LOCUS       NM_020975               5617 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens ret proto-oncogene (RET), transcript variant 2, mRNA.
ACCESSION   NM_020975
VERSION     NM_020975.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5617)
  AUTHORS   Stanescu,L.S., Ghemigian,A., Ciobica,M.L., Nistor,C., Ciuche,A.,
            Radu,A.M., Sandru,F. and Carsote,M.
  TITLE     Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points
            Amid RET Pathogenic Variants in Medullary Thyroid Cancer/Multiple
            Endocrine Neoplasia Type 2 (MEN2)
  JOURNAL   Int J Mol Sci 25 (18), 9765 (2024)
   PUBMED   39337252
  REMARK    GeneRIF: Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key
            Points Amid RET Pathogenic Variants in Medullary Thyroid
            Cancer/Multiple Endocrine Neoplasia Type 2 (MEN2).
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5617)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   3  (bases 1 to 5617)
  AUTHORS   Scholfield,D.W., Fitzgerald,C.W.R., Boe,L.A., Eagan,A., Levyn,H.,
            Xu,B., Tuttle,R.M., Fagin,J.A., Shaha,A.R., Shah,J.P., Wong,R.J.,
            Patel,S.G., Ghossein,R. and Ganly,I.
  TITLE     Defining the Genomic Landscape of Diffuse Sclerosing Papillary
            Thyroid Carcinoma: Prognostic Implications of RET Fusions
  JOURNAL   Ann Surg Oncol 31 (9), 5525-5536 (2024)
   PUBMED   38847983
  REMARK    GeneRIF: Defining the Genomic Landscape of Diffuse Sclerosing
            Papillary Thyroid Carcinoma: Prognostic Implications of RET
            Fusions.
REFERENCE   4  (bases 1 to 5617)
  AUTHORS   Qiu,T., Kong,Y., Wei,G., Sun,K., Wang,R., Wang,Y., Chen,Y.,
            Wang,W., Zhang,Y., Jiang,C., Yang,P., Xie,T. and Chen,X.
  TITLE     CCDC6-RET fusion protein regulates Ras/MAPK signaling through the
            fusion- GRB2-SHC1 signal niche
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2322359121 (2024)
   PUBMED   38805286
  REMARK    GeneRIF: CCDC6-RET fusion protein regulates Ras/MAPK signaling
            through the fusion- GRB2-SHC1 signal niche.
REFERENCE   5  (bases 1 to 5617)
  AUTHORS   Romei,C., Ciampi,R. and Elisei,R.
  TITLE     A comprehensive overview of the role of the RET proto-oncogene in
            thyroid carcinoma
  JOURNAL   Nat Rev Endocrinol 12 (4), 192-202 (2016)
   PUBMED   26868437
  REMARK    Review article
REFERENCE   6  (bases 1 to 5617)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   7  (bases 1 to 5617)
  AUTHORS   Eng,C. and Plitt,G.
  TITLE     Multiple Endocrine Neoplasia Type 2
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301434
REFERENCE   8  (bases 1 to 5617)
  AUTHORS   Itoh,F., Ishizaka,Y., Tahira,T., Yamamoto,M., Miya,A., Imai,K.,
            Yachi,A., Takai,S., Sugimura,T. and Nagao,M.
  TITLE     Identification and analysis of the ret proto-oncogene promoter
            region in neuroblastoma cell lines and medullary thyroid carcinomas
            from MEN2A patients
  JOURNAL   Oncogene 7 (6), 1201-1206 (1992)
   PUBMED   1350670
REFERENCE   9  (bases 1 to 5617)
  AUTHORS   Santoro,M., Carlomagno,F., Hay,I.D., Herrmann,M.A., Grieco,M.,
            Melillo,R., Pierotti,M.A., Bongarzone,I., Della Porta,G., Berger,N.
            et al.
  TITLE     Ret oncogene activation in human thyroid neoplasms is restricted to
            the papillary cancer subtype
  JOURNAL   J Clin Invest 89 (5), 1517-1522 (1992)
   PUBMED   1569189
REFERENCE   10 (bases 1 to 5617)
  AUTHORS   Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
  TITLE     Localization of the 5' end of the MCF2 oncogene to human chromosome
            15q15----q23
  JOURNAL   Cytogenet Cell Genet 60 (2), 114-116 (1992)
   PUBMED   1611909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010864.11, BC003072.2,
            BC004257.1, X12949.1 and BM661773.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020975.5.
