LOCUS       NM_001286611            4533 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens RALBP1 associated Eps domain containing 1 (REPS1),
            transcript variant 3, mRNA.
ACCESSION   NM_001286611 XM_005267176
VERSION     NM_001286611.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4533)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4533)
  AUTHORS   Kim,S.H., Cho,J.H., Park,B.O., Park,B.C., Kim,J.H., Park,S.G. and
            Kim,S.
  TITLE     Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling
            of transferrin receptor
  JOURNAL   BMB Rep 54 (5), 272-277 (2021)
   PUBMED   33407999
  REMARK    GeneRIF: Phosphorylation of REPS1 at Ser709 by RSK attenuates the
            recycling of transferrin receptor.
REFERENCE   4  (bases 1 to 4533)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   5  (bases 1 to 4533)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4533)
  AUTHORS   Cullis,D.N., Philip,B., Baleja,J.D. and Feig,L.A.
  TITLE     Rab11-FIP2, an adaptor protein connecting cellular components
            involved in internalization and recycling of epidermal growth
            factor receptors
  JOURNAL   J Biol Chem 277 (51), 49158-49166 (2002)
   PUBMED   12364336
REFERENCE   7  (bases 1 to 4533)
  AUTHORS   Xu,J., Zhou,Z., Zeng,L., Huang,Y., Zhao,W., Cheng,C., Xu,M., Xie,Y.
            and Mao,Y.
  TITLE     Cloning, expression and characterization of a novel human REPS1
            gene
  JOURNAL   Biochim Biophys Acta 1522 (2), 118-121 (2001)
   PUBMED   11750063
REFERENCE   8  (bases 1 to 4533)
  AUTHORS   Ikeda,M., Ishida,O., Hinoi,T., Kishida,S. and Kikuchi,A.
  TITLE     Identification and characterization of a novel protein interacting
            with Ral-binding protein 1, a putative effector protein of Ral
  JOURNAL   J Biol Chem 273 (2), 814-821 (1998)
   PUBMED   9422736
REFERENCE   9  (bases 1 to 4533)
  AUTHORS   Yamaguchi,A., Urano,T., Goi,T. and Feig,L.A.
  TITLE     An Eps homology (EH) domain protein that binds to the Ral-GTPase
            target, RalBP1
  JOURNAL   J Biol Chem 272 (50), 31230-31234 (1997)
   PUBMED   9395447
REFERENCE   10 (bases 1 to 4533)
  AUTHORS   Cantor,S.B., Urano,T. and Feig,L.A.
  TITLE     Identification and characterization of Ral-binding protein 1, a
            potential downstream target of Ral GTPases
  JOURNAL   Mol Cell Biol 15 (8), 4578-4584 (1995)
   PUBMED   7623849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012764.2, AF251052.1,
            AK312938.1, CA424106.1, AA025663.1, AA653442.1, R51073.1 and
            AL121834.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001286611.1.
            
            SUMMARY: This gene encodes a signaling adaptor protein with two EH
            domains that interacts with proteins that participate in signaling,
            endocytosis and cytoskeletal changes. The encoded protein has been
            found in association with intersectin 1 and Src homology 3-domain
            growth factor receptor-bound 2-like (endophilin) interacting
            protein 1 when intersectin 1 was isolated from clathrin-coated
            pits. The encoded protein has also been shown to interact with
            amphiphysin, a cytoplasmic protein at the surface of synaptic
            vesicles. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Mar
            2014].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2257912.1, AF251052.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450536.7/ ENSP00000392065.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               BC012764.2         9-642
            635-2453            AF251052.1         1-1819
            2454-2538           AK312938.1         2158-2242
            2539-3154           AF251052.1         1905-2520
            3155-3357           CA424106.1         199-401             c
            3358-3372           AA025663.1         1-15                c
            3373-3543           CA424106.1         18-188              c
            3544-3986           AA653442.1         24-466              c
            3987-4011           R51073.1           18-42               c
            4012-4533           AL121834.20        131352-131873       c
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..4533
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="RALBP1 associated Eps domain containing 1"
                     /db_xref="GeneID:85021"
                     /db_xref="HGNC:HGNC:15578"
                     /db_xref="MIM:614825"
     exon            1..724
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..2962
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="isoform c is encoded by transcript variant 3;
