LOCUS       NM_178126               3749 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens reticulophagy regulator family member 3 (RETREG3),
            transcript variant 1, mRNA.
ACCESSION   NM_178126
VERSION     NM_178126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Reggio,A., Buonomo,V., Berkane,R., Bhaskara,R.M., Tellechea,M.,
            Peluso,I., Polishchuk,E., Di Lorenzo,G., Cirillo,C., Esposito,M.,
            Hussain,A., Huebner,A.K., Hubner,C.A., Settembre,C., Hummer,G.,
            Grumati,P. and Stolz,A.
  TITLE     Role of FAM134 paralogues in endoplasmic reticulum remodeling,
            ER-phagy, and Collagen quality control
  JOURNAL   EMBO Rep 22 (9), e52289 (2021)
   PUBMED   34338405
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Kumar,D., Lak,B., Suntio,T., Vihinen,H., Belevich,I., Viita,T.,
            Xiaonan,L., Vartiainen,A., Vartiainen,M., Varjosalo,M. and
            Jokitalo,E.
  TITLE     RTN4B interacting protein FAM134C promotes ER membrane curvature
            and has a functional role in autophagy
  JOURNAL   Mol Biol Cell 32 (12), 1158-1170 (2021)
   PUBMED   33826365
  REMARK    GeneRIF: RTN4B interacting protein FAM134C promotes ER membrane
            curvature and has a functional role in autophagy.
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Gordon,D.E., Hiatt,J., Bouhaddou,M., Rezelj,V.V., Ulferts,S.,
            Braberg,H., Jureka,A.S., Obernier,K., Guo,J.Z., Batra,J.,
            Kaake,R.M., Weckstein,A.R., Owens,T.W., Gupta,M., Pourmal,S.,
            Titus,E.W., Cakir,M., Soucheray,M., McGregor,M., Cakir,Z., Jang,G.,
            O'Meara,M.J., Tummino,T.A., Zhang,Z., Foussard,H., Rojc,A.,
            Zhou,Y., Kuchenov,D., Huttenhain,R., Xu,J., Eckhardt,M.,
            Swaney,D.L., Fabius,J.M., Ummadi,M., Tutuncuoglu,B., Rathore,U.,
            Modak,M., Haas,P., Haas,K.M., Naing,Z.Z.C., Pulido,E.H., Shi,Y.,
            Barrio-Hernandez,I., Memon,D., Petsalaki,E., Dunham,A.,
            Marrero,M.C., Burke,D., Koh,C., Vallet,T., Silvas,J.A.,
            Azumaya,C.M., Billesbolle,C., Brilot,A.F., Campbell,M.G.,
            Diallo,A., Dickinson,M.S., Diwanji,D., Herrera,N., Hoppe,N.,
            Kratochvil,H.T., Liu,Y., Merz,G.E., Moritz,M., Nguyen,H.C.,
            Nowotny,C., Puchades,C., Rizo,A.N., Schulze-Gahmen,U., Smith,A.M.,
            Sun,M., Young,I.D., Zhao,J., Asarnow,D., Biel,J., Bowen,A.,
            Braxton,J.R., Chen,J., Chio,C.M., Chio,U.S., Deshpande,I., Doan,L.,
            Faust,B., Flores,S., Jin,M., Kim,K., Lam,V.L., Li,F., Li,J.,
            Li,Y.L., Li,Y., Liu,X., Lo,M., Lopez,K.E., Melo,A.A., Moss,F.R.
            3rd, Nguyen,P., Paulino,J., Pawar,K.I., Peters,J.K., Pospiech,T.H.
