LOCUS       NM_024293               4556 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens reticulophagy regulator family member 2 (RETREG2),
            transcript variant 1, mRNA.
ACCESSION   NM_024293
VERSION     NM_024293.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4556)
  AUTHORS   Toyoda,Y., Cattin,C.J., Stewart,M.P., Poser,I., Theis,M.,
            Kurzchalia,T.V., Buchholz,F., Hyman,A.A. and Muller,D.J.
  TITLE     Genome-scale single-cell mechanical phenotyping reveals
            disease-related genes involved in mitotic rounding
  JOURNAL   Nat Commun 8 (1), 1266 (2017)
   PUBMED   29097687
  REMARK    GeneRIF: Depleting the endoplasmic reticulum-localized protein
            FAM134A impairs mitotic progression by affecting metaphase plate
            alignment and pressure generation by delocalizing cortical myosin
            II.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4556)
  AUTHORS   Khaminets,A., Heinrich,T., Mari,M., Grumati,P., Huebner,A.K.,
            Akutsu,M., Liebmann,L., Stolz,A., Nietzsche,S., Koch,N., Mauthe,M.,
            Katona,I., Qualmann,B., Weis,J., Reggiori,F., Kurth,I., Hubner,C.A.
            and Dikic,I.
  TITLE     Regulation of endoplasmic reticulum turnover by selective autophagy
  JOURNAL   Nature 522 (7556), 354-358 (2015)
   PUBMED   26040720
REFERENCE   3  (bases 1 to 4556)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   4  (bases 1 to 4556)
  AUTHORS   Zhang,J., Liu,G., Meng,Y., Lin,H. and Lu,Y.
  TITLE     MAG-2 promotes invasion, mobility and adherence capability of lung
            cancer cells by MMP-2, CD44 and intracellular calcium in vitro
  JOURNAL   Oncol Rep 21 (3), 697-706 (2009)
   PUBMED   19212629
  REMARK    GeneRIF: MAG-2 may be a novel causal gene for lung cancer invasion
            and metastasis.
REFERENCE   5  (bases 1 to 4556)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG723788.1, BG700888.1, BC141851.1, AL136758.2, AC068946.4 and
            BU615764.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024293.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.10067.1, AK074983.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430297.7/ ENSP00000395249.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               BG723788.1         64-446
            384-679             BG700888.1         409-704
            680-1546            BC141851.1         640-1506
            1547-2570           AL136758.2         179-1202
            2571-3915           AC068946.4         77848-79192
            3916-4556           BU615764.1         12-652              c
FEATURES             Location/Qualifiers
     source          1..4556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..4556
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="reticulophagy regulator family member 2"
                     /db_xref="GeneID:79137"
                     /db_xref="HGNC:HGNC:28450"
     exon            1..359
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1710
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM134A; metastasis associated gene-2; family with
                     sequence similarity 134 member A; reticulophagy regulator
                     2"
                     /codon_start=1
                     /product="reticulophagy regulator 2 isoform 1"
                     /protein_id="NP_077269.3"
                     /db_xref="CCDS:CCDS2434.1"
                     /db_xref="GeneID:79137"
                     /db_xref="HGNC:HGNC:28450"
                     /translation="MASGGGGGNTGAGGGPGMGLSLGLGLGLSLGMSEATSEAEEEAA
                     TAEAVGRLATTLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAAALNGLFWLLSSSSLR
                     PFFLLSVSLLAYFLLDLWQPRFLPDVSASSPEEPHSDSEGAGSGARPHLLSVPELCRY
