LOCUS       NM_020415                516 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens resistin (RETN), transcript variant 1, mRNA.
ACCESSION   NM_020415
VERSION     NM_020415.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Yoshida,A., Takata,Y., Tabara,Y., Maruyama,K., Inoue,S., Osawa,H.
            and Sugiyama,T.
  TITLE     Interaction effect between low birthweight and resistin gene
            rs1862513 variant on insulin resistance and type 2 diabetes
            mellitus in adulthood: Toon Genome Study
  JOURNAL   J Diabetes Investig 15 (6), 725-735 (2024)
   PUBMED   38421160
  REMARK    GeneRIF: Interaction effect between low birthweight and resistin
            gene rs1862513 variant on insulin resistance and type 2 diabetes
            mellitus in adulthood: Toon Genome Study.
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Dizen-Namdar,N., Akcilar,R., Yukcu,F., Arslan-Utku,S. and
            Bayat-Sarioglu,Z.
  TITLE     Resistin Gene Promoter -420C>G (rs1862513) and +299 G>A (rs3745367)
            Polymorphisms in Psoriasis
  JOURNAL   Acta Dermatovenerol Croat 32 (1), 1-6 (2024)
   PUBMED   38946181
  REMARK    GeneRIF: Resistin Gene Promoter -420C>G (rs1862513) and +299 G>A
            (rs3745367) Polymorphisms in Psoriasis.
REFERENCE   3  (bases 1 to 516)
  AUTHORS   Rana,M., Cheema,M.A., Khan,R.A., Kanwal,A., Rana,A.M. and Lone,K.P.
  TITLE     Serum resistin and lipid profile in primigravida females with and
            without preeclampsia: An analytical cross-sectional study
  JOURNAL   J Pak Med Assoc 74 (1), 62-66 (2024)
   PUBMED   38219167
  REMARK    GeneRIF: Serum resistin and lipid profile in primigravida females
            with and without preeclampsia: An analytical cross-sectional study.
REFERENCE   4  (bases 1 to 516)
  AUTHORS   Wu,Z., Liu,S., Yang,Z., Meng,X., An,Y. and Zhang,H.
  TITLE     Study on the correlation between gene polymorphisms of adiponectin
            and resistin levels and abdominal aortic aneurysm
  JOURNAL   Clinics (Sao Paulo) 78, 100298 (2023)
   PUBMED   37897936
  REMARK    GeneRIF: Study on the correlation between gene polymorphisms of
            adiponectin and resistin levels and abdominal aortic aneurysm.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 516)
  AUTHORS   Liu,C.W., Peng,H.Y., Siao,A.C., Tsuei,Y.W., Lin,Y.Y., Shiah,S.G.,
            Shih,L.J., Yeh,C.C., Lee,S.W. and Kao,Y.H.
  TITLE     Resistin stimulates PC-3 prostate cancer cell growth through
            stimulation of SOCS3 and SOCS5 genes
  JOURNAL   Exp Biol Med (Maywood) 248 (20), 1695-1707 (2023)
   PUBMED   37646261
  REMARK    GeneRIF: Resistin stimulates PC-3 prostate cancer cell growth
            through stimulation of SOCS3 and SOCS5 genes.
REFERENCE   6  (bases 1 to 516)
  AUTHORS   Harris,T.A., Gattu,S., Propheter,D.C., Kuang,Z., Bel,S., Ruhn,K.A.,
            Chara,A.L., Edwards,M., Zhang,C., Jo,J.H., Raj,P., Zouboulis,C.C.,
            Kong,H.H., Segre,J.A. and Hooper,L.V.
  TITLE     Resistin-like Molecule alpha Provides Vitamin-A-Dependent
            Antimicrobial Protection in the Skin
  JOURNAL   Cell Host Microbe 25 (6), 777-788 (2019)
   PUBMED   31101494
  REMARK    GeneRIF: RETN displays antimicrobial activity against Gram negative
            and Gram positive bacteria.
REFERENCE   7  (bases 1 to 516)
  AUTHORS   Steppan,C.M., Bailey,S.T., Bhat,S., Brown,E.J., Banerjee,R.R.,
            Wright,C.M., Patel,H.R., Ahima,R.S. and Lazar,M.A.
  TITLE     The hormone resistin links obesity to diabetes
  JOURNAL   Nature 409 (6818), 307-312 (2001)
   PUBMED   11201732
REFERENCE   8  (bases 1 to 516)
  AUTHORS   Kubota,T., Kawano,S., Chih,D.Y., Hisatake,Y., Chumakov,A.M.,
            Taguchi,H. and Koeffler,H.P.
