LOCUS       NM_002910               1334 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens renin binding protein (RENBP), mRNA.
ACCESSION   NM_002910
VERSION     NM_002910.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Wong,E.H., So,H.C., Li,M., Wang,Q., Butler,A.W., Paul,B., Wu,H.M.,
            Hui,T.C., Choi,S.C., So,M.T., Garcia-Barcelo,M.M., McAlonan,G.M.,
            Chen,E.Y., Cheung,E.F., Chan,R.C., Purcell,S.M., Cherny,S.S.,
            Chen,R.R., Li,T. and Sham,P.C.
  TITLE     Common variants on Xq28 conferring risk of schizophrenia in Han
            Chinese
  JOURNAL   Schizophr Bull 40 (4), 777-786 (2014)
   PUBMED   24043878
  REMARK    GeneRIF: rs2269372 in RENBP was associated with risk of
            schizophrenia in a Han Chinese population.
REFERENCE   3  (bases 1 to 1334)
  AUTHORS   Dong,Y., Ding,Y., Cun,Y. and Xiao,C.
  TITLE     Association of renin binding protein (RnBP) gene polymorphisms with
            essential hypertension in the Hani minority of southwestern China
  JOURNAL   J Genet Genomics 40 (8), 433-436 (2013)
   PUBMED   23969252
  REMARK    GeneRIF: several SNPs and haplotypes of the RnBP gene are
            associated with either increased or decreased risk of developing
            essential hypertension.
REFERENCE   4  (bases 1 to 1334)
  AUTHORS   Bergfeld,A.K., Pearce,O.M., Diaz,S.L., Pham,T. and Varki,A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   5  (bases 1 to 1334)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 1334)
  AUTHORS   Faranda,S., Frattini,A. and Vezzoni,P.
  TITLE     The human genes encoding renin-binding protein and host cell factor
            are closely linked in Xq28 and transcribed in the same direction
  JOURNAL   Gene 155 (2), 237-239 (1995)
   PUBMED   7721097
REFERENCE   7  (bases 1 to 1334)
  AUTHORS   Takahashi,S., Inoue,H. and Miyake,Y.
  TITLE     The human gene for renin-binding protein
  JOURNAL   J Biol Chem 267 (18), 13007-13013 (1992)
   PUBMED   1618798
REFERENCE   8  (bases 1 to 1334)
  AUTHORS   Inoue,H., Takahashi,S., Fukui,K. and Miyake,Y.
  TITLE     Genetic and molecular properties of human and rat renin-binding
            proteins with reference to the function of the leucine zipper motif
  JOURNAL   J Biochem 110 (4), 493-500 (1991)
   PUBMED   1723410
REFERENCE   9  (bases 1 to 1334)
  AUTHORS   Takahashi,S., Miura,R. and Miyake,Y.
  TITLE     A study on renin binding protein (RnBP) in the human kidney
  JOURNAL   J Biochem 97 (2), 671-677 (1985)
   PUBMED   3924907
REFERENCE   10 (bases 1 to 1334)
  AUTHORS   Murakami,K., Hirose,S., Chino,S., Ueno,N. and Miyazaki,H.
  TITLE     Properties of renin-binding protein
  JOURNAL   Clin Exp Hypertens A 4 (11-12), 2073-2081 (1982)
   PUBMED   6756682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK298125.1, D10232.1 and
            BC015558.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002910.5.
            
            Summary: The gene product inhibits renin activity by forming a
            dimer with renin, a complex known as high molecular weight renin.
            The encoded protein contains a leucine zipper domain, which is
            essential for its dimerization with renin. The gene product can
            catalyze the interconversion of N-acetylglucosamine to
            N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase.