                     LAESWLTFQIHLQELLQYKRQNPAQFCVRVCSGCAVLAVLGHYVPGIMISYIVLLSIL
                     LWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEANALHHKHDKRKRQGKNAPPGGDEPL
                     AETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLT
                     DVSEDLDQQSLPSEPEETLSRDLGEGEEGELAPPEDLLGRPQALSRQALDSEEEEEDV
                     AAKETLLRLSSPLHFVNTHFNGAGSPPDGVKCSPGGPVETLSPETVSGGLTALPGTLS
                     PPLCLVGSDPAPSPSILPPVPQDSPQPLPAPEEEEALTTEDFELLDQGELEQLNAELG
                     LEPETPPKPPDAPPLGPDIHSLVQSDQEAQAVAEP"
     exon            360..466
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..497
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..633
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..718
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..862
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..957
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1093
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..4556
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="hexamer: AATAAA"
     polyA_site      2573
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="major polyA site"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="hexamer: AATAAA"
     polyA_site      2807
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="major polyA site"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="hexamer: CATAAA"
     polyA_site      2863
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
     regulatory      4532..4537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
                     /note="hexamer: AATAAA"
     polyA_site      4556
                     /gene="RETREG2"
                     /gene_synonym="C2orf17; FAM134A; MAG-2"
ORIGIN      
        1 cttccgcctg acgcgccccc ggcggcggcc gcgcagccct ggctcctcgc gggctcgggc
       61 ggcggctgcg gcggggctat ggcgagcggc ggtggcgggg gtaacactgg cgcgggtggg
      121 gggccgggga tgggcctgag cctgggcctg ggtctgggtc tgagcctagg catgagtgag
      181 gccaccagtg aggcagagga ggaggcggcc acggccgagg cggtgggacg cctggccacg
      241 acgctgtggc tgcggctccg cggctgggag gcggtgctgg cggcggcgca gcggttgctg
      301 gtgtgggaga agccgctgca cagcctggtc acggcggccg cgctcaacgg cctcttctgg
      361 ttgctgtctt cctcgtccct ccggcccttc ttcctactca gcgtctcact tttggcctat
      421 tttctgctgg atctctggca gcctcgcttt ctccctgacg tttcagcatc atccccagag
      481 gagccacact ctgacagtga gggtgcgggg tcaggcgccc ggccgcacct gctgagtgtg
      541 cccgagttgt gcagatacct ggctgagagc tggctcacct tccagattca cctgcaggag
      601 ctgctgcagt acaagaggca gaatccagct cagttctgcg ttcgagtctg ctctggctgt
      661 gctgtgttgg ctgtgttggg acactatgtt ccagggatta tgatttccta cattgtcttg
      721 ttgagtatcc tgctgtggcc cctggtggtt tatcatgagc tgatccagag gatgtacact
      781 cgcctggagc ccctgctcat gcagctggac tacagcatga aggcagaagc caatgccctg
      841 catcacaaac acgacaagag gaagcgtcag gggaagaatg cacccccagg aggtgatgag
      901 ccactggcag agacagagag tgaaagcgag gcagagctgg ctggcttctc cccagtggtg
      961 gatgtgaaga aaacagcatt ggccttggcc attacagact cagagctgtc agatgaggag
     1021 gcttctatct tggagagtgg tggcttctcc gtatcccggg ccacaactcc gcagctgact
     1081 gatgtctccg aggatttgga ccagcagagc ctgccaagtg aaccagagga gaccctaagc
     1141 cgggacctag gggagggaga ggagggagag ctggcccctc ccgaagacct actaggccgt
     1201 cctcaagctc tgtcaaggca agccctggac tcggaggaag aggaagagga tgtggcagct
     1261 aaggaaacct tgttgcggct ctcatccccc ctccactttg tgaacacgca cttcaatggg
     1321 gcagggtccc ccccagatgg agtgaaatgc tcccctggag gaccagtgga gacactgagc
     1381 cccgagacag tgagtggtgg cctcactgct ctgcccggca ccctgtcacc tccactttgc
     1441 cttgttggaa gtgacccagc cccctcccct tccattctcc cacctgttcc ccaggactca
     1501 ccccagcccc tgcctgcccc tgaggaagaa gaggcactca ccactgagga ctttgagttg
