LOCUS       NM_001042681            8009 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens arginine-glutamic acid dipeptide repeats (RERE),
            transcript variant 2, mRNA.
ACCESSION   NM_001042681
VERSION     NM_001042681.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8009)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 8009)
  AUTHORS   Fregeau,B., Kim,B.J., Hernandez-Garcia,A., Jordan,V.K., Cho,M.T.,
            Schnur,R.E., Monaghan,K.G., Juusola,J., Rosenfeld,J.A., Bhoj,E.,
            Zackai,E.H., Sacharow,S., Baranano,K., Bosch,D.G.M., de
            Vries,B.B.A., Lindstrom,K., Schroeder,A., James,P., Kulch,P.,
            Lalani,S.R., van Haelst,M.M., van Gassen,K.L.I., van Binsbergen,E.,
            Barkovich,A.J., Scott,D.A. and Sherr,E.H.
  TITLE     De Novo Mutations of RERE Cause a Genetic Syndrome with Features
            that Overlap Those Associated with Proximal 1p36 Deletions
  JOURNAL   Am J Hum Genet 98 (5), 963-970 (2016)
   PUBMED   27087320
  REMARK    GeneRIF: suggest that mutations in RERE cause a genetic syndrome
            and that haploinsufficiency of RERE might be sufficient to cause
            many of the phenotypes associated with proximal 1p36 deletions
REFERENCE   3  (bases 1 to 8009)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   4  (bases 1 to 8009)
  AUTHORS   Springelkamp,H., Hohn,R., Mishra,A., Hysi,P.G., Khor,C.C.,
            Loomis,S.J., Bailey,J.N., Gibson,J., Thorleifsson,G., Janssen,S.F.,
            Luo,X., Ramdas,W.D., Vithana,E., Nongpiur,M.E., Montgomery,G.W.,
            Xu,L., Mountain,J.E., Gharahkhani,P., Lu,Y., Amin,N., Karssen,L.C.,
            Sim,K.S., van Leeuwen,E.M., Iglesias,A.I., Verhoeven,V.J.,
            Hauser,M.A., Loon,S.C., Despriet,D.D., Nag,A., Venturini,C.,
            Sanfilippo,P.G., Schillert,A., Kang,J.H., Landers,J., Jonasson,F.,
            Cree,A.J., van Koolwijk,L.M., Rivadeneira,F., Souzeau,E.,
            Jonsson,V., Menon,G., Weinreb,R.N., de Jong,P.T., Oostra,B.A.,
            Uitterlinden,A.G., Hofman,A., Ennis,S., Thorsteinsdottir,U.,
            Burdon,K.P., Spector,T.D., Mirshahi,A., Saw,S.M., Vingerling,J.R.,
            Teo,Y.Y., Haines,J.L., Wolfs,R.C., Lemij,H.G., Tai,E.S.,
            Jansonius,N.M., Jonas,J.B., Cheng,C.Y., Aung,T., Viswanathan,A.C.,
            Klaver,C.C., Craig,J.E., Macgregor,S., Mackey,D.A., Lotery,A.J.,
            Stefansson,K., Bergen,A.A., Young,T.L., Wiggs,J.L., Pfeiffer,N.,
            Wong,T.Y., Pasquale,L.R., Hewitt,A.W., van Duijn,C.M. and
            Hammond,C.J.