                     ralBP1-interacting protein 1"
                     /codon_start=1
                     /product="ralBP1-associated Eps domain-containing protein
                     1 isoform c"
                     /protein_id="NP_001273540.1"
                     /db_xref="CCDS:CCDS69213.1"
                     /db_xref="GeneID:85021"
                     /db_xref="HGNC:HGNC:15578"
                     /db_xref="MIM:614825"
                     /translation="MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQL
                     PNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFV
                     ASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEP
                     ASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVW
                     SGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYD
                     DPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDK
                     DGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGS
                     PAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAI
                     VHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNT
                     VADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMN
                     RTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQ
                     PNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTA
                     ASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRS
                     VGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL"
     exon            725..848
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1045
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1199
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1324
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1487
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1551
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1706
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1828
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1909
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1997
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2099
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2172
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2291
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2356
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2542
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2638
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2787
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2893
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..4533
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3061..3066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3091
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
     regulatory      3136..3141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="major polyA site"
     polyA_site      3477
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
     regulatory      3522..3527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="hexamer: AATACA"
     polyA_site      3543
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
     regulatory      3989..3994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="hexamer: AATAAA"
     polyA_site      4011
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="hexamer: ATTAAA"
     polyA_site      4324
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
                     /note="hexamer: AATAAA"
     polyA_site      4533
                     /gene="REPS1"
                     /gene_synonym="NBIA7; RALBP1"
ORIGIN      
        1 gtcactgttg gtgcgggcgc gtcggggccg ggccggggca ctgtaaatgg cggcggaggg
       61 aggcggagcg gcggccacgc tcagcccaga tcccccgaaa ctttaggttc gaagccccac
      121 aactttccgg gaagcgctgc cgctccggag gcgtggacgg aaggggaagc cgaggcggga
      181 agtctggggg aatcggcagg gagccgggga gactcgaacc cgcggcgggg gcggagtccg
      241 ccagtgcctc gcgcctccgc ggcccccgcc tctttctctg caccctcccc gcggccggag
      301 ccggagccgg agccggagcc gtagtcgcag ccgcagccgc agccgcgcgc cgggcctcgc
      361 aggcagcggc gcggcgagcg cagccgggcc ccctcctcgc gacctccggg ccctgttgct
      421 cgggcgcacc tggcgcgtgt gaggccgggg ccggcgtttt cgggaagcta gcaggaggcc
      481 gggccacgcg cagcccctgc cggcccaggt tcctggggcc gggccccgag tagtgcatgc
      541 ggggcggggc ggccgtgagc cggaggcgaa gatggaaggc ttaacgctga gcgatgcgga
      601 gcagaaatac tattcagatc tcttctccta ctgcgacatt gagagcacca agaaggtggt
      661 ggtcaacggg cgggtgctgg agctgttccg ggccgcgcag ctgccgaacg acgtggtcct
      721 acagatcatg gagctttgtg gtgcaacaag acttggttat tttggaagaa gtcagttcta
      781 cattgctttg aaacttgtag ctgttgccca gtctggtttc cctttaagag tggaaagtat
