LOCUS       NM_001029874            1150 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB15 effector protein (REP15), mRNA.
ACCESSION   NM_001029874 XM_370686
VERSION     NM_001029874.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Strick,D.J. and Elferink,L.A.
  TITLE     Rab15 effector protein: a novel protein for receptor recycling from
            the endocytic recycling compartment
  JOURNAL   Mol Biol Cell 16 (12), 5699-5709 (2005)
   PUBMED   16195351
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009509.7.
            
            On May 17, 2019 this sequence version replaced NM_001029874.2.
            
            Summary: The protein encoded by this intronless gene interacts with
            GTP-bound Rab15 and is involved in recycling of transferrin
            receptor from the endocytic recycling compartment to the cell
            surface. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803611.34150.1, BC140921.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310791.4/ ENSP00000310335.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AC009509.7         110351-111500
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..1150
                     /gene="REP15"
                     /gene_synonym="RAB15EP"
                     /note="RAB15 effector protein"
                     /db_xref="GeneID:387849"
                     /db_xref="HGNC:HGNC:33748"
                     /db_xref="MIM:610848"
     exon            1..1150
                     /gene="REP15"
                     /gene_synonym="RAB15EP"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..827
                     /gene="REP15"
                     /gene_synonym="RAB15EP"
                     /codon_start=1
                     /product="rab15 effector protein"
                     /protein_id="NP_001025045.3"
                     /db_xref="CCDS:CCDS31762.1"
                     /db_xref="GeneID:387849"
                     /db_xref="HGNC:HGNC:33748"
                     /db_xref="MIM:610848"
                     /translation="MGQKASQQLALKDSKEVPVVCEVVSEAIVHAAQKLKEYLGFEYP
                     PSKLCPAANTLNEIFLIHFITFCQEKGVDEWLTTTKMTKHQAFLFGADWIWTFWGSNK
                     QIKLQLAVQTLQMSSPPPVESKPCDLSNPESRVEESSWKKSRFDKLEEFCNLIGEDCL
                     GLFIIFGMPGKPKDIRGVVLDSVKSQMVRSHLPGGKAVAQFVLETEDCVFIKELLRNC
                     LSKKDGLREVGKVYISIL"
     regulatory      865..870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REP15"
                     /gene_synonym="RAB15EP"
                     /note="hexamer: AAGAAA"
     polyA_site      889
                     /gene="REP15"
                     /gene_synonym="RAB15EP"
                     /note="major polyA site"
ORIGIN      
        1 gtagagttag aaaaacatga accattaaca gatgtggcct ccctgcagaa cttttacttt
       61 gaaaaagaag tacgtctgaa ccagattcac atgtttgata tttggatgca gagaaaatgg
      121 ggcagaaagc atcgcaacag ttggctctga aggacagcaa agaggtgccc gtcgtctgtg
      181 aggtggtcag tgaagctata gtccatgcag ctcagaaact gaaggagtac cttggatttg
      241 aatatcctcc aagtaaactc tgcccagctg caaatactct gaatgagatc ttcttaatcc
      301 atttcatcac tttctgccaa gaaaagggag ttgatgagtg gctgaccacc accaagatga
      361 ccaagcacca agccttcctg tttggtgcag actggatttg gaccttttgg ggatccaaca
      421 agcaaataaa gcttcagctc gcagtacaga ctctgcagat gtcttcacct cctcctgtgg
      481 aatctaagcc ttgtgacctt tccaatccag aatcaagggt agaggagtct tcctggaaga
      541 aaagtagatt tgataagctg gaagaattct gtaacttaat aggagaggat tgcctgggtc
      601 tgtttatcat ctttggtatg ccaggaaagc ctaaagacat caggggagtt gtcctggaca
      661 gtgtcaaaag tcagatggtg aggagccatc tgccaggagg gaaggctgtg gctcagtttg
      721 tcctggaaac tgaagattgt gtgttcatca aagagctgct cagaaattgt ctgagtaaga
      781 aagacgggct gagagaggtg ggcaaggttt atatcagcat tctctgactt ggatatgtat
      841 tatgtgagtg gcctgtaaga ggaaaagaaa aaaagattct aataagcaag ctcacctatt
      901 tgcatcattc cagcatggga ttttttttca tttgttttcc cattgattga aaatgattac
      961 tgggatcaaa gtacattcat gtcgcaatta cagagagaga gagaaaaaaa gaaaaccctg
     1021 gctctgccta tgatttaaaa acagttcagg aaaagttata atttagttta atatttcatt
     1081 cacttattca ataataaaaa tggaagagag ataataaagt cacatttaaa gtttgatttg
     1141 caaaaaaaaa
//