  CONSRTM   Blue Mountains Eye Study-GWAS group; NEIGHBORHOOD Consortium;
            Wellcome Trust Case Control Consortium 2 (WTCCC2)
  TITLE     Meta-analysis of genome-wide association studies identifies novel
            loci that influence cupping and the glaucomatous process
  JOURNAL   Nat Commun 5, 4883 (2014)
   PUBMED   25241763
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8009)
  AUTHORS   Medici,M., Porcu,E., Pistis,G., Teumer,A., Brown,S.J., Jensen,R.A.,
            Rawal,R., Roef,G.L., Plantinga,T.S., Vermeulen,S.H., Lahti,J.,
            Simmonds,M.J., Husemoen,L.L., Freathy,R.M., Shields,B.M.,
            Pietzner,D., Nagy,R., Broer,L., Chaker,L., Korevaar,T.I.,
            Plia,M.G., Sala,C., Volker,U., Richards,J.B., Sweep,F.C.,
            Gieger,C., Corre,T., Kajantie,E., Thuesen,B., Taes,Y.E.,
            Visser,W.E., Hattersley,A.T., Kratzsch,J., Hamilton,A., Li,W.,
            Homuth,G., Lobina,M., Mariotti,S., Soranzo,N., Cocca,M., Nauck,M.,
            Spielhagen,C., Ross,A., Arnold,A., van de Bunt,M.,
            Liyanarachchi,S., Heier,M., Grabe,H.J., Masciullo,C.,
            Galesloot,T.E., Lim,E.M., Reischl,E., Leedman,P.J., Lai,S.,
            Delitala,A., Bremner,A.P., Philips,D.I., Beilby,J.P., Mulas,A.,
            Vocale,M., Abecasis,G., Forsen,T., James,A., Widen,E., Hui,J.,
            Prokisch,H., Rietzschel,E.E., Palotie,A., Feddema,P.,
            Fletcher,S.J., Schramm,K., Rotter,J.I., Kluttig,A., Radke,D.,
            Traglia,M., Surdulescu,G.L., He,H., Franklyn,J.A., Tiller,D.,
            Vaidya,B., de Meyer,T., Jorgensen,T., Eriksson,J.G., O'Leary,P.C.,
            Wichmann,E., Hermus,A.R., Psaty,B.M., Ittermann,T., Hofman,A.,
            Bosi,E., Schlessinger,D., Wallaschofski,H., Pirastu,N.,
            Aulchenko,Y.S., de la Chapelle,A., Netea-Maier,R.T., Gough,S.C.,
            Meyer Zu Schwabedissen,H., Frayling,T.M., Kaufman,J.M.,
            Linneberg,A., Raikkonen,K., Smit,J.W., Kiemeney,L.A.,
            Rivadeneira,F., Uitterlinden,A.G., Walsh,J.P., Meisinger,C., den
            Heijer,M., Visser,T.J., Spector,T.D., Wilson,S.G., Volzke,H.,
            Cappola,A., Toniolo,D., Sanna,S., Naitza,S. and Peeters,R.P.
  TITLE     Identification of novel genetic Loci associated with thyroid
            peroxidase antibodies and clinical thyroid disease
  JOURNAL   PLoS Genet 10 (2), e1004123 (2014)
   PUBMED   24586183
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8009)
  AUTHORS   Yi,J., Kloeker,S., Jensen,C.C., Bockholt,S., Honda,H., Hirai,H. and
            Beckerle,M.C.
  TITLE     Members of the Zyxin family of LIM proteins interact with members
            of the p130Cas family of signal transducers
  JOURNAL   J Biol Chem 277 (11), 9580-9589 (2002)
   PUBMED   11782456
REFERENCE   7  (bases 1 to 8009)
  AUTHORS   Waerner,T., Gardellin,P., Pfizenmaier,K., Weith,A. and Kraut,N.
  TITLE     Human RERE is localized to nuclear promyelocytic leukemia oncogenic
            domains and enhances apoptosis
  JOURNAL   Cell Growth Differ 12 (4), 201-210 (2001)
   PUBMED   11331249
REFERENCE   8  (bases 1 to 8009)
  AUTHORS   Yanagisawa,H., Bundo,M., Miyashita,T., Okamura-Oho,Y., Tadokoro,K.,
            Tokunaga,K. and Yamada,M.
  TITLE     Protein binding of a DRPLA family through arginine-glutamic acid
            dipeptide repeats is enhanced by extended polyglutamine
  JOURNAL   Hum Mol Genet 9 (9), 1433-1442 (2000)
   PUBMED   10814707
REFERENCE   9  (bases 1 to 8009)
  AUTHORS   Amler,L.C., Bauer,A., Corvi,R., Dihlmann,S., Praml,C.,
            Cavenee,W.K., Schwab,M. and Hampton,G.M.
  TITLE     Identification and characterization of novel genes located at the
            t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma
            cell line NGP
  JOURNAL   Genomics 64 (2), 195-202 (2000)
   PUBMED   10729226
REFERENCE   10 (bases 1 to 8009)
  AUTHORS   Scott,D.A. and Sherr,E.H.
  TITLE     RERE-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   30896913
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA868444.1, BC062342.1,
            AL356072.21 and CD679363.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001042681.1.
            
            Summary: This gene encodes a member of the atrophin family of
            arginine-glutamic acid (RE) dipeptide repeat-containing proteins.
