccaaa aacacagaag
     7021 ttgagtaata agaaaggaag taatactgac actcttagaa gagtactgtt aacacaagca
     7081 aagaatcaat ttgcagcagt aaatacccca cagaaagaaa cttctcagat tgatggacca
     7141 tctttaaaca atacttacgg tttcaaagtc agcatacaaa acttacagga ggcaaaagct
     7201 ttacatgaga tacaaaatct taccctaatc agtgtggagt tgcatgctcg aactagacga
     7261 gacttagaac cggatcctga atttgaccca atctgtgctc tgttctactg catctcatct
     7321 gacactccac tgccagatac agaaaaaaca gaactcacag gtgtaatagt gattgataaa
     7381 gacaagacag ttttcagtca agatatcaga tatcagactc cattacttat tagatctgga
     7441 attacaggac tcgaagtcac ctatgctgct gatgagaagg cactttttca tgaaattgca
     7501 aatataataa agaggtatga tcctgatatt ctgctaggat atgagattca gatgcattcc
     7561 tggggttacc tcttacaaag ggctgccgct ttaagtattg acttatgtcg gatgatctct
     7621 cgggtgccag atgacaaaat tgagaacaga tttgcagctg aaagagatga gtatggatca
     7681 tatacaatga gtgagataaa tattgttggc cgaattacac taaatctttg gagaatcatg
     7741 agaaatgagg tggctctaac taactacacc tttgaaaatg tgagctttca tgttcttcat
     7801 cagcgttttc ccctctttac ctttcgagtc ttgtcagact ggtttgataa caagacagat
     7861 ctatacagat ggaaaatggt tgatcattat gttagccgtg tccgtggaaa tctccaaatg
     7921 ttagaacagc tggacctgat tgggaaaacc agtgagatgg ctagactttt tggcattcag
     7981 tttttacatg tactgacaag gggttcacag taccgtgtgg aatcaatgat gttgcgtatt
     8041 gctaaaccaa tgaactatat tcctgtgaca cctagtgttc agcaaagatc ccagatgaga
     8101 gccccacagt gtgttcctct aattatggag cctgaatccc gcttctatag caactctgtt
     8161 ctcgttttgg atttccaatc actttatcct tctattgtga ttgcatataa ctactgcttt
     8221 tccacctgcc ttggccatgt ggagaacttg ggaaagtatg atgagttcaa atttggctgt
     8281 acctctctga gagtacctcc agatttactt taccaagtta ggcatgatat cacagtgtcc
     8341 cccaatggag tagcttttgt caagccttca gtaagaaaag gtgtactacc aagaatgctt
     8401 gaagaaattt tgaagactag atttatggtg aagcagtcaa tgaaggctta caagcaagac
     8461 agagccctgt cacgaatgct tgatgcgcgt cagttgggac ttaagctgat agcaaatgtc
     8521 acatttggct atacatctgc taatttttct gggagaatgc catgcattga ggttggcgat
     8581 agtattgttc acaaagccag agagaccttg gaacgagcta ttaaactggt gaatgatacc
     8641 aagaaatggg gggctagggt tgtatatggc gatactgaca gtatgtttgt gctactgaaa
     8701 ggagccacta aggagcagtc ttttaagatt ggtcaggaaa ttgccgaagc tgtaactgct
     8761 accaatccta aaccagtgaa attgaagttt gaaaaggtat atttgccctg tgttttacaa
     8821 acaaaaaaga ggtatgtggg ttacatgtat gaaacactgg atcagaagga cccagtattt
     8881 gatgcaaaag gaatagaaac agtcagaaga gattcctgcc ctgctgtttc taagatactt
     8941 gagcgttctc taaagctgct atttgaaacg agagatataa gtctaattaa acagtatgtt
     9001 cagcgacaat gtatgaagct tctggaagga aaggccagca tacaagactt tatctttgcc
     9061 aaggaataca gaggaagttt ttcttataaa ccaggagctt gtgtgccagc ccttgaactt
     9121 acaaggaaaa tgctgactta tgaccggcgc tctgagcctc aggttgggga gcgagtgcca
     9181 tacgtcatca tttatgggac ccccggagta ccacttatcc agcttgtaag gcgcccagtg
     9241 gaagtcctgc aggacccaac tctgagactg aatgctactt actatattac caagcaaatc
     9301 cttccaccct tggcaagaat cttctcactt attggtattg atgtcttcag ctggtatcat
     9361 gaattaccaa ggatccataa agctaccagc tcctcgcgaa gtgaacctga agggcggaaa
     9421 ggcactattt cacaatattt tactacctta cactgtcctg tgtgtgatga cctaactcag
     9481 catggcatct gtagtaaatg tcggagccaa cctcagcatg ttgcagtcat cctcaaccaa
     9541 gaaatccggg agttggaacg tcaacaggag caacttgtaa agatatgcaa gaactgtaca
     9601 ggttgctttg atcgacacat cccatgtgtt tctctgaact gcccagtact tttcaaactc
     9661 tcccgagtaa atagagaatt gtccaaggca ccatatctcc ggcagttatt agaccagttt
     9721 taaattgtca atatcacagt attacaggtg ctattttttt cagtgcttac cactaaactg
     9781 ttgtgcatgg tgctttttaa ctttcatcga gtcaaggatg ttcactgtct gttatctgaa
     9841 gactatgaag acttctatgc taaccgaatt aaaatgtact tgttgatctc tgaatagctc
     9901 acttcttaca atgtacaaat tcctcattct gtcacctttt aaacattgtt ttataatgca
     9961 ggtgttggat ttgctccagt atgtgtacca tcttgtaaat tcatttgagt agatcatgtt
    10021 tacttcccag tggaaggagc actgaaaacc tcttaaagaa aaagcatttg tgtgttttcc
    10081 ttgaactgtc tgtatcaaga cgtgttactt cgagatatcc attcacttta taattttgac
    10141 tgcaaaatat tttgtaaata cactttttta cttttcaaac gagcaaaata atgtgcaatg
    10201 atttttatac aaatgatttt caagttgttt ggtatatttc ctctaggttt tgcttgactc
    10261 aaagtagatc gttattttga tcaaactgtg caaacagtag taccacgtgt agcattttga
    10321 aacattattt ttttttaaaa aatgctgtct tgctttagct attaatgggg cattgtgagg
    10381 aactgtgcaa agacattttt gttacaaacc tgtgggcctg ttgcaatact ttaaaaataa
    10441 aaaattttat tccatttgct tgttttgtat agacatttct attgcttcta aatatactta
    10501 aaatattttc tttccttatg tactgtacag ttaatcttat ttgccatcat cttgaacaca
    10561 aaatgtgtat ttagaatatt tgtataactg tgtaaaataa aaaaggaatt atgtggtcag
    10621 tgcattgttt tttaaactgg aaatcatttt gttttaaaag ttaataatgg aaaccatatt
    10681 aaaattgaat aaaatataaa ataata
//
