LOCUS       NP_060220                610 aa            linear   PRI 06-AUG-2024
DEFINITION  all-trans-retinol 13,14-reductase precursor [Homo sapiens].
ACCESSION   NP_060220
VERSION     NP_060220.3
DBSOURCE    REFSEQ: accession NM_017750.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 610)
  AUTHORS   Kiefer,M.F., Meng,Y., Yang,N., Vahrenbrink,M., Wulff,S., Li,C.,
            Wowro,S.J., Petricek,K.M., Sommerfeld,M., Flores,R.E.,
            Obermayer,B., Piepelow,K., Klaus,S., Hartl,K., Guillot,A.,
            Tacke,F., Sigal,M. and Schupp,M.
  TITLE     Intestinal retinol saturase is implicated in the development of
            obesity and epithelial homeostasis upon injury
  JOURNAL   Am J Physiol Endocrinol Metab 327 (2), E203-E216 (2024)
   PUBMED   38895981
  REMARK    GeneRIF: Intestinal retinol saturase is implicated in the
            development of obesity and epithelial homeostasis upon injury.
REFERENCE   2  (residues 1 to 610)
  AUTHORS   Tu,Q., Liu,X., Yao,X., Li,R., Liu,G., Jiang,H., Li,K., Chen,Q.,
            Huang,X., Chang,Q., Xu,G., Zhu,H., Shi,P. and Zhao,B.
  TITLE     RETSAT associates with DDX39B to promote fork restarting and
            resistance to gemcitabine based chemotherapy in pancreatic ductal
            adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 41 (1), 274 (2022)
   PUBMED   36109793
  REMARK    GeneRIF: RETSAT associates with DDX39B to promote fork restarting
            and resistance to gemcitabine based chemotherapy in pancreatic
            ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 610)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (residues 1 to 610)
  AUTHORS   Schupp,M., Lefterova,M.I., Janke,J., Leitner,K., Cristancho,A.G.,
            Mullican,S.E., Qatanani,M., Szwergold,N., Steger,D.J., Curtin,J.C.,
            Kim,R.J., Suh,M.J., Albert,M.R., Engeli,S., Gudas,L.J. and
            Lazar,M.A.
  TITLE     Retinol saturase promotes adipogenesis and is downregulated in
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 106 (4), 1105-1110 (2009)
   PUBMED   19139408
  REMARK    GeneRIF: RetSat plays an important role in the biology of
            adipocytes, where it favors normal differentiation, yet is reduced
            in the obese state.
            Erratum:[Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4571. Suh,
            Moojin [corrected to Suh, Moo-Jin]]
REFERENCE   5  (residues 1 to 610)
  AUTHORS   Moise,A.R., Kuksa,V., Imanishi,Y. and Palczewski,K.
  TITLE     Identification of all-trans-retinol:all-trans-13,14-dihydroretinol
            saturase
  JOURNAL   J Biol Chem 279 (48), 50230-50242 (2004)
   PUBMED   15358783
REFERENCE   6  (residues 1 to 610)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075261.1, DB001412.1, BC068517.1 and BQ448420.1.
            
            On Sep 17, 2008 this sequence version replaced NP_060220.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068517.1, SRR1803617.125033.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295802.9/ ENSP00000295802.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     Protein         1..610
                     /product="all-trans-retinol 13,14-reductase precursor"
                     /EC_number="1.3.99.23"
                     /note="all-trans-13,14-dihydroretinol saturase;
                     all-trans-retinol 13,14-reductase; PPAR-alpha-regulated
                     and starvation-induced gene protein"
                     /calculated_mol_wt=64844
     sig_peptide     1..18
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6NUM9.2)"
                     /calculated_mol_wt=1994
     mat_peptide     19..610
                     /product="All-trans-retinol 13,14-reductase.
                     /id=PRO_0000225665"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NUM9.2)"
                     /calculated_mol_wt=64844
     Region          69..590
                     /region_name="COG1233"
                     /note="Phytoene dehydrogenase-related protein [Secondary
                     metabolites biosynthesis, transport and catabolism]"
                     /db_xref="CDD:440846"
     CDS             1..610
                     /gene="RETSAT"
                     /coded_by="NM_017750.4:22..1854"
                     /db_xref="CCDS:CCDS1972.1"
                     /db_xref="GeneID:54884"
                     /db_xref="HGNC:HGNC:25991"
                     /db_xref="MIM:617597"
ORIGIN      
        1 mwlplvllla vlllavlckv ylglfsgssp npfsedvkrp paplvtdkea rkkvlkqafs
       61 anqvpekldv vvigsgfggl aaaailakag krvlvleqht kaggcchtfg knglefdtgi
      121 hyigrmeegs igrfildqit egqldwapls spfdimvleg pngrkeypmy sgekayiqgl
      181 kekfpqeeai idkyiklvkv vssgaphail lkflplpvvq lldrcglltr fspflqastq
      241 slaevlqqlg asselqavls yifptygvtp nhsafsmhal lvnhymkggf yprggsseia
      301 fhtipviqra ggavltkatv qsvlldsagk acgvsvkkgh elvniycpiv vsnaglfnty
      361 ehllpgnarc lpgvkqqlgt vrpglgmtsv ficlrgtked lhlpstnyyv yydtdmdqam
      421 eryvsmpree aaehipllff afpsakdptw edrfpgrstm imliptayew feewqaelkg
      481 krgsdyetfk nsfveasmsv vlklfpqleg kvesvtagsp ltnqfylaap rgacygadhd
      541 lgrlhpcvma slraqspipn lyltgqdift cglvgalqga llcssailkr nlysdlknld
      601 sriraqkkkn
//