            Jr., Safari,M., Sangwan,S., Schaefer,K., Thomas,P.V., Thwin,A.C.,
            Trenker,R., Tse,E., Tsui,T.K.M., Wang,F., Whitis,N., Yu,Z.,
            Zhang,K., Zhang,Y., Zhou,F., Saltzberg,D., Hodder,A.J.,
            Shun-Shion,A.S., Williams,D.M., White,K.M., Rosales,R., Kehrer,T.,
            Miorin,L., Moreno,E., Patel,A.H., Rihn,S., Khalid,M.M.,
            Vallejo-Gracia,A., Fozouni,P., Simoneau,C.R., Roth,T.L., Wu,D.,
            Karim,M.A., Ghoussaini,M., Dunham,I., Berardi,F., Weigang,S.,
            Chazal,M., Park,J., Logue,J., McGrath,M., Weston,S., Haupt,R.,
            Hastie,C.J., Elliott,M., Brown,F., Burness,K.A., Reid,E.,
            Dorward,M., Johnson,C., Wilkinson,S.G., Geyer,A., Giesel,D.M.,
            Baillie,C., Raggett,S., Leech,H., Toth,R., Goodman,N., Keough,K.C.,
            Lind,A.L., Klesh,R.J., Hemphill,K.R., Carlson-Stevermer,J., Oki,J.,
            Holden,K., Maures,T., Pollard,K.S., Sali,A., Agard,D.A., Cheng,Y.,
            Fraser,J.S., Frost,A., Jura,N., Kortemme,T., Manglik,A.,
            Southworth,D.R., Stroud,R.M., Alessi,D.R., Davies,P., Frieman,M.B.,
            Ideker,T., Abate,C., Jouvenet,N., Kochs,G., Shoichet,B., Ott,M.,
            Palmarini,M., Shokat,K.M., Garcia-Sastre,A., Rassen,J.A.,
            Grosse,R., Rosenberg,O.S., Verba,K.A., Basler,C.F., Vignuzzi,M.,
            Peden,A.A., Beltrao,P. and Krogan,N.J.
  CONSRTM   QCRG Structural Biology Consortium; Zoonomia Consortium
  TITLE     Comparative host-coronavirus protein interaction networks reveal
            pan-viral disease mechanisms
  JOURNAL   Science 370 (6521) (2020)
   PUBMED   33060197
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Khaminets,A., Heinrich,T., Mari,M., Grumati,P., Huebner,A.K.,
            Akutsu,M., Liebmann,L., Stolz,A., Nietzsche,S., Koch,N., Mauthe,M.,
            Katona,I., Qualmann,B., Weis,J., Reggiori,F., Kurth,I., Hubner,C.A.
            and Dikic,I.
  TITLE     Regulation of endoplasmic reticulum turnover by selective autophagy
  JOURNAL   Nature 522 (7556), 354-358 (2015)
   PUBMED   26040720
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Wang,J.L., Tong,C.W., Chang,W.T. and Huang,A.M.
  TITLE     Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and
            differentially regulate neurite outgrowth in neuroblastoma cells
            and hippocampal neurons
  JOURNAL   Gene 529 (1), 7-15 (2013)
   PUBMED   23939472
  REMARK    GeneRIF: We verified that NRF-1 positively regulates FAM134C and
            ENOX1, and negatively regulates C3orf10 in human neuroblastoma
            IMR-32 cells and primary rat cortical neurons.
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Rommens,J.M., Durocher,F., McArthur,J., Tonin,P., LeBlanc,J.F.,
            Allen,T., Samson,C., Ferri,L., Narod,S., Morgan,K. et al.
  TITLE     Generation of a transcription map at the HSD17B locus centromeric
            to BRCA1 at 17q21
  JOURNAL   Genomics 28 (3), 530-542 (1995)
   PUBMED   7490091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC067852.23.
            
            On Nov 23, 2018 this sequence version replaced NM_178126.3.
