LOCUS       NM_005612               7309 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RE1 silencing transcription factor (REST), transcript
            variant 1, mRNA.
ACCESSION   NM_005612
VERSION     NM_005612.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7309)
  AUTHORS   Yu,W., Han,S., Hu,S., Ru,L., Hua,C., Xue,G., Zhang,G., Lv,K.,
            Ge,H., Wang,M., Zheng,L., Zhou,J., Hou,S., Teng,Y., Deng,W. and
            Guo,W.
  TITLE     KIF15 promotes human glioblastoma progression under the synergistic
            transactivation of REST and P300
  JOURNAL   Int J Biol Sci 20 (13), 5127-5144 (2024)
   PUBMED   39430242
  REMARK    GeneRIF: KIF15 promotes human glioblastoma progression under the
            synergistic transactivation of REST and P300.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7309)
  AUTHORS   Abedin,Y., Minchella,P., Peterson,R., Gonnella,F., Graham,A.,
            Cook,I., Javellana,M., Jewell,A., Spoozak,L. and Nothnick,W.B.
  TITLE     Functional Analysis of RE1 Silencing Transcription Factor as a
            Putative Tumor Suppressor in Human Endometrial Cancer
  JOURNAL   Int J Mol Sci 25 (17), 9693 (2024)
   PUBMED   39273639
  REMARK    GeneRIF: Functional Analysis of RE1 Silencing Transcription Factor
            as a Putative Tumor Suppressor in Human Endometrial Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7309)
  AUTHORS   Redin,E., Sridhar,H., Zhan,Y.A., Pereira Mello,B., Zhong,H.,
            Durani,V., Sabet,A., Manoj,P., Linkov,I., Qiu,J., Koche,R.P., de
            Stanchina,E., Astorkia,M., Betel,D., Quintanal-Villalonga,A. and
            Rudin,C.M.
  TITLE     SMARCA4 controls state plasticity in small cell lung cancer through
            regulation of neuroendocrine transcription factors and REST
            splicing
  JOURNAL   J Hematol Oncol 17 (1), 58 (2024)
   PUBMED   39080761
  REMARK    GeneRIF: SMARCA4 controls state plasticity in small cell lung
            cancer through regulation of neuroendocrine transcription factors
            and REST splicing.
            Erratum:[J Hematol Oncol. 2024 Sep 29;17(1):89. doi:
            10.1186/s13045-024-01609-7.. PMID: 39343962]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7309)
  AUTHORS   Luo,J., Yu,H., Yuan,Z., Tang,W. and Wang,C.
  TITLE     REST Promotes Autophagy in Gastric Cancer by Transcriptionally
            Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 212 (2024)
   PUBMED   38940038
  REMARK    GeneRIF: REST Promotes Autophagy in Gastric Cancer by
            Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR
            Signaling Pathway.
REFERENCE   5  (bases 1 to 7309)
  AUTHORS   Singh,A., Cheng,D., Swaminathan,J., Yang,Y., Zheng,Y., Gordon,N.
            and Gopalakrishnan,V.
  TITLE     REST-dependent downregulation of von Hippel-Lindau tumor suppressor
            promotes autophagy in SHH-medulloblastoma
  JOURNAL   Sci Rep 14 (1), 13596 (2024)
   PUBMED   38866867
  REMARK    GeneRIF: REST-dependent downregulation of von Hippel-Lindau tumor
            suppressor promotes autophagy in SHH-medulloblastoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7309)
  AUTHORS   Thiel,G., Lietz,M. and Cramer,M.
  TITLE     Biological activity and modular structure of RE-1-silencing
            transcription factor (REST), a repressor of neuronal genes
  JOURNAL   J Biol Chem 273 (41), 26891-26899 (1998)
   PUBMED   9756936
REFERENCE   7  (bases 1 to 7309)
  AUTHORS   Scholl,T., Stevens,M.B., Mahanta,S. and Strominger,J.L.
  TITLE     A zinc finger protein that represses transcription of the human MHC
            class II gene, DPA
  JOURNAL   J Immunol 156 (4), 1448-1457 (1996)
   PUBMED   8568247
REFERENCE   8  (bases 1 to 7309)
  AUTHORS   Chong,J.A., Tapia-Ramirez,J., Kim,S., Toledo-Aral,J.J., Zheng,Y.,
            Boutros,M.C., Altshuller,Y.M., Frohman,M.A., Kraner,S.D. and
            Mandel,G.
