LOCUS       NM_001362747            2929 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens replication initiator 1 (REPIN1), transcript variant
            6, mRNA.
ACCESSION   NM_001362747 XM_006715953
VERSION     NM_001362747.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2929)
  AUTHORS   Xia,Y., Ge,G., Xiao,H., Wu,M., Wang,T., Gu,C., Yang,H. and Geng,D.
  TITLE     REPIN1 regulates iron metabolism and osteoblast apoptosis in
            osteoporosis
  JOURNAL   Cell Death Dis 14 (9), 631 (2023)
   PUBMED   37749079
  REMARK    GeneRIF: REPIN1 regulates iron metabolism and osteoblast apoptosis
            in osteoporosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2929)
  AUTHORS   Sun,Y., Sun,W., Hua,H., Zhang,J., Yu,Q., Wang,J., Liu,X. and
            Dong,A.
  TITLE     Overexpression of miR-127 Predicts Poor Prognosis and Contributes
            to the Progression of Papillary Thyroid Cancer by Targeting REPIN1
  JOURNAL   Horm Metab Res 53 (3), 197-203 (2021)
   PUBMED   33339069
  REMARK    GeneRIF: Overexpression of miR-127 Predicts Poor Prognosis and
            Contributes to the Progression of Papillary Thyroid Cancer by
            Targeting REPIN1.
REFERENCE   3  (bases 1 to 2929)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2929)
  AUTHORS   Abshagen,K., Berger,C., Dietrich,A., Schutz,T., Wittekind,C.,
            Stumvoll,M., Bluher,M. and Kloting,N.
  TITLE     A Human REPIN1 Gene Variant: Genetic Risk Factor for the
            Development of Nonalcoholic Fatty Liver Disease
  JOURNAL   Clin Transl Gastroenterol 11 (1), e00114 (2020)
   PUBMED   31922994
  REMARK    GeneRIF: A Human REPIN1 Gene Variant: Genetic Risk Factor for the
            Development of Nonalcoholic Fatty Liver Disease.
REFERENCE   5  (bases 1 to 2929)
  AUTHORS   Wang,Y. and Lin,Y.
  TITLE     Hsa-mir-127 impairs survival of patients with glioma and promotes
            proliferation, migration and invasion of cancerous cells by
            modulating replication initiator 1
  JOURNAL   Neuroreport 29 (14), 1166-1173 (2018)
   PUBMED   29979259
  REMARK    GeneRIF: Increased expression of hsa-mir-127 and decreased
            expression of REPIN1 were both associated with poor overall
            survival
REFERENCE   6  (bases 1 to 2929)
  AUTHORS   Montigny,W.J., Houchens,C.R., Illenye,S., Gilbert,J., Coonrod,E.,
            Chang,Y.C. and Heintz,N.H.
  TITLE     Condensation by DNA looping facilitates transfer of large DNA
            molecules into mammalian cells
  JOURNAL   Nucleic Acids Res 29 (9), 1982-1988 (2001)
   PUBMED   11328883
REFERENCE   7  (bases 1 to 2929)
  AUTHORS   Houchens,C.R., Montigny,W., Zeltser,L., Dailey,L., Gilbert,J.M. and
            Heintz,N.H.
  TITLE     The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers:
            DNA binding and looping by the central three fingers and an
            associated proline-rich region
  JOURNAL   Nucleic Acids Res 28 (2), 570-581 (2000)
   PUBMED   10606657
REFERENCE   8  (bases 1 to 2929)
  AUTHORS   Mastrangelo,I.A., Held,P.G., Dailey,L., Wall,J.S., Hough,P.V.,
            Heintz,N. and Heintz,N.H.
  TITLE     RIP60 dimers and multiples of dimers assemble link structures at an
            origin of bidirectional replication in the dihydrofolate reductase
            amplicon of Chinese hamster ovary cells
  JOURNAL   J Mol Biol 232 (3), 766-778 (1993)
   PUBMED   8355269
REFERENCE   9  (bases 1 to 2929)
  AUTHORS   Caddle,M.S., Dailey,L. and Heintz,N.H.
  TITLE     RIP60, a mammalian origin-binding protein, enhances DNA bending
            near the dihydrofolate reductase origin of replication
  JOURNAL   Mol Cell Biol 10 (12), 6236-6243 (1990)
   PUBMED   2247056
REFERENCE   10 (bases 1 to 2929)
  AUTHORS   Dailey,L., Caddle,M.S., Heintz,N. and Heintz,N.H.