  TITLE     Representational difference analysis using myeloid cells from C/EBP
            epsilon deletional mice
  JOURNAL   Blood 96 (12), 3953-3957 (2000)
   PUBMED   11090083
REFERENCE   9  (bases 1 to 516)
  AUTHORS   Holcomb,I.N., Kabakoff,R.C., Chan,B., Baker,T.W., Gurney,A.,
            Henzel,W., Nelson,C., Lowman,H.B., Wright,B.D., Skelton,N.J.,
            Frantz,G.D., Tumas,D.B., Peale,F.V. Jr., Shelton,D.L. and
            Hebert,C.C.
  TITLE     FIZZ1, a novel cysteine-rich secreted protein associated with
            pulmonary inflammation, defines a new gene family
  JOURNAL   EMBO J 19 (15), 4046-4055 (2000)
   PUBMED   10921885
REFERENCE   10 (bases 1 to 516)
  AUTHORS   Bennett,M. and Reed,R.
  TITLE     Correspondence between a mammalian spliceosome component and an
            essential yeast splicing factor
  JOURNAL   Science 262 (5130), 105-108 (1993)
   PUBMED   8211113
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008763.9, BC069302.1 and
            AF205952.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020415.3.
            
            Summary: This gene belongs to the family defined by the mouse
            resistin-like genes. The characteristic feature of this family is
            the C-terminal stretch of 10 cys residues with identical spacing.
            The mouse homolog of this protein is secreted by adipocytes, and
            may be the hormone potentially linking obesity to type II diabetes.
            The encoded protein also has an antimicrobial role in skin,
            displaying antibacterial activity against both Gram positive and
            Gram negative bacteria. Alternatively spliced transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) encodes isoform a. Variants
            1-3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323081.1, AA311223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000221515.6/
                                                  ENSP00000221515.1
            Protein has antimicrobial activity :: PMID: 31101494
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC008763.9         99861-99897
            38-460              BC069302.1         1-423
            461-515             AF205952.1         402-456
            516-516             AC008763.9         101267-101267
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..516
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /note="resistin"
                     /db_xref="GeneID:56729"
                     /db_xref="HGNC:HGNC:20389"
                     /db_xref="MIM:605565"
     exon            1..73
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..201
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..410
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; C/EBP-epsilon regulated myeloid-specific
                     secreted cysteine-rich protein precursor 1; found in
                     inflammatory zone 3; cysteine-rich secreted protein FIZZ3;
                     adipose tissue-specific secretory factor; cysteine-rich
                     secreted protein A12-alpha-like 2; c/EBP-epsilon-regulated
                     myeloid-specific secreted cysteine-rich protein; resistin
                     delta2"
                     /codon_start=1
                     /product="resistin isoform a precursor"
                     /protein_id="NP_065148.1"
                     /db_xref="CCDS:CCDS12182.1"
                     /db_xref="GeneID:56729"
                     /db_xref="HGNC:HGNC:20389"
                     /db_xref="MIM:605565"
                     /translation="MKALCLLLLPVLGLLVSSKTLCSMEEAINERIQEVAGSLIFRAI
                     SSIGLECQSVTSRGDLATCPRGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGAR
                     CCRVQP"
     exon            202..279
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..516
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      482..487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /note="hexamer: AATAAA"
     polyA_site      516
                     /gene="RETN"
                     /gene_synonym="ADSF; FIZZ3; RENT; RETN1; RSTN; XCP1"
                     /note="major polyA site"
ORIGIN      
        1 aagaggcctc aaagaaagag ctgcggtgca ggaattcgtg tgccggattt ggttagctga
       61 gcccaccgag aggcgcctgc aggatgaaag ctctctgtct cctcctcctc cctgtcctgg
      121 ggctgttggt gtctagcaag accctgtgct ccatggaaga agccatcaat gagaggatcc
      181 aggaggtcgc cggctcccta atatttaggg caataagcag cattggcctg gagtgccaga
      241 gcgtcacctc caggggggac ctggctactt gcccccgagg cttcgccgtc accggctgca
      301 cttgtggctc cgcctgtggc tcgtgggatg tgcgcgccga gaccacatgt cactgccagt
      361 gcgcgggcat ggactggacc ggagcgcgct gctgtcgtgt gcagccctga ggtcgcgcgc
      421 agcgcgtgca cagcgcgggc ggaggcggct ccaggtccgg aggggttgcg ggggagctgg
      481 aaataaacct ggagatgatg atgatgatga tgatga
//