            
            Summary: This gene encodes a transmembrane receptor and member of
            the tyrosine protein kinase family of proteins. Binding of ligands
            such as GDNF (glial cell-line derived neurotrophic factor) and
            other related proteins to the encoded receptor stimulates receptor
            dimerization and activation of downstream signaling pathways that
            play a role in cell differentiation, growth, migration and
            survival. The encoded receptor is important in development of the
            nervous system, and the development of organs and tissues derived
            from the neural crest. This proto-oncogene can undergo oncogenic
            activation through both cytogenetic rearrangement and activating
            point mutations. Mutations in this gene are associated with
            Hirschsprung disease and central hypoventilation syndrome and have
            been identified in patients with renal agenesis. [provided by
            RefSeq, Sep 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355710.8/ ENSP00000347942.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC010864.11        75327-75336
            11-324              BC003072.2         1-314
            325-325             AC010864.11        98778-98778
            326-1477            BC003072.2         316-1467
            1478-2260           BC004257.1         1468-2250
            2261-2496           X12949.1           2002-2237
            2497-2497           AC010864.11        116653-116653
            2498-4134           X12949.1           2239-3875
            4135-4135           AC010864.11        127127-127127
            4136-4708           X12949.1           3877-4449
            4709-5126           AC010864.11        127701-128118
            5127-5617           BM661773.1         13-503              c
FEATURES             Location/Qualifiers
     source          1..5617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..5617
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /note="ret proto-oncogene"
                     /db_xref="GeneID:5979"
                     /db_xref="HGNC:HGNC:9967"
                     /db_xref="MIM:164761"
     exon            1..263
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3535
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; cadherin-related family member 16; RET receptor
                     tyrosine kinase; ret proto-oncogene (multiple endocrine
                     neoplasia and medullary thyroid carcinoma 1, Hirschsprung
                     disease); cadherin family member 12; proto-oncogene
                     tyrosine-protein kinase receptor Ret; proto-oncogene
                     c-Ret; rearranged during transfection"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase receptor
                     Ret isoform a precursor"
                     /protein_id="NP_066124.1"
                     /db_xref="CCDS:CCDS7200.1"
                     /db_xref="GeneID:5979"
                     /db_xref="HGNC:HGNC:9967"
                     /db_xref="MIM:164761"
                     /translation="MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQ
                     AAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLD
                     HSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSL
                     KPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAP
                     DSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGV
                     DTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHW
                     PNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLH
                     FNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
                     TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSY
                     VAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCP
                     DGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPED
                     IQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQA
                     FPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVK
                     ATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG
                     PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAW
                     QISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP
                     VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMER
                     PDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYD
                     DGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFP
                     RYPNDSVYANWMLSPSAAKLMDTFDS"
     exon            264..527
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..815
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1057
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1253
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1453
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1712
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1838
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1949
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2069
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2326
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2474
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2582
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2797
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2920
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..2991
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3129
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3229
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3377
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..5617
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5596..5601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /note="hexamer: AATAAA"
     polyA_site      5617
                     /gene="RET"
                     /gene_synonym="CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1;
                     PTC; RET-ELE1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcga ccgaagcagg gcgcgcagca gcgctgagtg ccccggaacg tgcgtcgcgc
       61 ccccagtgtc cgtcgcgtcc gccgcgcccc gggcggggat ggggcggcca gactgagcgc
      121 cgcacccgcc atccagaccc gccggcccta gccgcagtcc ctccagccgt ggccccagcg
      181 cgcacgggcg atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct
      241 gctgctgccg ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg
      301 ggagaagctg tatgtggacc aggcagccgg cacgcccttg ctgtacgtcc atgccctgcg
      361 ggacgcccct gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg
      421 cacacggctg catgagaaca actggatctg catccaggag gacaccggcc tcctctacct
      481 taaccggagc ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc
      541 cctgctcacc gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg
      601 ccagtggcca ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg
      661 cagctccctc aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg
      721 ggagaaccga cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg
      781 ccccaacatc agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc
      841 cccggacagc ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta
      901 cgagctggtg gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc
      961 cttcccggtg accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga
     1021 caccgccagc gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg
     1081 tgtcttcgat gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac
     1141 gctgctcccc ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga
     1201 gacctcggtc caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt
     1261 tctcaaccgg aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa
     1321 tgactcagac ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt
     1381 gctgccggtc agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg
     1441 ccgatttgcc cagatcggga aagtctgtgt ggaaaactgc caggcattca gtggcatcaa
     1501 cgtccagtac aagctgcatt cctctggtgc caactgcagc acgctagggg tggtcacctc
     1561 agccgaggac acctcgggga tcctgtttgt gaatgacacc aaggccctgc ggcggcccaa
     1621 gtgtgccgaa cttcactaca tggtggtggc caccgaccag cagacctcta ggcaggccca
     1681 ggcccagctg cttgtaacag tggaggggtc atatgtggcc gaggaggcgg gctgccccct
     1741 gtcctgtgca gtcagcaaga gacggctgga gtgtgaggag tgtggcggcc tgggctcccc
     1801 aacaggcagg tgtgagtgga ggcaaggaga tggcaaaggg atcaccagga acttctccac
     1861 ctgctctccc agcaccaaga cctgccccga cggccactgc gatgttgtgg agacccaaga
     1921 catcaacatt tgccctcagg actgcctccg gggcagcatt gttgggggac acgagcctgg
     1981 ggagccccgg gggattaaag ctggctatgg cacctgcaac tgcttccctg aggaggagaa
     2041 gtgcttctgc gagcccgaag acatccagga tccactgtgc gacgagctgt gccgcacggt
     2101 gatcgcagcc gctgtcctct tctccttcat cgtctcggtg ctgctgtctg ccttctgcat
