LOCUS       NM_032918               2264 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAS like estrogen regulated growth inhibitor (RERG),
            transcript variant 1, mRNA.
ACCESSION   NM_032918
VERSION     NM_032918.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Jin,S., Li,X., Dai,Y., Li,C. and Wang,D.
  TITLE     NF-kappaB-mediated miR-650 plays oncogenic roles and activates
            AKT/ERK/NF-kappaB pathways by targeting RERG in glioma cells
  JOURNAL   Cell Oncol (Dordr) 43 (6), 1035-1048 (2020)
   PUBMED   32986146
  REMARK    GeneRIF: NF-kappaB-mediated miR-650 plays oncogenic roles and
            activates AKT/ERK/NF-kappaB pathways by targeting RERG in glioma
            cells.
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Xiong,Y., Huang,H., Chen,S., Dai,H. and Zhang,L.
  TITLE     ERK5-regulated RERG expression promotes cancer progression in
            prostatic carcinoma
  JOURNAL   Oncol Rep 41 (2), 1160-1168 (2019)
   PUBMED   30431143
  REMARK    GeneRIF: Study revealed that ERK5 can inhibit Raslike
            oestrogenregulated growth inhibitor (RERG) protein expression and
            that the inhibition of RERG expression promotes prostatic carcinoma
            cell proliferation and migration.
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Zhao,W., Mo,Y., Wang,S., Midorikawa,K., Ma,N., Hiraku,Y.,
            Oikawa,S., Huang,G., Zhang,Z., Murata,M. and Takeuchi,K.
  TITLE     Quantitation of DNA methylation in Epstein-Barr virus-associated
            nasopharyngeal carcinoma by bisulfite amplicon sequencing
  JOURNAL   BMC Cancer 17 (1), 489 (2017)
   PUBMED   28716111
  REMARK    GeneRIF: In particular, methylation levels of ITGA4, RERG, and
            ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients
            from non-cancer nasopharyngeal epithelium (NNE) subjects.  We
            identified the DNA methylation rates of previously unidentified NPC
            candidate genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Ho,J.Y., Hsu,R.J., Liu,J.M., Chen,S.C., Liao,G.S., Gao,H.W. and
            Yu,C.P.
  TITLE     MicroRNA-382-5p aggravates breast cancer progression by regulating
            the RERG/Ras/ERK signaling axis
  JOURNAL   Oncotarget 8 (14), 22443-22459 (2017)
   PUBMED   27705918
  REMARK    GeneRIF: this study shows that miR-382-5p expression is negatively
            correlated with RERG expression, and functions as an independent
            oncomiR for the higher incidence and poorer prognosis of breast
            cancer
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Monsivais,D., Dyson,M.T., Yin,P., Coon,J.S., Navarro,A., Feng,G.,
            Malpani,S.S., Ono,M., Ercan,C.M., Wei,J.J., Pavone,M.E., Su,E. and
            Bulun,S.E.
  TITLE     ERbeta- and prostaglandin E2-regulated pathways integrate cell
            proliferation via Ras-like and estrogen-regulated growth inhibitor
            in endometriosis
  JOURNAL   Mol Endocrinol 28 (8), 1304-1315 (2014)
   PUBMED   24992181
  REMARK    GeneRIF: Estradiol estrogen receptor-beta and PGE2 integrate at
            RERG, leading to increased endometriotic cell proliferation.
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Chile,T., Correa-Giannella,M.L., Fortes,M.A., Bronstein,M.D.,
            Cunha-Neto,M.B., Giannella-Neto,D. and Giorgi,R.R.
  TITLE     Expression of CRABP1, GRP, and RERG mRNA in clinically
            non-functioning and functioning pituitary adenomas
  JOURNAL   J Endocrinol Invest 34 (8), e214-e218 (2011)
   PUBMED   21270509
  REMARK    GeneRIF: Results describe the mRNA expression of CRABP1, RERG, and
            GRP in pituitary adenomas.
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Habashy,H.O., Powe,D.G., Glaab,E., Ball,G., Spiteri,I.,
            Krasnogor,N., Garibaldi,J.M., Rakha,E.A., Green,A.R., Caldas,C. and
            Ellis,I.O.
  TITLE     RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression
            in breast cancer: a marker of ER-positive luminal-like subtype
  JOURNAL   Breast Cancer Res Treat 128 (2), 315-326 (2011)
   PUBMED   20697807
  REMARK    GeneRIF: Loss of RERG expression is associated with breast cancer
            and distant metastasis.
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   Finlin,B.S., Gau,C.L., Murphy,G.A., Shao,H., Kimel,T., Seitz,R.S.,
            Chiu,Y.F., Botstein,D., Brown,P.O., Der,C.J., Tamanoi,F.,
            Andres,D.A. and Perou,C.M.
  TITLE     RERG is a novel ras-related, estrogen-regulated and
            growth-inhibitory gene in breast cancer
  JOURNAL   J Biol Chem 276 (45), 42259-42267 (2001)
   PUBMED   11533059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC331754.1 and BC007997.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032918.2.