  TITLE     Purification of RIP60 and RIP100, mammalian proteins with
            origin-specific DNA-binding and ATP-dependent DNA helicase
            activities
  JOURNAL   Mol Cell Biol 10 (12), 6225-6235 (1990)
   PUBMED   2174103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD675150.1, CX166683.1 and BC000363.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001362747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.166977.1,
                                           DRR138512.201015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               CD675150.1         4-480
            478-545             CX166683.1         748-815
            546-2929            BC000363.2         470-2853
FEATURES             Location/Qualifiers
     source          1..2929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2929
                     /gene="REPIN1"
                     /gene_synonym="AP4; RIP60; Zfp464; ZNF464"
                     /note="replication initiator 1"
                     /db_xref="GeneID:29803"
                     /db_xref="HGNC:HGNC:17922"
                     /db_xref="MIM:619039"
     exon            1..120
                     /gene="REPIN1"
                     /gene_synonym="AP4; RIP60; Zfp464; ZNF464"
                     /inference="alignment:Splign:2.1.0"
     exon            121..2929
                     /gene="REPIN1"
                     /gene_synonym="AP4; RIP60; Zfp464; ZNF464"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1835
                     /gene="REPIN1"
                     /gene_synonym="AP4; RIP60; Zfp464; ZNF464"
                     /note="isoform 1 is encoded by transcript variant 6;
                     replication initiation region protein (60kD); zinc finger
                     protein 464 (RIP60); H_DJ0584D14.12; zinc finger protein
                     AP4; ATT-binding protein; DHFR oribeta-binding protein
                     RIP60; 60 kDa origin-specific DNA-binding protein; 60 kDa
                     replication initiation region protein; DNA-binding protein
                     REPIN1"
                     /codon_start=1
                     /product="DNA-binding protein REPIN1 isoform 1"
                     /protein_id="NP_001349676.1"
                     /db_xref="CCDS:CCDS43677.1"
                     /db_xref="GeneID:29803"
                     /db_xref="HGNC:HGNC:17922"
                     /db_xref="MIM:619039"
                     /translation="MLERRCRGPLAMGLAQPRLLSGPSQESPQTLGKESRGLRQQGTS
                     VAQSGAQAPGRAHRCAHCRRHFPGWVALWLHTRRCQARLPLPCPECGRRFRHAPFLAL
                     HRQVHAAATPDLGFACHLCGQSFRGWVALVLHLRAHSAAKRPIACPKCERRFWRRKQL
                     RAHLRRCHPPAPEARPFICGNCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPRPRG
                     RPAVTAPRPGGDAVDRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQCPECGKRFTNK
                     PYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEGSAQAAPGPGSPQLPA
                     GPQESAAEPTPAVPLKPAQEPPPGAPPEHPQDPIEAPPSLYSCDDCGRSFRLERFLRA
                     HQRQHTGERPFTCAECGKNFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHR
                     RDHAPDRPFVCPDCGKAFRHKPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNLVSHRRI
                     HTGERPYACPDCDRSFSQKSNLITHRKSHIRDGAFCCAICGQTFDDEERLLAHQKKHD
                     V"
     regulatory      2909..2914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REPIN1"
                     /gene_synonym="AP4; RIP60; Zfp464; ZNF464"
                     /note="hexamer: AATAAA"
     polyA_site      2929
                     /gene="REPIN1"
                     /gene_synonym="AP4; RIP60; Zfp464; ZNF464"
                     /note="major polyA site"
