LOCUS       NM_001286201             990 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens RERG like (RERGL), transcript variant 2, mRNA.
ACCESSION   NM_001286201 XM_005253483
VERSION     NM_001286201.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 990)
  AUTHORS   Yang,R., Chen,B., Pfutze,K., Buch,S., Steinke,V.,
            Holinski-Feder,E., Stocker,S., von Schonfels,W., Becker,T.,
            Schackert,H.K., Royer-Pokora,B., Kloor,M., Schmiegel,W.H.,
            Buttner,R., Engel,C., Lascorz Puertolas,J., Forsti,A., Kunkel,N.,
            Bugert,P., Schreiber,S., Krawczak,M., Schafmayer,C., Propping,P.,
            Hampe,J., Hemminki,K. and Burwinkel,B.
  TITLE     Genome-wide analysis associates familial colorectal cancer with
            increases in copy number variations and a rare structural variation
            at 12p12.3
  JOURNAL   Carcinogenesis 35 (2), 315-323 (2014)
   PUBMED   24127187
  REMARK    GeneRIF: Loss of RERGL expression is associated with familial
            colorectal cancer.
REFERENCE   2  (bases 1 to 990)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   3  (bases 1 to 990)
  AUTHORS   Claudio,J.O., Liew,C.C., Dempsey,A.A., Cukerman,E., Stewart,A.K.,
            Na,E., Atkins,H.L., Iscove,N.N. and Hawley,R.G.
  TITLE     Identification of sequence-tagged transcripts differentially
            expressed within the human hematopoietic hierarchy
  JOURNAL   Genomics 50 (1), 44-52 (1998)
   PUBMED   9628821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DT220095.1, BX422875.2 and BC042888.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 20, 2020 this sequence version replaced NM_001286201.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate upstream start codon, compared to variant 1. The encoded
            isoform (b) has a distinct N-terminus and is shorter than isoform
            a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX422874.2, BX422875.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538724.6/ ENSP00000437814.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DT220095.1         1-52
            53-778              BX422875.2         1-726
            779-990             BC042888.1         923-1134
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..990
                     /gene="RERGL"
                     /note="RERG like"
                     /db_xref="GeneID:79785"
                     /db_xref="HGNC:HGNC:26213"
     exon            1..105
                     /gene="RERGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..668
                     /gene="RERGL"
                     /EC_number="3.6.5.2"
                     /note="isoform b is encoded by transcript variant 2;
                     ras-related and estrogen-regulated growth inhibitor-like
                     protein; RERG/RAS-like"
                     /codon_start=1
                     /product="ras-related and estrogen-regulated growth
                     inhibitor-like protein isoform b"
                     /protein_id="NP_001273130.1"
                     /db_xref="CCDS:CCDS66332.1"
                     /db_xref="GeneID:79785"
                     /db_xref="HGNC:HGNC:26213"
                     /translation="MNDVKLAVLGGEGTGKSALTVRFLTKRFIGEYASNFESIYKKHL
                     CLERKQLNLEIYDPCSQTQKAKFSLTSELHWADGFVIVYDISDRSSFAFAKALIYRIR
                     EPQTSHCKRAVESAVFLVGNKRDLCHVREVGWEEGQKLALENRCQFCELSAAEQSLEV
                     EMMFIRIIKDILINFKLKEKRRPSGSKSMAKLINNVFGKRRKSV"
     exon            106..162
                     /gene="RERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            163..236
                     /gene="RERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            237..385
                     /gene="RERGL"
                     /inference="alignment:Splign:2.1.0"
     exon            386..990
                     /gene="RERGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      948..953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RERGL"
                     /note="hexamer: AATAAA"
     polyA_site      990
                     /gene="RERGL"
                     /note="major polyA site"
ORIGIN      
        1 acagggcagt gtagttccag aaaataggac tgaccaagaa gcagaaaagc aagatgaatg
       61 atgtgaagct tgctgtcttg ggtggtgaag gaacaggcaa atctgccctt acagtgaggt
      121 ttcttactaa gcgattcatt ggagaatatg cttctaattt tgaatctatc tataagaagc
      181 acttgtgttt ggaaaggaaa caactaaatc tagaaatata tgacccttgt tctcaaacac
      241 agaaagcaaa attctccctc acaagtgagc ttcactgggc agatgggttt gttattgtgt
      301 atgacatcag tgataggtct tcatttgctt ttgcaaaagc gctgatctac agaatccggg
      361 agccacaaac tagtcattgt aaaagagctg tggaatcagc agtgtttttg gttggcaaca
      421 aacgagatct ttgtcatgtg cgagaggttg gctgggaaga agggcaaaag ctggcactgg
      481 aaaaccgatg ccaattctgt gaactgtctg cagcagagca gtctctggag gtggaaatga
      541 tgtttatcag aattatcaag gacatcctga taaacttcaa actcaaagaa aagagacgtc
      601 ccagtggatc taaatcaatg gccaaattga tcaataatgt atttggaaag agaaggaaat
      661 ctgtttagta gacaggtaat cctgggagat ttcctatatc agagagtttc aaacattcac
      721 atgataatta aactaacctt tgtatgcaat ttttttttgg taaaaagaat tctcttggag
      781 atatgaaatg attgagtatg aaccacagct gtgttttcaa atatgtagtt tgcctttttg
      841 gttgttgtac cctgctcact ctccttcaca cagaaccttt catttattgt acaacatcac
      901 actcacccta acctactggc ggacagcgat cccagtttgc cttgccaaat aaactctgtt
      961 tatgtgaatt tattaaacga ccatgccata
//