            
            Transcript Variant: This variant (1) represents the longer, protein
            coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049370.1, BX647175.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309428.10/ ENSP00000309432.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC067852.23        68654-68942
            290-396             AC067852.23        85866-85972
            397-427             AC067852.23        90164-90194
            428-554             AC067852.23        91137-91263
            555-639             AC067852.23        91891-91975
            640-777             AC067852.23        92766-92903
            778-860             AC067852.23        94448-94530
            861-993             AC067852.23        95222-95354
            994-3749            AC067852.23        95758-98513
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..3749
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /note="reticulophagy regulator family member 3"
                     /db_xref="GeneID:162427"
                     /db_xref="HGNC:HGNC:27258"
                     /db_xref="MIM:616498"
     exon            1..289
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1451
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /note="protein FAM134C; family with sequence similarity
                     134 member C"
                     /codon_start=1
                     /product="reticulophagy regulator 3"
                     /protein_id="NP_835227.1"
                     /db_xref="CCDS:CCDS11432.1"
                     /db_xref="GeneID:162427"
                     /db_xref="HGNC:HGNC:27258"
                     /db_xref="MIM:616498"
                     /translation="MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVE
                     VLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVC
                     IDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLL
                     FKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVR
                     LKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTV
                     ARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFP
                     SINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSN
                     LTSNLASLVSQGMIQLALSGASQPGPSGAPAQRATRGFLRSPSSDLDTDAEGDDFELL
                     DQSELSQLDPASSRSH"
     exon            290..396
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            397..427
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            428..554
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            555..639
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            640..777
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            778..860
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            861..993
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     exon            994..3749
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3728..3733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /note="hexamer: AATAAA"
     polyA_site      3749
                     /gene="RETREG3"
                     /gene_synonym="FAM134C"
                     /note="major polyA site"
ORIGIN      
        1 attgtgactt gtcgggccac ggccccggat gttgtggctg ccgcggggag atggctgagg
       61 ccgaaggggt tcccacgacc ccaggcccgg cttcggggtc gactttcagg ggccgccgag
      121 atgtgtcagg ctcctgggag cgggaccagc aggttgaggc ggcgcagcgg gccctggtgg
      181 aggtgctggg gccttacgag cctctgctga gtcgggtgca ggcagccctg gtgtgggagc
      241 ggccagctag gagcgctctg tggtgcctgg ggctgaacgc ggctttctgg ttttttgccc
      301 tgacatctct tcgtcttgtg tttttacttg catttggctt gatgatcatt gtgtgtattg
      361 atcaatggaa gaacaaaatc tggcctgaaa taaaagtgcc aagacccgac gcattagaca
      421 atgagagctg gggctttgtg caccctcggt tgctcagcgt gcccgagctc tgccaccatg
      481 tagctgaagt ctgggttagt gggaccattt tcataaggaa tgttttgctt ttcaaaaagc
      541 aaaacccagg caagttctgc ttgctgagct gtgggatact gacctttttg gctgtcttgg