ORIGIN      
        1 agttgtgaac tcgaacctgc cgctgtcgcc gcggcggggc ggggagcgag agtgggccgc
       61 ggaggccggc cttcgggctc catggacggg cgccgcgtcc ctgcacagcc cgccgcagag
      121 aggaagaacc gatgctggaa cgtcgttgca ggggccccct ggccatgggc ctggcccagc
      181 cccgactcct ttctgggccc tcccaggagt caccccagac cctggggaag gagtcccgcg
      241 ggctgaggca acaaggcacg tcagtggccc agtctggtgc ccaagcccca ggcagggccc
      301 atcgctgtgc ccactgtcga aggcacttcc ctggctgggt ggctctgtgg cttcacaccc
      361 gccggtgcca ggcccggctg cccttgccct gccctgagtg tggccgtcgc tttcgccatg
      421 cccccttctt agcactgcac cgccaggtcc atgctgctgc caccccagac ctgggctttg
      481 cctgccacct ctgtgggcag agcttccgag gctgggtggc cctggttctg catctgcggg
      541 cccattcagc tgcaaagcgg cccatcgctt gtcccaaatg cgagagacgc ttctggcgac
      601 gaaagcagct tcgagctcat ctgcggcggt gccaccctcc cgccccggag gcccggccct
      661 tcatatgcgg caactgtggc cggagctttg cccagtggga ccagctagtt gcccacaagc
      721 gggtgcacgt agctgaggcc ctggaggagg ccgcagccaa ggctctgggg ccccggccca
      781 ggggccgccc cgcggtgacc gccccccggc ccggtggaga tgccgtcgac cgccccttcc
      841 agtgtgcctg ttgtggcaag cgcttccggc acaagcccaa cttgatcgct caccgccgcg
      901 tgcacacggg cgagcggccc caccagtgcc ccgagtgcgg gaagcgcttt accaataagc
      961 cctatctgac ttcgcaccgg cgcatccaca ccggcgagaa gccctacccg tgcaaagagt
     1021 gcggccgccg cttccggcac aaacccaacc tgctgtctca cagcaagatt cacaagcgat
     1081 ccgaggggtc ggcccaggcc gcccccggcc cggggagccc ccagctgcca gccggccccc
     1141 aggagtccgc ggccgagccc accccggcgg tacctctgaa accggcccag gagccgccgc
     1201 caggggcccc gccagagcac ccgcaggacc cgatcgaagc ccccccctcc ctctacagct
     1261 gcgacgactg cggcaggagc ttccggctgg agcgcttcct gcgggcccac cagcggcagc
     1321 acaccgggga gcggcccttc acctgcgccg agtgcgggaa gaacttcggc aagaagacgc
     1381 acctggtggc gcactcgcgc gtgcactccg gcgagcggcc cttcgcctgc gaggagtgcg
     1441 gccgccgctt ctcccagggc agccatctgg cggcgcatcg gcgcgaccac gcccccgatc
     1501 ggcccttcgt gtgtcccgac tgcggcaagg ccttccgcca caaaccctac ctggcggcgc
     1561 accggcgcat ccacaccggc gagaagccct acgtctgccc cgactgcggc aaagccttca
     1621 gccagaagtc caacctggtg tcgcaccggc gcatccacac gggcgagcgg ccctacgcct
     1681 gtcccgactg cgaccgcagc ttcagccaga agtccaacct catcacccac cgcaagagcc
     1741 acatccggga cggcgccttc tgctgtgcca tctgtggcca gaccttcgac gacgaggaga
     1801 gactcctggc ccaccagaag aagcacgatg tctgagacgg tgggcggggc cgtgttggct
     1861 gagagagggc tggggtcctt cgtggtggga gtcgcagtgg gctgggggtg cctgcctagt
     1921 gctggagtag gggacaatgg gaatcctaga ggggatggaa gacgcgggga gtgagctggg
     1981 tgggccctgc tagcgagaga ggtcaacccc ggtggccagg gaacccactt ccaagcgcag
     2041 ggacgccggc ctccagctgg tgtgtgctaa ggctccgtcc tgactgccct gtgccctgga
     2101 aaagcagcaa tagcatccgc cccttagagc cctctggcta gaggagccac cagtggaaag
     2161 gaagaccctc catcctctgg tattaacgcc ttaatgcccc tgtcttttac tgtaagttac
     2221 ttaagatcat ttttggaagc aggcgtggta gagtcctgta aatgaatgct ctgggctaga
     2281 tacagcttgg agaacctgct ggccttgtta gacagcactt gggcctttgc cagcagcaag
     2341 aggtgaagcg aagccactct tacctctccc ttcccctccc acctgccccc tgcgtaggca
     2401 cccagacttg gagagacccg tctgctgtta atacttccat cctcttcctt cccaaagagc
     2461 agatcccaag gcatttactc cttggtctgt ctcgctttat ctgtcgcccc tcccagcgct
     2521 gagagcctcc cctggctgtc agcagcactg tgtccaggct cttgtctgaa caccgcagcc
     2581 cctccttcgc tccttccaga gctcagcatg tcacggcaag gactgccgca ttggtgatgg
     2641 agggccagct gaggggaagt tgctggtgag tttccttttc tccatttcta gcatatggac
     2701 acctggcctc tgcttgagca cttaggtgac aggaacttcc gcacctcctg aggccctgga
     2761 tgattctaat tgttagaaat tctaattgtt agaaatcctt ccttataatg aatgaattct
     2821 gctttcctat aatttctacc tattgggcct tgttctgttc tctggaacta aacagaacaa
     2881 ccatttaccc ctccttttca aactagagaa taaagatttg gttttagaa
//
