LOCUS       NM_032579                701 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens resistin like beta (RETNLB), transcript variant 1,
            mRNA.
ACCESSION   NM_032579
VERSION     NM_032579.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 701)
  AUTHORS   Di Rosa,M., Di Cataldo,A., Broggi,G., Caltabiano,R., Tibullo,D.,
            Castrogiovanni,P., Imbesi,R., Lanteri,R., Salomone,F., Raciti,G.
            and Li Volti,G.
  TITLE     Resistin-like beta reduction is associated to low survival rate and
            is downregulated by adjuvant therapy in colorectal cancer patients
  JOURNAL   Sci Rep 13 (1), 1490 (2023)
   PUBMED   36707698
  REMARK    GeneRIF: Resistin-like beta reduction is associated to low survival
            rate and is downregulated by adjuvant therapy in colorectal cancer
            patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 701)
  AUTHORS   Jin,H., Miao,H., Nie,Y.W. and Lin,Y.Y.
  TITLE     Investigating resistin like beta (RETNLB) as a tumor promoter for
            oral squamous cell carcinoma
  JOURNAL   Head Face Med 17 (1), 20 (2021)
   PUBMED   34158059
  REMARK    GeneRIF: Investigating resistin like beta (RETNLB) as a tumor
            promoter for oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 701)
  AUTHORS   Li,H.J., Fang,E.H., Wang,J.Q., Zheng,L.D. and Tong,Q.S.
  TITLE     Helicobacter pylori Infection Facilitates the Expression of
            Resistin-like Molecule Beta in Gastric Carcinoma and Precursor
            Lesions
  JOURNAL   Curr Med Sci 40 (1), 95-103 (2020)
   PUBMED   32166670
  REMARK    GeneRIF: Helicobacter pylori Infection Facilitates the Expression
            of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor
            Lesions.
REFERENCE   4  (bases 1 to 701)
  AUTHORS   Luo,J., Li,H.P., Xu,F., Wu,B.Q. and Lin,H.C.
  TITLE     Early diagnosis of necrotizing enterocolitis by plasma RELMbeta and
            thrombocytopenia in preterm infants: A pilot study
  JOURNAL   Pediatr Neonatol 60 (4), 447-452 (2019)
   PUBMED   30799148
  REMARK    GeneRIF: Plasma RELMbeta levels in necrotizing enterocolitis group
            were significantly higher than control group.
REFERENCE   5  (bases 1 to 701)
  AUTHORS   Jiang,Y., Zhou,X., Hu,R. and Dai,A.
  TITLE     TGF-beta1-induced SMAD2/3/4 activation promotes RELM-beta
            transcription to modulate the endothelium-mesenchymal transition in
            human endothelial cells
  JOURNAL   Int J Biochem Cell Biol 105, 52-60 (2018)
   PUBMED   30120989
  REMARK    GeneRIF: Investigated the function and mechanism of RELM-beta in
            TGF-beta1-induced endothelium-mesenchymal transition in endothelial
            cell lines. We found that TGF-beta1 stimulation significantly
            upregulated RELM-beta expression; RELM-beta knockdown could
            attenuate TGF-beta1-induced cell proliferation and migration of
            endothelial cell lines.
REFERENCE   6  (bases 1 to 701)
  AUTHORS   Stutz,A.M., Pickart,L.A., Trifilieff,A., Baumruker,T.,
            Prieschl-Strassmayr,E. and Woisetschlager,M.
  TITLE     The Th2 cell cytokines IL-4 and IL-13 regulate found in
            inflammatory zone 1/resistin-like molecule alpha gene expression by
            a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism
  JOURNAL   J Immunol 170 (4), 1789-1796 (2003)
   PUBMED   12574343
REFERENCE   7  (bases 1 to 701)
  AUTHORS   De Young,M.P., Damania,H., Scheurle,D., Zylberberg,C. and
            Narayanan,R.
  TITLE     Bioinformatics-based discovery of a novel factor with apparent
            specificity to colon cancer
  JOURNAL   In Vivo 16 (4), 239-248 (2002)
   PUBMED   12224133
  REMARK    GeneRIF: Supernatant from COS cells transfected with the CCRG
            (RETNLB) expression vector stimulated proliferation of colon cancer
            cells, which supports the growth factor nature of the RETNLB gene.
REFERENCE   8  (bases 1 to 701)
  AUTHORS   Steppan,C.M., Brown,E.J., Wright,C.M., Bhat,S., Banerjee,R.R.,
            Dai,C.Y., Enders,G.H., Silberg,D.G., Wen,X., Wu,G.D. and Lazar,M.A.
  TITLE     A family of tissue-specific resistin-like molecules
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 502-506 (2001)
   PUBMED   11209052
REFERENCE   9  (bases 1 to 701)
  AUTHORS   Kubota,T., Kawano,S., Chih,D.Y., Hisatake,Y., Chumakov,A.M.,
            Taguchi,H. and Koeffler,H.P.