            
            Summary: RERG, a member of the RAS superfamily of GTPases, inhibits
            cell proliferation and tumor formation (Finlin et al., 2001 [PubMed
            11533059]).[supplied by OMIM, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007997.1, AK313881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256953.6/ ENSP00000256953.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DC331754.1         61-107
            48-2264             BC007997.1         1-2217
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..2264
                     /gene="RERG"
                     /note="RAS like estrogen regulated growth inhibitor"
                     /db_xref="GeneID:85004"
                     /db_xref="HGNC:HGNC:15980"
                     /db_xref="MIM:612664"
     exon            1..223
                     /gene="RERG"
                     /inference="alignment:Splign:2.1.0"
     exon            224..398
                     /gene="RERG"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..937
                     /gene="RERG"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related and estrogen-regulated growth inhibitor"
                     /codon_start=1
                     /product="ras-related and estrogen-regulated growth
                     inhibitor isoform 1"
                     /protein_id="NP_116307.1"
                     /db_xref="CCDS:CCDS8673.1"
                     /db_xref="GeneID:85004"
                     /db_xref="HGNC:HGNC:15980"
                     /db_xref="MIM:612664"
                     /translation="MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYR
                     HQATIDDEVVSMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNIL
                     DEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIF
                     YELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS"
     exon            399..455
                     /gene="RERG"
                     /inference="alignment:Splign:2.1.0"
     exon            456..529
                     /gene="RERG"
                     /inference="alignment:Splign:2.1.0"
     exon            530..2264
                     /gene="RERG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RERG"
                     /note="hexamer: AATAAA"
     polyA_site      2264
                     /gene="RERG"
                     /note="major polyA site"
ORIGIN      
        1 gcagtccctc cgccgctagt cggagcgagc gcgagtgagg agacccccgc cgggccactg
       61 gcacttgctt ctgcggcgag tcccacccac gaccgcagcc cagcaactcg caaacgcaac
      121 ctgaagcctg ggctgcgcag tgtgggaggg cttcgcgatc ttgggggacc cattccgaac
      181 ttgcagagga ccgtagctct cctggcctgg agagtgtgaa caggattgtg gactcttcca
      241 agattcacaa tgatatggtg aatccaaaga ctggaaccaa aaagatttac tcagtgcttt
      301 agttttaaca acagtaaatt gtctaccaac acccatcatg gctaaaagtg cggaggtcaa
      361 actggcaata tttgggagag caggcgtggg caagtcagct cttgtagtga gatttctgac
      421 caaacggttc atctgggaat atgatcccac cctcgaatca acctaccgac accaagcaac
      481 catcgatgat gaagttgttt ccatggagat actagacact gctggtcagg aagataccat
      541 tcagagggag gggcacatgc gatgggggga aggctttgtg ctggtctacg acattactga
      601 ccgaggaagt tttgaggaag tgctgccact taagaacatc ctagatgaga tcaaaaagcc
      661 caagaatgtg actctcatct tggttggaaa caaagctgac ttggaccact ccaggcaggt
      721 tagcacagaa gaaggagaga agctggccac agaattggct tgtgcttttt acgagtgctc
      781 tgcctgcact ggagaaggga acatcacaga gatattctat gaattgtgtc gagaggtgcg
      841 tcgccggagg atggtgcagg gcaagacgag gcgacgcagc tccaccacgc atgtcaagca
      901 agccattaac aagatgctca ccaaaatcag tagttaggca gcccagctga ggtggaccaa
      961 ctaattggaa acactcttcc ccttctgttc ccctttcaaa aataaaacaa aatattgcat
     1021 tctttgtttg gattctgaga aatgtctggg cttcccattg tttctggcct ctaataggtt
     1081 gggaagtttt agcgtgtttt atgcaatttc agtgctaaca atttcttcct ttcctgcttg
     1141 aataagatac actctaatgg catttgaaca tgtaatcacc agagattctg aaatgactgg
     1201 tttatgttaa gctattttta ggcatcttca ccttgcttta agtaggttga agtttttgca
     1261 aaggcattta aaaattcaat ttcttgtcag atactacaaa taattttctt aaaagtctaa
     1321 gatagcagaa aatacagtaa aaacacagga gaagaagctg agctattgga acaggaaata
     1381 gaaggaactc tagtttctgt ttgaagtgag gattttctga attatctaat atcatctagg
     1441 ttttctttaa aattttattt tgttcttcag ttcaagcatc ttctcactaa tgtttttcac
     1501 tataacagag aattcatttc aatttgagtt ggttctctca atgatctatt gatcattaca
     1561 ccctaactct ccttccttgg ctcaaacaat attttcccta taacaaaggc aataggacac
     1621 aaaattcaca tcctgctggg ccttttttca tcaagtcagg gtgatataaa aacattggaa
     1681 gtcttttcac caaaccctga ctttattgaa tgctagtaga agatgtagaa ttagagacat
     1741 ctgatttgtt tatcacctta gcagaaaaac cacagtccaa aagacaagca aattaagaat
     1801 ggagcttaac catgcctcca ttgggaagtc tagactttga gccaggtaca gtaagaaaaa
     1861 ttagcctctg attcattaag tttgccacat gacttatttt gatattttgg atacattaac
     1921 tcacttagga gaattcagaa aagaatgggt gattaaagtt cattacagct gaataaatgt
     1981 gtctaaaaca gactcttgta ttctgaaagt acagtctaca actgataaaa ccttatgatt
     2041 cttttctccc ccattatgcc cctatatata tcaagatttg ggtactttat tttagtagaa
     2101 aatatatatc ttttacatat gtatgtattt ataaatgcat agatatatgt ataaaaattt
     2161 gtaagcgtta gcggcattaa ttcaccaatg catttggaca acttgatgta actgacttta
     2221 ttttatgtga ctataataaa aagcataatt ttctcattct gtca
//
