LOCUS       NM_000537               1462 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens renin (REN), mRNA.
ACCESSION   NM_000537
VERSION     NM_000537.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Buonfiglio,F., Pfeiffer,N. and Gericke,A.
  TITLE     Glaucoma and the ocular renin-angiotensin-aldosterone system:
            Update on molecular signalling and treatment perspectives
  JOURNAL   Cell Signal 122, 111343 (2024)
   PUBMED   39127136
  REMARK    GeneRIF: Glaucoma and the ocular renin-angiotensin-aldosterone
            system: Update on molecular signalling and treatment perspectives.
            Review article
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Labandeira-Garcia,J.L., Labandeira,C.M., Guerra,M.J. and
            Rodriguez-Perez,A.I.
  TITLE     The role of the brain renin-angiotensin system in Parkinson s
            disease
  JOURNAL   Transl Neurodegener 13 (1), 22 (2024)
   PUBMED   38622720
  REMARK    GeneRIF: The role of the brain renin-angiotensin system in
            Parkinson s disease.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Chakradhar,A., Baron,R.M., Vera,M.P., Devarajan,P., Chawla,L. and
            Hou,P.C.
  TITLE     Plasma renin as a novel prognostic biomarker of sepsis-associated
            acute respiratory distress syndrome
  JOURNAL   Sci Rep 14 (1), 6667 (2024)
   PUBMED   38509149
  REMARK    GeneRIF: Plasma renin as a novel prognostic biomarker of
            sepsis-associated acute respiratory distress syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Mkhize,B.C., Mosili,P., Ngubane,P.S., Sibiya,N.H. and Khathi,A.
  TITLE     The Relationship between Renin-Angiotensin-Aldosterone System
            (RAAS) Activity, Osteoporosis and Estrogen Deficiency in Type 2
            Diabetes
  JOURNAL   Int J Mol Sci 24 (15), 11963 (2023)
   PUBMED   37569338
  REMARK    GeneRIF: The Relationship between Renin-Angiotensin-Aldosterone
            System (RAAS) Activity, Osteoporosis and Estrogen Deficiency in
            Type 2 Diabetes.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Chen,H., Peng,J., Wang,T., Wen,J., Chen,S., Huang,Y. and Zhang,Y.
  TITLE     Counter-regulatory renin-angiotensin system in hypertension: Review
            and update in the era of COVID-19 pandemic
  JOURNAL   Biochem Pharmacol 208, 115370 (2023)
   PUBMED   36481346
  REMARK    GeneRIF: Counter-regulatory renin-angiotensin system in
            hypertension: Review and update in the era of COVID-19 pandemic.
            Review article
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Zivna,M., Kidd,K., Kmoch,S. and Bleyer,A.J.
  TITLE     Autosomal Dominant Tubulointerstitial Kidney Disease - REN
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21473025
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Dhanaraj,V., Dealwis,C.G., Frazao,C., Badasso,M., Sibanda,B.L.,
            Tickle,I.J., Cooper,J.B., Driessen,H.P., Newman,M., Aguilar,C. et
            al.
  TITLE     X-ray analyses of peptide-inhibitor complexes define the structural
            basis of specificity for human and mouse renins
  JOURNAL   Nature 357 (6378), 466-472 (1992)
   PUBMED   1608447
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Benjannet,S., Reudelhuber,T., Mercure,C., Rondeau,N., Chretien,M.
            and Seidah,N.G.
  TITLE     Proprotein conversion is determined by a multiplicity of factors
            including convertase processing, substrate specificity, and
            intracellular environment. Cell type-specific processing of human
            prorenin by the convertase PC1
  JOURNAL   J Biol Chem 267 (16), 11417-11423 (1992)
   PUBMED   1597471
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   van Hooft,I.M., Grobbee,D.E., Derkx,F.H., de Leeuw,P.W.,
            Schalekamp,M.A. and Hofman,A.
  TITLE     Renal hemodynamics and the renin-angiotensin-aldosterone system in
            normotensive subjects with hypertensive and normotensive parents
  JOURNAL   N Engl J Med 324 (19), 1305-1311 (1991)
   PUBMED   2017226
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Ishizuka,Y., Shoda,A., Yoshida,S., Kawamura,Y., Haraguchi,K. and
            Murakami,K.
  TITLE     Isolation and characterization of recombinant human prorenin in
            Chinese hamster ovary cells
  JOURNAL   J Biochem 109 (1), 30-35 (1991)
   PUBMED   2016271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP321283.1 and BC033474.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000537.3.