      601 gccgctacgt ccctgggctt ctgctgtcct acttgatgct tgtcactgtc atgatgtggc
      661 cccttgctgt gtaccaccga ctgtgggatc gagcatatgt gcggctgaag ccagctctgc
      721 agcggctaga cttcagtgtc cgtggctaca tgatgtccaa gcagagagag agacaattac
      781 gccgcagagc tctccaccca gaacgagcca tggacaacca cagtgacagc gaagaggagc
      841 ttgctgcctt ctgtcctcag ctggacgatt ctactgttgc cagggaattg gccatcacag
      901 actctgagca ctcagacgct gaagtctcct gtacagacaa tggcacattc aatctttcaa
      961 ggggccaaac acctctaacg gaaggctctg aagacctaga tggtcacagt gatccagagg
     1021 aatcctttgc cagagacctt ccagacttcc cttccattaa tatggatcct gctggcctgg
     1081 atgatgagga cgacactagc attggcatgc ccagcttgat gtaccgttct ccgccagggg
     1141 ctgaggagcc ccaggcccca cctgccagcc gggacgaggc tgcgctgccg gagctcctgc
     1201 ttggtgctct tcctgtagga tccaacctca ccagcaacct tgccagcctg gtctcccagg
     1261 gtatgattca gctggccttg tcaggggcct cccaaccagg cccttctgga gcacctgccc
     1321 agagagcaac gagaggcttc ctccggtccc ccagttcaga cctggacact gatgctgagg
     1381 gggatgactt tgaacttctg gaccagtcgg agctgagtca gctggaccct gccagttcta
     1441 ggagccactg aggcagagac tccttttggg agtcactgtg gtttaggttt ttttctcccc
     1501 atcccactta aggtgatggg gcaagggaag aactcagctc ccctcccctg aattatattt
     1561 gtatgctggg tggcctggct gatgctcaga ggcctcctta gagaggacac tcactcccct
     1621 cccaccagct ggatgcccat ttctgagctc agtcactgaa gtgagagtgt gctcccccaa
     1681 gggaggcttc tctccatcag gatggtactt tgggggaaca aaatagtcag ggatattggt
     1741 tcccctttga ggaggtgctg ctgtttgctt ttaggtatga gtgctcaggg gccctcactg
     1801 aaagagccca tgcctgcctt cctcctttca tcgcctctct agagccccca aagtcaggca
     1861 gcagctggag tagttacatt gtcatcatct ttttttttga gacagtttcg ctctgttgcc
     1921 caggctggag tgcagtggtg tgatcttggc tttctgcaac gtctgccttc caggttgaag
     1981 aggttctcct gcctcagcct ccttagtagt gggattacag gtgcccgcta ctatgcccgg
     2041 ctaatttttc ttttggtatt tttagtagaa atggggtttc accatgttgg ccaggctggt
     2101 ctcaaactcc tgacctcaag tgagctgact gccttggcct cccagagtgc tgggattagt
     2161 cgtcatcttt tgttaaacca ggatttgatt tttttctttt cttttctttt cttttttttt
     2221 tttttgagac agagtctctc tctgttgccc aggctggagt gcagtggcac aatctcggct
     2281 cactgcagcc tccgcctgcc gggtcaagcg attctcctac ctcagcctcc tcagtagctg
     2341 agattacagg catgcaccac catgcccggc taattttttt gtgtttttag tagagatggg
     2401 gtttcaccgt gctggccagg ctggtctaga actcctgact gcaaatgatc agcccgcctc
     2461 agccacccaa agtgttggga ttacaggtgt gagccactgt gcccagcgtg attttttttt
     2521 ttttttaaag caaacttgtc ctttggtttt gcagaacagg cctgctccct ctcatctagc
     2581 ccatcatttc ttggggcctg aaccccagtg gtccaaagta ttgcttgtga aatttaaaaa
     2641 atgtgaatat gatgtgggga tgggcctctt ctacattacc ttggcccagg gggatcagct
     2701 ggctgggagg attagtgagc acctctgtat tttgaggtct gagtcttctg gagctgtgta
     2761 gttaatcttc ggtttctgat aacccctggg tccatctggc catcagcctc agcagtgagc
     2821 aaagcaatac catactcatt tctatgttcc tgttccttcc tctgctcctc ctttggagaa
     2881 gcaataattc atgggggatg atacagtagc actttacaaa tggctccatg tcattcatcc
     2941 caggggccat aatctcttgc accacctatt cttacttcct gttcagctcc tttacagctt
     3001 ttattttcaa ctgcttccca acttggtggg gcctccttta aggatgagcc aatagtaaga
     3061 atgtggctgt aatcagcaga gacccctctg aggggtatct gttctgcagc ccctagtgaa
     3121 atcatgtgat gtgagacaga aacctaaaca tggtacttga ttctaaacct gtgccagtct
     3181 atagcctctg cctccccaag cagagctcaa gccaaacgct tctgtcctct ttccttctgc
     3241 attaaccctt tgctgatcct caggggccac tcccccaaca cccctgtact tgggtgaggg
     3301 atgttggaca gagcctgttt tcatgtactg caggtggggg tgtgctgaca tgtttgctct
     3361 tggttgatgg agaaggtaca gaggccaggg agtgaaaatg gttgacagaa gagggaagag
     3421 ttaggtgtct catagtcact catagtgggg tggtcagggg taatggcatc tccccacttt
     3481 aggcttctca aacagacttt tgacacctct caagttcaga gctctgatgt ggaaagacag
     3541 gaggtgtggg gaaggagggg gatttcgtgt gtttgcatga gtgtgcgctt caggccttgg
     3601 gagttggcaa gagggaggga aggaaggaga gcaaaatctt cggaaggtgt ttcttgtacc
     3661 tgagggatcc tgccctgaat ctccatagtc tccactgtga actgaggagg ggaggggtgt
     3721 gctggggaat aaatcttgta tgagaacaa
//