      841 aaatacagta aaggaccttc ctctgccaag atttgttgct tcaaagaatg aacaggaatc
      901 tcgccatgca gcctcatatt cttcagattc tgaaaatcaa gggtcgtatt ctggtgtaat
      961 tcccccacca cctggcaggg ggcaagtgaa aaagggatcc gtaagccatg atacggttca
     1021 gcctcgtaca tctgcagatg cacaggaacc tgcatcccca gtagtttcac cacagcaatc
     1081 cccaccaact tctccacaca catggaggaa gcacagccgt catcccagcg gtgggaatag
     1141 tgagaggcct ctcgcgggac ctgggccatt ttggtctccc tttggtgaag cacaatcagg
     1201 ttcttctgct ggtgatgcag tgtggtcagg gcattcccca cctccacctc aagaaaactg
     1261 ggtcagtttt gcagatactc caccaaccag tactctttta accatgcatc ctgcttctgt
     1321 ccaggaccag acaacagtac gaactgtagc atcagctaca actgccattg aaattcgtag
     1381 gcaatccagt agttatgatg atccctggaa aataacagat gaacaaagac agtattatgt
     1441 aaatcagttt aaaaccattc agcctgatct aaacggattt attccaggat ctgcagctaa
     1501 agagtttttt acaaaatcaa aacttcctat tcttgaactt tctcatattt gggaactctc
     1561 agactttgat aaagatggtg cattgacact ggatgagttt tgtgctgctt ttcatctggt
     1621 ggttgctagg aagaatggct atgatttacc agaaaaactt cctgaaagct taatgcccaa
     1681 actgattgat ttggaagatt cagcagatgt tggggatcag ccaggtgagg taggttattc
     1741 aggctctcct gctgaagctc ctccaagcaa gtcaccatcg atgccatcac taaaccagac
     1801 atggcctgag ctgaatcaga gcagtgagca gtgggagaca tttagtgaac gctcttcaag
     1861 ctcacaaact ctgacccaat ttgattctaa cattgcacca gctgatcctg atactgctat
     1921 tgttcatcca gttcccattc gtatgactcc aagcaaaatc cacatgcagg aaatggaact
     1981 taaaagaact ggcagcgatc atacaaatcc cactagccca ttacttgtga aaccatctga
     2041 ccttttagaa gaaaataaga taaattcatc ggtgaaattc gcttctggta atactgtagc
     2101 agatggttac agtagttcag actcttttac ttctgaccca gaacagatcg ggagcaatgt
     2161 aactcgtcaa aggtctcatt caggaacgtc gcctgataac actgcaccac cacctccccc
     2221 tccaaggcca cagccctctc attctagatc atcatcttta gatatgaatc ggacctttac
     2281 agtcaccaca ggacaacaac aggctggagt tgttgcccat cctcctgcag tgcctccaag
     2341 accacagccc tcacaggctc ctggtcctgc tgtgcatcgc ccagtggatg ccgatggcct
     2401 cataactcac actagtacct cacctcagca gataccagag caaccaaatt ttgcagattt
     2461 cagtcagttt gaagtatttg ctgcatcaaa tgtaaacgac gaacaagatg atgaagccga
     2521 gaaacatcca gaagtcctgc cggctgaaaa agcttctgat cctgcaagtt ctcttcgagt
     2581 tgccaaaaca gatagtaaaa ctgaagaaaa gacagctgct agtgctcctg ccaatgtgag
     2641 caaaggcaca acaccacttg ctccaccacc taaacctgtt cgaagaagat taaaatcaga
     2701 agatgaatta aggccagaag ttgatgaaca tacacaaaag acgggtgtct tagctgctgt
     2761 tcttgcatca caaccttcta ttcccagatc tgttgggaaa gataagaaag ctattcaggc
     2821 atcaattaga cgtaataagg aaaccaacac cgttttggcc agattgaata gcgaattgca
     2881 gcaacaatta aaggatgttc ttgaggagag aatttccctg gaagttcaac tggaacaact
     2941 tcgaccattc tctcacctat aagccaattg ccgttaactg tgaacatact tgtttttaag
     3001 tggttttggg ttcaaagcca atttggagac ctagacattc agctcactgc ttaactcaac
     3061 attaaatttt atgattctgt tttgccctat atgttcaccg ttgtatttaa gtatctttta
     3121 ttttttaatt tcgacaataa aaaggtcagg atggcgtttt ctggagggta gattgtgttt
     3181 gttggcacac ccaccttttc tgttccctag catctgggat atgcaatgct tctatggcta
     3241 ataccacaca ccaatttaat ttatagaatg ggctcctcat ttacatctca gtcacagact
     3301 cagaaataaa ttgtcagttt gtccttttat gtttaatatt ttacataaag catctattct
     3361 ataaaaatct ttagaaagag tttcccattt aattttgatt ttaaagaatt atattggata
     3421 aggtggtttt caccataagc taatttactc tctgcagccg tctacattct tcacaaatca
     3481 tgtggtacat tgaagcctct tttacatgtc aacttgtgac aaatacaaac atgtgagatt
     3541 ttatattttc cttgtggaaa tgtgatcaac ttcatcagcg acttcgaact attttatgag
     3601 attcaataat tcagcagtca tgtaaactta tgaaataggt atgagtaatg gcctttctta
     3661 atttttttaa gtattgtttt aaaacttctg aggatatcag ttattcccag aataaaggga
     3721 aattccttag gatttctagt ttacctttag ccatcttgtc actcattctt ttgctataca
     3781 gacaagtttt tcctattaat gagtttctgg agtatgcctt attcaggaca atatgctgtt
     3841 ttagattttg tttaatatta aatgatatat acatttcgat ccattgctaa cagcagatat
     3901 tccctttaag atttattctg tctataggat catagatttt aaactgcatg gatatatctt
     3961 ggcagaatca gaagtgtggt tttacaccaa taaaacagca taatatttta acttttgttc
     4021 atctttttaa caagatttaa agttttaaga aatagaagat tttgtatttt catttctgaa
     4081 agaaaaaatg tttaaatact atagattcac agtcctaaac tgcaccgata gactttgtta
     4141 ctgtaaacaa gaatttgaag aacaagggaa actgacaacc tcaagcttcc aagattaata
     4201 caatttttac ctgacaatat ctaggtaaaa atatacatca gctgaagttt ccaagtggct
     4261 ttcagtatgg ctttagttgt taaataataa atttaaagca ttaaaggccc aggaaactac
     4321 tcaacacctg tttttctgag tgtctttgtt ttcaaagaaa catttttact cagctgtatt
     4381 tcattacaag caagttttgc tgtttccatt tagttttgtt ttttaaaata tgctttttaa
     4441 aaatagcctt ctaatttaac aatgtcaaaa atatttgtta aagcttctta gaatttagcc
     4501 ttccaataaa taacacttaa aaattataga aaa
//