            Transcript variants utilizing alternative promoters have been
            described in the literature. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and PMID:1618798.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015558.2, SRR1163657.3013.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393700.8/ ENSP00000377303.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-720               AK298125.1         1-720
            721-1333            D10232.1           688-1300
            1334-1334           BC015558.2         1314-1314
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1334
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /note="renin binding protein"
                     /db_xref="GeneID:5973"
                     /db_xref="HGNC:HGNC:9959"
                     /db_xref="MIM:312420"
     exon            1..60
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1317
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /EC_number="5.1.3.8"
                     /note="GlcNAc 2-epimerase; N-acetyl-D-glucosamine
                     2-epimerase; AGE"
                     /codon_start=1
                     /product="N-acylglucosamine 2-epimerase"
                     /protein_id="NP_002901.2"
                     /db_xref="CCDS:CCDS14738.2"
                     /db_xref="GeneID:5973"
                     /db_xref="HGNC:HGNC:9959"
                     /db_xref="MIM:312420"
                     /translation="MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQE
                     HGGFFTCLGREGRVYDDLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLL
                     RYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEM
                     MDQIVHWVQEDASGLGRPQLQGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGD
                     WCARRILQHVQRDGQAVLENVSEGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDP
                     ELRAHVIDKFLLLPFHSGWDPDHGGLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFL
                     MGYSDSGDPVLLRLFYQVAEYTFRQFRDPEYGEWFGYLSREGKVALSIKGGPFKGCFH
                     VPRCLAMCEEMLGALLSRPAPAPSPAPTPACRGAE"
     exon            61..170
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            171..246
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            247..322
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            323..495
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            496..720
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            721..802
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            803..978
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1110
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1198
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1334
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1313..1318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /note="hexamer: AATAAA"
     polyA_site      1334
                     /gene="RENBP"
                     /gene_synonym="RBP; RNBP"
                     /note="major polyA site"
ORIGIN      
        1 aactctgtct ggcttcctag aggagcagga gggatgagca agggtctccc agcgcgacag
       61 gacatggaga aagagcgaga gactctgcag gcctggaagg agcgcgtggg gcaggagctg
      121 gaccgcgtgg tggctttctg gatggagcac tcccacgacc aggagcacgg gggcttcttc
      181 acgtgccttg gccgcgaggg gcgggtgtat gatgacctca agtatgtgtg gctgcagggg
      241 aggcaggtat ggatgtattg tcgcctgtac cgcactttcg agcgcttccg ccatgctcag
      301 cttctggacg cagcaaaagc aggtggtgag ttcttgctgc ggtatgcccg ggtggcacct
      361 cctggcaaga agtgtgcctt tgtgctgact cgggacggcc gcccggtcaa ggtgcagcga
      421 accatcttca gtgagtgttt ctacaccatg gccatgaacg agctgtggag agccacaggg
      481 gaagtgcggt accagacgga agcggtggag atgatggatc agatcgtcca ctgggtgcag
      541 gaggacgcgt cgggactggg ccggccccag ctccaggggg ccccggctgc ggagcccatg
      601 gcggtgccca tgatgctact gaacctggtg gagcagctcg gggaggcaga tgaggagctg
      661 gcgggcaaat acgcagagct gggggactgg tgcgcccgga ggattctgca gcacgtgcag
      721 agggatggac aagctgtgct ggagaatgtg tcagagggtg gcaaggaact tcctggctgc
      781 ctggggagac agcagaaccc aggccacacg ctggaagccg gctggtttct gctccgtcat
      841 tgcattcgga aaggcgaccc cgaacttcga gcccacgtga ttgacaagtt cctattgttg
      901 cccttccact ccggatggga ccctgaccac ggaggcctct tttacttcca ggatgctgat
      961 aacttctgcc ccacccagct ggagtgggcc atgaagctct ggtggccaca cagtgaagcc
     1021 atgattgcct tcctcatggg ttacagtgac agtggggacc ctgtgctgct gcgcctcttc
     1081 taccaagtgg ctgagtacac cttccgccag tttcgcgatc ccgagtacgg ggaatggttt
     1141 ggctacctga gccgagaggg caaggtggcc ctctccatca agggaggtcc tttcaaaggc
     1201 tgcttccacg tgccgcggtg cctagccatg tgcgaggaga tgctgggcgc cctgctgagc
     1261 cgccccgccc ccgccccctc ccccgccccc acccccgcct gccgaggcgc ggaataaagg
     1321 ctgagtccgc tcca
//