  TITLE     REST: a mammalian silencer protein that restricts sodium channel
            gene expression to neurons
  JOURNAL   Cell 80 (6), 949-957 (1995)
   PUBMED   7697725
REFERENCE   9  (bases 1 to 7309)
  AUTHORS   Schoenherr,C.J. and Anderson,D.J.
  TITLE     The neuron-restrictive silencer factor (NRSF): a coordinate
            repressor of multiple neuron-specific genes
  JOURNAL   Science 267 (5202), 1360-1363 (1995)
   PUBMED   7871435
REFERENCE   10 (bases 1 to 7309)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069307.7 and BC136491.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005612.4.
            
            Summary: This gene was initially identified as a transcriptional
            repressor that represses neuronal genes in non-neuronal tissues.
            However, depending on the cellular context, this gene can act as
            either an oncogene or a tumor suppressor. The encoded protein is a
            member of the Kruppel-type zinc finger transcription factor family.
            It represses transcription by binding a DNA sequence element called
            the neuron-restrictive silencer element. The protein is also found
            in undifferentiated neuronal progenitor cells and it is thought
            that this repressor may act as a master negative regulator of
            neurogenesis. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, May 2018].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.130457.1,
                                           SRR1803615.176357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309042.12/ ENSP00000311816.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC069307.7         21757-22070
            315-2198            BC136491.1         15-1898
            2199-7309           AC069307.7         44591-49701
FEATURES             Location/Qualifiers
     source          1..7309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..7309
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /note="RE1 silencing transcription factor"
                     /db_xref="GeneID:5978"
                     /db_xref="HGNC:HGNC:9966"
                     /db_xref="MIM:600571"
     exon            1..314
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /inference="alignment:Splign:2.1.0"
     exon            315..1221
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..3617
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /note="repressor binding to the X2 box; neuron restrictive
                     silencer factor; neural-restrictive silencer factor"
                     /codon_start=1
                     /product="RE1-silencing transcription factor"
                     /protein_id="NP_005603.3"
                     /db_xref="CCDS:CCDS3509.1"
                     /db_xref="GeneID:5978"
                     /db_xref="HGNC:HGNC:9966"
                     /db_xref="MIM:600571"
                     /translation="MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAP
                     QLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGE
                     PHGLENMELRSLELSVVEPQPVFEASGAPDIYSSNKDLPPETPGAEDKGKSSKTKPFR
                     CKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGSSTAEEGDFSKGPIRC
                     DRCGYNTNRYDHYTAHLKHHTRAGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVY
                     TCGKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKC
                     DQCSYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCP
                     VCDYAASKKCNLQYHFKSKHPTCPNKTMDVSKVKLKKTKKREADLPDNITNEKTEIEQ
                     TKIKGDVAGKKNEKSVKAEKRDVSKEKKPSNNVSVIQVTTRTRKSVTEVKEMDVHTGS
                     NSEKFSKTKKSKRKLEVDSHSLHGPVNDEESSTKKKKKVESKSKNNSQEVPKGDSKVE
                     ENKKQNTCMKKSTKKKTLKNKSSKKSSKPPQKEPVEKGSAQMDPPQMGPAPTEAVQKG
                     PVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEGPAQKELLPPVEPAQMVGAQIVL
                     AHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAPMQVVQKEPVQMELSPPMEVV
                     QKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQKEPVQMELSPPMGVVQKEPAQREPP
                     PPREPPLHMEPISKKPPLRKDKKEKSNMQSERARKEQVLIEVGLVPVKDSWLLKESVS
                     TEDLSPPSPPLPKENLREEASGDQKLLNTGEGNKEAPLQKVGAEEADESLPGLAANIN
                     ESTHISSSGQNLNTPEGETLNGKHQTDSIVCEMKMDTDQNTRENLTGINSTVEEPVSP
                     MLPPSAVEEREAVSKTALASPPATMAANESQEIDEDEGIHSHEGSDLSDNMSEGSDDS
                     GLHGARPVPQESSRKNAKEALAVKAAKGDFVCIFCDRSFRKGKDYSKHLNRHLVNVYY
                     LEEAAQGQE"
     exon            1222..1305
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..7309
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7291..7296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /note="hexamer: AATAAA"
     polyA_site      7309
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcggcg cagcgtcctg tgttggaatg tgcggctgcc gcgagctcgc ggcgcagcag
       61 cggagcgagc gccgccgagg cccggggccc cagaccctgg cggcggctgc cgcagccgag
      121 acggcagggc gaggcccgga ggcctgagca ccctctgcag ccccactcct gggccttctt
      181 ggtccacgac ggccccagca cccaacttta ccaccctccc ccacctctcc cccgaaactc
      241 cagcaacaaa gaaaagtagt cggagaagga gcggcgactc agggtcgccc gcccctcctc
      301 accgaggaag gccgaataca gttatggcca cccaggtaat ggggcagtct tctggaggag
      361 gagggctgtt taccagcagt ggcaacattg gaatggccct gcctaacgac atgtatgact
      421 tgcatgacct ttccaaagct gaactggccg cacctcagct tattatgctg gcaaatgtgg
      481 ccttaactgg ggaagtaaat ggcagctgct gtgattacct ggtcggtgaa gaaagacaga
      541 tggcagaact gatgccggtt ggggataaca acttttcaga tagtgaagaa ggagaaggac
      601 ttgaagagtc tgctgatata aaaggtgaac ctcatggact ggaaaacatg gaactgagaa
      661 gtttggaact cagcgtcgta gaacctcagc ctgtatttga ggcatcaggt gctccagata
      721 tttacagttc aaataaagat cttccccctg aaacacctgg agcggaggac aaaggcaaga
      781 gctcgaagac caaacccttt cgctgtaagc catgccaata tgaagcagaa tctgaagaac
      841 agtttgtgca tcacatcaga gttcacagtg ctaagaaatt ttttgtggaa gagagtgcag
      901 agaagcaggc aaaagccagg gaatctggct cttccactgc agaagaggga gatttctcca
      961 agggccccat tcgctgtgac cgctgcggct acaatactaa tcgatatgat cactatacag
     1021 cacacctgaa acaccacacc agagctgggg ataatgagcg agtctacaag tgtatcattt
     1081 gcacatacac aacagtgagc gagtatcact ggaggaaaca tttaagaaac cattttccaa
     1141 ggaaagtata cacatgtgga aaatgcaact atttttcaga cagaaaaaac aattatgttc
     1201 agcatgttag aactcataca ggagaacgcc catataaatg tgaactttgt ccttactcaa
     1261 gttctcagaa gactcatcta actagacata tgcgtactca ttcaggtgag aagccattta
     1321 aatgtgatca gtgcagttat gtggcctcta atcaacatga agtaacccgc catgcaagac
     1381 aggttcacaa tgggcctaaa cctcttaatt gcccacactg tgattacaaa acagcagata
     1441 gaagcaactt caaaaaacat gtagagctac atgtgaaccc acggcagttc aattgccctg
     1501 tatgtgacta tgcagcttcc aagaagtgta atctacagta tcacttcaaa tctaagcatc
     1561 ctacttgtcc taataaaaca atggatgtct caaaagtgaa actaaagaaa accaaaaaac
     1621 gagaggctga cttgcctgat aatattacca atgaaaaaac agaaatagaa caaacaaaaa
     1681 taaaagggga tgtggctgga aagaaaaatg aaaagtccgt caaagcagag aaaagagatg