            The encoded protein co-localizes with a transcription factor in the
            nucleus, and its overexpression triggers apoptosis. A similar
            protein in mouse associates with histone deacetylase and is thought
            to function as a transcriptional co-repressor during embryonic
            development. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062342.1, SRR7346977.2559560.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400908.7/ ENSP00000383700.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               DA868444.1         1-179
            180-319             DA868444.1         182-321
            320-873             BC062342.1         1-554
            874-2988            BC062342.1         556-2670
            2989-3100           AL356072.21        76868-76979         c
            3101-4569           BC062342.1         2783-4251
            4570-4576           AL356072.21        74420-74426         c
            4577-5787           BC062342.1         4259-5469
            5788-7589           AL356072.21        68660-70461         c
            7590-8009           CD679363.1         1-420
FEATURES             Location/Qualifiers
     source          1..8009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..8009
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /note="arginine-glutamic acid dipeptide repeats"
                     /db_xref="GeneID:473"
                     /db_xref="HGNC:HGNC:9965"
                     /db_xref="MIM:605226"
     exon            1..481
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            482..950
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..5326
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /note="isoform a is encoded by transcript variant 2;
                     atrophin 2; atrophin-1 related protein; atrophin-1 like
                     protein; arginine-glutamic acid dipeptide (RE) repeats"
                     /codon_start=1
                     /product="arginine-glutamic acid dipeptide repeats protein
                     isoform a"
                     /protein_id="NP_001036146.1"
                     /db_xref="CCDS:CCDS95.1"
                     /db_xref="GeneID:473"
                     /db_xref="HGNC:HGNC:9965"
                     /db_xref="MIM:605226"
                     /translation="MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLE
                     GGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDD
                     VVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQ
                     PPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVIT
                     DPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPET
                     RRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAA
                     RSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLI
                     EKCWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAH
                     RRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACR
                     HCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGL
                     SGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDS
                     KAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSE
                     GEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPA
                     LQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHT
                     HIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHS
                     LQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPR
                     EQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPL
                     SSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAP
                     QPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPL
                     PTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCAR
                     TDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAER
                     AAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARP
                     HVMSPTNRNHPFYMPLNPTDPLLAYHMPGLYNVDPTIRERELREREIREREIRERELR
                     ERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPFASFHPGLNPLERER
                     LALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHL
                     HLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPV
                     FGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQE
                     DYYSRLKKEGDKQL"
     exon            951..1021
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1147
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1253
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1350
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1455
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1504
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1629
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1729
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1828
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1909
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2072
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2165
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2365
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2527
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2641
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..4020
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4243
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4964
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4965..5111
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5112..5292
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5293..8009
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7987..7992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /note="hexamer: AATAAA"
     polyA_site      8009
                     /gene="RERE"
                     /gene_synonym="ARG; ARP; ATN1L; DNB1; NEDBEH"
                     /note="major polyA site"
ORIGIN      
        1 agacgctcgc gagcaaccct ccgcgctccg gagcctcctc agcctcccgc acaccccgag
       61 acgctcgccc cgctgggcct cggtccccgc ctcctccccc gtccttttcc cctctctcgc
      121 tccccacatt gtctctgcct cattttctct cctagttgag gattaaaaaa aaaaaaaaat
      181 caccatcatc ctcagggagc cccctcgccc tcggaaaaca aaaccagaca tgatcctggg
      241 ctcctgcttc tgaaagatct gcccgaccga ggaggaggga gcctaggttc aagtcgcagg
      301 aaaggtcacg gcagggaagc cccctcagcc cctccgcgtc gcctccccgc gggccgcccc
      361 tctcggccct gcgccccgcg gccccgcagc ctccgcgcgg cctcccgccc catccccgcc
      421 actttccccg gagctgggcc gcgaacacct cactattgat ggtgtagcgc tttaggggaa
      481 gcatttttga aacgttgggg ttgttggagt ggttggattt tccctggaat tgagtgagaa
      541 attcagaaga ctgaagccca ggcttactgt ctacctttca cggaggccta gccgtgagag
      601 gacagaagaa ggcacgtggc gaatcatgac agcggacaaa gacaaagaca aagacaaaga
      661 gaaggaccgg gaccgagacc gggaccgaga gagagagaaa agagacaaag caagagagag
      721 tgagaattca aggccacgcc ggagctgtac cttggaagga ggagccaaaa attatgctga
      781 gagtgatcac agtgaagacg aggacaatga caacaatagt gccaccgcag aggagtccac
      841 gaagaagaat aagaagaaac caccgaaaaa aaagtctcgt tatgaaagga cagataccgg
      901 tgagataaca tcctacatca ctgaagatga tgtggtctac agaccaggag actgtgtgta
      961 tatcgagagt cggaggccaa acacaccgta tttcatctgt agcattcaag acttcaaact
     1021 ggtccacaac tcccaggcct gttgcagatc tccaactcct gctttgtgtg accccccagc
     1081 atgctctctg ccggtggcat cacagccacc acagcatctt tctgaagccg ggagagggcc
     1141 tgtagggagt aagagggacc atctcctcat gaacgtcaaa tggtactacc gtcaatctga
     1201 ggttccagat tctgtgtatc agcatttggt tcaggatcga cataatgaaa atgactctgg
     1261 aagagaactt gtcattacag acccagttat caagaaccga gagctcttca tttctgatta
     1321 cgttgacact taccatgctg ctgcccttag agggaagtgt aacatctccc atttttctga
     1381 catatttgct gctagagagt ttaaagcccg agtggattca tttttctaca tattaggata
     1441 taaccctgag acaaggaggc tgaacagtac ccagggggag attcgtgtcg gtcctagtca
     1501 tcaggccaaa cttccagatc tgcaaccatt tccttctcca gatggtgata cagtgaccca
     1561 acatgaggaa ctggtctgga tgcctggagt taacgactgt gacctcctta tgtacttgag