     1561 ctggatcagg gggagctgga gcagctgaat gcagagctgg gcttggagcc agagacaccg
     1621 ccaaaacccc ctgatgctcc acccctgggg cccgacatcc attctctggt acagtcagac
     1681 caagaagctc aggccgtggc agagccatga gccagccgtt gaggaaggag ctgcaggcac
     1741 agtagggctt cctggctagg agtgttgctg tttcctcctt tgcctaccac tctggggtgg
     1801 ggcagtgtgt ggggaagctg gctgtcggat ggtagctatt ccaccctctg cctgcctgcc
     1861 tgcctgctgt cctgggcatg gtgcagtacc tgtgcctagg attggtttta aatttgtaaa
     1921 taattttcca tttgggttag tggatgtgaa cagggctagg gaagtccttc ccacagcctg
     1981 cgcttgcctc cctgcctcat ctctattctc attccactat gccccaagcc ctggtggtct
     2041 ggccctttct ttttcctcct atcctcaggg acctgtgctg ctctgccctc atgtcccact
     2101 tggttgttta gttgaggcac tttataattt ttctcttgtc ttgtgttcct ttctgcttta
     2161 tttccctgct gtgtcctgtc cttagcagct caaccccatc ctttgccagc tcctcctatc
     2221 ccgtgggcac tggccaagct ttagggaggc tcctggtctg ggaagtaaag agtaaacctg
     2281 gggcagtggg tcaggccagt agttacactc ttaggtcact gtagtctgtg taaccttcac
     2341 tgcatccttg ccccattcag cccggccttt catgatgcag gagagcaggg atcccgcagt
     2401 acatggcgcc agcactggag ttggtgagca tgtgctctct cttgagatta ggagcttcct
     2461 tactgctcct ctgggtgatc caagtgtagt gggaccccct actagggtca ggaagtggac
     2521 actaacatct gtgcaggtgt tgacttgaaa aataaagtgt tgattggcta gaactgctgc
     2581 ctccctgact gtgagctgcc ttccacaccc tgcactgcac tgtgttctct cctcaccctt
     2641 aacctgcttc actccagtct gttctggctg tttattacct tgttgcaaaa cagggccgaa
     2701 gcaaggatta ccttgacaac cctagcttct ccttagccat cttccttgac agtgtgatct
     2761 gtttagtgag atttagcatg tgtgaataaa gtatatgcag gaggaaattg ctttgtcttc
     2821 ccaatcggta gaaattcggg accataaaaa ttgtgtttta ccatgtggcc tacaacctta
     2881 acactgcttt cttaagaagt cttcacccat ctacatgcta acaactcact cagcctggat
     2941 ttatctttac tggggaagcc aaacaagcaa tagaggacct ttacctgtgt tagaaatgag
     3001 ttggagccaa ggaacactga agaaatagta tcttaacagt tactgagtcc attgtatgtg
     3061 cttggctctg ctctgagtga tttatatgta ttaagatttt tcctcacagg tcagatatat
     3121 actgttacta acttcatttt atagacaggt taagcttcct gaaggccaca ggtcccagta
     3181 aattgtggag ccagaaccca aacccaagaa gttttggctt cagcaaatgc atcagacagc
     3241 ccctgtccat taatagggca caggtaggaa gatgcacaag gatgtgggaa ctatagagaa
     3301 ccaatctgat gccttggctt aacaaagagt ggacatggca agccttcctc tttggggaag
     3361 aaaagcccag aactgagcag atggcctcct ttatgagttc atgtcctccg ccttcagctg
     3421 gaggtaccat atggcgatgc tacctgtctt tctgctggag gtaccatatg gtaatgctgc
     3481 ctggctgtct gctggaggta ccatatggta atgctgcctg tctttctgag gttgactttt
     3541 atgccatgtc tttcctaagt gtgtaagaat ttttctgttt gcttcacatt tgactgagaa
     3601 tcattctagg gtttgattga gcccctgtcc tgtgccacta aaggaactcg aacttttcat
     3661 cacttagaga tttcagaggg gaatggaaaa acagttctaa tcaataagca agcaattcaa
     3721 gaaaaataga attaatcagg caatgactgc aacatgtcct atctttaatc tattttctta
     3781 ttaagcttgg acattgacaa tagaaccaga agcttgtagc tggatcaaaa tattctccat
     3841 aggcctggag tttcatgagg gtctattctt ttgttgttgt tgttttggtt ttttgttttt
     3901 tgtgggtttt tttttttttt tttttgagac ggagtcttgt tctgttgccc aggctggagt
     3961 gcaatggtgc agtcttggtt cactgcaacc tctgcctccc aggttcaaac aattctcctg
     4021 cctcagccgt ccaagtagct gggattacag gtgcatgcca cgatgcctgg ctattttttg
     4081 tatttttagt agaggtgggg tttcaccatg ttggccaggc tggtctcgaa ctcctgacct
     4141 caggtgattc acccacctcg gcctcccaaa gtgctgggat tacaggtgtg agccacggcg
     4201 cccagcctca tgagggtcta ttctttacat tcaccatggt ctgatggttg ctacatgttt
     4261 gtctatgatt ttttttttct attatcaggt gtcttggccg gttcatgccc cacgatgaaa
     4321 gggccagagg ttttcatatg agtaaaagaa aaaagcagaa atgtgaaacc tacaattagg
     4381 ctaaacaaaa atcaactgga aaagtacagg ctgaggggag aagagttggc tacatgttta
     4441 tgttagggga ggagggagta cattttagct atgtattcaa acagctaata gtttaatgtt
     4501 gctgcttata aacttaattt taggctgcat taataaaagt gtagtctcca aaacaa
//
