LOCUS       NP_005603               1097 aa            linear   PRI 11-FEB-2025
DEFINITION  RE1-silencing transcription factor [Homo sapiens].
ACCESSION   NP_005603
VERSION     NP_005603.3
DBSOURCE    REFSEQ: accession NM_005612.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1097)
  AUTHORS   Yu,W., Han,S., Hu,S., Ru,L., Hua,C., Xue,G., Zhang,G., Lv,K.,
            Ge,H., Wang,M., Zheng,L., Zhou,J., Hou,S., Teng,Y., Deng,W. and
            Guo,W.
  TITLE     KIF15 promotes human glioblastoma progression under the synergistic
            transactivation of REST and P300
  JOURNAL   Int J Biol Sci 20 (13), 5127-5144 (2024)
   PUBMED   39430242
  REMARK    GeneRIF: KIF15 promotes human glioblastoma progression under the
            synergistic transactivation of REST and P300.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1097)
  AUTHORS   Abedin,Y., Minchella,P., Peterson,R., Gonnella,F., Graham,A.,
            Cook,I., Javellana,M., Jewell,A., Spoozak,L. and Nothnick,W.B.
  TITLE     Functional Analysis of RE1 Silencing Transcription Factor as a
            Putative Tumor Suppressor in Human Endometrial Cancer
  JOURNAL   Int J Mol Sci 25 (17), 9693 (2024)
   PUBMED   39273639
  REMARK    GeneRIF: Functional Analysis of RE1 Silencing Transcription Factor
            as a Putative Tumor Suppressor in Human Endometrial Cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1097)
  AUTHORS   Redin,E., Sridhar,H., Zhan,Y.A., Pereira Mello,B., Zhong,H.,
            Durani,V., Sabet,A., Manoj,P., Linkov,I., Qiu,J., Koche,R.P., de
            Stanchina,E., Astorkia,M., Betel,D., Quintanal-Villalonga,A. and
            Rudin,C.M.
  TITLE     SMARCA4 controls state plasticity in small cell lung cancer through
            regulation of neuroendocrine transcription factors and REST
            splicing
  JOURNAL   J Hematol Oncol 17 (1), 58 (2024)
   PUBMED   39080761
  REMARK    GeneRIF: SMARCA4 controls state plasticity in small cell lung
            cancer through regulation of neuroendocrine transcription factors
            and REST splicing.
            Erratum:[J Hematol Oncol. 2024 Sep 29;17(1):89. doi:
            10.1186/s13045-024-01609-7.. PMID: 39343962]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1097)
  AUTHORS   Luo,J., Yu,H., Yuan,Z., Tang,W. and Wang,C.
  TITLE     REST Promotes Autophagy in Gastric Cancer by Transcriptionally
            Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 212 (2024)
   PUBMED   38940038
  REMARK    GeneRIF: REST Promotes Autophagy in Gastric Cancer by
            Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR
            Signaling Pathway.
REFERENCE   5  (residues 1 to 1097)
  AUTHORS   Singh,A., Cheng,D., Swaminathan,J., Yang,Y., Zheng,Y., Gordon,N.
            and Gopalakrishnan,V.
  TITLE     REST-dependent downregulation of von Hippel-Lindau tumor suppressor
            promotes autophagy in SHH-medulloblastoma
  JOURNAL   Sci Rep 14 (1), 13596 (2024)
   PUBMED   38866867
  REMARK    GeneRIF: REST-dependent downregulation of von Hippel-Lindau tumor
            suppressor promotes autophagy in SHH-medulloblastoma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1097)
  AUTHORS   Thiel,G., Lietz,M. and Cramer,M.
  TITLE     Biological activity and modular structure of RE-1-silencing
            transcription factor (REST), a repressor of neuronal genes
  JOURNAL   J Biol Chem 273 (41), 26891-26899 (1998)
   PUBMED   9756936
REFERENCE   7  (residues 1 to 1097)
  AUTHORS   Scholl,T., Stevens,M.B., Mahanta,S. and Strominger,J.L.
  TITLE     A zinc finger protein that represses transcription of the human MHC
            class II gene, DPA
  JOURNAL   J Immunol 156 (4), 1448-1457 (1996)
   PUBMED   8568247
REFERENCE   8  (residues 1 to 1097)
  AUTHORS   Chong,J.A., Tapia-Ramirez,J., Kim,S., Toledo-Aral,J.J., Zheng,Y.,
            Boutros,M.C., Altshuller,Y.M., Frohman,M.A., Kraner,S.D. and
            Mandel,G.
  TITLE     REST: a mammalian silencer protein that restricts sodium channel
            gene expression to neurons
  JOURNAL   Cell 80 (6), 949-957 (1995)
   PUBMED   7697725
REFERENCE   9  (residues 1 to 1097)
  AUTHORS   Schoenherr,C.J. and Anderson,D.J.