     1621 ggcagcaagg agcatggcgg catttgcagg aatgtgtgat ggaggctcta cagaggacgg
     1681 ctgtgtcgca gcctctcggg atgacaccac tctgaatgca ctgaacacac tgcatgaaag
     1741 cggttacgat gctggcaaag ccctgcagcg cctggtgaag aagcctgtgc ccaagctcat
     1801 cgagaagtgc tggaccgagg acgaagtgaa acgcttcgtt aagggactca ggcagtacgg
     1861 gaagaacttc ttcagaatta gaaaggagct gcttcccaat aaggaaacag gggagctgat
     1921 caccttctat tactattgga agaagacccc cgaagcagcc agctcccgag cccatcgtag
     1981 gcaccgcagg caggccgtgt tcaggaggat taagactcgc accgcgtcca cacccgtcaa
     2041 cacaccctcc agacccccgt ccagtgaatt cttggaccta agttcagcca gtgaagatga
     2101 cttcgacagt gaggacagtg agcaggagct gaaggggtac gcctgccgcc actgcttcac
     2161 caccacctcc aaagattggc accacggagg ccgggagaac atcctgcttt gcaccgactg
     2221 tcgcatccac ttcaagaaat acggtgagct cccgcccatt gagaagcccg tggacccgcc
     2281 accgtttatg ttcaaacccg tcaaggaaga ggatgatggg ctcagtggga agcatagcat
     2341 gaggacacgg cggagtcggg gctcgatgtc gacactacgc agtggtcgga agaagcagcc
     2401 agccagccct gatggtcgca cctcacccat caatgaagac atccgctcca gcggccggaa
     2461 ctcccccagc gctgccagta cctccagcaa tgacagtaaa gcagagacag tgaagaagtc
     2521 ggccaagaag gtgaaggagg aagcctcttc ccctcttaag agtaacaaac gccagcggga
     2581 gaaggtggcc tctgatacgg aggaggctga caggaccagc tccaagaaga caaaaacgca
     2641 ggagatcagc aggcccaact cgccatctga aggtgaggga gagagttcag acagtcgcag
     2701 cgtcaacgat gagggtagca gtgaccccaa agacatcgac caggacaatc gcagcacgtc
     2761 cccgagcatc cccagccccc aggacaatga gagtgactcg gactcgtcag cccagcagca
     2821 gatgctgcag gcccagcccc cagccttgca ggctcccact ggggtcaccc cagctccctc
     2881 ctcagctcct ccagggaccc ctcagctgcc cacgccaggg cccacgccct ctgccactgc
     2941 agttccccca cagggctccc ccacggcctc ccaggcccct aaccagccac aggctcccac
     3001 agcgcctgtt ccccacaccc acatccaaca ggcaccggcc ttgcaccccc agcggccgcc
     3061 ctcaccgcat cccccgccgc atccctcgcc acatcccccg ctgcagcctc tgactgggtc
     3121 ggcgggccag ccttctgcac cctctcatgc ccagccccca ctgcacggtc agggcccacc
     3181 cggccctcac agcctgcagg ctgggcccct gctgcagcac ccaggccccc cacagccctt
     3241 tggcctccct ccccaggcct cccaaggcca ggcccctctg gggacctccc cagcagcagc
     3301 gtaccctcac acctccctgc agctgccagc ctctcagtca gcgctgcagt cccaacagcc
     3361 tccacgggag cagcccctgc caccagcgcc cttggccatg ccccacatca agcccccgcc
     3421 taccactccc atcccccagc tgccggcgcc acaggcccac aagcaccctc cccacctctc
     3481 ggggccctca cccttctcca tgaatgccaa cctgcctccc cctccagccc tgaagcccct
     3541 gagctccctg tccacacatc accccccgtc ggctcacccc ccacccctgc aactcatgcc
     3601 tcagagccag ccattgccct cctcgcccgc ccagcccccc gggctgaccc agagccagaa
     3661 cctgcccccg ccccctgcct cccacccccc tacaggcctc caccaggtgg ccccccaacc
     3721 cccgtttgct cagcacccct ttgtccctgg aggccctcct cccatcaccc ctccgacctg
     3781 cccctccacc tctaccccac cggcgggacc tggcacctcg gcccagccac cctgctctgg
     3841 tgcggcggct tcaggaggca gcatagcggg ggggtcgtcc tgcccactcc ccaccgtcca
     3901 gatcaaggag gaggctctgg acgacgctga ggagcctgag agcccccctc ccccaccaag
     3961 gagcccgtcc ccggagccca ctgtggtgga cacccccagt cacgccagcc agtcagctag
     4021 gttctacaaa cacctggacc ggggctacaa ctcgtgtgcc cggacagacc tgtacttcat
     4081 gcctctggcc gggtccaagc tggccaagaa gagggaggag gccattgaga aggccaagcg
     4141 cgaggctgag cagaaagccc gagaggagcg agagcgggag aaggagaagg agaaggagcg
     4201 ggagcgggag cgagagcggg agcgcgaggc agagcgggcg gctaaggcgt ccagctcagc
     4261 gcatgaaggt cgcctcagtg acccacagct cagtggtcct ggccacatgc ggccatcctt
     4321 cgagccacca ccaaccacca ttgctgctgt gcccccctac atcgggcccg acacacctgc
     4381 ccttcggact ctgagcgagt acgcccggcc ccacgtcatg tcgcccacca accgcaacca
     4441 ccccttctac atgcccctta accccacgga ccccctgctg gcctaccaca tgcctggcct
     4501 ctacaacgtc gaccccacca tccgcgagcg ggagctccgg gagcgggaga tccgagagcg
     4561 ggagatccga gagcgggagc tgcgggagag gatgaagccg ggcttcgagg tgaagccccc
     4621 agagctggac cccctgcacc cagccgccaa ccccatggag cactttgccc ggcacagcgc
     4681 cctcaccatc cccccgaccg ccgggcccca cccttttgct tctttccacc cgggcctgaa
     4741 ccccttggag agggagagac tggccctggc gggcccccag ctgcggcccg agatgagcta