     1741 tctcaaaaga gaaaaagcct tctaataatg tgtcagtgat ccaggtgact accagaactc
     1801 gaaaatcagt aacagaggtg aaagagatgg atgtgcatac aggaagcaat tcagaaaaat
     1861 tcagtaaaac taagaaaagc aaaaggaagc tggaagttga cagccattct ttacatggtc
     1921 ctgtgaatga tgaggaatct tcaacaaaaa agaaaaagaa ggtagaaagc aaatccaaaa
     1981 ataatagtca ggaagtgcca aagggtgaca gcaaagtgga ggagaataaa aagcaaaata
     2041 cttgcatgaa aaaaagtaca aagaagaaaa ctctgaaaaa taaatcaagt aagaaaagca
     2101 gtaagcctcc tcagaaggaa cctgttgaga agggatctgc tcagatggac cctcctcaga
     2161 tggggcctgc tcccacagag gcggttcaga aggggcccgt tcaggtggag ccgccacctc
     2221 ccatggagca tgctcagatg gagggtgccc agatacggcc tgctcctgac gagcctgttc
     2281 agatggaggt ggttcaggag gggcctgctc agaaggagct gctgcctccc gtggagcctg
     2341 ctcagatggt gggtgcccaa attgtacttg ctcacatgga gctgcctcct cccatggaga
     2401 ctgctcagac ggaggttgcc caaatggggc ctgctcccat ggaacctgct cagatggagg
     2461 ttgcccaggt agaatctgct cccatgcagg tggtccagaa ggagcctgtt cagatggagc
     2521 tgtctcctcc catggaggtg gtccagaagg agcctgttca gatagagctg tctcctccca
     2581 tggaggtggt ccagaaggaa cctgttaaga tagagctgtc tcctcccata gaggtggtcc
     2641 agaaggagcc tgttcagatg gagttgtctc ctcccatggg ggtggttcag aaggagcctg
     2701 ctcagaggga gccacctcct cccagagagc ctccccttca catggagcca atttccaaaa
     2761 agcctcctct ccgaaaagat aaaaaggaaa agtctaacat gcagagtgaa agggcacgga
     2821 aggagcaagt ccttattgaa gttggcttag tgcctgttaa agatagctgg cttctaaagg
     2881 aaagtgtaag cacagaggat ctctcaccac catcaccacc actgccaaag gaaaatttaa
     2941 gagaagaggc atcaggagac caaaaattac tcaacacagg tgaaggaaat aaagaagccc
     3001 ctcttcagaa agtaggagca gaagaggcag atgagagcct acctggtctt gctgctaata
     3061 tcaacgaatc tacccatatt tcatcctctg gacaaaactt gaatacgcca gagggtgaaa
     3121 ctttaaatgg taaacatcag actgacagta tagtttgtga aatgaaaatg gacactgatc
     3181 agaacacaag agagaatctc actggtataa attcaacagt tgaagaacca gtttcaccaa
     3241 tgcttccccc ttcagcagta gaagaacgtg aagcagtgtc caaaactgca ctggcatcac
     3301 ctcctgctac aatggcagca aatgagtctc aggaaattga tgaagatgaa ggcatccaca
     3361 gccatgaagg aagtgaccta agtgacaaca tgtcagaggg tagtgatgat tctggattgc
     3421 atggggctcg gccagttcca caagaatcta gcagaaaaaa tgcaaaggaa gccttggcag
     3481 tcaaagcggc taagggagat tttgtttgta tcttctgtga tcgttctttc agaaagggaa
     3541 aagattacag caaacacctc aatcgccatt tggttaatgt gtactatctt gaagaagcag
     3601 ctcaagggca ggagtaatga aactttgaac aaggtttcag ttcttagttt gtaaggtata
     3661 ttacatttta tattcattta tgatagcaga caacctttta agattgcttt aattagtatc
     3721 tgatgttgat ttttaagtgg cattcttttc cttaggactt tttatgtata cctgttgatt
     3781 gttgtgtaaa ttttagtaaa tctaagagag tgtactaaac cagcaggtat ctgttagctt
     3841 atgtgtttaa ttgaaattag aaggctaaga tggtataaca gcattttatt gctttgtcca
     3901 gctacaactt gtcatttttt tctccatgtc ttatcttcct gtttcacttt agtttattct
     3961 tcgtttttta ttgagatcta taaaaaattg gcttacttaa tagcaaatta cttgaagaat
     4021 ttgcctgctt tatataaagt tagcacttta agattttttt ttttagagat gagaagacat
     4081 ttaaattgaa gaaaaattcc cccagcaata gacagtctat cagtccaagt atttacttcc
     4141 tgagttttga tcaatatttt ttatttgtgt atgttaatcg tcataaaaac agtgattttg
     4201 gtgtgttttt tattttggtg ctttaatggc ttaagatgtt gcacattttt tttttctttt
     4261 ggtttctgtt tatgtttttt tgcctatgca gttaaatttt tcctagaaat agcatttgtg
     4321 ttgaacagta acactttata catatatata tgcatgttta ttttgtttgg cgtctttgga
     4381 gggatgcttt tagacttgtt tgcaaaaggg cagttttctt tttctttgct gcagttgtct
     4441 attttgcaga ataatagtgt gtgcaagttt gtgagcaaat gaaatatgca ggttcaatct