            
            Summary: This gene encodes renin, an aspartic protease that is
            secreted by the kidneys. Renin is a part of the
            renin-angiotensin-aldosterone system involved in regulation of
            blood pressure, and electrolyte balance. This enzyme catalyzes the
            first step in the activation pathway of angiotensinogen by cleaving
            angiotensinogen to form angiotensin I, which is then converted to
            angiotensin II by angiotensin I converting enzyme. This cascade can
            result in aldosterone release, narrowing of blood vessels, and
            increase in blood pressure as angiotension II is a vasoconstrictive
            peptide. Transcript variants that encode different protein isoforms
            and that arise from alternative splicing and the use of alternative
            promoters have been described, but their full-length nature has not
            been determined. Mutations in this gene have been shown to cause
            hyperuricemic nephropathy familial juvenile 2, familial
            hyperproreninemia, and renal tubular dysgenesis. [provided by
            RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.71284.1,
                                           SRR5189667.180113.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000272190.9/ ENSP00000272190.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP321283.1         1-18
            19-1462             BC033474.1         1-1444
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1462
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /note="renin"
                     /db_xref="GeneID:5972"
                     /db_xref="HGNC:HGNC:9958"
                     /db_xref="MIM:179820"
     exon            1..142
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1265
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /EC_number="3.4.23.15"
                     /note="renin precursor, renal; angiotensin-forming enzyme;
                     angiotensinogenase"
                     /codon_start=1
                     /product="renin preproprotein"
                     /protein_id="NP_000528.1"
                     /db_xref="CCDS:CCDS30981.1"
                     /db_xref="GeneID:5972"
                     /db_xref="HGNC:HGNC:9958"
                     /db_xref="MIM:179820"
                     /translation="MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRE
                     SLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVV
                     FDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQ
                     DIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGV
                     LKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSV
                     GSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDI
                     SFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTE
                     FDRRNNRIGFALAR"
     exon            143..293
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            294..417
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            418..536
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            537..733
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            734..742
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            743..862
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1004
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1103
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1462
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /note="hexamer: AATAAA"
     polyA_site      1462
                     /gene="REN"
                     /gene_synonym="ADTKD4; HNFJ2; RTD"
                     /note="major polyA site"
ORIGIN      
        1 agaacctcag tggatctcag agagagcccc agactgaggg aagcatggat ggatggagaa
       61 ggatgcctcg ctggggactg ctgctgctgc tctggggctc ctgtaccttt ggtctcccga
      121 cagacaccac cacctttaaa cggatcttcc tcaagagaat gccctcaatc cgagaaagcc
      181 tgaaggaacg aggtgtggac atggccaggc ttggtcccga gtggagccaa cccatgaaga
      241 ggctgacact tggcaacacc acctcctccg tgatcctcac caactacatg gacacccagt
      301 actatggcga gattggcatc ggcaccccac cccagacctt caaagtcgtc tttgacactg
      361 gttcgtccaa tgtttgggtg ccctcctcca agtgcagccg tctctacact gcctgtgtgt
      421 atcacaagct cttcgatgct tcggattcct ccagctacaa gcacaatgga acagaactca
      481 ccctccgcta ttcaacaggg acagtcagtg gctttctcag ccaggacatc atcaccgtgg
      541 gtggaatcac ggtgacacag atgtttggag aggtcacgga gatgcccgcc ttacccttca
      601 tgctggccga gtttgatggg gttgtgggca tgggcttcat tgaacaggcc attggcaggg
      661 tcacccctat cttcgacaac atcatctccc aaggggtgct aaaagaggac gtcttctctt
      721 tctactacaa cagagattcc gagaattccc aatcgctggg aggacagatt gtgctgggag
      781 gcagcgaccc ccagcattac gaagggaatt tccactatat caacctcatc aagactggtg
      841 tctggcagat tcaaatgaag ggggtgtctg tggggtcatc caccttgctc tgtgaagacg
      901 gctgcctggc attggtagac accggtgcat cctacatctc aggttctacc agctccatag
      961 agaagctcat ggaggccttg ggagccaaga agaggctgtt tgattatgtc gtgaagtgta
     1021 acgagggccc tacactcccc gacatctctt tccacctggg aggcaaagaa tacacgctca
     1081 ccagcgcgga ctatgtattt caggaatcct acagtagtaa aaagctgtgc acactggcca
     1141 tccacgccat ggatatcccg ccacccactg gacccacctg ggccctgggg gccaccttca
     1201 tccgaaagtt ctacacagag tttgatcggc gtaacaaccg cattggcttc gccttggccc
     1261 gctgaggccc tctgccaccc aggcaggccc tgccttcagc cctggcccag agctggaaca
     1321 ctctctgaga tgcccctctg cctgggctta tgccctcaga tggagacatt ggatgtggag
     1381 ctcctgctgg atgcgtgccc tgacccctgc accagccctt ccctgctttg aggacaaaga
     1441 gaataaagac ttcatgttca ca
//