     4801 ccctgacaga ctggcagccg agcgtatcca cgcagagcgc atggcatcgc tgaccagcga
     4861 tcccctggcc cgactgcaga tgttcaacgt gactccgcac catcaccagc actctcacat
     4921 tcactcccac ctccacctcc accagcagga ccccctccac caaggttcag caggccccgt
     4981 tcacccgctg gtcgaccccc tgactgccgg tccccacctg gctcgcttcc cctacccgcc
     5041 tggcactctc cccaaccctc tgcttggaca gcccccacac gagcacgaga tgcttcgcca
     5101 cccagttttc ggcaccccct acccccgtga cctgcctggg gccatcccac cccccatgtc
     5161 agcagcccac cagctgcagg ccatgcatgc ccagtcggcc gagctgcaga gactggccat
     5221 ggagcagcag tggctgcatg gacaccccca catgcatggt ggccacctac caagtcagga
     5281 agattattac agtcgactga agaaagaagg tgacaagcag ttataagtta tttatttgtt
     5341 aacgctggct gtggaaaccc cagttcttgg ggggagaaac aggacttttt acataaaata
     5401 ggagctgcaa aagcaaaaag aatatcttct aaagatttct ttatatattt aaaaacccac
     5461 aactaaaaat gtatccacat agtagtgttc gtttgtcgag aggatttcct gagactggtt
     5521 tggatctccc tgcatgacag tcccccagaa acttagtgag tcctggactg gactgaacat
     5581 ccagaaagct tccctgcaat cttggggttt ggctttagtt ttcttttcct tgatttctca
     5641 gtaggtgcta gaatccagtt cacacccttc actgtgcgtg cagacacact gacacactcc
     5701 gccacgagtg ctccagagcc cacgaggctt gcagatcggg ggcataggaa tttggaatcc
     5761 aagagctata atttttaaaa aaaaaaatct tttattttaa tacattgtag gaaatcttca
     5821 taattggaga aagttctgca gcatggcttt ttacgtctgt aaataaataa ttttagaaca
     5881 gccttttttt cttccataaa ctactattgt gatctatttt ttccagccat gtcactaatt
     5941 gtgaattcct accaactatt gacagaatac agagttgatt ttttaataaa aagttatata
     6001 taattatccc tttaattaaa gggagcaaag gggcgttcca catggacaga ggcttggacc
     6061 gaggcctggt cacagcagcg agcatccagg gtttgcaggg acgatgttac agactctgtt
     6121 ttctgcctgg cgtttcactt gtgtctgctc ctagcctgtg ctctgccagc agcacagaca
     6181 tctgctccat cagacctctt ccattttgca cagggagtgc aggaggtgaa tgttcacttt
     6241 ctgttctcca gtgtcactgt tctgtttcca cgggatggaa agcgcatggg cctgtgtcca
     6301 ttgtagattt ccttctagat ttctgtgtac acacacttga ttgttctgga tgaatgtctt
     6361 ttttaatact ccgaaaattt catcatctaa gaaaatgatt ccatacaaat aactcagcac
     6421 acaagtgacc caggacatat gcctgccaaa gggatgtgtt agaaggctgc cttctcatgc
     6481 gcattgtcac ttggatcttg tggtgaggac ggccccatct ttcttgccac agattgaggc
     6541 cacttttgag caagggagat cctggagtta agacaggtgt tgggggcagc ctgtatttta
     6601 ccctaggggc aggtctgcat ggtgacccca cattgcactg gtaaaccatt tgagtcccac
     6661 tcttcatcct ggaagtggga actggagtcc cacccacagt gcattcagaa agcatgctgt
     6721 gtgggggctg cttctcagga ggccaggccc ttctgagcgg aaccgtcctg gagagagcct
     6781 gccctcgttt ccaggctgca gccgtaacgc actttctccc aggctgaggg cgggtgttct
     6841 ggggtgtctg ccctctgtcg gccctgcttc ctgccaggac gtggcctctt ccgatccttt
     6901 tctctcagac actggaggtc tcttctgcca ttgtgctggt cccatcccaa gaattgtagg
     6961 acagagacca cactgggtcg gcggacacaa agtccatcca ggacccaggc cgcagaggga
     7021 gcaggaagag atgctgatag tttgatctag aaaccagcag ctactggctc aaattcaggt
     7081 tctggcgtca aatagcgaca tttccagttt ctcttaaaaa ccgtgtttgg tttcagttgg
     7141 gataggcttg ttttgtctgt tgaaaatgtt tctagttttt tttctttcat ttttctctca
     7201 ttccatttct gccttaactt tagtttgttc acagggaggc aaagctgaca tgaacctttt
     7261 gtcgtgggac ttcaggccac attggcttga aggcattcgt ttccttctgg ggtggggaca
     7321 ggccctcatg gcaggcttgt tcccgtggct ctgagcgagg cctcttcctg ctgggctccc
     7381 agactcctgc atccaggccc ccaccttctc ggcttctggt ttttctttct ttttggtaga
     7441 acacaacatc taccattcag ttaaaccttc tttatctcct cctttggcat ccatttttcc
     7501 aaagaagagt cgagtcctct gaggtctgtg cttgaaagcc gtccgaaggc attcttgtta
     7561 gctttgcttt tctccccata tcccaaggcg aagcgctgag attcttccat ctaaaaaacc
     7621 ctcgacccga aaccctcacc agataaacta cagtttgttt aggaggccct gaccttcatg
     7681 gtgtctttga agcccaacca ctcggtttcc ttcggatttt cctccctttg ttcggggttt
     7741 ggtttggctc ctctgtgtgt gtccgtatct tgttcggtgt cctcgaggtt gagcttcact
     7801 ccactgcggc agaggcagcg tgcacactcg gatttgctac gtttctatat atcttgaagc
     7861 taaatgtata tatgagtagt ttgccatgag ataacacagt gtaaacagta gacacccaga
     7921 aatcgtgact tctgtgttct ctccatttga gtattttgta atttttttga aatatttgtg
     7981 gacataaata aaaccaagct acactacaa
//