  TITLE     The neuron-restrictive silencer factor (NRSF): a coordinate
            repressor of multiple neuron-specific genes
  JOURNAL   Science 267 (5202), 1360-1363 (1995)
   PUBMED   7871435
REFERENCE   10 (residues 1 to 1097)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069307.7 and BC136491.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 30, 2010 this sequence version replaced NP_005603.2.
            
            Summary: This gene was initially identified as a transcriptional
            repressor that represses neuronal genes in non-neuronal tissues.
            However, depending on the cellular context, this gene can act as
            either an oncogene or a tumor suppressor. The encoded protein is a
            member of the Kruppel-type zinc finger transcription factor family.
            It represses transcription by binding a DNA sequence element called
            the neuron-restrictive silencer element. The protein is also found
            in undifferentiated neuronal progenitor cells and it is thought
            that this repressor may act as a master negative regulator of
            neurogenesis. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, May 2018].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.130457.1,
                                           SRR1803615.176357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309042.12/ ENSP00000311816.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     Protein         1..1097
                     /product="RE1-silencing transcription factor"
                     /note="repressor binding to the X2 box; neuron restrictive
                     silencer factor; neural-restrictive silencer factor"
                     /calculated_mol_wt=121742
     Region          32..122
                     /region_name="Interaction with SIN3A.
                     /evidence=ECO:0000269|PubMed:10734093"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          43..57
                     /region_name="Interaction with SIN3B.
                     /evidence=ECO:0000269|PubMed:16288918"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          83..103
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          127..159
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          145..418
                     /region_name="Interaction with ZFP90.
                     /evidence=ECO:0000269|PubMed:21284946"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          201..212
                     /region_name="Required for binding to the
                     neuron-restrictive silencer element.
                     /evidence=ECO:0000250|UniProtKB:Q8VIG1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          218..238
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          250..270
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          278..298
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(280,284,287,289..290,293..294,297,311,313,317..318,
                     321..322,325,339,341,343,345..346,349..350,354)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          290..315
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          304..328
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          306..326
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          318..343
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          334..355
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          363..383
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          363..383
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          391..407
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          452..642
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          <599..>767
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          774..837
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Region          853..938
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Site            864
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13127.3)"
     Region          961..1049
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     Site            971
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O54963; propagated from
                     UniProtKB/Swiss-Prot (Q13127.3)"
     Region          1009..1087
                     /region_name="Interaction with RCOR1.
                     /evidence=ECO:0000269|PubMed:10449787"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13127.3)"
     CDS             1..1097
                     /gene="REST"
                     /gene_synonym="DFNA27; GINGF5; HGF5; NRSF; WT6; XBR"
                     /coded_by="NM_005612.5:324..3617"
                     /db_xref="CCDS:CCDS3509.1"
                     /db_xref="GeneID:5978"
                     /db_xref="HGNC:HGNC:9966"
                     /db_xref="MIM:600571"
ORIGIN      
        1 matqvmgqss gggglftssg nigmalpndm ydlhdlskae laapqlimla nvaltgevng
       61 sccdylvgee rqmaelmpvg dnnfsdseeg egleesadik gephglenme lrslelsvve
      121 pqpvfeasga pdiyssnkdl ppetpgaedk gkssktkpfr ckpcqyeaes eeqfvhhirv
      181 hsakkffvee saekqakare sgsstaeegd fskgpircdr cgyntnrydh ytahlkhhtr
      241 agdnervykc iictyttvse yhwrkhlrnh fprkvytcgk cnyfsdrknn yvqhvrthtg
      301 erpykcelcp ysssqkthlt rhmrthsgek pfkcdqcsyv asnqhevtrh arqvhngpkp
      361 lncphcdykt adrsnfkkhv elhvnprqfn cpvcdyaask kcnlqyhfks khptcpnktm
      421 dvskvklkkt kkreadlpdn itnekteieq tkikgdvagk kneksvkaek rdvskekkps
      481 nnvsviqvtt rtrksvtevk emdvhtgsns ekfsktkksk rklevdshsl hgpvndeess
      541 tkkkkkvesk sknnsqevpk gdskveenkk qntcmkkstk kktlknkssk ksskppqkep
      601 vekgsaqmdp pqmgpaptea vqkgpvqvep pppmehaqme gaqirpapde pvqmevvqeg
      661 paqkellppv epaqmvgaqi vlahmelppp metaqtevaq mgpapmepaq mevaqvesap
      721 mqvvqkepvq melsppmevv qkepvqiels ppmevvqkep vkielsppie vvqkepvqme
      781 lsppmgvvqk epaqrepppp repplhmepi skkpplrkdk keksnmqser arkeqvliev
      841 glvpvkdswl lkesvstedl sppspplpke nlreeasgdq kllntgegnk eaplqkvgae
      901 eadeslpgla aninesthis ssgqnlntpe getlngkhqt dsivcemkmd tdqntrenlt
      961 ginstveepv spmlppsave ereavsktal asppatmaan esqeidedeg ihshegsdls
     1021 dnmsegsdds glhgarpvpq essrknakea lavkaakgdf vcifcdrsfr kgkdyskhln
     1081 rhlvnvyyle eaaqgqe
//