  TITLE     Representational difference analysis using myeloid cells from C/EBP
            epsilon deletional mice
  JOURNAL   Blood 96 (12), 3953-3957 (2000)
   PUBMED   11090083
REFERENCE   10 (bases 1 to 701)
  AUTHORS   Holcomb,I.N., Kabakoff,R.C., Chan,B., Baker,T.W., Gurney,A.,
            Henzel,W., Nelson,C., Lowman,H.B., Wright,B.D., Skelton,N.J.,
            Frantz,G.D., Tumas,D.B., Peale,F.V. Jr., Shelton,D.L. and
            Hebert,C.C.
  TITLE     FIZZ1, a novel cysteine-rich secreted protein associated with
            pulmonary inflammation, defines a new gene family
  JOURNAL   EMBO J 19 (15), 4046-4055 (2000)
   PUBMED   10921885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092185.3 and AY358655.1.
            
            On Sep 25, 2020 this sequence version replaced NM_032579.2.
            
            Transcript Variant: This variant (1) uses the same exon combination
            as variant 2 but represents the allele encoded by the GRCh38
            reference genome. The encoded isoform (1) has a longer N-terminus
            than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX097733.1, AY358655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295755.7/ ENSP00000295755.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC092185.3         153236-153362       c
            128-700             AY358655.1         2-574
            701-701             AC092185.3         151590-151590       c
FEATURES             Location/Qualifiers
     source          1..701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..701
                     /gene="RETNLB"
                     /gene_synonym="FIZZ1; FIZZ2; HXCP2; RELM-beta; RELMb;
                     RELMbeta; XCP2"
                     /note="resistin like beta"
                     /db_xref="GeneID:84666"
                     /db_xref="HGNC:HGNC:20388"
                     /db_xref="MIM:605645"
     exon            1..352
                     /gene="RETNLB"
                     /gene_synonym="FIZZ1; FIZZ2; HXCP2; RELM-beta; RELMb;
                     RELMbeta; XCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..561
                     /gene="RETNLB"
                     /gene_synonym="FIZZ1; FIZZ2; HXCP2; RELM-beta; RELMb;
                     RELMbeta; XCP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; C/EBP-epsilon regulated myeloid-specific
                     secreted cysteine-rich protein precursor 2; colon and
                     small intestine-specific cysteine-rich protein; found in
                     inflammatory zone 1; cysteine-rich secreted A12-alpha-like
                     protein 1; colon carcinoma-related gene protein;
                     cysteine-rich secreted protein FIZZ2; cysteine-rich
                     secreted protein A12-alpha-like 1"
                     /codon_start=1
                     /product="resistin-like beta isoform 1 precursor"
                     /protein_id="NP_115968.1"
                     /db_xref="CCDS:CCDS2953.1"
                     /db_xref="GeneID:84666"
                     /db_xref="HGNC:HGNC:20388"
                     /db_xref="MIM:605645"
                     /translation="MGPSSCLLLILIPLLQLINPGSTQCSLDSVMDKKIKDVLNSLEY
                     SPSPISKKLSCASVKSQGRPSSCPAGMAVTGCACGYGCGSWDVQLETTCHCQCSVVDW
                     TTARCCHLT"
     exon            353..433
                     /gene="RETNLB"
                     /gene_synonym="FIZZ1; FIZZ2; HXCP2; RELM-beta; RELMb;
                     RELMbeta; XCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..701
                     /gene="RETNLB"
                     /gene_synonym="FIZZ1; FIZZ2; HXCP2; RELM-beta; RELMb;
                     RELMbeta; XCP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagaccttc tctgaatgtt ttggtgaata aatctgttct tcagcaaccc tacctgcttc
       61 tccaaactgc ctaaagagat ccagtactga tgacgctgtt cttccatctt tactccctgg
      121 aaactaacca cgttgtcttc tttccttcac caccacccag gagctcagag atctaagctg
      181 ctttccatct tttctcccag ccccaggaca ctgactctgt acaggatggg gccgtcctct
      241 tgcctccttc tcatcctaat cccccttctc cagctgatca acccggggag tactcagtgt
      301 tccttagact ccgttatgga taagaagatc aaggatgttc tcaacagtct agagtacagt
      361 ccctctccta taagcaagaa gctctcgtgt gctagtgtca aaagccaagg cagaccgtcc
      421 tcctgccctg ctgggatggc tgtcactggc tgtgcttgtg gctatggctg tggttcgtgg
      481 gatgttcagc tggaaaccac ctgccactgc cagtgcagtg tggtggactg gaccactgcc
      541 cgctgctgcc acctgacctg acagggagga ggctgagaac tcagttttgt gaccatgaca
      601 gtaatgaaac cagggtccca accaagaaat ctaactcaaa cgtcccactt catttgttcc
      661 attcctgatt cttgggtaat aaagacaaac tttgtacctc t
//