     2161 ccactgctac cacaagtttg cccacaagcc acccatctcc tcagctgaga tgaccttccg
     2221 gaggcccgcc caggccttcc cggtcagcta ctcctcttcc ggtgcccgcc ggccctcgct
     2281 ggactccatg gagaaccagg tctccgtgga tgccttcaag atcctggagg atccaaagtg
     2341 ggaattccct cggaagaact tggttcttgg aaaaactcta ggagaaggcg aatttggaaa
     2401 agtggtcaag gcaacggcct tccatctgaa aggcagagca gggtacacca cggtggccgt
     2461 gaagatgctg aaagagaacg cctccccgag tgagctgcga gacctgctgt cagagttcaa
     2521 cgtcctgaag caggtcaacc acccacatgt catcaaattg tatggggcct gcagccagga
     2581 tggcccgctc ctcctcatcg tggagtacgc caaatacggc tccctgcggg gcttcctccg
     2641 cgagagccgc aaagtggggc ctggctacct gggcagtgga ggcagccgca actccagctc
     2701 cctggaccac ccggatgagc gggccctcac catgggcgac ctcatctcat ttgcctggca
     2761 gatctcacag gggatgcagt atctggccga gatgaagctc gttcatcggg acttggcagc
     2821 cagaaacatc ctggtagctg aggggcggaa gatgaagatt tcggatttcg gcttgtcccg
     2881 agatgtttat gaagaggatt cctacgtgaa gaggagccag ggtcggattc cagttaaatg
     2941 gatggcaatt gaatcccttt ttgatcatat ctacaccacg caaagtgatg tatggtcttt
     3001 tggtgtcctg ctgtgggaga tcgtgaccct agggggaaac ccctatcctg ggattcctcc
     3061 tgagcggctc ttcaaccttc tgaagaccgg ccaccggatg gagaggccag acaactgcag
     3121 cgaggagatg taccgcctga tgctgcaatg ctggaagcag gagccggaca aaaggccggt
     3181 gtttgcggac atcagcaaag acctggagaa gatgatggtt aagaggagag actacttgga
     3241 ccttgcggcg tccactccat ctgactccct gatttatgac gacggcctct cagaggagga
     3301 gacaccgctg gtggactgta ataatgcccc cctccctcga gccctccctt ccacatggat
     3361 tgaaaacaaa ctctatggca tgtcagaccc gaactggcct ggagagagtc ctgtaccact
     3421 cacgagagct gatggcacta acactgggtt tccaagatat ccaaatgata gtgtatatgc
     3481 taactggatg ctttcaccct cagcggcaaa attaatggac acgtttgata gttaacattt
     3541 ctttgtgaaa ggtaatggac tcacaagggg aagaaacatg ctgagaatgg aaagtctacc
     3601 ggccctttct ttgtgaacgt cacattggcc gagccgtgtt cagttcccag gtggcagact
     3661 cgtttttggt agtttgtttt aacttccaag gtggttttac ttctgatagc cggtgatttt
     3721 ccctcctagc agacatgcca caccgggtaa gagctctgag tcttagtggt taagcattcc
     3781 tttctcttca gtgcccagca gcacccagtg ttggtctgtg tccatcagtg accaccaaca
     3841 ttctgtgttc acatgtgtgg gtccaacact tactacctgg tgtatgaaat tggacctgaa
     3901 ctgttggatt tttctagttg ccgccaaaca aggcaaaaaa atttaaacat gaagcacaca
     3961 cacaaaaaag gcagtaggaa aaatgctggc cctgatgacc tgtccttatt cagaatgaga
     4021 gactgcgggg ggggcctggg ggtagtgtca atgcccctcc agggctggag gggaagaggg
     4081 gccccgagga tgggcctggg ctcagcattc gagatcttga gaatgatttt ttttaaatca
     4141 tgcaaccttt ccttaggaag acatttggtt ttcatcatga ttaagatgat tcctagattt
     4201 agcacaatgg agagattcca tgccatcttt actatgtgga tggtggtatc agggaagagg
     4261 gctcacaaga cacatttgtc ccccgggccc accacatcat cctcacgtgt tcggtactga
     4321 gcagccacta cccctgatga gaacagtatg aagaaagggg gctgttggag tcccagaatt
     4381 gctgacagca gaggctttgc tgctgtgaat cccacctgcc accagcctgc agcacacccc
     4441 acagccaagt agaggcgaaa gcagtggctc atcctacctg ttaggagcag gtagggcttg
     4501 tactcacttt aatttgaatc ttatcaactt actcataaag ggacaggcta gctagctgtg
     4561 ttagaagtag caatgacaat gaccaaggac tgctacacct ctgattacaa ttctgatgtg
     4621 aaaaagatgg tgtttggctc ttatagagcc tgtgtgaaag gcccatggat cagctcttcc
     4681 tgtgtttgta atttaatgct gctacaagat gtttctgttt cttagattct gaccatgact
     4741 cataagcttc ttgtcattct tcattgcttg tttgtggtca cagatgcaca acactcctcc
     4801 agtcttgtgg gggcagcttt tgggaagtct cagcagctct tctggctgtg ttgtcagcac
     4861 tgtaacttcg cagaaaagag tcggattacc aaaacactgc ctgctcttca gacttaaagc
     4921 actgatagga cttaaaatag tctcattcaa atactgtatt ttatataggc atttcacaaa
     4981 aacagcaaaa ttgtggcatt ttgtgaggcc aaggcttgga tgcgtgtgta atagagcctt
     5041 gtggtgtgtg cgcacacacc cagagggaga gtttgaaaaa tgcttattgg acacgtaacc
     5101 tggctctaat ttgggctgtt tttcagatac actgtgataa gttcttttac aaatatctat
     5161 agacatggta aacttttggt tttcagatat gcttaatgat agtcttacta aatgcagaaa
     5221 taagaataaa ctttctcaaa ttattaaaaa tgcctacaca gtaagtgtga attgctgcaa
     5281 caggtttgtt ctcaggaggg taagaactcc aggtctaaac agctgaccca gtgatgggga
     5341 atttatcctt gaccaattta tccttgacca ataacctaat tgtctattcc tgagttataa
     5401 aagtccccat ccttattagc tctactggaa ttttcataca cgtaaatgca gaagttacta
     5461 agtattaagt attactgagt attaagtagt aatctgtcag ttattaaaat ttgtaaaatc
     5521 tatttatgaa aggtcattaa accagatcat gttccttttt ttgtaatcaa ggtgactaag
     5581 aaaatcagtt gtgtaaataa aatcatgtat cataaaa
//