     4501 attgattttg atttttacat cttatatcta tgccagaatc tgtatttcat ataacttatt
     4561 tatttcgaat ggatgtagta aattcacagc tatcagtttt gattttgcaa taaataaacc
     4621 actaggttgc atgtcgaaca aatttttatc tcaaatacca accatcagtt ttttttttca
     4681 tgtgttttgg tacagctaat tcctaattgt agagtgttaa atgtttgagg agaacctttt
     4741 ctcatagatg gttggtgttc atatggctac tttacaataa agagaactgt aagtgatatt
     4801 tggaaactac aaacctggaa ttaggagata taattattcc ttcaagtttt atagaatatc
     4861 acttgggaga ttccaaagcc atagctatta cgcggcaaac ctaggataag aaaggtagta
     4921 tgagtgctgg tagaccagct gcaactttcc tatacagtga aaaaggctgg tgaaacaagt
     4981 acagtccaga ttttttaaaa tcatactttc tcagggatct ccacaaactg gtgggtgtcc
     5041 tggctgtctg tgtgatagcc tctttctata ggtgaggcct caaatgaatt gcagctatcc
     5101 tggtgttcct atgagggcac tttgtatgaa aaagggcatg tactccaaaa catttttgta
     5161 ggttctttgg ccagttgcca aagagtgtga aagaatccaa tagaggattt ttcttactga
     5221 tagcagtcat tcattgcagt aaaataaaat atgatcccat tagggaatct tgaattctga
     5281 cctcccatac tccgttttga aataaccact ttatatttca ttttttaaaa atctgatgat
     5341 ctctttgagg caggtttcag atttggcagt acaacatgaa agattaggaa aagcattaat
     5401 aacgtgtggg tggaaagctt gttaaaaatc tgagagtgaa gtttgagtta aaagttgttt
     5461 gaacatggca ttgactggga ggccaaagat ttaaagaagc ggaagattct tctcttaaga
     5521 catgaggagt aagttgtgtg ataatggtat gtgttttgtg tgcatgaatg gacattgtaa
     5581 atgttgaatt ctaggctccg acaatcattg tcaacagaag atcaagctgc aaatatttat
     5641 gttttaaaac ttaaattata aagctagtta agtctttcta atgactagtt ttaatgttca
     5701 tgggtacatt ttacctaagt taccgtttac attgtataga aaaagataca tcttaagcac
     5761 agattggtta ttaggaatta gtttggggaa gaggtttttt tgtggattct ttcatactgc
     5821 aaagaaaaac catttgcctt ttggggaatt gagctaactt ctaatctagt cttaagacta
     5881 gaatgctaaa aacaaaaaca tgaaggaaat taaaacccct tattattaaa ttgatttgta
     5941 aaaacattgt tactggaaat ttattggact tgaggccttc ctccagaaaa taaggacttg
     6001 attgtcaggc ctatattagg ttctgaacct taatgccatg tatttgtact tactaaaaat
     6061 tgtttcaatg aaaagtacat tagcagtatg aacttctggt ccagttggaa gtttttccat
     6121 ttgaaaaatg tgatgtttgc atggaactgt ttgaaacttt tttattttct agtccccctc
     6181 ccccacactg gatagaattt agcctagaat tttccctttg gataaaagaa caaaaattga
     6241 acatgttatt tgtaaattga tgtttagtaa ttagtgataa acttgaaata ctagcatata
     6301 ttataagcct taatcttagg tagtcttatg aaaatgaatc tcttaactat cttttgaacc
     6361 tgtattcaca ttggttttca agatatttta agttatattt tttcctcttt tcagagctgc
     6421 ttcttattct ggggctactt ttttttttag ttgtgtaatt cacaaagggc tgcatttttt
     6481 ttttttttta ataaggctta taactatggc tggatctttt gctctagtct tctaagaagg
     6541 gccattttat tttttagagt cacttctaaa gtcatgtggt aattaacttt ggagactgtt
     6601 ttgcgtatga gtgctgatac aaattaaaac ccaagtagac ctcattgcat gtcaccctat
     6661 gaatgttgac aatggaagga ataccttgcc tgtagtatac tgtcacttct ggattgataa
     6721 gctgaggaag aaagttaagt ttctttttta cataagtcag aaaaacttac agctggtgtt
     6781 cctagtttcc tggttgacct cagcagatga agtgaacaga tagtgttaat tcagattgaa
     6841 gaaattatct gaatcttggt ttgtgtagat ttacaatcta catgcaatat taactaaatc
     6901 agatagcttt tacagtttca catgtgtaca taggttccct cccggtccct tccatatcca
     6961 ttagttattg aactttctaa actggcattg aaacattaca acaatgtttt gttgcaccaa
     7021 ttttataaac ttaagcagtg caatacgtgt tacttttctg aggcaaacca aaggtaaatt
     7081 tctcaaggtt cttgctgcct tctttagcag catttgatgg aagatctttt atacatttgt
     7141 aatagataaa aataaaccag attgcaaatc cttttttaaa atcctaaacc atgtaccaag
     7201 tttttggtcc aaattatgta ggataagtta aacttaaatt gcattctatt aaccaatatg
     7261 agtgtatttc tgtaagcata gttatgttga aataaagttt taaaaacca
//
